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The map label for this gene is argD [H]

Identifier: 221635768

GI number: 221635768

Start: 350521

End: 351810

Strand: Reverse

Name: argD [H]

Synonym: trd_A0362

Alternate gene names: 221635768

Gene position: 351810-350521 (Counterclockwise)

Preceding gene: 221635775

Following gene: 221635767

Centisome position: 38.33

GC content: 64.88

Gene sequence:

>1290_bases
ATGGAAACGATCCAGAAGTATCGCGAGTATGTCTGCACCAGCTTCGTGGCAGCAGTGGAGCCGGTCGTGGTGGAGCGCGC
CAGCGGTGCGACCGTCGTCGACACCTCAGGACGCGAGTATATCGACTGCTTCGCCGGAATCGCGGTCACCAATGCTGGTC
ATTGCCATCCCAAAGTAGTCGCCGCAGCCAAAGCGCAGGCCGACAAGCTGGTGCATGCCGCCAGCTACGTCTATCACGTT
CCGGTGGTCGCCGATCTGGCCGAGCGGCTCGCCCAAATCACGCCGGGTGCACTCAAGAAGACGTTCTTCGGCAACAGCGG
GGCCGAGGGGATCGAGACGGCGCTCCGCATGGCCAAGGCCTACACTGGACGCAACGAGTTCATCGCGCTGACCCACTCCT
TCCACGGTCGAACGGTCGGTACGCTTTCGGTCACCGGCAACATGCTGCGCAAGAAGCGCGGCGGACCGTACCTTCCCGGC
GTCGCGTTCGCTCCGGCACCTTACCTCTACCGTAATCCCTTCGGGACCGACGATCCGGAAGTCCTCGCCCAGCGCTGCGC
GGACATGGTCGAGTGGGCGATCAAGTACCAAACGTCCGGCAACGTCGCGGCCTTCATCGCCGAGCCGGTGCTGGGCGAGG
GCGGCATCATCGTGCCGCCAGCCAATTACTTTCGCTACGTCAAAGAGGTGCTCGATCGCTACGGCATCTTGTTCATCGTC
GACGAGGTGCAAAGCGGCTTCGGTCGCACCGGCAAGCTCTTCGCCATCGAGCATTACGGCGTCGAGCCGGACATCATGGT
GATGGCCAAGGGGATCGCCGATGGCTTCCCGCTCTCGGCCTGCATCGCCCGCGCCGAGATCGCCGACGCCTTCCAGCCCG
GCGAGCACCTCTCGACCTTCGGCGGTAACCCGGTATCCTGCGCGGCAGCGCTGGCGAACATCGAGGTCATGCTGGAGGAG
GACCTGCCAGGTCAAGCGGCTCGCAAGGGTGAACAGGCACTCGCACAACTCCGGGAACTGGCTGCCGAGCACGAGCTGAT
CGGCGACGTACGCGGGCTCGGCCTGATGATCGGTGTGGAACTGGTCAGTGATCGCCGGACCAAGCAGCCAGCGGCCAAGC
AAGCCGCAGCCTTGCGCGCCTACTGCCGCGAGCACGGGGTCCTCATCGGGGTCGGCGGGCAAGAGGGGAACGTGGTCCGC
TTCCAACCGCCGCTCACCATCACGTGGGAGCAACTCGAGCGCGCGCTGACCGTCTTCGCTGATGGACTCCGGACCGTCAG
CCGCTCCTGA

Upstream 100 bases:

>100_bases
ACTCTCCGGTTGAAGACGGGCTGTGCCCGTCGGGTAGAATGAGTCGAGCGAACAGGAACGTTTTTGCCGGTTCGGATCCG
GAAACCGAGGGGAGCTGCCG

Downstream 100 bases:

>100_bases
GGGTGAGAGCAGCGAGCCGTCCGCTCGCCGATGCTGGCATCTTTGGCTCATCTCGGCGAGCGGTCGAGATGGGTCACGGA
TACGAGCCGAACCCGGCCAC

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
METIQKYREYVCTSFVAAVEPVVVERASGATVVDTSGREYIDCFAGIAVTNAGHCHPKVVAAAKAQADKLVHAASYVYHV
PVVADLAERLAQITPGALKKTFFGNSGAEGIETALRMAKAYTGRNEFIALTHSFHGRTVGTLSVTGNMLRKKRGGPYLPG
VAFAPAPYLYRNPFGTDDPEVLAQRCADMVEWAIKYQTSGNVAAFIAEPVLGEGGIIVPPANYFRYVKEVLDRYGILFIV
DEVQSGFGRTGKLFAIEHYGVEPDIMVMAKGIADGFPLSACIARAEIADAFQPGEHLSTFGGNPVSCAAALANIEVMLEE
DLPGQAARKGEQALAQLRELAAEHELIGDVRGLGLMIGVELVSDRRTKQPAAKQAAALRAYCREHGVLIGVGGQEGNVVR
FQPPLTITWEQLERALTVFADGLRTVSRS

