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The map label for this gene is adk [H]

Identifier: 222093901

GI number: 222093901

Start: 131321

End: 131971

Strand: Direct

Name: adk [H]

Synonym: BCQ_0144

Alternate gene names: 222093901

Gene position: 131321-131971 (Clockwise)

Preceding gene: 222093900

Following gene: 222093902

Centisome position: 2.52

GC content: 39.94

Gene sequence:

>651_bases
ATGAACTTAATTTTAATGGGGCTTCCTGGTGCTGGTAAAGGTACACAAGCCGAACAGATTGTTGCCAAGTATAACATCCC
TCACATCTCAACAGGAGATATGTTCCGTGCAGCTATGAAGGCTGAAACTGAAATGGGTTTACAAGCAAAATCCTTTATTG
ATAAAGGTGCACTTGTTCCAGATGAAGTTACAATCGGAATCGTTCGTGAACGTTTAAGTCAAGAAGACTGCGTAAGAGGC
TTCTTATTAGACGGTTTCCCACGAACTGTTGCACAAGCATCAGCTCTTGAAGAGATTATGAAAGATCTTGGCAAAAAAAT
CGACTATGTTTTAAACATTAATGTGGATTCAGGATTGTTATTAAAACGCCTTACAGGCCGTCGCATTTGTAAAGAGTGCG
GTGCGACTTACCACTTAGAATTCAATCCGCCAGCAAAAGCTGACGTGTGCGATAAATGTGGTGGCGAGTTATATCAACGC
TCTGATGACAATGAAGAAACTGTAGCAAATCGCTTAGATGTAAATATTAAGCAAACTAAACCTTTGCTTGATTTCTACGA
GGAGCTTGGTTACTTACAAAGCATTAATGGTGAGCAAGATATCAATAAAGTATTTGCTGATATCGATGTTCTCATCGGAG
GCTTAGCGTAA

Upstream 100 bases:

>100_bases
GCCAACTGGTAAAACGCCATTACAAAGGGTTTATCAAGCAGTGAGTAAGTGGGAAGTATTGTCTTCCCTACATGCTCATG
TACTCTGAGGGGGAACAAGG

Downstream 100 bases:

>100_bases
TGATAATCTGCAAAACTCCTCGCGAGATAGAAATCATGCGAGAAGCGGGCAGGATCGTTGCTTTGACTCATCAAGAGTTA
AAACAGCACATTACTCCAGG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MNLILMGLPGAGKGTQAEQIVAKYNIPHISTGDMFRAAMKAETEMGLQAKSFIDKGALVPDEVTIGIVRERLSQEDCVRG
FLLDGFPRTVAQASALEEIMKDLGKKIDYVLNINVDSGLLLKRLTGRRICKECGATYHLEFNPPAKADVCDKCGGELYQR
SDDNEETVANRLDVNIKQTKPLLDFYEELGYLQSINGEQDINKVFADIDVLIGGLA

Sequences:

>Translated_216_residues
MNLILMGLPGAGKGTQAEQIVAKYNIPHISTGDMFRAAMKAETEMGLQAKSFIDKGALVPDEVTIGIVRERLSQEDCVRG
FLLDGFPRTVAQASALEEIMKDLGKKIDYVLNINVDSGLLLKRLTGRRICKECGATYHLEFNPPAKADVCDKCGGELYQR
SDDNEETVANRLDVNIKQTKPLLDFYEELGYLQSINGEQDINKVFADIDVLIGGLA
>Mature_216_residues
MNLILMGLPGAGKGTQAEQIVAKYNIPHISTGDMFRAAMKAETEMGLQAKSFIDKGALVPDEVTIGIVRERLSQEDCVRG
FLLDGFPRTVAQASALEEIMKDLGKKIDYVLNINVDSGLLLKRLTGRRICKECGATYHLEFNPPAKADVCDKCGGELYQR
SDDNEETVANRLDVNIKQTKPLLDFYEELGYLQSINGEQDINKVFADIDVLIGGLA

