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The map label for this gene is gabT [H]

Identifier: 222094083

GI number: 222094083

Start: 353849

End: 355213

Strand: Direct

Name: gabT [H]

Synonym: BCQ_0376

Alternate gene names: 222094083

Gene position: 353849-355213 (Clockwise)

Preceding gene: 222094082

Following gene: 222094084

Centisome position: 6.79

GC content: 39.12

Gene sequence:

>1365_bases
ATGAATATAAAAAAATTTGCTAAAGTAAATGAACAAATTCCTGGACCGAAAGCAGCGTCTTTATTAGAACGCCGCCAAAG
TATAGTACCAAAAGGAGTAAGTAACGGCATCCCAACGTTTGTACAATCTGCAAATGGTGCTCTTGTTACTGATGTTGATG
GTAATCAGTACATTGATTTCGCTGGAGCGATAGGAACAATTAACGTAGGACATTGTCACCCAGCTGTTAAAGAAGCGCTC
CATAAACAAGTAGATCAATACATTCATACTGGCTTTAATGTCATGATGTATGAGCCATATATTGAATTAGCAGAAAAACT
TGCGGCATTAGCGCCGGGAAGTTTTGATAAGCAAGTACTATTTTTAAATAGTGGTGCAGAAGCAGTTGAGAATGCGGTGA
AAATCGCTCGTAAATATACAAAAAGACCTGGTATTATTGCATTTTCTAAAGGTTTCCATGGACGCACATTAATGACAATG
ACGATGACAAGTAAAGTAAAACCATATAAGTTTGGATTTGGTCCATTTGCGCCTGAAGTCTATAAAGCACCATTCCCGTA
CGAATATCGCCGCCCAGAAGGATTAACGGAAGAGCAGTACGATAACTTTATGATTGAAGAGCTTAAGAATTTCTTCGTAT
CAGAAGTAGCACCAGAAACGATTGCAGCCGTTGTAATGGAACCTGTTCAAGGGGAAGGTGGATTTATCGTCCCAAGTAAG
AAGTTTGTGCAAGAAGTACGCAATATTTGTTCAGAACACGGCATCTTATTTGTAGCGGATGAAATTCAAACTGGATTTAG
CCGTACAGGAAAATATTTCGCCATTGATCATTATGATGTCGTTCCGGATTTAATTACGGTATCTAAATCATTAGGTGCTG
GTGTACCGATTAGTGGTGTTATTGGGCGCAAAGAAATTATGAATGAGTCTGCACCAGGAGAACTTGGTGGAACGTATGCA
GGAAGCCCGCTAGGATGTGCGGCAGCATTAGCAGTACTTGATGTAATAGAAAAAGAGAATTTAAATGATAGAGCGATAGA
ATTAGGAAAAGTCGTAATGAACCGATTCGAAGAGATGAAAAATAAATATAATTGCATCGGTGATGTGCGCGGTTTAGGAG
CAATGTGTGCATTTGAGCTCGTTCAAGATCGTAAGACGAAAGCACCTGATAAAACGTTAACAGCTAATTTATGCGCAGAA
GCAAATAAACGCGGCTTACTTCTACTATCAGCAGGAACATACGGTAATGTTATTCGTGTGCTAATGCCATTAGTGATTAC
AGATGAGCAACTGGAAGAAGGATTAACAATCATTGAAGAATCGTTGCAAGTCTGTTATGAGAAAGCAAATATTGCTCGTG
TTTAA

Upstream 100 bases:

>100_bases
TTATTTTTTATGGCGAAATAGATGAATACTAGAAAAGAATATTGGCATACATTTTGCAATGAAAAGAGAAAACAATGTAA
AGAAAAGGATGGGGTACGTA

Downstream 100 bases:

>100_bases
AAGTTAAATAATAAAACAGCAAACATTCTAGCTGACTCTATATAAAATGCAGAAAATTCACTTTATAATAAAGGTAGTGA
AGTGAATCGACGGAGTGGAA

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MNIKKFAKVNEQIPGPKAASLLERRQSIVPKGVSNGIPTFVQSANGALVTDVDGNQYIDFAGAIGTINVGHCHPAVKEAL
HKQVDQYIHTGFNVMMYEPYIELAEKLAALAPGSFDKQVLFLNSGAEAVENAVKIARKYTKRPGIIAFSKGFHGRTLMTM
TMTSKVKPYKFGFGPFAPEVYKAPFPYEYRRPEGLTEEQYDNFMIEELKNFFVSEVAPETIAAVVMEPVQGEGGFIVPSK
KFVQEVRNICSEHGILFVADEIQTGFSRTGKYFAIDHYDVVPDLITVSKSLGAGVPISGVIGRKEIMNESAPGELGGTYA
GSPLGCAAALAVLDVIEKENLNDRAIELGKVVMNRFEEMKNKYNCIGDVRGLGAMCAFELVQDRKTKAPDKTLTANLCAE
ANKRGLLLLSAGTYGNVIRVLMPLVITDEQLEEGLTIIEESLQVCYEKANIARV

Sequences:

>Translated_454_residues
MNIKKFAKVNEQIPGPKAASLLERRQSIVPKGVSNGIPTFVQSANGALVTDVDGNQYIDFAGAIGTINVGHCHPAVKEAL
HKQVDQYIHTGFNVMMYEPYIELAEKLAALAPGSFDKQVLFLNSGAEAVENAVKIARKYTKRPGIIAFSKGFHGRTLMTM
TMTSKVKPYKFGFGPFAPEVYKAPFPYEYRRPEGLTEEQYDNFMIEELKNFFVSEVAPETIAAVVMEPVQGEGGFIVPSK
KFVQEVRNICSEHGILFVADEIQTGFSRTGKYFAIDHYDVVPDLITVSKSLGAGVPISGVIGRKEIMNESAPGELGGTYA
GSPLGCAAALAVLDVIEKENLNDRAIELGKVVMNRFEEMKNKYNCIGDVRGLGAMCAFELVQDRKTKAPDKTLTANLCAE
ANKRGLLLLSAGTYGNVIRVLMPLVITDEQLEEGLTIIEESLQVCYEKANIARV
>Mature_454_residues
MNIKKFAKVNEQIPGPKAASLLERRQSIVPKGVSNGIPTFVQSANGALVTDVDGNQYIDFAGAIGTINVGHCHPAVKEAL
HKQVDQYIHTGFNVMMYEPYIELAEKLAALAPGSFDKQVLFLNSGAEAVENAVKIARKYTKRPGIIAFSKGFHGRTLMTM
TMTSKVKPYKFGFGPFAPEVYKAPFPYEYRRPEGLTEEQYDNFMIEELKNFFVSEVAPETIAAVVMEPVQGEGGFIVPSK
KFVQEVRNICSEHGILFVADEIQTGFSRTGKYFAIDHYDVVPDLITVSKSLGAGVPISGVIGRKEIMNESAPGELGGTYA
GSPLGCAAALAVLDVIEKENLNDRAIELGKVVMNRFEEMKNKYNCIGDVRGLGAMCAFELVQDRKTKAPDKTLTANLCAE
ANKRGLLLLSAGTYGNVIRVLMPLVITDEQLEEGLTIIEESLQVCYEKANIARV

