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The map label for this gene is mutM

Identifier: 221633868

GI number: 221633868

Start: 1904743

End: 1905612

Strand: Reverse

Name: mutM

Synonym: trd_1895

Alternate gene names: 221633868

Gene position: 1905612-1904743 (Counterclockwise)

Preceding gene: 221633870

Following gene: 221633866

Centisome position: 95.14

GC content: 68.28

Gene sequence:

>870_bases
ATGCCAGAGCTACCGGAAGTCGAAACCATCCGCCGCACCCTGGCGCCCGTTCTCATCGGCGCGCTGGTCATCGGCGCGCT
CCGCGGCGAGCACCCCGAGGATATTCTGCTCGATCCTTGGCCAGTCTTCGCCCGCCGCGTGCGCCGGCACCGCATCGTCG
CACTCGAACGGCGCGGGAAGTATCTCGCTGCTCGCTTCGAGGACGGTGACCGGCTCGTGATCCATCTCGGCATGACGGGG
GAACTCCGACTCAGCCACCCCGCTACCGCCCCAGGCAAGCATTGTCACCTGGCGCTGGTCCTGCGCTCGCTGCGACCCTT
GCCCCCGTCGCTCGTCGATCAGCGGCAACGGTTCCTGCTTCGCTATCTGGACATCCGGCGGTTCGGGCGCATCGCTCTCC
TCGATCAGGCAGGGTGGGAAACCTTCACCGCGCGACTCGGCCCCGAGCCGCTCGATCCGACCCTCGACCCACGCGCGCTC
TGGTCGCGCCTGCGCGAGCGTCGGACAGCGATCAAGGCAGCACTGCTCGATCAAGCGCTCCTGGCCGGAATCGGGAACAT
CTACGCGGACGAGGCCTTATTCCAGGCGCGCCTCCATCCAGCACGGCGCTGCCAGACGCTCTCCCTGGACGAGGTCGAGC
GGCTGCTGGTGGCGCTGCGCACTGTCCTGTCGGCAGCGATCGAGAACGCCGGAACCACCATCCGCGATTACCGCGACGGT
CAAGGACGAGCCGGCTCCTTCCAGTCCCGGCTCCAGGTATACGGCAAGCCGGCTGGGACGCCATGCCCGCGCTGCGGAAC
CGGACTCGCGCGGATCCGGATCGCTGGCCGGAGCAGCGTGTTCTGCCCACGCTGTCAGCCCCTCCACTGA

Upstream 100 bases:

>100_bases
CGTCCTGATGGACGAGGCGCGCTGGCTGGCGACCAGCGACGATCTCACAGAAGATACAGAAATCAGCCATTCCCTTCCCT
CCTCGGTTCGTGAGGTCGAT

Downstream 100 bases:

>100_bases
AGCCCAGCGCTGTCACGCTCTCACCGAGTCCAGCCGGTTCAGCCGACCGGCGGATCGGGCAGCGAGTCAGCGTCCGGCTC
GAGGACCGGGCACTGCTCGT

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MPELPEVETIRRTLAPVLIGALVIGALRGEHPEDILLDPWPVFARRVRRHRIVALERRGKYLAARFEDGDRLVIHLGMTG
ELRLSHPATAPGKHCHLALVLRSLRPLPPSLVDQRQRFLLRYLDIRRFGRIALLDQAGWETFTARLGPEPLDPTLDPRAL
WSRLRERRTAIKAALLDQALLAGIGNIYADEALFQARLHPARRCQTLSLDEVERLLVALRTVLSAAIENAGTTIRDYRDG
QGRAGSFQSRLQVYGKPAGTPCPRCGTGLARIRIAGRSSVFCPRCQPLH

Sequences:

>Translated_289_residues
MPELPEVETIRRTLAPVLIGALVIGALRGEHPEDILLDPWPVFARRVRRHRIVALERRGKYLAARFEDGDRLVIHLGMTG
ELRLSHPATAPGKHCHLALVLRSLRPLPPSLVDQRQRFLLRYLDIRRFGRIALLDQAGWETFTARLGPEPLDPTLDPRAL
WSRLRERRTAIKAALLDQALLAGIGNIYADEALFQARLHPARRCQTLSLDEVERLLVALRTVLSAAIENAGTTIRDYRDG
QGRAGSFQSRLQVYGKPAGTPCPRCGTGLARIRIAGRSSVFCPRCQPLH
>Mature_288_residues
PELPEVETIRRTLAPVLIGALVIGALRGEHPEDILLDPWPVFARRVRRHRIVALERRGKYLAARFEDGDRLVIHLGMTGE
LRLSHPATAPGKHCHLALVLRSLRPLPPSLVDQRQRFLLRYLDIRRFGRIALLDQAGWETFTARLGPEPLDPTLDPRALW
SRLRERRTAIKAALLDQALLAGIGNIYADEALFQARLHPARRCQTLSLDEVERLLVALRTVLSAAIENAGTTIRDYRDGQ
GRAGSFQSRLQVYGKPAGTPCPRCGTGLARIRIAGRSSVFCPRCQPLH

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=294, Percent_Identity=37.4149659863946, Blast_Score=181, Evalue=5e-47,
Organism=Escherichia coli, GI1786932, Length=298, Percent_Identity=26.510067114094, Blast_Score=71, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_THERP (B9L1Z5)

Other databases:

- EMBL:   CP001275
- RefSeq:   YP_002523094.1
- GeneID:   7356411
- GenomeReviews:   CP001275_GR
- KEGG:   tro:trd_1895
- OMA:   RMTGQLL
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 32371; Mature: 32240

Theoretical pI: Translated: 11.14; Mature: 11.14

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 60-60 ACT_SITE 277-277 BINDING 94-94 BINDING 126-126 BINDING 167-167

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETIRRTLAPVLIGALVIGALRGEHPEDILLDPWPVFARRVRRHRIVALERRGK
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
YLAARFEDGDRLVIHLGMTGELRLSHPATAPGKHCHLALVLRSLRPLPPSLVDQRQRFLL
EEEEEECCCCEEEEEECCCCCEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
RYLDIRRFGRIALLDQAGWETFTARLGPEPLDPTLDPRALWSRLRERRTAIKAALLDQAL
HHHHHHHHCCEEEEECCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LAGIGNIYADEALFQARLHPARRCQTLSLDEVERLLVALRTVLSAAIENAGTTIRDYRDG
HHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCC
QGRAGSFQSRLQVYGKPAGTPCPRCGTGLARIRIAGRSSVFCPRCQPLH
CCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVETIRRTLAPVLIGALVIGALRGEHPEDILLDPWPVFARRVRRHRIVALERRGK
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
YLAARFEDGDRLVIHLGMTGELRLSHPATAPGKHCHLALVLRSLRPLPPSLVDQRQRFLL
EEEEEECCCCEEEEEECCCCCEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
RYLDIRRFGRIALLDQAGWETFTARLGPEPLDPTLDPRALWSRLRERRTAIKAALLDQAL
HHHHHHHHCCEEEEECCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LAGIGNIYADEALFQARLHPARRCQTLSLDEVERLLVALRTVLSAAIENAGTTIRDYRDG
HHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCC
QGRAGSFQSRLQVYGKPAGTPCPRCGTGLARIRIAGRSSVFCPRCQPLH
CCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA