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The map label for this gene is map [H]

Identifier: 221635843

GI number: 221635843

Start: 422355

End: 423104

Strand: Reverse

Name: map [H]

Synonym: trd_A0436

Alternate gene names: 221635843

Gene position: 423104-422355 (Counterclockwise)

Preceding gene: 221635850

Following gene: 221635840

Centisome position: 46.1

GC content: 67.2

Gene sequence:

>750_bases
GTGGCGATCGTTCTCAAGCGTCCCGAGCAGATCCGCCTCATGCGCGAGGCTGGCAAGATCGTCGCCGAAGTCCTAGCCAC
GCTCGCCGAGACGGTCCGCCCCGGTATCACCACGGCCGAACTCGACCGGATCGCCGAGCGGATCATTCGCCGGCACGGTG
CGGTGCCCTCCTTCAAGGGCTACCGCGGCTTCCCGGCCTCCATCTGCGTGTCGGTCAACGAGGAAGTCGTGCACGGCATC
CCCGGCTCGCGCATGCTCGCCGAGGGGGATATCGTCGGGATCGATGTCGGTGCCCGCTACCGCGGCTACCATGGGGACGC
GACGATCACCGTTCCCGTGGGGCGGGTTTCCCCGGAGGCCGAGAAGCTCCTGCGCGTCTGCCGCGAAGCGCTGGAGATCG
GCATCGCCCAGGCGCATGCCGGTCGGCGACTGACCGATATTTCCCACGCTATCCAGCAGCACGTCGAGGCACACGGCTTC
TCGGTCATCCGTAACCTGTACGGACATGGGATCGGCCGCAGCCTGCACGAGGAACCGATGCTTCCGCACTACGGTCCCCC
CGGTCAGGGACCCCTTCTCCGGCCCGGTATGGTCATCACCATCGAGCCGATGATCGCCGCTGGCCGACCGGAGACCCGTG
TCCTCCCCGATCGCTGGACAGTCGTTACGGCGGACGGCAGTCTCTCCGCCCAGTTCGAGCACACCGTCGCCATCACCGAG
AACGGCCCGGAGATCCTCACCCTGCCCTAA

Upstream 100 bases:

>100_bases
CAGCTACCTCGAGCACGAACCGCCCGGCCGGTGCGACGGGCAGACTAGTGGTATACTTTCCAGTTGGCCGCGTCGCAGCG
GCCAACTGGAGGAGCGAGGC

Downstream 100 bases:

>100_bases
TCGTCAGCCAGCAGGGTACTCGCGCGTGCCGTGCGCCCTCGCCAGGCCGACCAACCGGCTCGCCCCTGGACGACCGCCAT
CCCCAACAGGATGAGGATGA

Product: methionine aminopeptidase, type I

Products: NA

Alternate protein names: MAP 1; Peptidase M [H]

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MAIVLKRPEQIRLMREAGKIVAEVLATLAETVRPGITTAELDRIAERIIRRHGAVPSFKGYRGFPASICVSVNEEVVHGI
PGSRMLAEGDIVGIDVGARYRGYHGDATITVPVGRVSPEAEKLLRVCREALEIGIAQAHAGRRLTDISHAIQQHVEAHGF
SVIRNLYGHGIGRSLHEEPMLPHYGPPGQGPLLRPGMVITIEPMIAAGRPETRVLPDRWTVVTADGSLSAQFEHTVAITE
NGPEILTLP

Sequences:

>Translated_249_residues
MAIVLKRPEQIRLMREAGKIVAEVLATLAETVRPGITTAELDRIAERIIRRHGAVPSFKGYRGFPASICVSVNEEVVHGI
PGSRMLAEGDIVGIDVGARYRGYHGDATITVPVGRVSPEAEKLLRVCREALEIGIAQAHAGRRLTDISHAIQQHVEAHGF
SVIRNLYGHGIGRSLHEEPMLPHYGPPGQGPLLRPGMVITIEPMIAAGRPETRVLPDRWTVVTADGSLSAQFEHTVAITE
NGPEILTLP
>Mature_248_residues
AIVLKRPEQIRLMREAGKIVAEVLATLAETVRPGITTAELDRIAERIIRRHGAVPSFKGYRGFPASICVSVNEEVVHGIP
GSRMLAEGDIVGIDVGARYRGYHGDATITVPVGRVSPEAEKLLRVCREALEIGIAQAHAGRRLTDISHAIQQHVEAHGFS
VIRNLYGHGIGRSLHEEPMLPHYGPPGQGPLLRPGMVITIEPMIAAGRPETRVLPDRWTVVTADGSLSAQFEHTVAITEN
GPEILTLP

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=245, Percent_Identity=42.4489795918367, Blast_Score=194, Evalue=4e-50,
Organism=Homo sapiens, GI40385867, Length=246, Percent_Identity=42.2764227642276, Blast_Score=192, Evalue=2e-49,
Organism=Escherichia coli, GI1786364, Length=250, Percent_Identity=48.4, Blast_Score=240, Evalue=6e-65,
Organism=Escherichia coli, GI1789275, Length=272, Percent_Identity=26.8382352941176, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1788728, Length=207, Percent_Identity=27.0531400966184, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71996291, Length=240, Percent_Identity=42.0833333333333, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6323273, Length=246, Percent_Identity=43.4959349593496, Blast_Score=207, Evalue=9e-55,
Organism=Drosophila melanogaster, GI21355531, Length=239, Percent_Identity=45.6066945606695, Blast_Score=206, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24583427, Length=245, Percent_Identity=40, Blast_Score=177, Evalue=5e-45,
Organism=Drosophila melanogaster, GI19920384, Length=268, Percent_Identity=23.8805970149254, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27002; Mature: 26870

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIVLKRPEQIRLMREAGKIVAEVLATLAETVRPGITTAELDRIAERIIRRHGAVPSFKG
CEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCC
YRGFPASICVSVNEEVVHGIPGSRMLAEGDIVGIDVGARYRGYHGDATITVPVGRVSPEA
CCCCCCEEEEECCHHHHHCCCCCCEEECCCEEEEECCCCCCCCCCCEEEEEECCCCCHHH
EKLLRVCREALEIGIAQAHAGRRLTDISHAIQQHVEAHGFSVIRNLYGHGIGRSLHEEPM
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCC
LPHYGPPGQGPLLRPGMVITIEPMIAAGRPETRVLPDRWTVVTADGSLSAQFEHTVAITE
CCCCCCCCCCCCCCCCEEEEECCCEECCCCCCCCCCCCEEEEEECCCCCEEEEEEEEEEC
NGPEILTLP
CCCEEEECC
>Mature Secondary Structure 
AIVLKRPEQIRLMREAGKIVAEVLATLAETVRPGITTAELDRIAERIIRRHGAVPSFKG
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCC
YRGFPASICVSVNEEVVHGIPGSRMLAEGDIVGIDVGARYRGYHGDATITVPVGRVSPEA
CCCCCCEEEEECCHHHHHCCCCCCEEECCCEEEEECCCCCCCCCCCEEEEEECCCCCHHH
EKLLRVCREALEIGIAQAHAGRRLTDISHAIQQHVEAHGFSVIRNLYGHGIGRSLHEEPM
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCC
LPHYGPPGQGPLLRPGMVITIEPMIAAGRPETRVLPDRWTVVTADGSLSAQFEHTVAITE
CCCCCCCCCCCCCCCCEEEEECCCEECCCCCCCCCCCCEEEEEECCCCCEEEEEEEEEEC
NGPEILTLP
CCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2113521; 8635744; 9384377 [H]