Click here to switch to the map view.

The map label for this gene is hemL [H]

Identifier: 222094266

GI number: 222094266

Start: 557896

End: 559200

Strand: Reverse

Name: hemL [H]

Synonym: BCQ_0559

Alternate gene names: 222094266

Gene position: 559200-557896 (Counterclockwise)

Preceding gene: 222094273

Following gene: 222094265

Centisome position: 10.72

GC content: 39.77

Gene sequence:

>1305_bases
ATGGTAGTGAAATTCACAAAATCAGAAGCATTACATAAAGAAGCTTTAGAACATATCGTTGGCGGTGTTAATAGTCCTTC
TCGTTCTTTTAAAGCAGTTGGTGGCGGCGCTCCTGTTGCTATGGAACGTGGAAAAGGTGCTTATTTCTGGGATGTAGACG
GAAATAAATATATCGATTATTTAGCAGCATACGGTCCTATTATTACTGGACATGCTCACCCGCACATTACAAAAGCAATT
ACAACAGCTGCTGAAAATGGTGTACTTTACGGAACTCCAACAGCGCTAGAAGTAAAATTTGCAAAAATGTTAAAAGAAGC
AATGCCTGCATTAGATAAAGTTCGCTTCGTAAACTCTGGTACTGAAGCTGTAATGACAACAATTCGTGTCGCTCGCGCTT
ACACAGGCCGCACAAAAATTATGAAATTCGCTGGTTGTTACCACGGTCATTCTGATTTAGTACTTGTAGCAGCTGGATCT
GGCCCTTCTACACTAGGAACTCCTGACTCAGCGGGTGTACCACAAAGTATCGCTCAAGAAGTTATTACCGTTCCATTTAA
TAATGTAGAAACTTTAAAAGAAGCATTAGATAAATGGGGACATGAAGTAGCAGCTATTCTTGTAGAACCAATCGTTGGAA
ACTTCGGTATTGTAGAGCCAAAACCTGGCTTCCTTGAGAAAGTGAATGAACTTGTTCACGAAGCTGGTGCACTAGTAATT
TATGATGAAGTTATTACTGCTTTCCGCTTCATGTACGGTGGTGCTCAAGACTTACTTGGCGTAACACCAGACTTAACAGC
GCTTGGTAAAGTTATTGGCGGCGGACTTCCAATCGGTGCTTACGGTGGTAAGAAAGAAATTATGGAACAAGTTGCCCCTC
TTGGACCTGCATATCAAGCTGGTACAATGGCAGGAAATCCTGCTTCTATGGCATCTGGTATTGCTTGTCTAGAAGTTCTT
CAACAAGAAGGGCTTTATGAAAAATTAGATGAACTTGGTGCAATGCTTGAAAAAGGAATTTTAGAGCAGGCTGAAAAACA
TAATATCGATATTACATTAAACCGCCTAAAAGGCGCTTTAACTGTATACTTCACAACAAATACAATTGAAGATTACGATG
CAGCACAAGATACAGACGGAGAAATGTTCGGTAAATTCTTCAAGCTTATGCTGCAAGAAGGAATTAACTTAGCACCTTCT
AAATACGAGGCATGGTTCTTAACGACAGAACATACAAAAGAAGATATTGAATATACAATTGAAGCTGTAGGTAGAGCATT
TGCTGCTTTAGCAAACAATAAATAA

Upstream 100 bases:

>100_bases
GTCACAACGAATAGTTTACCCAACTGCCTTCTCTATCACAAACAATACGTCTTTTCGAAAAACATGTTAGAATAATACAT
AGATTTTTGTAAGGAGATGA

Downstream 100 bases:

