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The map label for this gene is nupC [H]

Identifier: 222094089

GI number: 222094089

Start: 361159

End: 362355

Strand: Reverse

Name: nupC [H]

Synonym: BCQ_0382

Alternate gene names: 222094089

Gene position: 362355-361159 (Counterclockwise)

Preceding gene: 222094094

Following gene: 222094088

Centisome position: 6.95

GC content: 35.76

Gene sequence:

>1197_bases
ATGCAATATGTAATGAGCATTATCGGTATTCTTGTCGTTTTAGGTTTATGCTTTGCTTTGTCAAACAACAAAAGTAAAAT
CAACTTCCGTGCAATTGCTATTATGATTGGTTTTCAAATTTTAATCGGTTGGTTTATGTTTGGCACAAAGATTGGTCAAC
AAATCATTATTTTCATTGGTAAAGTTTTCAACAAACTAATTAAACTTGGTACGACAGGTGTCGATTTTCTCTTTAATGGG
ATTCAAAGAGATTTTGTCTTTTTCTTAAACGTACTATTAATTATCGTATTTTTCTCAGCACTACTTTCTATCTTTAGTTA
CTTAGGGGTTTTACCATTCATCGTTCGCGTTGTCGGCGGTGCCATTTCAAAAATTACTGGTTTACCACGCGTTGAATCAT
TCCACGCAGTAAACTCTGTATTCTTTGGTTCAAGTGAAGCGTTAATCGTTATTAAAAATGATTTACAACATTTCAATAAA
AACCGTATGTTTATCATTTGTTGTTCTGCAATGAGTTCAGTTTCTGCCTCTGTTACAGCATCATACGTAATGATGTTAGA
TGCGAAATATGTACTAGCAGCTCTTCCGTTAAACTTATTCTCAAGCTTAATCGTTTGTTCGTTATTAACACCTGTTGATA
CGAAAAAAGAAGACGAAGTAGTTCAGAAATTTGATCGTACTTTATTCGGAGACAGCTTTATCGGTGCAATGATTAACGGT
GCACTTGACGGTTTAAAAGTAGCTGGTATCGTTGCCGCATTAATGATCGCCTTCATCGGTGTGATGGAAGTTGTAAACTA
CGTAATTAGTGCCGCTTCAGGTGCAATGGGATATGCTGTTACGTTACAACAAATCTTCGGTTATATACTTGCTCCATTCG
CGTTCTTAATGGGTATTCCAACTCAAGATATTATCCCAGCTGGTGGTATTATGGGTACGAAGATTGTATTAAACGAGTTT
GTAGCAATACTTGATTTAAAAGGTGTTGCATCAACATTATCTCCACGTACAGTTGGAATCGTTACAGTATTCTTAATTAG
CTTCGCAAGTATTAGCCAAATTGGTGCAATCGTTGGTACAATCCGTGCCCTTTCTGAAAAACAAGGAAGCGTTGTTTCTA
AATTTGGTTGGAAAATGCTATTTGCATCAACACTTGCTTCTATTTTATCTGCGACAATCGCTGGATTGTTTATTTAA

Upstream 100 bases:

>100_bases
ACATCTTACGTATGACATAAAACCTCCTTGTTTTATTTTTAGTAATATAACGAGCGTTTTATGTACAAACTTTATACGAA
CTTCTGAAAGGGGCAACTAC

Downstream 100 bases:

>100_bases
TAAAAAATCACCTTACTCGTCGTTGAAGTAAGGTGTTTTTTTATCTATTGTTACTTTTCTCATTCCATACATATTCTTCA
AATGCTATGATGAACAAGGG

Product: nucleoside transporter

Products: uridine [Cytoplasm]; thymidine [Cytoplasm]; inosine [Cytoplasm]; Deoxyuridine [Cytoplasm]; deoxyinosine [Cytoplasm]; deoxycytidine [Cytoplasm]; deoxyadenosine [Cytoplasm]; cytidine [Cytoplasm]; Proton [Cytoplasm]; adenosine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MQYVMSIIGILVVLGLCFALSNNKSKINFRAIAIMIGFQILIGWFMFGTKIGQQIIIFIGKVFNKLIKLGTTGVDFLFNG
IQRDFVFFLNVLLIIVFFSALLSIFSYLGVLPFIVRVVGGAISKITGLPRVESFHAVNSVFFGSSEALIVIKNDLQHFNK
NRMFIICCSAMSSVSASVTASYVMMLDAKYVLAALPLNLFSSLIVCSLLTPVDTKKEDEVVQKFDRTLFGDSFIGAMING
ALDGLKVAGIVAALMIAFIGVMEVVNYVISAASGAMGYAVTLQQIFGYILAPFAFLMGIPTQDIIPAGGIMGTKIVLNEF
VAILDLKGVASTLSPRTVGIVTVFLISFASISQIGAIVGTIRALSEKQGSVVSKFGWKMLFASTLASILSATIAGLFI