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=205, Percent_Identity=41.4634146341463, Blast_Score=174, Evalue=7e-44,
Organism=Homo sapiens, GI4502013, Length=205, Percent_Identity=41.4634146341463, Blast_Score=173, Evalue=9e-44,
Organism=Homo sapiens, GI19923437, Length=205, Percent_Identity=40.4878048780488, Blast_Score=159, Evalue=1e-39,
Organism=Homo sapiens, GI310110345, Length=215, Percent_Identity=36.7441860465116, Blast_Score=138, Evalue=3e-33,
Organism=Homo sapiens, GI53832003, Length=215, Percent_Identity=36.7441860465116, Blast_Score=138, Evalue=3e-33,
Organism=Homo sapiens, GI8051579, Length=215, Percent_Identity=36.7441860465116, Blast_Score=138, Evalue=3e-33,
Organism=Homo sapiens, GI53832001, Length=215, Percent_Identity=36.7441860465116, Blast_Score=138, Evalue=3e-33,
Organism=Homo sapiens, GI4502011, Length=209, Percent_Identity=32.5358851674641, Blast_Score=114, Evalue=5e-26,
Organism=Homo sapiens, GI22749187, Length=208, Percent_Identity=30.7692307692308, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI7706497, Length=211, Percent_Identity=27.9620853080569, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI28144899, Length=210, Percent_Identity=29.5238095238095, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI28144897, Length=210, Percent_Identity=29.5238095238095, Blast_Score=92, Evalue=3e-19,
Organism=Escherichia coli, GI1786680, Length=218, Percent_Identity=47.7064220183486, Blast_Score=198, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17552384, Length=209, Percent_Identity=40.1913875598086, Blast_Score=164, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17567503, Length=206, Percent_Identity=33.495145631068, Blast_Score=117, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17537943, Length=202, Percent_Identity=31.1881188118812, Blast_Score=97, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17533833, Length=208, Percent_Identity=26.9230769230769, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17550688, Length=210, Percent_Identity=27.1428571428571, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6320432, Length=210, Percent_Identity=40.4761904761905, Blast_Score=177, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6321018, Length=196, Percent_Identity=35.2040816326531, Blast_Score=135, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6322828, Length=211, Percent_Identity=27.9620853080569, Blast_Score=92, Evalue=9e-20,
Organism=Drosophila melanogaster, GI22026816, Length=212, Percent_Identity=40.5660377358491, Blast_Score=174, Evalue=6e-44,
Organism=Drosophila melanogaster, GI17737899, Length=196, Percent_Identity=35.2040816326531, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24645822, Length=196, Percent_Identity=35.2040816326531, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI221459597, Length=213, Percent_Identity=26.7605633802817, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21356893, Length=213, Percent_Identity=26.7605633802817, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24663208, Length=207, Percent_Identity=25.1207729468599, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17647141, Length=207, Percent_Identity=25.1207729468599, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23770; Mature: 23770

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLILMGLPGAGKGTQAEQIVAKYNIPHISTGDMFRAAMKAETEMGLQAKSFIDKGALVP
CCEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCC
DEVTIGIVRERLSQEDCVRGFLLDGFPRTVAQASALEEIMKDLGKKIDYVLNINVDSGLL
CHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCHH
LKRLTGRRICKECGATYHLEFNPPAKADVCDKCGGELYQRSDDNEETVANRLDVNIKQTK
HHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHCHHHHHCCCCCHHHHHHHHCCCHHHCC
PLLDFYEELGYLQSINGEQDINKVFADIDVLIGGLA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNLILMGLPGAGKGTQAEQIVAKYNIPHISTGDMFRAAMKAETEMGLQAKSFIDKGALVP
CCEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCC
DEVTIGIVRERLSQEDCVRGFLLDGFPRTVAQASALEEIMKDLGKKIDYVLNINVDSGLL
CHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCHH
LKRLTGRRICKECGATYHLEFNPPAKADVCDKCGGELYQRSDDNEETVANRLDVNIKQTK
HHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHCHHHHHCCCCCHHHHHHHHCCCHHHCC
PLLDFYEELGYLQSINGEQDINKVFADIDVLIGGLA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA