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The map label for this gene is yusP [H]

Identifier: 221636135

GI number: 221636135

Start: 719114

End: 720757

Strand: Reverse

Name: yusP [H]

Synonym: trd_A0729

Alternate gene names: 221636135

Gene position: 720757-719114 (Counterclockwise)

Preceding gene: 221636137

Following gene: 221636134

Centisome position: 78.54

GC content: 69.95

Gene sequence:

>1644_bases
ATGGTAATCGCGGCAGTGCCGGTTGACGAGCACGAGGACGGTTCCGACGAGGTTCGCTGCCTTTCTGACCGGGTCGAGAG
GGTCGCCATGGTGTGGCCGCTAGCACAACGACCGGAGCTCGGACGGAGGCGGACCGTCGCCATCGTGAGCGGCGTGCTCG
CGGCGACCTTTCTGGCTGCCCTGGACGTTTCGATCGTCGGGACGGCCATGCCGACGATCGTCGGGGAATTGCGCGGTTTC
GCGCTCTACCCCTGGGTCGTTACGGCGTATCTGTTGACCTCGACGACCACGATCCCCTTGTACGGTCGGCTGGCTGACCT
GTATGGGCGCAAGCGGATCCTGCTCGCAGCGATCACGCTCTTCCTGGCCGGATCGGCGCTCTGTGGCCTGGCCCAATCGA
TGCTGCAGCTGGTCCTGTTCCGCGCGCTGCAGGGACTGGGAGCGGGCGGAATCATCCCAGTGACGCTGACCGTCCTGGGG
GATCTCTTCCCGCTCGAGCAGCGGGCCCGCTTGCAGGGGCTGACGAGCGCCGTCTGGGGTGCTGCGGCGGTGGCGGGACC
GAGCGTGGGGGCTGCGGTCACCGACCTGGCCGGTTGGCGCTGGATCTTCTACCTGAACGTGCCGGTCGGGCTGGTCGCGC
TCGGCCTGTTGGGGGCAGCACTGCAGGAGCGGGTGGGGCGGCGTGAGCACCGGCTGGACTATCGGGGTGCGCTCCTCCTG
ACGGCTGGGATGACGCTGCTGCTCTCGGGACTTTCGGCTGCTGGGGAGGGACGAGGAGCGGCGCCGGTCGTCGCAGTCGG
GGCGGCGCTGGGAGGAGCGGCGCTCCTCGTGCTCTTTTGGCGTACGGAGCAGCGGGCGGCCCTGCCGATCGTTCCACCGG
AACTCGTCCGCCGTCGGTTGATGGCCGTCGTCGGGCTGGGCAGCATCCTGATCGGAGCGGGGATGTTCGGGCTGATCTCG
TTCCTCCCGCTGGCGATGCAGGGTCTGGGAGCGGGGACGGCGACGACGGCTGGCCTGACGATCATGCCGTTCGCTGTCAG
CTGGTCGGTAGCCTCGACGGCAGCTGGTCGCGTCATCCTGCGCTTCGGCTTCCGGAGTTCGGTGGTGCTCGGTATGGGCG
CGATGCTGGCTGGTGCGCTCGTCCTGCAAGTCGTCCCGCGTTGGCCGGTCCTGGGGTGGGCGGTGGCTGCGGCAGCGCTC
TTCGGGGTCGGGATGGGGTTCAGCGCGACGGCGTTCCTGATCGCGGTGCAGAACGCGGTCGCGTGGAGCGAGCGGGGCAT
CGCGACGGCGCTGGTCGGCTTGTCGCGGACGATCGGTGGGGCGGTGGGGGTGGCCGTGCTGGGTGCCGTGCTCAACGGGG
TGATCCAGCAGCGGCTGGGGGAACGGGCAGCGATCGACGCATTGCTCGATCCGGCGCAGCGGCCGAGCCTGAGCGACGCG
CTGCGTGCCAGCTCGGAGCGCGCGCTGGCCGAGGCGCTGAGCGTGGCTTTTCTCCTGATCCTCCTCGTCGTCACCGCGGC
CGTCGCGCTGGAGGTGGTCGGCTTTCCGCGCGAGGTGCTGGCTGGGCGGGTGGGAGCGCGCGGACCAGTGGCGGTCAGTG
ACGGGGCACGTCCCGGTGACGCACGGGAGGAAGTGGAGCGATGA