Sequences:

>Translated_429_residues
METIQKYREYVCTSFVAAVEPVVVERASGATVVDTSGREYIDCFAGIAVTNAGHCHPKVVAAAKAQADKLVHAASYVYHV
PVVADLAERLAQITPGALKKTFFGNSGAEGIETALRMAKAYTGRNEFIALTHSFHGRTVGTLSVTGNMLRKKRGGPYLPG
VAFAPAPYLYRNPFGTDDPEVLAQRCADMVEWAIKYQTSGNVAAFIAEPVLGEGGIIVPPANYFRYVKEVLDRYGILFIV
DEVQSGFGRTGKLFAIEHYGVEPDIMVMAKGIADGFPLSACIARAEIADAFQPGEHLSTFGGNPVSCAAALANIEVMLEE
DLPGQAARKGEQALAQLRELAAEHELIGDVRGLGLMIGVELVSDRRTKQPAAKQAAALRAYCREHGVLIGVGGQEGNVVR
FQPPLTITWEQLERALTVFADGLRTVSRS
>Mature_429_residues
METIQKYREYVCTSFVAAVEPVVVERASGATVVDTSGREYIDCFAGIAVTNAGHCHPKVVAAAKAQADKLVHAASYVYHV
PVVADLAERLAQITPGALKKTFFGNSGAEGIETALRMAKAYTGRNEFIALTHSFHGRTVGTLSVTGNMLRKKRGGPYLPG
VAFAPAPYLYRNPFGTDDPEVLAQRCADMVEWAIKYQTSGNVAAFIAEPVLGEGGIIVPPANYFRYVKEVLDRYGILFIV
DEVQSGFGRTGKLFAIEHYGVEPDIMVMAKGIADGFPLSACIARAEIADAFQPGEHLSTFGGNPVSCAAALANIEVMLEE
DLPGQAARKGEQALAQLRELAAEHELIGDVRGLGLMIGVELVSDRRTKQPAAKQAAALRAYCREHGVLIGVGGQEGNVVR
FQPPLTITWEQLERALTVFADGLRTVSRS

Specific function: Unknown

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI37574042, Length=432, Percent_Identity=36.8055555555556, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI24119277, Length=419, Percent_Identity=35.799522673031, Blast_Score=252, Evalue=5e-67,
Organism=Homo sapiens, GI226442705, Length=432, Percent_Identity=35.8796296296296, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI226442709, Length=391, Percent_Identity=37.5959079283887, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI13994255, Length=424, Percent_Identity=33.7264150943396, Blast_Score=238, Evalue=8e-63,
Organism=Homo sapiens, GI4557809, Length=408, Percent_Identity=31.8627450980392, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI284507298, Length=324, Percent_Identity=31.4814814814815, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI188536080, Length=438, Percent_Identity=25.7990867579909, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI38679950, Length=438, Percent_Identity=25.7990867579909, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI38679946, Length=438, Percent_Identity=25.7990867579909, Blast_Score=106, Evalue=4e-23,
Organism=Escherichia coli, GI145693181, Length=430, Percent_Identity=39.5348837209302, Blast_Score=274, Evalue=9e-75,
Organism=Escherichia coli, GI1789016, Length=412, Percent_Identity=38.3495145631068, Blast_Score=262, Evalue=3e-71,
Organism=Escherichia coli, GI1787560, Length=403, Percent_Identity=39.454094292804, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI1789759, Length=409, Percent_Identity=33.7408312958435, Blast_Score=214, Evalue=8e-57,
Organism=Escherichia coli, GI1788044, Length=424, Percent_Identity=31.8396226415094, Blast_Score=202, Evalue=3e-53,
Organism=Escherichia coli, GI1786991, Length=424, Percent_Identity=33.0188679245283, Blast_Score=167, Evalue=8e-43,
Organism=Escherichia coli, GI1786349, Length=299, Percent_Identity=27.7591973244147, Blast_Score=106, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI32564660, Length=447, Percent_Identity=34.675615212528, Blast_Score=248, Evalue=5e-66,
Organism=Caenorhabditis elegans, GI71992977, Length=426, Percent_Identity=34.5070422535211, Blast_Score=237, Evalue=8e-63,
Organism=Caenorhabditis elegans, GI25144271, Length=416, Percent_Identity=32.2115384615385, Blast_Score=214, Evalue=8e-56,
Organism=Caenorhabditis elegans, GI25144274, Length=297, Percent_Identity=35.016835016835, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17541228, Length=464, Percent_Identity=24.1379310344828, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71981843, Length=156, Percent_Identity=27.5641025641026, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323470, Length=420, Percent_Identity=33.8095238095238, Blast_Score=221, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6324432, Length=423, Percent_Identity=32.8605200945626, Blast_Score=200, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6324386, Length=462, Percent_Identity=24.6753246753247, Blast_Score=100, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6321456, Length=439, Percent_Identity=23.6902050113895, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28574759, Length=443, Percent_Identity=35.8916478555305, Blast_Score=260, Evalue=1e-69,
Organism=Drosophila melanogaster, GI161085790, Length=447, Percent_Identity=35.3467561521253, Blast_Score=260, Evalue=1e-69,
Organism=Drosophila melanogaster, GI21356575, Length=437, Percent_Identity=35.2402745995423, Blast_Score=225, Evalue=4e-59,
Organism=Drosophila melanogaster, GI21357415, Length=408, Percent_Identity=31.3725490196078, Blast_Score=208, Evalue=5e-54,
Organism=Drosophila melanogaster, GI281366494, Length=420, Percent_Identity=23.3333333333333, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24667139, Length=420, Percent_Identity=23.3333333333333, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24667143, Length=420, Percent_Identity=23.3333333333333, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 46097; Mature: 46097

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METIQKYREYVCTSFVAAVEPVVVERASGATVVDTSGREYIDCFAGIAVTNAGHCHPKVV
CCHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEECCCCHHHHHHHHHHCCCCCCCCHHHH
AAAKAQADKLVHAASYVYHVPVVADLAERLAQITPGALKKTFFGNSGAEGIETALRMAKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHH
YTGRNEFIALTHSFHGRTVGTLSVTGNMLRKKRGGPYLPGVAFAPAPYLYRNPFGTDDPE
HCCCCCEEEEEECCCCCEEEEEEHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
VLAQRCADMVEWAIKYQTSGNVAAFIAEPVLGEGGIIVPPANYFRYVKEVLDRYGILFIV
HHHHHHHHHHHHHHEECCCCCEEEEEECCCCCCCCEEECCHHHHHHHHHHHHHCCEEEEE
DEVQSGFGRTGKLFAIEHYGVEPDIMVMAKGIADGFPLSACIARAEIADAFQPGEHLSTF
EHHHHCCCCCCEEEEEEECCCCCCCEEEEHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHC
GGNPVSCAAALANIEVMLEEDLPGQAARKGEQALAQLRELAAEHELIGDVRGLGLMIGVE
CCCHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVSDRRTKQPAAKQAAALRAYCREHGVLIGVGGQEGNVVRFQPPLTITWEQLERALTVFA
HHHCCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCEEEECCCCEEEHHHHHHHHHHHH
DGLRTVSRS
HHHHHHCCC
>Mature Secondary Structure
METIQKYREYVCTSFVAAVEPVVVERASGATVVDTSGREYIDCFAGIAVTNAGHCHPKVV
CCHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEECCCCHHHHHHHHHHCCCCCCCCHHHH
AAAKAQADKLVHAASYVYHVPVVADLAERLAQITPGALKKTFFGNSGAEGIETALRMAKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHH
YTGRNEFIALTHSFHGRTVGTLSVTGNMLRKKRGGPYLPGVAFAPAPYLYRNPFGTDDPE
HCCCCCEEEEEECCCCCEEEEEEHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
VLAQRCADMVEWAIKYQTSGNVAAFIAEPVLGEGGIIVPPANYFRYVKEVLDRYGILFIV
HHHHHHHHHHHHHHEECCCCCEEEEEECCCCCCCCEEECCHHHHHHHHHHHHHCCEEEEE
DEVQSGFGRTGKLFAIEHYGVEPDIMVMAKGIADGFPLSACIARAEIADAFQPGEHLSTF
EHHHHCCCCCCEEEEEEECCCCCCCEEEEHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHC
GGNPVSCAAALANIEVMLEEDLPGQAARKGEQALAQLRELAAEHELIGDVRGLGLMIGVE
CCCHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVSDRRTKQPAAKQAAALRAYCREHGVLIGVGGQEGNVVRFQPPLTITWEQLERALTVFA
HHHCCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCEEEECCCCEEEHHHHHHHHHHHH
DGLRTVSRS
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]