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The map label for this gene is garR [H]

Identifier: 221636045

GI number: 221636045

Start: 629390

End: 630322

Strand: Reverse

Name: garR [H]

Synonym: trd_A0639

Alternate gene names: 221636045

Gene position: 630322-629390 (Counterclockwise)

Preceding gene: 221636046

Following gene: 221636039

Centisome position: 68.68

GC content: 64.09

Gene sequence:

>933_bases
ATGGATGACAAGCCGACGCTCGGTCTCGTCGGGTTAGGAAACCTGGGGCGGGCGATCGCGCTGCGCTTGCTCGGCGCGGG
ATACCGGCTGCTGGTCAACGACCGTCGCTGGGAGGTGGCACAGGCATTGGAACTGCATGGTGCGACAGCCATTCCGACAC
CGCTTCTGCTGGCCGAAGAGGTCGATATGTTTCTGACCTGTTTGCCGGGGGACGAGGAACTGTTCGAGGTCTATATCGGG
CCGGAGGGAGCACTCGAGCACTTGCGGCCAGGAGCGACGGTGATCGACTTCAGTACTGCCTCACCGATGATGATGCAACG
CATCGATCGAGAAGCGCGGCTGCGTCAGATCGACGTGGTCGATGCGCCGGTCGGAGGGGGGCCAGTCGAGGCCAACAGTG
GCCAGCTGACGATGATGGTTGGGGCCGAGCCGGCGGTGTTCGAGCGGATGATGCCGCTCCTCGGAGTGTTGGGTCGAGAG
ACCTATCTGGTCGGCCCGCCTGGCATGGGGAAAGTGGTCAAGCTGATCAACCAGCTGCTCGCGGGGGTGAGCTTGGTTGT
CATCGGGGAAGCTCTGGCATTGGCGGCGAATGCTGGGGCCGATCTCGCGACCGTCTACGAGGCGCTGCGCTCGAGTACCG
GTGGTTGGAAGCTCTGGCGGGACGTGGTGCCGGAACTCTTGCGGGAAAGTGGTGAAGTGTCCTTTCGACTGGAGCTGATG
AAGCGTGACATGGAACTGGCAATGCGGCTCGGGAGCGATGTGGGCTCGCCCGTGCCGATGACCGCGCTCGCTCATCAGTT
CTATGTGGCCGCGATGGCGCGGGGCTGGGGTCAGCTTCCGGCACACGAGGTCGCGCGGTTGGTCGGTCGGTTGGCCAATG
CGAGCTTCAGCGCGAGCAGCGCGCGTGGCGACGATCTTCTCGCCGCGGAATGA

Upstream 100 bases:

>100_bases
CGTGATGGCCGATGCGAGGCGAGCGGAGAAGGCTTGTCGCCGTTTGCTGTGCTCCGGCATGATGGAAGGCACGAGGGTCG
GAGAACAGGGAGGAGTGAGG

Downstream 100 bases:

>100_bases
CGCTCAGGCTGCACCGAGATAGGCAGCTTGAACGCGCGGATCCGCAGCGAGTTCGGCTGCTGGGCCGCTCAGGACGATAC
GGCCAGTCTCCAAAACGTAC

Product: tartronate semialdehyde reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MDDKPTLGLVGLGNLGRAIALRLLGAGYRLLVNDRRWEVAQALELHGATAIPTPLLLAEEVDMFLTCLPGDEELFEVYIG
PEGALEHLRPGATVIDFSTASPMMMQRIDREARLRQIDVVDAPVGGGPVEANSGQLTMMVGAEPAVFERMMPLLGVLGRE
TYLVGPPGMGKVVKLINQLLAGVSLVVIGEALALAANAGADLATVYEALRSSTGGWKLWRDVVPELLRESGEVSFRLELM
KRDMELAMRLGSDVGSPVPMTALAHQFYVAAMARGWGQLPAHEVARLVGRLANASFSASSARGDDLLAAE

Sequences:

>Translated_310_residues
MDDKPTLGLVGLGNLGRAIALRLLGAGYRLLVNDRRWEVAQALELHGATAIPTPLLLAEEVDMFLTCLPGDEELFEVYIG
PEGALEHLRPGATVIDFSTASPMMMQRIDREARLRQIDVVDAPVGGGPVEANSGQLTMMVGAEPAVFERMMPLLGVLGRE
TYLVGPPGMGKVVKLINQLLAGVSLVVIGEALALAANAGADLATVYEALRSSTGGWKLWRDVVPELLRESGEVSFRLELM
KRDMELAMRLGSDVGSPVPMTALAHQFYVAAMARGWGQLPAHEVARLVGRLANASFSASSARGDDLLAAE
>Mature_310_residues
MDDKPTLGLVGLGNLGRAIALRLLGAGYRLLVNDRRWEVAQALELHGATAIPTPLLLAEEVDMFLTCLPGDEELFEVYIG
PEGALEHLRPGATVIDFSTASPMMMQRIDREARLRQIDVVDAPVGGGPVEANSGQLTMMVGAEPAVFERMMPLLGVLGRE
TYLVGPPGMGKVVKLINQLLAGVSLVVIGEALALAANAGADLATVYEALRSSTGGWKLWRDVVPELLRESGEVSFRLELM
KRDMELAMRLGSDVGSPVPMTALAHQFYVAAMARGWGQLPAHEVARLVGRLANASFSASSARGDDLLAAE

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=287, Percent_Identity=30.3135888501742, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI40556376, Length=267, Percent_Identity=25.4681647940075, Blast_Score=102, Evalue=5e-22,
Organism=Escherichia coli, GI145693186, Length=291, Percent_Identity=31.2714776632302, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1786719, Length=287, Percent_Identity=30.6620209059233, Blast_Score=141, Evalue=7e-35,
Organism=Escherichia coli, GI1789092, Length=274, Percent_Identity=28.8321167883212, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1790315, Length=274, Percent_Identity=28.1021897810219, Blast_Score=107, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17557316, Length=271, Percent_Identity=29.1512915129151, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24655230, Length=282, Percent_Identity=29.4326241134752, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI19922568, Length=282, Percent_Identity=29.4326241134752, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI28574115, Length=281, Percent_Identity=23.4875444839858, Blast_Score=88, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 33107; Mature: 33107

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDKPTLGLVGLGNLGRAIALRLLGAGYRLLVNDRRWEVAQALELHGATAIPTPLLLAEE
CCCCCCEEEEECCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCCCCCHHHHHHH
VDMFLTCLPGDEELFEVYIGPEGALEHLRPGATVIDFSTASPMMMQRIDREARLRQIDVV
HCEEEEECCCCHHEEEEEECCCHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHEEEEE
DAPVGGGPVEANSGQLTMMVGAEPAVFERMMPLLGVLGRETYLVGPPGMGKVVKLINQLL
ECCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHH
AGVSLVVIGEALALAANAGADLATVYEALRSSTGGWKLWRDVVPELLRESGEVSFRLELM
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEHHHH
KRDMELAMRLGSDVGSPVPMTALAHQFYVAAMARGWGQLPAHEVARLVGRLANASFSASS
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCC
ARGDDLLAAE
CCCCCCCCCC
>Mature Secondary Structure
MDDKPTLGLVGLGNLGRAIALRLLGAGYRLLVNDRRWEVAQALELHGATAIPTPLLLAEE
CCCCCCEEEEECCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCCCCCHHHHHHH
VDMFLTCLPGDEELFEVYIGPEGALEHLRPGATVIDFSTASPMMMQRIDREARLRQIDVV
HCEEEEECCCCHHEEEEEECCCHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHEEEEE
DAPVGGGPVEANSGQLTMMVGAEPAVFERMMPLLGVLGRETYLVGPPGMGKVVKLINQLL
ECCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHH
AGVSLVVIGEALALAANAGADLATVYEALRSSTGGWKLWRDVVPELLRESGEVSFRLELM
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEHHHH
KRDMELAMRLGSDVGSPVPMTALAHQFYVAAMARGWGQLPAHEVARLVGRLANASFSASS
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCC
ARGDDLLAAE
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]