Upstream 100 bases:

>100_bases
CCGCGAATGGTGGTCACGCTCATCTTGCTGCCCTCCGGCTCGCACCGTAGACTGCGCCCTGCCGCCTGCAGGTCGTGCTT
GCCGATGCGGCTCACGCGAT

Downstream 100 bases:

>100_bases
GGCGCCTGCTCGACGTGCTCGAGCGTTGGGAGACGGAACTGTTCTTGCTCGGGGTGGCGGGCTGGGTCCTGCCGATGCTG
GACGACCGGCTAGCGGTGGT

Product: drug resistance MFS transporter, drug:H+ antiporter-1 (14 Spanner) (DHA2) family

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 547; Mature: 547

Protein sequence:

>547_residues
MVIAAVPVDEHEDGSDEVRCLSDRVERVAMVWPLAQRPELGRRRTVAIVSGVLAATFLAALDVSIVGTAMPTIVGELRGF
ALYPWVVTAYLLTSTTTIPLYGRLADLYGRKRILLAAITLFLAGSALCGLAQSMLQLVLFRALQGLGAGGIIPVTLTVLG
DLFPLEQRARLQGLTSAVWGAAAVAGPSVGAAVTDLAGWRWIFYLNVPVGLVALGLLGAALQERVGRREHRLDYRGALLL
TAGMTLLLSGLSAAGEGRGAAPVVAVGAALGGAALLVLFWRTEQRAALPIVPPELVRRRLMAVVGLGSILIGAGMFGLIS
FLPLAMQGLGAGTATTAGLTIMPFAVSWSVASTAAGRVILRFGFRSSVVLGMGAMLAGALVLQVVPRWPVLGWAVAAAAL
FGVGMGFSATAFLIAVQNAVAWSERGIATALVGLSRTIGGAVGVAVLGAVLNGVIQQRLGERAAIDALLDPAQRPSLSDA
LRASSERALAEALSVAFLLILLVVTAAVALEVVGFPREVLAGRVGARGPVAVSDGARPGDAREEVER

Sequences:

>Translated_547_residues
MVIAAVPVDEHEDGSDEVRCLSDRVERVAMVWPLAQRPELGRRRTVAIVSGVLAATFLAALDVSIVGTAMPTIVGELRGF
ALYPWVVTAYLLTSTTTIPLYGRLADLYGRKRILLAAITLFLAGSALCGLAQSMLQLVLFRALQGLGAGGIIPVTLTVLG
DLFPLEQRARLQGLTSAVWGAAAVAGPSVGAAVTDLAGWRWIFYLNVPVGLVALGLLGAALQERVGRREHRLDYRGALLL
TAGMTLLLSGLSAAGEGRGAAPVVAVGAALGGAALLVLFWRTEQRAALPIVPPELVRRRLMAVVGLGSILIGAGMFGLIS
FLPLAMQGLGAGTATTAGLTIMPFAVSWSVASTAAGRVILRFGFRSSVVLGMGAMLAGALVLQVVPRWPVLGWAVAAAAL
FGVGMGFSATAFLIAVQNAVAWSERGIATALVGLSRTIGGAVGVAVLGAVLNGVIQQRLGERAAIDALLDPAQRPSLSDA
LRASSERALAEALSVAFLLILLVVTAAVALEVVGFPREVLAGRVGARGPVAVSDGARPGDAREEVER
>Mature_547_residues
MVIAAVPVDEHEDGSDEVRCLSDRVERVAMVWPLAQRPELGRRRTVAIVSGVLAATFLAALDVSIVGTAMPTIVGELRGF
ALYPWVVTAYLLTSTTTIPLYGRLADLYGRKRILLAAITLFLAGSALCGLAQSMLQLVLFRALQGLGAGGIIPVTLTVLG
DLFPLEQRARLQGLTSAVWGAAAVAGPSVGAAVTDLAGWRWIFYLNVPVGLVALGLLGAALQERVGRREHRLDYRGALLL
TAGMTLLLSGLSAAGEGRGAAPVVAVGAALGGAALLVLFWRTEQRAALPIVPPELVRRRLMAVVGLGSILIGAGMFGLIS
FLPLAMQGLGAGTATTAGLTIMPFAVSWSVASTAAGRVILRFGFRSSVVLGMGAMLAGALVLQVVPRWPVLGWAVAAAAL
FGVGMGFSATAFLIAVQNAVAWSERGIATALVGLSRTIGGAVGVAVLGAVLNGVIQQRLGERAAIDALLDPAQRPSLSDA
LRASSERALAEALSVAFLLILLVVTAAVALEVVGFPREVLAGRVGARGPVAVSDGARPGDAREEVER

