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The map label for this gene is coxL [H]

Identifier: 221636181

GI number: 221636181

Start: 756170

End: 758524

Strand: Reverse

Name: coxL [H]

Synonym: trd_A0775

Alternate gene names: 221636181

Gene position: 758524-756170 (Counterclockwise)

Preceding gene: 221636182

Following gene: 221636180

Centisome position: 82.65

GC content: 64.71

Gene sequence:

>2355_bases
ATGACGCTTCAGATCTTGCCAAGGGGAAAGTGGGTCGGAGCTCGGGTCAAGCGGGTGGAGGATCCACGCTTTCTGACTGG
CGAAGCACGCTATCTGGCCGATATCCAGATCCCGGGAACAGTGCATGCGGCATTCGTGCGCTCGCCATACGGGCATGCGC
GGATCCGACGTATCGAGACGAGTGCAGCGGAGGCGCTGCCGGGAGTGATCGCGGTCTACACAGCTGAGGATGTGGCGGCG
CTCCCGCCACTGGCGAGTGGCCTCCCGATCGAGGGGCTCAAACCGACACCGCAGTCGGTGTTGGCCAAGGACAAGGTGCG
CTTCGTCGGTGAAGCGGTCGCGGTCGTGGTGGCCGAAAATCGCTACATTGCCGAAGATGCGGCGGAACTCGTCGAAGTGG
AGTACGAGCCGCTGCCAGCGGTGACGCATGCCGAGCGCGCGATGGCCGCGGATGCTCCCATCCTGCACGAGGATCTGGGG
ACGAACGTCGTCTACCAGAAGGTCACGACCCTCGGCGACGTCGAAGGTGCTTTCGCCCAGGCTGATCGAGTTTTCCGGCG
ACGCTTCCACACTAACCGGTTCGTGGCCTCGCCGATGGAGACACGCGGTTGCCTTTCGGTCTACGAGCGAGCGAGCGGGC
AACTGACGTTCTATTCTTCGACCCAGATGCCGCATATGTTGCGACTCTTCCTCTCGTTGTTCCTGGGGATTCCTGAGCAC
AAGGTGCGCGTCATCTCTCCAGAGGTCGGTGGCGGCTTCGGGCAGAAGATGACGATCTATCCGGAGGAAGTCGTCATCGC
CTATCTCGGCAAAGTTCTCGGGCGACCGGTCAAGTGGGTCGAGGACCGGCGGGAGAACCTCGCCGCCGCAACGCACGCGA
AGGAGCAGATCATCGAGCTCGAGGCAGCCGTCCGCGCTGATGGCAAGGTGCTGGGGATGAAGGCGCGGCTGATCGGCGAC
GGGGGCGCCTATTCGTTCAACACGGCGAGCGCGCTGATCGAACCCTTGGCGGCTGCGGGGATCGTGCCCGGCGTCTATGA
CATCCCAGCCTACCAGCACGAAGTGATCGCCGTCTGCACGAACAAGGCGCCGGTCGGGGCTTTCCGCGCCGTCGGCTGGA
CGGCCGCGCAGACGGCGCGGGAGCTGTTCTTCGACGAGATCGCGCGCGAACTCGGGCTGGACCCGGCGGAGTTCCGGCGC
CGCAACCTGATCAGCGAGTTCCCGCACACCACCGTGACCGGGATGGTCTACGACAGCGGCAGTTACCGGGAGTCGCTGGA
GCGGGCTCTGCAACTCGTCGGGTACGACGAGCTGCGACGCCGGCAAGCCGAGCTGCGGCAACAGGGTCGGTACCTGGGAA
TCGGGATCAGCTTGTACGTCGAGCCGACGGCGTGGGGTTCGGAAATCGCGTTGCAAGCCGGCTTCCCGTTCCCCTCGCAC
GACAACGCGACGGTGACGATCGATCCGACCGGAAAGGTGCGCGTCGCGGTCAGCGTGCACAGCCATGGTCAAGGGCACGA
AACGACGCTGGCCCAGGTGGCAGCCGAGATCCTGGGTGTCTCGATCGACGACGTGATCGTCGAGCATGGCGACACCGAGC
GTGCGCCCTGGGGCATGGGCACCTATGCCAGTCGAAGCGCGGTCATCGGTGGTGGCATGGTGGCACTGGCAGCGCAGGAA
GTGCGCGAGAAGGTGCTGCGCGTCGCCAGTCGCCTCCTCGAGGTGGCGCCGGAAGATCTAGAGATCCAAGACGGCACCGT
CTTCGTCCGCGGCGCACCGGATCGCTCGTTGAGCATGTTCCAGGTTGCCTTCGCAGCCTATTTGGACGGACGCGTGCGGG
CGGAGGGGGAGGAGCCGCTGCTTTCGGCGACCAAGTTCTACGATCCACGGGCCACGTATTCGAACGGATGCATCGTTACC
GTCTGCGAGGTGGACGGCGAGACGGGTCTCGTCCGGCTCGACAAGATCGTGGCGGTCGAAGACTGTGGGACGATGCTCAA
CCCGATGATCGTCGAAGGGCAAGTGATGGGTGCGATCGCTCAAGGGATCGGCGGTGCGCTCTACGAGGCGATGGTCTACG
ACGAGAACGGGCAGCTGCTCACCGATAGCTTCGTGACGTACGCGTTACCGACGGCGACCGAAGTGCCGGAGTTGGTAATC
GATCACCTCGAGACTCCCTCGCCGGTCACGATCGGTGGCATCAAAGGGATCGGTGAAGGTGGACTCTTGGCATCGCCGGC
ATCGGTCGCAGGCGCAGTACTCGATGCCATCTGGCCGGCTGGTCGAGCGATCGAGGAGCTGCCGCTGACGCCGGAGCGGG
TACTGGGCGCGCTCCAGAAGCAGGGCGGCGCGTGA

Upstream 100 bases:

>100_bases
AATCTCTGCCGGTGCACGGGATACCAGAACATCGTCCGGGCTGTCCGAGCGGCAGCGGAACAGATGCAAGCGGGCCGGGG
ATCATGAGAGGGGCGCAGCG

Downstream 100 bases:

>100_bases
GGAGGTGACGATCGAGCACGCGTCTCGTTTTCGGCACATGGATGGGATGGTCGCCATTCCCTGGCTTTCCGCCAGGGAAT
GGCACGAGTAGCTGGACGAA

Product: carbon monoxide dehydrogenase large chain (COdehydrogenase subunit L) (CO-DH L)

Products: NA

Alternate protein names: CO dehydrogenase subunit L; CO-DH L [H]

Number of amino acids: Translated: 784; Mature: 783

Protein sequence:

>784_residues
MTLQILPRGKWVGARVKRVEDPRFLTGEARYLADIQIPGTVHAAFVRSPYGHARIRRIETSAAEALPGVIAVYTAEDVAA
LPPLASGLPIEGLKPTPQSVLAKDKVRFVGEAVAVVVAENRYIAEDAAELVEVEYEPLPAVTHAERAMAADAPILHEDLG
TNVVYQKVTTLGDVEGAFAQADRVFRRRFHTNRFVASPMETRGCLSVYERASGQLTFYSSTQMPHMLRLFLSLFLGIPEH
KVRVISPEVGGGFGQKMTIYPEEVVIAYLGKVLGRPVKWVEDRRENLAAATHAKEQIIELEAAVRADGKVLGMKARLIGD
GGAYSFNTASALIEPLAAAGIVPGVYDIPAYQHEVIAVCTNKAPVGAFRAVGWTAAQTARELFFDEIARELGLDPAEFRR
RNLISEFPHTTVTGMVYDSGSYRESLERALQLVGYDELRRRQAELRQQGRYLGIGISLYVEPTAWGSEIALQAGFPFPSH
DNATVTIDPTGKVRVAVSVHSHGQGHETTLAQVAAEILGVSIDDVIVEHGDTERAPWGMGTYASRSAVIGGGMVALAAQE
VREKVLRVASRLLEVAPEDLEIQDGTVFVRGAPDRSLSMFQVAFAAYLDGRVRAEGEEPLLSATKFYDPRATYSNGCIVT
VCEVDGETGLVRLDKIVAVEDCGTMLNPMIVEGQVMGAIAQGIGGALYEAMVYDENGQLLTDSFVTYALPTATEVPELVI
DHLETPSPVTIGGIKGIGEGGLLASPASVAGAVLDAIWPAGRAIEELPLTPERVLGALQKQGGA

Sequences:

>Translated_784_residues
MTLQILPRGKWVGARVKRVEDPRFLTGEARYLADIQIPGTVHAAFVRSPYGHARIRRIETSAAEALPGVIAVYTAEDVAA
LPPLASGLPIEGLKPTPQSVLAKDKVRFVGEAVAVVVAENRYIAEDAAELVEVEYEPLPAVTHAERAMAADAPILHEDLG
TNVVYQKVTTLGDVEGAFAQADRVFRRRFHTNRFVASPMETRGCLSVYERASGQLTFYSSTQMPHMLRLFLSLFLGIPEH
KVRVISPEVGGGFGQKMTIYPEEVVIAYLGKVLGRPVKWVEDRRENLAAATHAKEQIIELEAAVRADGKVLGMKARLIGD
GGAYSFNTASALIEPLAAAGIVPGVYDIPAYQHEVIAVCTNKAPVGAFRAVGWTAAQTARELFFDEIARELGLDPAEFRR
RNLISEFPHTTVTGMVYDSGSYRESLERALQLVGYDELRRRQAELRQQGRYLGIGISLYVEPTAWGSEIALQAGFPFPSH
DNATVTIDPTGKVRVAVSVHSHGQGHETTLAQVAAEILGVSIDDVIVEHGDTERAPWGMGTYASRSAVIGGGMVALAAQE
VREKVLRVASRLLEVAPEDLEIQDGTVFVRGAPDRSLSMFQVAFAAYLDGRVRAEGEEPLLSATKFYDPRATYSNGCIVT
VCEVDGETGLVRLDKIVAVEDCGTMLNPMIVEGQVMGAIAQGIGGALYEAMVYDENGQLLTDSFVTYALPTATEVPELVI
DHLETPSPVTIGGIKGIGEGGLLASPASVAGAVLDAIWPAGRAIEELPLTPERVLGALQKQGGA
>Mature_783_residues
TLQILPRGKWVGARVKRVEDPRFLTGEARYLADIQIPGTVHAAFVRSPYGHARIRRIETSAAEALPGVIAVYTAEDVAAL
PPLASGLPIEGLKPTPQSVLAKDKVRFVGEAVAVVVAENRYIAEDAAELVEVEYEPLPAVTHAERAMAADAPILHEDLGT
NVVYQKVTTLGDVEGAFAQADRVFRRRFHTNRFVASPMETRGCLSVYERASGQLTFYSSTQMPHMLRLFLSLFLGIPEHK
VRVISPEVGGGFGQKMTIYPEEVVIAYLGKVLGRPVKWVEDRRENLAAATHAKEQIIELEAAVRADGKVLGMKARLIGDG
GAYSFNTASALIEPLAAAGIVPGVYDIPAYQHEVIAVCTNKAPVGAFRAVGWTAAQTARELFFDEIARELGLDPAEFRRR
NLISEFPHTTVTGMVYDSGSYRESLERALQLVGYDELRRRQAELRQQGRYLGIGISLYVEPTAWGSEIALQAGFPFPSHD
NATVTIDPTGKVRVAVSVHSHGQGHETTLAQVAAEILGVSIDDVIVEHGDTERAPWGMGTYASRSAVIGGGMVALAAQEV
REKVLRVASRLLEVAPEDLEIQDGTVFVRGAPDRSLSMFQVAFAAYLDGRVRAEGEEPLLSATKFYDPRATYSNGCIVTV
CEVDGETGLVRLDKIVAVEDCGTMLNPMIVEGQVMGAIAQGIGGALYEAMVYDENGQLLTDSFVTYALPTATEVPELVID
HLETPSPVTIGGIKGIGEGGLLASPASVAGAVLDAIWPAGRAIEELPLTPERVLGALQKQGGA

Specific function: Catalyzes the oxidation of carbon monoxide to carbon dioxide [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI91823271, Length=781, Percent_Identity=25.7362355953905, Blast_Score=176, Evalue=6e-44,
Organism=Homo sapiens, GI71773480, Length=793, Percent_Identity=25.094577553594, Blast_Score=157, Evalue=4e-38,
Organism=Escherichia coli, GI1789230, Length=772, Percent_Identity=31.4766839378238, Blast_Score=306, Evalue=3e-84,
Organism=Escherichia coli, GI1789246, Length=817, Percent_Identity=27.6621787025704, Blast_Score=265, Evalue=6e-72,
Organism=Escherichia coli, GI1786478, Length=778, Percent_Identity=27.7634961439589, Blast_Score=170, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17539860, Length=785, Percent_Identity=25.4777070063694, Blast_Score=187, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17540638, Length=798, Percent_Identity=24.937343358396, Blast_Score=163, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI32566215, Length=783, Percent_Identity=24.0102171136654, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI17737937, Length=783, Percent_Identity=27.2030651340996, Blast_Score=170, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24647193, Length=777, Percent_Identity=24.5817245817246, Blast_Score=141, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24647195, Length=790, Percent_Identity=25.0632911392405, Blast_Score=127, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24647197, Length=782, Percent_Identity=25.4475703324808, Blast_Score=126, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24647199, Length=756, Percent_Identity=24.6031746031746, Blast_Score=124, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR012780 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.2.99.2 [H]

Molecular weight: Translated: 84423; Mature: 84292

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLQILPRGKWVGARVKRVEDPRFLTGEARYLADIQIPGTVHAAFVRSPYGHARIRRIET
CEEEEECCCCCCCHHHHHCCCCCEEECCCEEEEEEECCCCCHHHHHCCCCCCHHHEEHHH
SAAEALPGVIAVYTAEDVAALPPLASGLPIEGLKPTPQSVLAKDKVRFVGEAVAVVVAEN
HHHHHCCCEEEEEECCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEEEECC
RYIAEDAAELVEVEYEPLPAVTHAERAMAADAPILHEDLGTNVVYQKVTTLGDVEGAFAQ
CEEHHHHHHHHEECCCCCCCHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHCCCCHHHHH
ADRVFRRRFHTNRFVASPMETRGCLSVYERASGQLTFYSSTQMPHMLRLFLSLFLGIPEH
HHHHHHHHHHCCCEECCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCC
KVRVISPEVGGGFGQKMTIYPEEVVIAYLGKVLGRPVKWVEDRRENLAAATHAKEQIIEL
CEEEECCCCCCCCCCEEEECHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
EAAVRADGKVLGMKARLIGDGGAYSFNTASALIEPLAAAGIVPGVYDIPAYQHEVIAVCT
HHHHCCCCEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEC
NKAPVGAFRAVGWTAAQTARELFFDEIARELGLDPAEFRRRNLISEFPHTTVTGMVYDSG
CCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEECCC
SYRESLERALQLVGYDELRRRQAELRQQGRYLGIGISLYVEPTAWGSEIALQAGFPFPSH
HHHHHHHHHHHHHCHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCEEEEECCCCCCC
DNATVTIDPTGKVRVAVSVHSHGQGHETTLAQVAAEILGVSIDDVIVEHGDTERAPWGMG
CCCEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHEECCCCCCCCCCCC
TYASRSAVIGGGMVALAAQEVREKVLRVASRLLEVAPEDLEIQDGTVFVRGAPDRSLSMF
CCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCEEEEECCCCCCHHHH
QVAFAAYLDGRVRAEGEEPLLSATKFYDPRATYSNGCIVTVCEVDGETGLVRLDKIVAVE
HHHHHHHHCCEEECCCCCCHHHHHHCCCCCCCCCCCCEEEEEEECCCCCEEEEEHEEEEH
DCGTMLNPMIVEGQVMGAIAQGIGGALYEAMVYDENGQLLTDSFVTYALPTATEVPELVI
HHHHHHCCEEECCHHHHHHHHHHCHHHHHEEEECCCCCEEECCHHHHCCCCCCCCHHHHH
DHLETPSPVTIGGIKGIGEGGLLASPASVAGAVLDAIWPAGRAIEELPLTPERVLGALQK
HHCCCCCCEEECCCCCCCCCCCEECCHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHH
QGGA
CCCC
>Mature Secondary Structure 
TLQILPRGKWVGARVKRVEDPRFLTGEARYLADIQIPGTVHAAFVRSPYGHARIRRIET
EEEEECCCCCCCHHHHHCCCCCEEECCCEEEEEEECCCCCHHHHHCCCCCCHHHEEHHH
SAAEALPGVIAVYTAEDVAALPPLASGLPIEGLKPTPQSVLAKDKVRFVGEAVAVVVAEN
HHHHHCCCEEEEEECCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEEEECC
RYIAEDAAELVEVEYEPLPAVTHAERAMAADAPILHEDLGTNVVYQKVTTLGDVEGAFAQ
CEEHHHHHHHHEECCCCCCCHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHCCCCHHHHH
ADRVFRRRFHTNRFVASPMETRGCLSVYERASGQLTFYSSTQMPHMLRLFLSLFLGIPEH
HHHHHHHHHHCCCEECCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCC
KVRVISPEVGGGFGQKMTIYPEEVVIAYLGKVLGRPVKWVEDRRENLAAATHAKEQIIEL
CEEEECCCCCCCCCCEEEECHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
EAAVRADGKVLGMKARLIGDGGAYSFNTASALIEPLAAAGIVPGVYDIPAYQHEVIAVCT
HHHHCCCCEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEC
NKAPVGAFRAVGWTAAQTARELFFDEIARELGLDPAEFRRRNLISEFPHTTVTGMVYDSG
CCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEECCC
SYRESLERALQLVGYDELRRRQAELRQQGRYLGIGISLYVEPTAWGSEIALQAGFPFPSH
HHHHHHHHHHHHHCHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCEEEEECCCCCCC
DNATVTIDPTGKVRVAVSVHSHGQGHETTLAQVAAEILGVSIDDVIVEHGDTERAPWGMG
CCCEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHEECCCCCCCCCCCC
TYASRSAVIGGGMVALAAQEVREKVLRVASRLLEVAPEDLEIQDGTVFVRGAPDRSLSMF
CCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCEEEEECCCCCCHHHH
QVAFAAYLDGRVRAEGEEPLLSATKFYDPRATYSNGCIVTVCEVDGETGLVRLDKIVAVE
HHHHHHHHCCEEECCCCCCHHHHHHCCCCCCCCCCCCEEEEEEECCCCCEEEEEHEEEEH
DCGTMLNPMIVEGQVMGAIAQGIGGALYEAMVYDENGQLLTDSFVTYALPTATEVPELVI
HHHHHHCCEEECCHHHHHHHHHHCHHHHHEEEECCCCCEEECCHHHHCCCCCCCCHHHHH
DHLETPSPVTIGGIKGIGEGGLLASPASVAGAVLDAIWPAGRAIEELPLTPERVLGALQK
HHCCCCCCEEECCCCCCCCCCCEECCHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHH
QGGA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7721710; 2818128; 12515558; 10430865; 12475995 [H]