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The map label for this gene is crt [H]

Identifier: 222094643

GI number: 222094643

Start: 973359

End: 974147

Strand: Direct

Name: crt [H]

Synonym: BCQ_0981

Alternate gene names: 222094643

Gene position: 973359-974147 (Clockwise)

Preceding gene: 222094642

Following gene: 222094646

Centisome position: 18.67

GC content: 39.42

Gene sequence:

>789_bases
ATGGAAGTAACAAGTAAAACAGAATCTGTCATTGTGAAATATGAAGGGCACGTTGCAACGGTTATGGTCAATCGCCCAGA
GGTGTTAAATGCATTAGATGAGCCAACGTTAAAAGAGCTATTACAAAAATTGAAAGAAGTAGCGGAGAGTTCTGCACACA
TTGTTGTGTTATGCGGGAACGGCCGTGGTTTTTCTGCGGGTGGAGATATTAAATCGATGCTTTCAAGTAATGATGAAAGT
AAGTTTGATGGTATTATGAATACTATTTCTGAAGTTGTTGTGACTTTATATACGATGCCGAAGCTTGTTATTAGTGCGAT
TCATGGACCAACTGCTGGTCTTGGATTAAGTATTGCACTAACAGCTGACTATGTGATGGCAGATATATCATCCATTATTG
CGATGAACTTTATTGGAATCGCTTTAATTCCAGATGGTGGCGGCCATTTCTTCCTTCAAAAACGCGTCGGTGAAAATATG
ACGAAGCAAATTATTTGGGAAGGAAAGAAATTATCGGCGAGCGAAGCGCTTGAAATCGGTTTAATTGATGAAGTAATCGG
CGAGGATTTCCAAACGGCTGTGAAGCAAAAAATTAGTGAATGGTCACAAAAGCCGATCAAAGCGATGATTCAAACGAAGC
AAATTTTATGTGAAGTAAACCGTTCTAATTTAGAACAAACACTGCAGCTTGAAAAACGCGGCCAATATGCGATGAGACAA
ACAGCGGATCATAAAGAGGGCATCGCTGCATTTTTAGAAAAACGTTTGCCAGCATTTAAAGGAGAATAA

Upstream 100 bases:

>100_bases
AGATTATTAGACAGAAAATTAAGAAAAAAAGAAGGGTTTTTCACATCCTTTCTATAATTATATAAGTATAATCTTTGTGT
AGAAAAGAGGGGTATATATA

Downstream 100 bases:

>100_bases
AGTGTAGTAATAGTTTTACTAACGGTTAATTTAAGGTAAAGGGGAGAAAGTGCTAACACATTTTAGTATAATTGTGTTAG
CACTTTTTTTAGGAGTAATA

Product: enoyl-CoA hydratase

Products: crotonoyl-CoA; H2O

Alternate protein names: NA

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MEVTSKTESVIVKYEGHVATVMVNRPEVLNALDEPTLKELLQKLKEVAESSAHIVVLCGNGRGFSAGGDIKSMLSSNDES
KFDGIMNTISEVVVTLYTMPKLVISAIHGPTAGLGLSIALTADYVMADISSIIAMNFIGIALIPDGGGHFFLQKRVGENM
TKQIIWEGKKLSASEALEIGLIDEVIGEDFQTAVKQKISEWSQKPIKAMIQTKQILCEVNRSNLEQTLQLEKRGQYAMRQ
TADHKEGIAAFLEKRLPAFKGE

Sequences:

>Translated_262_residues
MEVTSKTESVIVKYEGHVATVMVNRPEVLNALDEPTLKELLQKLKEVAESSAHIVVLCGNGRGFSAGGDIKSMLSSNDES
KFDGIMNTISEVVVTLYTMPKLVISAIHGPTAGLGLSIALTADYVMADISSIIAMNFIGIALIPDGGGHFFLQKRVGENM
TKQIIWEGKKLSASEALEIGLIDEVIGEDFQTAVKQKISEWSQKPIKAMIQTKQILCEVNRSNLEQTLQLEKRGQYAMRQ
TADHKEGIAAFLEKRLPAFKGE
>Mature_262_residues
MEVTSKTESVIVKYEGHVATVMVNRPEVLNALDEPTLKELLQKLKEVAESSAHIVVLCGNGRGFSAGGDIKSMLSSNDES
KFDGIMNTISEVVVTLYTMPKLVISAIHGPTAGLGLSIALTADYVMADISSIIAMNFIGIALIPDGGGHFFLQKRVGENM
TKQIIWEGKKLSASEALEIGLIDEVIGEDFQTAVKQKISEWSQKPIKAMIQTKQILCEVNRSNLEQTLQLEKRGQYAMRQ
TADHKEGIAAFLEKRLPAFKGE