Specific function: Unknown

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=402, Percent_Identity=29.6019900497512, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI87081983, Length=402, Percent_Identity=27.363184079602, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1789042, Length=432, Percent_Identity=27.7777777777778, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1788392, Length=406, Percent_Identity=29.8029556650246, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788710, Length=409, Percent_Identity=26.6503667481663, Blast_Score=96, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6319770, Length=427, Percent_Identity=28.3372365339578, Blast_Score=117, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6322958, Length=480, Percent_Identity=23.125, Blast_Score=106, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6323735, Length=437, Percent_Identity=25.858123569794, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6325455, Length=250, Percent_Identity=27.6, Blast_Score=84, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6321663, Length=149, Percent_Identity=32.2147651006711, Blast_Score=80, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6323520, Length=367, Percent_Identity=25.6130790190736, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323935, Length=365, Percent_Identity=22.7397260273973, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324954, Length=386, Percent_Identity=22.5388601036269, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 56449; Mature: 56449

Theoretical pI: Translated: 10.73; Mature: 10.73

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIAAVPVDEHEDGSDEVRCLSDRVERVAMVWPLAQRPELGRRRTVAIVSGVLAATFLAA
CEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LDVSIVGTAMPTIVGELRGFALYPWVVTAYLLTSTTTIPLYGRLADLYGRKRILLAAITL
HHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHH
FLAGSALCGLAQSMLQLVLFRALQGLGAGGIIPVTLTVLGDLFPLEQRARLQGLTSAVWG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
AAAVAGPSVGAAVTDLAGWRWIFYLNVPVGLVALGLLGAALQERVGRREHRLDYRGALLL
HHHHCCCCCCHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHH
TAGMTLLLSGLSAAGEGRGAAPVVAVGAALGGAALLVLFWRTEQRAALPIVPPELVRRRL
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHH
MAVVGLGSILIGAGMFGLISFLPLAMQGLGAGTATTAGLTIMPFAVSWSVASTAAGRVIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCEEEEHHHHHHHHHHHHCCEEE
RFGFRSSVVLGMGAMLAGALVLQVVPRWPVLGWAVAAAALFGVGMGFSATAFLIAVQNAV
EECCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
AWSERGIATALVGLSRTIGGAVGVAVLGAVLNGVIQQRLGERAAIDALLDPAQRPSLSDA
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHH
LRASSERALAEALSVAFLLILLVVTAAVALEVVGFPREVLAGRVGARGPVAVSDGARPGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCEEECCCCCCCC
AREEVER
HHHHHCC
>Mature Secondary Structure
MVIAAVPVDEHEDGSDEVRCLSDRVERVAMVWPLAQRPELGRRRTVAIVSGVLAATFLAA
CEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LDVSIVGTAMPTIVGELRGFALYPWVVTAYLLTSTTTIPLYGRLADLYGRKRILLAAITL
HHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHH
FLAGSALCGLAQSMLQLVLFRALQGLGAGGIIPVTLTVLGDLFPLEQRARLQGLTSAVWG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
AAAVAGPSVGAAVTDLAGWRWIFYLNVPVGLVALGLLGAALQERVGRREHRLDYRGALLL
HHHHCCCCCCHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHH
TAGMTLLLSGLSAAGEGRGAAPVVAVGAALGGAALLVLFWRTEQRAALPIVPPELVRRRL
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHH
MAVVGLGSILIGAGMFGLISFLPLAMQGLGAGTATTAGLTIMPFAVSWSVASTAAGRVIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCEEEEHHHHHHHHHHHHCCEEE
RFGFRSSVVLGMGAMLAGALVLQVVPRWPVLGWAVAAAALFGVGMGFSATAFLIAVQNAV
EECCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
AWSERGIATALVGLSRTIGGAVGVAVLGAVLNGVIQQRLGERAAIDALLDPAQRPSLSDA
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHH
LRASSERALAEALSVAFLLILLVVTAAVALEVVGFPREVLAGRVGARGPVAVSDGARPGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCEEECCCCCCCC
AREEVER
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]