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The map label for this gene is vanR [H]

Identifier: 222094028

GI number: 222094028

Start: 269926

End: 270627

Strand: Direct

Name: vanR [H]

Synonym: BCQ_0301

Alternate gene names: 222094028

Gene position: 269926-270627 (Clockwise)

Preceding gene: 222094027

Following gene: 222094029

Centisome position: 5.18

GC content: 35.19

Gene sequence:

>702_bases
GTGGCAAATGAAACGATACTTGTCGTAGATGATGAAAAAGAAATTAGGAATCTTATTACAATCTATTTAAAAAATGAAGG
ATATAAAGTATTGCAAGCAGGGGACGGAGAAGAAGGATTACGTTTACTAGAAGAAAATGAAGTACATCTAGTCGTATTAG
ATATTATGATGCCGAAAGTAGATGGCATTCATATGTGTATGAAAGTAAGGGAAGAAAAAGAAATGCCGATCATTATGCTT
TCCGCGAAAACGCAAGATATGGATAAGATTTTAGGGTTAACAACAGGGGCAGATGATTATGTAACGAAGCCATTTAATCC
GTTAGAGTTAATCGCAAGAATTAAATCTCAGTTACGCCGTTATATGAAAATGAATGGTTTTTCTATTCAAAATGAGGACG
AGCTAGAAATTGGAGAGATGAAAATAAACATCTCAACCCATAAAGTTATTGTAGAGGGAGAAGAAGTGAAGCTGACCCCG
AGGGAATTTTCAATTCTAGAATTACTAGCCCGTAATCCGGGAATGGTCTTTAGTGCAGAGCAAATTTATGAAAAGGTTTG
GAATGAAAGATCTTTCCAGTCTGATAATACTGTAATGGTGCATATTCGAAAAGTGCGTGAAAAGATTGAGGAGAATCCAA
GGAAACCTAGATATATAAAAACAGTATGGGGAGTGGGGTATAAGATTGAAAAAGATATTTAA

Upstream 100 bases:

>100_bases
TTTTTGCGTCTTCAGAAAAACTTAAGGATTTCCGAGCGTTTTTCTTCAGAAGTTTTCCTATAATAGAAGTTAGGGATTAA
AAAGTGATGGGGGAGATATT

Downstream 100 bases:

>100_bases
TCCGTTTACTTATATAAGGAAAACAAGACAATTGATTGAGAAATTAGTAAAGAGCGTACGAAAGAGTATAAGAATTCAAC
TGATTACTACTTTTGCTGCT

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 232

Protein sequence:

>233_residues
MANETILVVDDEKEIRNLITIYLKNEGYKVLQAGDGEEGLRLLEENEVHLVVLDIMMPKVDGIHMCMKVREEKEMPIIML
SAKTQDMDKILGLTTGADDYVTKPFNPLELIARIKSQLRRYMKMNGFSIQNEDELEIGEMKINISTHKVIVEGEEVKLTP
REFSILELLARNPGMVFSAEQIYEKVWNERSFQSDNTVMVHIRKVREKIEENPRKPRYIKTVWGVGYKIEKDI

Sequences:

>Translated_233_residues
MANETILVVDDEKEIRNLITIYLKNEGYKVLQAGDGEEGLRLLEENEVHLVVLDIMMPKVDGIHMCMKVREEKEMPIIML
SAKTQDMDKILGLTTGADDYVTKPFNPLELIARIKSQLRRYMKMNGFSIQNEDELEIGEMKINISTHKVIVEGEEVKLTP
REFSILELLARNPGMVFSAEQIYEKVWNERSFQSDNTVMVHIRKVREKIEENPRKPRYIKTVWGVGYKIEKDI
>Mature_232_residues
ANETILVVDDEKEIRNLITIYLKNEGYKVLQAGDGEEGLRLLEENEVHLVVLDIMMPKVDGIHMCMKVREEKEMPIIMLS
AKTQDMDKILGLTTGADDYVTKPFNPLELIARIKSQLRRYMKMNGFSIQNEDELEIGEMKINISTHKVIVEGEEVKLTPR
EFSILELLARNPGMVFSAEQIYEKVWNERSFQSDNTVMVHIRKVREKIEENPRKPRYIKTVWGVGYKIEKDI

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=232, Percent_Identity=39.2241379310345, Blast_Score=179, Evalue=1e-46,
Organism=Escherichia coli, GI1788394, Length=228, Percent_Identity=35.0877192982456, Blast_Score=157, Evalue=4e-40,
Organism=Escherichia coli, GI1786599, Length=227, Percent_Identity=35.2422907488987, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1790863, Length=236, Percent_Identity=33.8983050847458, Blast_Score=143, Evalue=8e-36,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=32.4444444444444, Blast_Score=141, Evalue=3e-35,
Organism=Escherichia coli, GI87082012, Length=225, Percent_Identity=34.2222222222222, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=35.2422907488987, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=36.7256637168142, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI1790552, Length=225, Percent_Identity=35.5555555555556, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1790860, Length=233, Percent_Identity=31.3304721030043, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=32.4444444444444, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=32.034632034632, Blast_Score=110, Evalue=9e-26,
Organism=Escherichia coli, GI1787375, Length=227, Percent_Identity=29.9559471365639, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=28.3842794759825, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1788550, Length=106, Percent_Identity=33.9622641509434, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1788905, Length=102, Percent_Identity=33.3333333333333, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27085; Mature: 26954

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANETILVVDDEKEIRNLITIYLKNEGYKVLQAGDGEEGLRLLEENEVHLVVLDIMMPKV
CCCCEEEEEECHHHHHCEEEEEECCCCEEEEECCCCHHHHHHHCCCCEEEEEEEEECCCC
DGIHMCMKVREEKEMPIIMLSAKTQDMDKILGLTTGADDYVTKPFNPLELIARIKSQLRR
CHHHHHHHHHHCCCCCEEEEECCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
YMKMNGFSIQNEDELEIGEMKINISTHKVIVEGEEVKLTPREFSILELLARNPGMVFSAE
HHHHCCCCCCCCCCCEEEEEEEEEEEEEEEEECCEEEECCCHHHHHHHHHCCCCCEEEHH
QIYEKVWNERSFQSDNTVMVHIRKVREKIEENPRKPRYIKTVWGVGYKIEKDI
HHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHCCCCCCEEEHHHCCCEEEECCC
>Mature Secondary Structure 
ANETILVVDDEKEIRNLITIYLKNEGYKVLQAGDGEEGLRLLEENEVHLVVLDIMMPKV
CCCEEEEEECHHHHHCEEEEEECCCCEEEEECCCCHHHHHHHCCCCEEEEEEEEECCCC
DGIHMCMKVREEKEMPIIMLSAKTQDMDKILGLTTGADDYVTKPFNPLELIARIKSQLRR
CHHHHHHHHHHCCCCCEEEEECCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
YMKMNGFSIQNEDELEIGEMKINISTHKVIVEGEEVKLTPREFSILELLARNPGMVFSAE
HHHHCCCCCCCCCCCEEEEEEEEEEEEEEEEECCEEEECCCHHHHHHHHHCCCCCEEEHH
QIYEKVWNERSFQSDNTVMVHIRKVREKIEENPRKPRYIKTVWGVGYKIEKDI
HHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHCCCCCCEEEHHHCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]