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The map label for this gene is gph [H]

Identifier: 222094082

GI number: 222094082

Start: 352960

End: 353706

Strand: Direct

Name: gph [H]

Synonym: BCQ_0375

Alternate gene names: 222094082

Gene position: 352960-353706 (Clockwise)

Preceding gene: 222094080

Following gene: 222094083

Centisome position: 6.77

GC content: 37.88

Gene sequence:

>747_bases
ATGGAGAAAGTAAAAGCAATACTATTTGATAAAGATGGGACATTAATGGATTTTCATTCAATTTGGATAAAAGTGGCTGA
AGAACTTGTGGCTGAATGTATAAAATTATACCAACTGCCACAATCAATGCAGCCGACTTTATTAAAAGAAATCGGTGTGG
ATGGGGTATTTGTTCACCCACGTAGCGCAATAGCGGCAGGAACGAGCCTTGATGTGGCAAAGGGGCTTTGTAAGTATATT
ACGTCATCTAAAGAAGAGGAAATGCATGAATGGGTAAGTGAAAAACTGTTTGCCCTTATGTACGAGCATCGTTCTTACAT
GAAAATGACGGCGGATTTACCGAGAATTTTACAAGGTTTAAAGGATAGAGGATTTATTTTAGGTGTTGTCACGGCGGATG
ATTTTGCACCGACAGAATTATTTTTAAAACAGTATCAATTAGAGACCTTTTTTGATTATGTTGTAGCTTCAGATACATTT
CCAGCACAAAAACCAGATAAAAGAATTGTAGAATCCTTTTGTGAGAGGTTTCATTTAGAGGCATGTGAAGTAGCGGTCGT
TGGAGATACACCGACTGATTTATATTTAGCGAAAAATGGCGGTGATTGCTATGCAATTGGAGTACTATCTGGTACAGGAG
ATCGTCAAACATTAGAACCACTTGCTGATTTAGTAGTACAGTCTGTTGGGGACCTTATTTCTCATTCAGGTGAGTTTGTT
TGGGAAAAAGGAAAGTCTAATGTGTAA

Upstream 100 bases:

>100_bases
GAAGTTAGTTTGATTTTCATGGTATTTTTACAATTCGTTTATTTTATATCCATACTTTATTGATACACTGGAGGAGATAA
GAGACGAGAGGTGGGGTGTT

Downstream 100 bases:

>100_bases
GAAAAATAAGTCTATAAAGACTCTTAATGAGTCTTTATAGACTTATTTTTTATGGCGAAATAGATGAATACTAGAAAAGA
ATATTGGCATACATTTTGCA

Product: haloacid dehalogenase

Products: NA

Alternate protein names: PGP; PGPase [H]

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MEKVKAILFDKDGTLMDFHSIWIKVAEELVAECIKLYQLPQSMQPTLLKEIGVDGVFVHPRSAIAAGTSLDVAKGLCKYI
TSSKEEEMHEWVSEKLFALMYEHRSYMKMTADLPRILQGLKDRGFILGVVTADDFAPTELFLKQYQLETFFDYVVASDTF
PAQKPDKRIVESFCERFHLEACEVAVVGDTPTDLYLAKNGGDCYAIGVLSGTGDRQTLEPLADLVVQSVGDLISHSGEFV
WEKGKSNV

Sequences:

>Translated_248_residues
MEKVKAILFDKDGTLMDFHSIWIKVAEELVAECIKLYQLPQSMQPTLLKEIGVDGVFVHPRSAIAAGTSLDVAKGLCKYI
TSSKEEEMHEWVSEKLFALMYEHRSYMKMTADLPRILQGLKDRGFILGVVTADDFAPTELFLKQYQLETFFDYVVASDTF
PAQKPDKRIVESFCERFHLEACEVAVVGDTPTDLYLAKNGGDCYAIGVLSGTGDRQTLEPLADLVVQSVGDLISHSGEFV
WEKGKSNV
>Mature_248_residues
MEKVKAILFDKDGTLMDFHSIWIKVAEELVAECIKLYQLPQSMQPTLLKEIGVDGVFVHPRSAIAAGTSLDVAKGLCKYI
TSSKEEEMHEWVSEKLFALMYEHRSYMKMTADLPRILQGLKDRGFILGVVTADDFAPTELFLKQYQLETFFDYVVASDTF
PAQKPDKRIVESFCERFHLEACEVAVVGDTPTDLYLAKNGGDCYAIGVLSGTGDRQTLEPLADLVVQSVGDLISHSGEFV
WEKGKSNV

Specific function: Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stres

COG id: COG0546

COG function: function code R; Predicted phosphatases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006439
- InterPro:   IPR006402
- InterPro:   IPR006346
- InterPro:   IPR023198 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: =3.1.3.18 [H]

Molecular weight: Translated: 27713; Mature: 27713

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKVKAILFDKDGTLMDFHSIWIKVAEELVAECIKLYQLPQSMQPTLLKEIGVDGVFVHP
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEECC
RSAIAAGTSLDVAKGLCKYITSSKEEEMHEWVSEKLFALMYEHRSYMKMTADLPRILQGL
CHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDRGFILGVVTADDFAPTELFLKQYQLETFFDYVVASDTFPAQKPDKRIVESFCERFHLE
CCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCC
ACEVAVVGDTPTDLYLAKNGGDCYAIGVLSGTGDRQTLEPLADLVVQSVGDLISHSGEFV
HHCEEEECCCCCEEEEEECCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCEE
WEKGKSNV
ECCCCCCC
>Mature Secondary Structure
MEKVKAILFDKDGTLMDFHSIWIKVAEELVAECIKLYQLPQSMQPTLLKEIGVDGVFVHP
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEECC
RSAIAAGTSLDVAKGLCKYITSSKEEEMHEWVSEKLFALMYEHRSYMKMTADLPRILQGL
CHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDRGFILGVVTADDFAPTELFLKQYQLETFFDYVVASDTFPAQKPDKRIVESFCERFHLE
CCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCC
ACEVAVVGDTPTDLYLAKNGGDCYAIGVLSGTGDRQTLEPLADLVVQSVGDLISHSGEFV
HHCEEEECCCCCEEEEEECCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCEE
WEKGKSNV
ECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]