>100_bases
CCCTGCCATTAAAAGGAAAAAAGAAAGCACACCTTTCTTTTTTCCTTTTTTCTATTTCATAAATCCCTCATTAATAGTAT
AATTATTCATAATTATCTGT

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA 1; Glutamate-1-semialdehyde aminotransferase 1; GSA-AT 1 [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MVVKFTKSEALHKEALEHIVGGVNSPSRSFKAVGGGAPVAMERGKGAYFWDVDGNKYIDYLAAYGPIITGHAHPHITKAI
TTAAENGVLYGTPTALEVKFAKMLKEAMPALDKVRFVNSGTEAVMTTIRVARAYTGRTKIMKFAGCYHGHSDLVLVAAGS
GPSTLGTPDSAGVPQSIAQEVITVPFNNVETLKEALDKWGHEVAAILVEPIVGNFGIVEPKPGFLEKVNELVHEAGALVI
YDEVITAFRFMYGGAQDLLGVTPDLTALGKVIGGGLPIGAYGGKKEIMEQVAPLGPAYQAGTMAGNPASMASGIACLEVL
QQEGLYEKLDELGAMLEKGILEQAEKHNIDITLNRLKGALTVYFTTNTIEDYDAAQDTDGEMFGKFFKLMLQEGINLAPS
KYEAWFLTTEHTKEDIEYTIEAVGRAFAALANNK

Sequences:

>Translated_434_residues
MVVKFTKSEALHKEALEHIVGGVNSPSRSFKAVGGGAPVAMERGKGAYFWDVDGNKYIDYLAAYGPIITGHAHPHITKAI
TTAAENGVLYGTPTALEVKFAKMLKEAMPALDKVRFVNSGTEAVMTTIRVARAYTGRTKIMKFAGCYHGHSDLVLVAAGS
GPSTLGTPDSAGVPQSIAQEVITVPFNNVETLKEALDKWGHEVAAILVEPIVGNFGIVEPKPGFLEKVNELVHEAGALVI
YDEVITAFRFMYGGAQDLLGVTPDLTALGKVIGGGLPIGAYGGKKEIMEQVAPLGPAYQAGTMAGNPASMASGIACLEVL
QQEGLYEKLDELGAMLEKGILEQAEKHNIDITLNRLKGALTVYFTTNTIEDYDAAQDTDGEMFGKFFKLMLQEGINLAPS
KYEAWFLTTEHTKEDIEYTIEAVGRAFAALANNK
>Mature_434_residues
MVVKFTKSEALHKEALEHIVGGVNSPSRSFKAVGGGAPVAMERGKGAYFWDVDGNKYIDYLAAYGPIITGHAHPHITKAI
TTAAENGVLYGTPTALEVKFAKMLKEAMPALDKVRFVNSGTEAVMTTIRVARAYTGRTKIMKFAGCYHGHSDLVLVAAGS
GPSTLGTPDSAGVPQSIAQEVITVPFNNVETLKEALDKWGHEVAAILVEPIVGNFGIVEPKPGFLEKVNELVHEAGALVI
YDEVITAFRFMYGGAQDLLGVTPDLTALGKVIGGGLPIGAYGGKKEIMEQVAPLGPAYQAGTMAGNPASMASGIACLEVL
QQEGLYEKLDELGAMLEKGILEQAEKHNIDITLNRLKGALTVYFTTNTIEDYDAAQDTDGEMFGKFFKLMLQEGINLAPS
KYEAWFLTTEHTKEDIEYTIEAVGRAFAALANNK