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=419, Percent_Identity=35.0835322195704, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI13994255, Length=425, Percent_Identity=32, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI37574042, Length=420, Percent_Identity=30.952380952381, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI24119277, Length=422, Percent_Identity=31.042654028436, Blast_Score=192, Evalue=8e-49,
Organism=Homo sapiens, GI226442709, Length=389, Percent_Identity=31.3624678663239, Blast_Score=189, Evalue=6e-48,
Organism=Homo sapiens, GI284507298, Length=330, Percent_Identity=36.0606060606061, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI226442705, Length=420, Percent_Identity=30.2380952380952, Blast_Score=182, Evalue=8e-46,
Organism=Homo sapiens, GI188536080, Length=467, Percent_Identity=25.6959314775161, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI38679950, Length=467, Percent_Identity=25.6959314775161, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI38679946, Length=467, Percent_Identity=25.6959314775161, Blast_Score=149, Evalue=7e-36,
Organism=Escherichia coli, GI1789016, Length=429, Percent_Identity=47.0862470862471, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1787560, Length=420, Percent_Identity=48.3333333333333, Blast_Score=397, Evalue=1e-112,
Organism=Escherichia coli, GI1789759, Length=397, Percent_Identity=35.264483627204, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI1788044, Length=396, Percent_Identity=33.8383838383838, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI145693181, Length=422, Percent_Identity=33.6492890995261, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1786991, Length=424, Percent_Identity=28.5377358490566, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1786349, Length=345, Percent_Identity=31.0144927536232, Blast_Score=149, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI71992977, Length=447, Percent_Identity=31.5436241610738, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI25144271, Length=415, Percent_Identity=30.6024096385542, Blast_Score=203, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI32564660, Length=419, Percent_Identity=31.5035799522673, Blast_Score=201, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI25144274, Length=298, Percent_Identity=29.8657718120805, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17541228, Length=470, Percent_Identity=24.2553191489362, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71981843, Length=161, Percent_Identity=31.055900621118, Blast_Score=75, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6323470, Length=422, Percent_Identity=33.4123222748815, Blast_Score=218, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6324432, Length=414, Percent_Identity=31.6425120772947, Blast_Score=197, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6321456, Length=432, Percent_Identity=25.2314814814815, Blast_Score=107, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6324386, Length=449, Percent_Identity=25.1670378619154, Blast_Score=103, Evalue=7e-23,
Organism=Drosophila melanogaster, GI161085790, Length=453, Percent_Identity=31.7880794701987, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI28574759, Length=431, Percent_Identity=32.4825986078886, Blast_Score=222, Evalue=4e-58,
Organism=Drosophila melanogaster, GI21357415, Length=419, Percent_Identity=33.1742243436754, Blast_Score=219, Evalue=4e-57,
Organism=Drosophila melanogaster, GI21356575, Length=418, Percent_Identity=31.8181818181818, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI281366494, Length=423, Percent_Identity=27.1867612293144, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24667139, Length=423, Percent_Identity=27.1867612293144, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24667143, Length=423, Percent_Identity=27.1867612293144, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 49663; Mature: 49663

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIKKFAKVNEQIPGPKAASLLERRQSIVPKGVSNGIPTFVQSANGALVTDVDGNQYIDF
CCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCEEEECCCCCEEEE
AGAIGTINVGHCHPAVKEALHKQVDQYIHTGFNVMMYEPYIELAEKLAALAPGSFDKQVL
CCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHCCCCCCCEEE
FLNSGAEAVENAVKIARKYTKRPGIIAFSKGFHGRTLMTMTMTSKVKPYKFGFGPFAPEV
EECCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCHHH
YKAPFPYEYRRPEGLTEEQYDNFMIEELKNFFVSEVAPETIAAVVMEPVQGEGGFIVPSK
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCEECCCH
KFVQEVRNICSEHGILFVADEIQTGFSRTGKYFAIDHYDVVPDLITVSKSLGAGVPISGV
HHHHHHHHHHHHCCEEEEEHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCCC
IGRKEIMNESAPGELGGTYAGSPLGCAAALAVLDVIEKENLNDRAIELGKVVMNRFEEMK
CCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
NKYNCIGDVRGLGAMCAFELVQDRKTKAPDKTLTANLCAEANKRGLLLLSAGTYGNVIRV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEEECCCHHHHHHH
LMPLVITDEQLEEGLTIIEESLQVCYEKANIARV
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNIKKFAKVNEQIPGPKAASLLERRQSIVPKGVSNGIPTFVQSANGALVTDVDGNQYIDF
CCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCEEEECCCCCEEEE
AGAIGTINVGHCHPAVKEALHKQVDQYIHTGFNVMMYEPYIELAEKLAALAPGSFDKQVL
CCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHCCCCCCCEEE
FLNSGAEAVENAVKIARKYTKRPGIIAFSKGFHGRTLMTMTMTSKVKPYKFGFGPFAPEV
EECCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCHHH
YKAPFPYEYRRPEGLTEEQYDNFMIEELKNFFVSEVAPETIAAVVMEPVQGEGGFIVPSK
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCEECCCH
KFVQEVRNICSEHGILFVADEIQTGFSRTGKYFAIDHYDVVPDLITVSKSLGAGVPISGV
HHHHHHHHHHHHCCEEEEEHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCCC
IGRKEIMNESAPGELGGTYAGSPLGCAAALAVLDVIEKENLNDRAIELGKVVMNRFEEMK
CCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
NKYNCIGDVRGLGAMCAFELVQDRKTKAPDKTLTANLCAEANKRGLLLLSAGTYGNVIRV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEEECCCHHHHHHH
LMPLVITDEQLEEGLTIIEESLQVCYEKANIARV
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]