Specific function: Could Possibly Oxidizes Fatty Acids Using Specific Components (By Similarity). [C]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=273, Percent_Identity=32.967032967033, Blast_Score=98, Evalue=8e-21,
Organism=Homo sapiens, GI45643119, Length=223, Percent_Identity=25.1121076233184, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI260275230, Length=223, Percent_Identity=25.1121076233184, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI260274832, Length=223, Percent_Identity=25.1121076233184, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4757966, Length=190, Percent_Identity=26.3157894736842, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI51538581, Length=190, Percent_Identity=26.3157894736842, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI25453481, Length=181, Percent_Identity=25.9668508287293, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI51538573, Length=181, Percent_Identity=25.9668508287293, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI4757968, Length=181, Percent_Identity=25.414364640884, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI49355787, Length=181, Percent_Identity=25.414364640884, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI116235487, Length=180, Percent_Identity=27.2222222222222, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI68989263, Length=212, Percent_Identity=26.8867924528302, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI70995211, Length=262, Percent_Identity=24.4274809160305, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1787659, Length=255, Percent_Identity=28.6274509803922, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1787660, Length=260, Percent_Identity=31.5384615384615, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI87082183, Length=254, Percent_Identity=25.9842519685039, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI221142681, Length=269, Percent_Identity=24.5353159851301, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI1788597, Length=265, Percent_Identity=22.6415094339623, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1788682, Length=176, Percent_Identity=25, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI25145438, Length=250, Percent_Identity=32.8, Blast_Score=100, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17554946, Length=254, Percent_Identity=30.3149606299213, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17535521, Length=254, Percent_Identity=25.9842519685039, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI25144157, Length=186, Percent_Identity=27.9569892473118, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25144160, Length=181, Percent_Identity=28.7292817679558, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17536985, Length=212, Percent_Identity=26.8867924528302, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI20129971, Length=249, Percent_Identity=29.718875502008, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24653477, Length=249, Percent_Identity=29.718875502008, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24654903, Length=239, Percent_Identity=22.5941422594142, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24653139, Length=274, Percent_Identity=23.3576642335766, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28571730, Length=161, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28571729, Length=161, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: 4.2.1.55

Molecular weight: Translated: 28651; Mature: 28651

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVTSKTESVIVKYEGHVATVMVNRPEVLNALDEPTLKELLQKLKEVAESSAHIVVLCGN
CCCCCCCCEEEEEECCEEEEEEECCHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEECC
GRGFSAGGDIKSMLSSNDESKFDGIMNTISEVVVTLYTMPKLVISAIHGPTAGLGLSIAL
CCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEH
TADYVMADISSIIAMNFIGIALIPDGGGHFFLQKRVGENMTKQIIWEGKKLSASEALEIG
HHHHHHHHHHHHHHHHHHEEEEEECCCCCEEHHHHHCCHHHHHHHHCCCCCCHHHHHHHH
LIDEVIGEDFQTAVKQKISEWSQKPIKAMIQTKQILCEVNRSNLEQTLQLEKRGQYAMRQ
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCHHHHHH
TADHKEGIAAFLEKRLPAFKGE
HCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MEVTSKTESVIVKYEGHVATVMVNRPEVLNALDEPTLKELLQKLKEVAESSAHIVVLCGN
CCCCCCCCEEEEEECCEEEEEEECCHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEECC
GRGFSAGGDIKSMLSSNDESKFDGIMNTISEVVVTLYTMPKLVISAIHGPTAGLGLSIAL
CCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEH
TADYVMADISSIIAMNFIGIALIPDGGGHFFLQKRVGENMTKQIIWEGKKLSASEALEIG
HHHHHHHHHHHHHHHHHHEEEEEECCCCCEEHHHHHCCHHHHHHHHCCCCCCHHHHHHHH
LIDEVIGEDFQTAVKQKISEWSQKPIKAMIQTKQILCEVNRSNLEQTLQLEKRGQYAMRQ
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCHHHHHH
TADHKEGIAAFLEKRLPAFKGE
HCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxybutanoyl-CoA

Specific reaction: (3R)-3-hydroxybutanoyl-CoA = crotonoyl-CoA + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377; 9579061 [H]