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=350, Percent_Identity=34, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI13994255, Length=337, Percent_Identity=28.1899109792285, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI37574042, Length=346, Percent_Identity=28.9017341040462, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI24119277, Length=331, Percent_Identity=27.4924471299094, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI226442705, Length=345, Percent_Identity=26.9565217391304, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI226442709, Length=305, Percent_Identity=29.8360655737705, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI284507298, Length=268, Percent_Identity=32.8358208955224, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI1786349, Length=426, Percent_Identity=49.5305164319249, Blast_Score=446, Evalue=1e-126,
Organism=Escherichia coli, GI1789016, Length=338, Percent_Identity=30.7692307692308, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI145693181, Length=438, Percent_Identity=31.0502283105023, Blast_Score=141, Evalue=7e-35,
Organism=Escherichia coli, GI1789759, Length=316, Percent_Identity=31.3291139240506, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1788044, Length=300, Percent_Identity=31, Blast_Score=118, Evalue=9e-28,
Organism=Escherichia coli, GI1787560, Length=323, Percent_Identity=29.7213622291022, Blast_Score=115, Evalue=8e-27,
Organism=Escherichia coli, GI1786991, Length=374, Percent_Identity=23.7967914438503, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI25144271, Length=316, Percent_Identity=32.9113924050633, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI32564660, Length=328, Percent_Identity=29.8780487804878, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71992977, Length=341, Percent_Identity=26.9794721407625, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI25144274, Length=306, Percent_Identity=30.0653594771242, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71981843, Length=168, Percent_Identity=29.1666666666667, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323470, Length=348, Percent_Identity=30.1724137931034, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6324432, Length=356, Percent_Identity=23.876404494382, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21357415, Length=313, Percent_Identity=33.8658146964856, Blast_Score=131, Evalue=8e-31,
Organism=Drosophila melanogaster, GI21356575, Length=326, Percent_Identity=28.8343558282209, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI161085790, Length=353, Percent_Identity=28.0453257790368, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI28574759, Length=353, Percent_Identity=28.0453257790368, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 46490; Mature: 46490

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVKFTKSEALHKEALEHIVGGVNSPSRSFKAVGGGAPVAMERGKGAYFWDVDGNKYIDY
CEEEECHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCEEEECCCCCEEEECCCCHHHHH
LAAYGPIITGHAHPHITKAITTAAENGVLYGTPTALEVKFAKMLKEAMPALDKVRFVNSG
HHHHCCEEECCCCCHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
TEAVMTTIRVARAYTGRTKIMKFAGCYHGHSDLVLVAAGSGPSTLGTPDSAGVPQSIAQE
HHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHH
VITVPFNNVETLKEALDKWGHEVAAILVEPIVGNFGIVEPKPGFLEKVNELVHEAGALVI
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCEEE
YDEVITAFRFMYGGAQDLLGVTPDLTALGKVIGGGLPIGAYGGKKEIMEQVAPLGPAYQA
HHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCC
GTMAGNPASMASGIACLEVLQQEGLYEKLDELGAMLEKGILEQAEKHNIDITLNRLKGAL
CCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEE
TVYFTTNTIEDYDAAQDTDGEMFGKFFKLMLQEGINLAPSKYEAWFLTTEHTKEDIEYTI
EEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHH
EAVGRAFAALANNK
HHHHHHHHHHHCCC
>Mature Secondary Structure
MVVKFTKSEALHKEALEHIVGGVNSPSRSFKAVGGGAPVAMERGKGAYFWDVDGNKYIDY
CEEEECHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCEEEECCCCCEEEECCCCHHHHH
LAAYGPIITGHAHPHITKAITTAAENGVLYGTPTALEVKFAKMLKEAMPALDKVRFVNSG
HHHHCCEEECCCCCHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
TEAVMTTIRVARAYTGRTKIMKFAGCYHGHSDLVLVAAGSGPSTLGTPDSAGVPQSIAQE
HHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHH
VITVPFNNVETLKEALDKWGHEVAAILVEPIVGNFGIVEPKPGFLEKVNELVHEAGALVI
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCEEE
YDEVITAFRFMYGGAQDLLGVTPDLTALGKVIGGGLPIGAYGGKKEIMEQVAPLGPAYQA
HHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCC
GTMAGNPASMASGIACLEVLQQEGLYEKLDELGAMLEKGILEQAEKHNIDITLNRLKGAL
CCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEE
TVYFTTNTIEDYDAAQDTDGEMFGKFFKLMLQEGINLAPSKYEAWFLTTEHTKEDIEYTI
EEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHH
EAVGRAFAALANNK
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA