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The map label for this gene is yisK [H]

Identifier: 222094001

GI number: 222094001

Start: 232181

End: 233137

Strand: Direct

Name: yisK [H]

Synonym: BCQ_0257

Alternate gene names: 222094001

Gene position: 232181-233137 (Clockwise)

Preceding gene: 222094000

Following gene: 222094002

Centisome position: 4.45

GC content: 38.87

Gene sequence:

>957_bases
ATGAAATTTGTTACATTTCGTCTTCCTTCAAAAGAAATGCGAGCTGGATGGCTTGAAGGTGACAAAGTAATCGATATGAA
TCTTGCTAGTGGTGGAAAATTACCTTCTTCTATGTTCGCCTTTTTAGAGAAAGCGGATGAGTATGTAGAAGTGTTGCGTA
ATATTAATAATCCGGAAAAGGGCATATATTCTTTAGAGGAAGTGCAATTAGCAGCAGCGATTCCTAATCCGAGTAGTATT
AGGGATTTTTATGCATTTGAACAGCACGTAAAAACGGCACGTAGCCGAAGAGGGTTAGATGTTGTACCTGAATGGTACGA
TATTCCGGTTTTTTATTTTACGAACCATCGTGCTGTAATTGGTCCAGATGATGTTGTAATTAGTCCGAAGAAATCTAAAA
AACTTGATTATGAGTTAGAGATTGCTTGCGTAATTGGGAAAGAAGGAAGAAATATTTCTCGTGAGCAAGCAGAGGAATAC
ATTTTTGGTTATTGTATTATGAATGATTGGAGTGCAAGGGACTTACAAGCAACAGAAATGAAGGTAGGACTTGGTCCAGC
GAAAGGAAAAGATTTTGCAACTTCATTAGGAGCGTACCTTGTTACGAAAGAGGAACTAGATATTTATCGTAATGGTGACC
GTTATGAGTTAGAGATGACTGCTCATGTAAATGGAAAGCTATTATCAAAAGGGAACTTCCGAGATATTTACTATACATTT
GCTGAAATGATTGAACGTGCTTCGGAAGACGTTACGTTATATCCAGGCGATGTGATTGGTTCTGGAACAGTAGGAACAGG
TTGCATTTTAGAACTAGGCACAGAAGAGTGGCTACAAGATGGTGATGTGGTAGAACTTACGATTACTGGTTTAGGTACAT
TACGTAATACGGTCAAAATAGAAAGGGAAGCAGGTGATGGGCATGTTTTATCGTCACATGGGGGAGCTACCTCATAA

Upstream 100 bases:

>100_bases
TGAAAGAGAACAAGAGCGTCGCGGGAATTTATAAAATTTATATCCACCAGCAATCATTCTTTTGCTGGTGGAAATTTCAT
TTTCATAAGGAGGAATCATG

Downstream 100 bases:

>100_bases
ACGACATGTACAATTCCGTAAAAAAGATGGGTCGCTTTATCGTGAGCAGGTAATGGGAACAAAAGGTTTTTCTGGTACGC
AATCTATTTTGTACCATCAT

Product: fumarylacetoacetate hydrolase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MKFVTFRLPSKEMRAGWLEGDKVIDMNLASGGKLPSSMFAFLEKADEYVEVLRNINNPEKGIYSLEEVQLAAAIPNPSSI
RDFYAFEQHVKTARSRRGLDVVPEWYDIPVFYFTNHRAVIGPDDVVISPKKSKKLDYELEIACVIGKEGRNISREQAEEY
IFGYCIMNDWSARDLQATEMKVGLGPAKGKDFATSLGAYLVTKEELDIYRNGDRYELEMTAHVNGKLLSKGNFRDIYYTF
AEMIERASEDVTLYPGDVIGSGTVGTGCILELGTEEWLQDGDVVELTITGLGTLRNTVKIEREAGDGHVLSSHGGATS

Sequences:

>Translated_318_residues
MKFVTFRLPSKEMRAGWLEGDKVIDMNLASGGKLPSSMFAFLEKADEYVEVLRNINNPEKGIYSLEEVQLAAAIPNPSSI
RDFYAFEQHVKTARSRRGLDVVPEWYDIPVFYFTNHRAVIGPDDVVISPKKSKKLDYELEIACVIGKEGRNISREQAEEY
IFGYCIMNDWSARDLQATEMKVGLGPAKGKDFATSLGAYLVTKEELDIYRNGDRYELEMTAHVNGKLLSKGNFRDIYYTF
AEMIERASEDVTLYPGDVIGSGTVGTGCILELGTEEWLQDGDVVELTITGLGTLRNTVKIEREAGDGHVLSSHGGATS
>Mature_318_residues
MKFVTFRLPSKEMRAGWLEGDKVIDMNLASGGKLPSSMFAFLEKADEYVEVLRNINNPEKGIYSLEEVQLAAAIPNPSSI
RDFYAFEQHVKTARSRRGLDVVPEWYDIPVFYFTNHRAVIGPDDVVISPKKSKKLDYELEIACVIGKEGRNISREQAEEY
IFGYCIMNDWSARDLQATEMKVGLGPAKGKDFATSLGAYLVTKEELDIYRNGDRYELEMTAHVNGKLLSKGNFRDIYYTF
AEMIERASEDVTLYPGDVIGSGTVGTGCILELGTEEWLQDGDVVELTITGLGTLRNTVKIEREAGDGHVLSSHGGATS

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI156231349, Length=310, Percent_Identity=30, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI40786394, Length=310, Percent_Identity=29.3548387096774, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4557587, Length=291, Percent_Identity=29.2096219931272, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI13654274, Length=219, Percent_Identity=28.310502283105, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI215422413, Length=208, Percent_Identity=28.3653846153846, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI66348062, Length=208, Percent_Identity=28.3653846153846, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17568863, Length=277, Percent_Identity=29.6028880866426, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28572127, Length=190, Percent_Identity=36.8421052631579, Blast_Score=120, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24657182, Length=303, Percent_Identity=27.7227722772277, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24663695, Length=305, Percent_Identity=24.9180327868852, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28571789, Length=199, Percent_Identity=26.1306532663317, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 35450; Mature: 35450

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFVTFRLPSKEMRAGWLEGDKVIDMNLASGGKLPSSMFAFLEKADEYVEVLRNINNPEK
CCEEEEECCCHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHH
GIYSLEEVQLAAAIPNPSSIRDFYAFEQHVKTARSRRGLDVVPEWYDIPVFYFTNHRAVI
HCEEHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCEEEE
GPDDVVISPKKSKKLDYELEIACVIGKEGRNISREQAEEYIFGYCIMNDWSARDLQATEM
CCCCEEECCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHEEEEEEEECCCCCCCCEEEEE
KVGLGPAKGKDFATSLGAYLVTKEELDIYRNGDRYELEMTAHVNGKLLSKGNFRDIYYTF
EECCCCCCCCHHHHHHCEEEEEECHHHEEECCCEEEEEEEEECCCEEECCCCCHHHHHHH
AEMIERASEDVTLYPGDVIGSGTVGTGCILELGTEEWLQDGDVVELTITGLGTLRNTVKI
HHHHHHCCCCEEEECCCCCCCCCCCCCEEEEECCHHHHCCCCEEEEEEECCCCCCCEEEE
EREAGDGHVLSSHGGATS
EEECCCCEEEECCCCCCC
>Mature Secondary Structure
MKFVTFRLPSKEMRAGWLEGDKVIDMNLASGGKLPSSMFAFLEKADEYVEVLRNINNPEK
CCEEEEECCCHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHH
GIYSLEEVQLAAAIPNPSSIRDFYAFEQHVKTARSRRGLDVVPEWYDIPVFYFTNHRAVI
HCEEHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCEEEE
GPDDVVISPKKSKKLDYELEIACVIGKEGRNISREQAEEYIFGYCIMNDWSARDLQATEM
CCCCEEECCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHEEEEEEEECCCCCCCCEEEEE
KVGLGPAKGKDFATSLGAYLVTKEELDIYRNGDRYELEMTAHVNGKLLSKGNFRDIYYTF
EECCCCCCCCHHHHHHCEEEEEECHHHEEECCCEEEEEEEEECCCEEECCCCCHHHHHHH
AEMIERASEDVTLYPGDVIGSGTVGTGCILELGTEEWLQDGDVVELTITGLGTLRNTVKI
HHHHHHCCCCEEEECCCCCCCCCCCCCEEEEECCHHHHCCCCEEEEEEECCCCCCCEEEE
EREAGDGHVLSSHGGATS
EEECCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353931; 9384377 [H]