Sequences:

>Translated_398_residues
MQYVMSIIGILVVLGLCFALSNNKSKINFRAIAIMIGFQILIGWFMFGTKIGQQIIIFIGKVFNKLIKLGTTGVDFLFNG
IQRDFVFFLNVLLIIVFFSALLSIFSYLGVLPFIVRVVGGAISKITGLPRVESFHAVNSVFFGSSEALIVIKNDLQHFNK
NRMFIICCSAMSSVSASVTASYVMMLDAKYVLAALPLNLFSSLIVCSLLTPVDTKKEDEVVQKFDRTLFGDSFIGAMING
ALDGLKVAGIVAALMIAFIGVMEVVNYVISAASGAMGYAVTLQQIFGYILAPFAFLMGIPTQDIIPAGGIMGTKIVLNEF
VAILDLKGVASTLSPRTVGIVTVFLISFASISQIGAIVGTIRALSEKQGSVVSKFGWKMLFASTLASILSATIAGLFI
>Mature_398_residues
MQYVMSIIGILVVLGLCFALSNNKSKINFRAIAIMIGFQILIGWFMFGTKIGQQIIIFIGKVFNKLIKLGTTGVDFLFNG
IQRDFVFFLNVLLIIVFFSALLSIFSYLGVLPFIVRVVGGAISKITGLPRVESFHAVNSVFFGSSEALIVIKNDLQHFNK
NRMFIICCSAMSSVSASVTASYVMMLDAKYVLAALPLNLFSSLIVCSLLTPVDTKKEDEVVQKFDRTLFGDSFIGAMING
ALDGLKVAGIVAALMIAFIGVMEVVNYVISAASGAMGYAVTLQQIFGYILAPFAFLMGIPTQDIIPAGGIMGTKIVLNEF
VAILDLKGVASTLSPRTVGIVTVFLISFASISQIGAIVGTIRALSEKQGSVVSKFGWKMLFASTLASILSATIAGLFI

Specific function: Transports Nucleosides With A High Affinity Except Guanosine And Deoxyguanosine. Driven By A Proton Motive Force. [C]

COG id: COG1972

COG function: function code F; Nucleoside permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family [H]

Homologues:

Organism=Homo sapiens, GI11545853, Length=415, Percent_Identity=26.2650602409639, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI42542381, Length=418, Percent_Identity=25.3588516746411, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI227116277, Length=416, Percent_Identity=25.7211538461538, Blast_Score=118, Evalue=1e-26,
Organism=Escherichia coli, GI1788737, Length=392, Percent_Identity=41.0714285714286, Blast_Score=301, Evalue=4e-83,
Organism=Escherichia coli, GI1788485, Length=417, Percent_Identity=31.89448441247, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1788488, Length=417, Percent_Identity=32.1342925659472, Blast_Score=192, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI71991794, Length=395, Percent_Identity=25.5696202531646, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17560276, Length=394, Percent_Identity=23.8578680203046, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI45552519, Length=394, Percent_Identity=25.6345177664975, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI45552517, Length=394, Percent_Identity=25.6345177664975, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI19921868, Length=394, Percent_Identity=25.6345177664975, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI281360430, Length=391, Percent_Identity=26.0869565217391, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008276
- InterPro:   IPR018270
- InterPro:   IPR011657
- InterPro:   IPR002668 [H]

Pfam domain/function: PF07662 Nucleos_tra2_C; PF01773 Nucleos_tra2_N [H]

EC number: NA

Molecular weight: Translated: 42759; Mature: 42759

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure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HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: uridine [Periplasm]; thymidine [Periplasm]; inosine [Periplasm]; Deoxyuridine [Periplasm]; deoxyinosine [Periplasm]; deoxycytidine [Periplasm]; deoxyadenosine [Periplasm]; cytidine [Periplasm]; Proton [Periplasm]; adenosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uridine [Periplasm] = Proton [Cytoplasm] + uridine [Cytoplasm] Proton [Periplasm] + thymidine [Periplasm] = Proton [Cytoplasm] + thymidine [Cytoplasm] Proton [Periplasm] + inosine [Periplasm] = Proton [Cytoplasm] + inosine [Cytoplasm]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8550462; 8867804; 9384377 [H]