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The map label for this gene is proC [H]

Identifier: 221636262

GI number: 221636262

Start: 838761

End: 839648

Strand: Reverse

Name: proC [H]

Synonym: trd_A0856

Alternate gene names: 221636262

Gene position: 839648-838761 (Counterclockwise)

Preceding gene: 221636263

Following gene: 221636260

Centisome position: 91.49

GC content: 67.0

Gene sequence:

>888_bases
GTGCGTGCGGAGTTCGCAGGGCGTCCGGTGGGGCAGCAGCCGTCACCGCTGAGTGGCAAGCGGATCGCCTTCATCGGTTG
CGGAGTGATGGCGGAAGCGATGGCAGCAGCGCTGCTGCGGACCGGATCGGTGAGCGTGCACCAGCTGACCGGCGGGGAGC
CGAACGCGCGCCGGCGGCAAGAGCTCGTCGCACGGTTGGGACTGGAGACGGTTCCGGACAATGCTGCTGCGGCGAGCGAG
GCTGACCTCGTGGTGCTTTCGGTGAAGCCACAGACGCTGGATGCGGCGATGCGCGATCTGGCGGGGCGACTCCGTGCCGA
ACAAGTGGTTCTGTCGATCGTGGCTGGAGCCACGATCGAACGATTGCAATCAGGGCTGCGACACGAGCGAGTCGTGCGTT
CGATGCCGAATACGCCAGCCCAGATCGGGTACGGGGCGACCGTGTGGTGCCCAGCGCCGGTGGTCACGGCGGAGGACGAG
CGGCTGGTGCGGACGGTCCTGGAAGCGATGGGGCTGGCGATCCGCGTCGACAACGAGGACTTCGTGGACATGGCGACGGC
GCTCAGCGGGACTGGTCCAGCCTACGTCTTCCTGATCATGGAAGCGTTGATCGATGCGGGCGTGCATCTCGGTTTCTCGC
GCAGTGTGGCGGAGCAGCTCGTCCAGCAGACGATCCTGGGTTCTGTCCTGTTCGCGCAGGAAACCGGTAAGCACCCGGCG
GAGCTGCGAAACATGGTGACGACGCCGGGCGGTACGTCTGCGGCCGCGCTCTACGAGATGGAGCGCGGTGGATTGCGGAC
CGTGATCGCGCGCGCGGTCTGGGCAGCCTACCGGCGTGCCAAGGAACTGGGGGCTGGAAAGCCGAATGGTGGCCCCAGCG
ACCTCTGA

Upstream 100 bases:

>100_bases
CACTGAACCGGCTGGTCGAGTTCGTGGAGGCGTTCATCGAGGAAGGCGAGTTCGAGGAACTCGAGCTGGAGGAGGAAGAA
GAAGAGTGAGGTCGGGTGGA

Downstream 100 bases:

>100_bases
CCGCTTCATCGACTCGAGCGGAGCGTGGGAACCAGCTTGACGACTTGTCCCGTGCCGGCGTCCGCAATGTAGATCGTGCC
ATCCAGACCGATAGCGAGAG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MRAEFAGRPVGQQPSPLSGKRIAFIGCGVMAEAMAAALLRTGSVSVHQLTGGEPNARRRQELVARLGLETVPDNAAAASE
ADLVVLSVKPQTLDAAMRDLAGRLRAEQVVLSIVAGATIERLQSGLRHERVVRSMPNTPAQIGYGATVWCPAPVVTAEDE
RLVRTVLEAMGLAIRVDNEDFVDMATALSGTGPAYVFLIMEALIDAGVHLGFSRSVAEQLVQQTILGSVLFAQETGKHPA
ELRNMVTTPGGTSAAALYEMERGGLRTVIARAVWAAYRRAKELGAGKPNGGPSDL

Sequences:

>Translated_295_residues
MRAEFAGRPVGQQPSPLSGKRIAFIGCGVMAEAMAAALLRTGSVSVHQLTGGEPNARRRQELVARLGLETVPDNAAAASE
ADLVVLSVKPQTLDAAMRDLAGRLRAEQVVLSIVAGATIERLQSGLRHERVVRSMPNTPAQIGYGATVWCPAPVVTAEDE
RLVRTVLEAMGLAIRVDNEDFVDMATALSGTGPAYVFLIMEALIDAGVHLGFSRSVAEQLVQQTILGSVLFAQETGKHPA
ELRNMVTTPGGTSAAALYEMERGGLRTVIARAVWAAYRRAKELGAGKPNGGPSDL
>Mature_295_residues
MRAEFAGRPVGQQPSPLSGKRIAFIGCGVMAEAMAAALLRTGSVSVHQLTGGEPNARRRQELVARLGLETVPDNAAAASE
ADLVVLSVKPQTLDAAMRDLAGRLRAEQVVLSIVAGATIERLQSGLRHERVVRSMPNTPAQIGYGATVWCPAPVVTAEDE
RLVRTVLEAMGLAIRVDNEDFVDMATALSGTGPAYVFLIMEALIDAGVHLGFSRSVAEQLVQQTILGSVLFAQETGKHPA
ELRNMVTTPGGTSAAALYEMERGGLRTVIARAVWAAYRRAKELGAGKPNGGPSDL

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=272, Percent_Identity=36.3970588235294, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI24797097, Length=267, Percent_Identity=32.2097378277154, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI24797095, Length=267, Percent_Identity=32.2097378277154, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI21361454, Length=267, Percent_Identity=31.8352059925094, Blast_Score=154, Evalue=1e-37,
Organism=Escherichia coli, GI1786585, Length=265, Percent_Identity=33.2075471698113, Blast_Score=155, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17569021, Length=269, Percent_Identity=36.8029739776952, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17540664, Length=281, Percent_Identity=29.1814946619217, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320861, Length=289, Percent_Identity=30.7958477508651, Blast_Score=130, Evalue=2e-31,
Organism=Drosophila melanogaster, GI21358587, Length=265, Percent_Identity=35.8490566037736, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24648116, Length=275, Percent_Identity=36.3636363636364, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=39.0532544378698, Blast_Score=126, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 31159; Mature: 31159

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS00962 RIBOSOMAL_S2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAEFAGRPVGQQPSPLSGKRIAFIGCGVMAEAMAAALLRTGSVSVHQLTGGEPNARRRQ
CCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHH
ELVARLGLETVPDNAAAASEADLVVLSVKPQTLDAAMRDLAGRLRAEQVVLSIVAGATIE
HHHHHHCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLQSGLRHERVVRSMPNTPAQIGYGATVWCPAPVVTAEDERLVRTVLEAMGLAIRVDNED
HHHHHHHHHHHHHHCCCCCHHCCCCCEEECCCCCEECCHHHHHHHHHHHCCCEEEECCCH
FVDMATALSGTGPAYVFLIMEALIDAGVHLGFSRSVAEQLVQQTILGSVLFAQETGKHPA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHH
ELRNMVTTPGGTSAAALYEMERGGLRTVIARAVWAAYRRAKELGAGKPNGGPSDL
HHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MRAEFAGRPVGQQPSPLSGKRIAFIGCGVMAEAMAAALLRTGSVSVHQLTGGEPNARRRQ
CCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHH
ELVARLGLETVPDNAAAASEADLVVLSVKPQTLDAAMRDLAGRLRAEQVVLSIVAGATIE
HHHHHHCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLQSGLRHERVVRSMPNTPAQIGYGATVWCPAPVVTAEDERLVRTVLEAMGLAIRVDNED
HHHHHHHHHHHHHHCCCCCHHCCCCCEEECCCCCEECCHHHHHHHHHHHCCCEEEECCCH
FVDMATALSGTGPAYVFLIMEALIDAGVHLGFSRSVAEQLVQQTILGSVLFAQETGKHPA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHH
ELRNMVTTPGGTSAAALYEMERGGLRTVIARAVWAAYRRAKELGAGKPNGGPSDL
HHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]