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The map label for this gene is lctP [H]

Identifier: 222094362

GI number: 222094362

Start: 672825

End: 674444

Strand: Reverse

Name: lctP [H]

Synonym: BCQ_0676

Alternate gene names: 222094362

Gene position: 674444-672825 (Counterclockwise)

Preceding gene: 222094365

Following gene: 222094361

Centisome position: 12.93

GC content: 35.8

Gene sequence:

>1620_bases
ATGAGTACTTGGACACAAATTTATGACCCATTAAACAATATTTGGTTATCTGCTCTAATCGCAGCACTTCCAATTTTTTG
CTTCATCATTTGTTTAATGGGACTGAAAATGAAAAGTTATATCGCTGGGCTTTACAGTGTGATTGTCGCTATTATTCTTG
CTATATTCGTTTATAAAATGCCAGCAACAGTAGCTGTAGCATCTGCCGGATTCGGTATTTTATCTGGATTTTACCCAATT
TGTACTATCGTTATCGCAGCAATTTTCCTTTACAAATTAACTGTTAAAACAGAGCAATTCAACATCATTCGTGATAGTAT
TTCAAGCATTACAAATGATCAACGTTTACAAGTATTATTAATCGCTTATTCTTTCGGTGCTTTCTTAGAAGGCGCAGCTG
GTCTAGGGGTTCCAGTTGCTATTACAGCTGCACTACTTGTAGGTATGGGCTTTAATCCATTAAAAGCAGCAGGTATTTGT
TTAGTAGCAAACATCGCTGGTGGTGCTATGGGTGCTATGGGTATCCCAGTTACAGTACCAGCACAATTAACTGAATTAGA
TGCATTAACTATCGGTCGTCAAACTGTTCTTATTCTACCATTCATTAGTATTGTATTACCTTTCTTACTTGTTTCAATGG
TCGATGGAATTAAAGGTATTAAAGAAACTTGGCAAGGTATTCTTGTAAGTGGTATTTCTTTCGCAATTACTCAGTTCGTT
GTAACTTACTTCTTAGGCGCAGAACTTACTAATATTTTCGCAGCCGTTGTAAGTATGATCTCTCTTGCATTATTCTTACG
TGTTTGGCAGCCAAAATCTTCTGCTAAAGAAGAAAAACAAGAAGAAAACGAATCTCATACATTCAATCAAATTTTATATG
CTTGGTCTCCATTCGTATTCTTAACTGCATTTGTAACAATTTTTAATTTAAAACCAATTAAAGCTTTATTTGCTCCGGAT
GGCGCACTAGCAAACCTAGTATTTAACATTCAATTCCCTGGTCTTCATAACGCTGTTATGAAAACTACACCAATTACAAA
AGCTGATACACCTTTCGCAGCGGTTTTCAAATTTGATGTATTCTCATCTACAACTACTGCAATCGTATTAGCAATTATCG
TTTCACTTATCGTGTACCGCGTAAAAGGTAAAATGGTTAAAGAATTAATGGTTGAAACAATAAAAGAACTAAAAGCTCCA
GTGTATACAATCTGTAGTGTTATCGCTTTAGCTTACGTGGAAAACTACTCTGGTATGTCATCTACACTTGGACTTGCATT
CTCTTCTACTGGTAATGCATTCCCAATTCTTTCTCCAATCTTAGGATGGATTGGCGTATTCATTACAGGTTCAGTAGTAT
CAAGTGGTTCATTATTCGCACCGCTTCAAGCAGTAACTGCAGATCAATTAAACATCGTTCCTTCTACTCTTGTTGCATTA
AACGTAGTAGGTGGTACAATGGCAAAAATGGTTTCACCACAATCTGTAGCAGTTGCTTGTGCAGCAGTTGGACTAGTTGG
TAAAGAATCTGCCCTATTTAAAACAGCAATGAAATACAGTTTAATCTTCTTAGCTATCATTAGCTTACTTCAATTAAACG
CTGTATTTAATATCTTTTAA

Upstream 100 bases:

>100_bases
AGTGTTGAAGGAGAATATACTAAGCATGTAAGTTGATTGTGAATAGTTTCACAAATTATGTGAATTTCTTCACATAAAAT
AGATAGGAGTTGTCATTATT

Downstream 100 bases:

>100_bases
AAATTAAAATAAGTGATAATAAAGAAGGAAAAAGTCCCGTTACAAATCGGGACTTTTCCTTTTTTCAATTTCTTAATAAA
TCATTTTAATGGTTAAATTT

Product: L-lactate permease

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 539; Mature: 538

Protein sequence:

>539_residues
MSTWTQIYDPLNNIWLSALIAALPIFCFIICLMGLKMKSYIAGLYSVIVAIILAIFVYKMPATVAVASAGFGILSGFYPI
CTIVIAAIFLYKLTVKTEQFNIIRDSISSITNDQRLQVLLIAYSFGAFLEGAAGLGVPVAITAALLVGMGFNPLKAAGIC
LVANIAGGAMGAMGIPVTVPAQLTELDALTIGRQTVLILPFISIVLPFLLVSMVDGIKGIKETWQGILVSGISFAITQFV
VTYFLGAELTNIFAAVVSMISLALFLRVWQPKSSAKEEKQEENESHTFNQILYAWSPFVFLTAFVTIFNLKPIKALFAPD
GALANLVFNIQFPGLHNAVMKTTPITKADTPFAAVFKFDVFSSTTTAIVLAIIVSLIVYRVKGKMVKELMVETIKELKAP
VYTICSVIALAYVENYSGMSSTLGLAFSSTGNAFPILSPILGWIGVFITGSVVSSGSLFAPLQAVTADQLNIVPSTLVAL
NVVGGTMAKMVSPQSVAVACAAVGLVGKESALFKTAMKYSLIFLAIISLLQLNAVFNIF

Sequences:

>Translated_539_residues
MSTWTQIYDPLNNIWLSALIAALPIFCFIICLMGLKMKSYIAGLYSVIVAIILAIFVYKMPATVAVASAGFGILSGFYPI
CTIVIAAIFLYKLTVKTEQFNIIRDSISSITNDQRLQVLLIAYSFGAFLEGAAGLGVPVAITAALLVGMGFNPLKAAGIC
LVANIAGGAMGAMGIPVTVPAQLTELDALTIGRQTVLILPFISIVLPFLLVSMVDGIKGIKETWQGILVSGISFAITQFV
VTYFLGAELTNIFAAVVSMISLALFLRVWQPKSSAKEEKQEENESHTFNQILYAWSPFVFLTAFVTIFNLKPIKALFAPD
GALANLVFNIQFPGLHNAVMKTTPITKADTPFAAVFKFDVFSSTTTAIVLAIIVSLIVYRVKGKMVKELMVETIKELKAP
VYTICSVIALAYVENYSGMSSTLGLAFSSTGNAFPILSPILGWIGVFITGSVVSSGSLFAPLQAVTADQLNIVPSTLVAL
NVVGGTMAKMVSPQSVAVACAAVGLVGKESALFKTAMKYSLIFLAIISLLQLNAVFNIF
>Mature_538_residues
STWTQIYDPLNNIWLSALIAALPIFCFIICLMGLKMKSYIAGLYSVIVAIILAIFVYKMPATVAVASAGFGILSGFYPIC
TIVIAAIFLYKLTVKTEQFNIIRDSISSITNDQRLQVLLIAYSFGAFLEGAAGLGVPVAITAALLVGMGFNPLKAAGICL
VANIAGGAMGAMGIPVTVPAQLTELDALTIGRQTVLILPFISIVLPFLLVSMVDGIKGIKETWQGILVSGISFAITQFVV
TYFLGAELTNIFAAVVSMISLALFLRVWQPKSSAKEEKQEENESHTFNQILYAWSPFVFLTAFVTIFNLKPIKALFAPDG
ALANLVFNIQFPGLHNAVMKTTPITKADTPFAAVFKFDVFSSTTTAIVLAIIVSLIVYRVKGKMVKELMVETIKELKAPV
YTICSVIALAYVENYSGMSSTLGLAFSSTGNAFPILSPILGWIGVFITGSVVSSGSLFAPLQAVTADQLNIVPSTLVALN
VVGGTMAKMVSPQSVAVACAAVGLVGKESALFKTAMKYSLIFLAIISLLQLNAVFNIF

Specific function: Transports glycolate across the membrane. Can also transport L-lactate and D-lactate. Seems to be driven by a proton motive force [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=550, Percent_Identity=50.9090909090909, Blast_Score=528, Evalue=1e-151,
Organism=Escherichia coli, GI1790031, Length=538, Percent_Identity=49.814126394052, Blast_Score=503, Evalue=1e-143,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 57541; Mature: 57410

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STWTQIYDPLNNIWLSALIAALPIFCFIICLMGLKMKSYIAGLYSVIVAIILAIFVYKM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PATVAVASAGFGILSGFYPICTIVIAAIFLYKLTVKTEQFNIIRDSISSITNDQRLQVLL
CHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCHHEEEH
IAYSFGAFLEGAAGLGVPVAITAALLVGMGFNPLKAAGICLVANIAGGAMGAMGIPVTVP
HHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHCCCCEEEECCCCCCCCCCCCEECC
AQLTELDALTIGRQTVLILPFISIVLPFLLVSMVDGIKGIKETWQGILVSGISFAITQFV
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTYFLGAELTNIFAAVVSMISLALFLRVWQPKSSAKEEKQEENESHTFNQILYAWSPFVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LTAFVTIFNLKPIKALFAPDGALANLVFNIQFPGLHNAVMKTTPITKADTPFAAVFKFDV
HHHHHHHHCCCHHHHHHCCCCCCEEEEEEEECCCCHHHHHHCCCCCCCCCCHHHHEEEHH
FSSTTTAIVLAIIVSLIVYRVKGKMVKELMVETIKELKAPVYTICSVIALAYVENYSGMS
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCC
STLGLAFSSTGNAFPILSPILGWIGVFITGSVVSSGSLFAPLQAVTADQLNIVPSTLVAL
HHHCEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHH
NVVGGTMAKMVSPQSVAVACAAVGLVGKESALFKTAMKYSLIFLAIISLLQLNAVFNIF
HHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 11283302; 11785976 [H]