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The map label for this gene is cutL [H]

Identifier: 221633821

GI number: 221633821

Start: 1858691

End: 1861150

Strand: Reverse

Name: cutL [H]

Synonym: trd_1848

Alternate gene names: 221633821

Gene position: 1861150-1858691 (Counterclockwise)

Preceding gene: 221633822

Following gene: 221633820

Centisome position: 92.92

GC content: 63.94

Gene sequence:

>2460_bases
GTGACCGTTCGGCAATCTCGACCTTCCCTCTTGACGAACGGGTACTTCAGGACTGACAATGAGACCGAGCGATTCGCACG
ACGCAGAACCGTCGGCAGAAGGGAACAGCAGTCGGGAAGGGGTTCGGTGATGGTACTCACTCGAATGGTCGGGGCACGTG
TCCGTCGCAAGGAAGACCCGCGGCTCATCACCGGCTCGTCACAATACGTCGATGATCTTCAGCTCGGGGGGATGCTGTAC
GCGGCGTTCGTCCGCAGTGCGTATCCGCACGCGATCATCAAGCGGATCGACCCTTCGCCCGCCTTGGCTCTGCCCGGCGT
GGTCGCGGTGATCACGCACAAGGAACTGGAGCAGTGGCTGAAGGGAGCAGTCCAGTTGGGCGCGGGCGAGGGGGAAGCTG
AAGCACCGGCCCAGCAAGAGGATCAGGCTGGTCCACCGCAGCACGAGCTCCTGGCGATCGACCGCGTGCGCTACGTCGGA
CAGCCGATCGCCGTCGTGCTGGCAACCGAACGGTATCGCGCCTATGACGCGGCTGCTGCCGTCGAGATCGAGTACGAGCC
ACTGCCCGCGGTCGTCGATCCTGAAGAAACGATGAAGGAAGGCGCGCCCCAACTCCACGCGACGGTGAAGAACAATATCG
CAATGCACACCAGTCACCAGCATGGGGATATCGAGAAGGCGTTCGCCGAGGCCGACGTCATCGTCAAGCAGCGTTTTTAC
CAGCAACGCCTCGTCTCGGTTCCGATGGAGCCACGCGCAGTGGTTGCTGCCCCTGATCCGCTGACACGCGGTGTCACCGT
CTGGTCATCGACGCAAGCCCCACACAATAACCGGAACTCGCTCGCCCAAGCGCTCGGCTTGAGCCATGGGCAGGTGCGCG
TCATCGCTCCAGAAGTCGGTGGGGGTTTCGGTGCCAAGATCGGTGCCTATCCGGAAGACATCATCCTGGCTGCGCTGGCC
CTGCACCTGCACCGACCGGTCAAGTGGTACGAGACGCGCTCCGAGCATTTCATGGCGACAAATCAGGGACGAGGGCAGGT
CGCCTACTACGAACTGGCCGCAACGAAGGAGGGGCGCATCCTCGGCTTGCGGGCCAAAGTGATCCAGGATCTCGGGGCCT
ACCCCAAGCTCCTGCTCCTGGCAGGACTGACTGCCATGATGTCCGTCGGGGTCTACGATATTCCCAATCTCTCGATCGAG
ACCTACAGCGTGCTCACCAACACCACACCGGTCGGTGCCTACCGCGGCGCTGGTCGACCCGAGGCGGCCTACTACATCGA
ACGGATGATGGACCTCTTGGCCCGCAAGCTCGGCAAGGATCCCGCTGAGGTCCGGCGCCTGAACTACATCCCGCCCGAGA
AGTTCCCTTGCCAAACGCCGGCGGGTGCACGCTACGATTCGGCCGAATACGAGAAGAACCTGAACAAGGCGCTGGAGATT
TCCCGCTACCACGAGTGGCGACAGAAGCAACAGGAACTTTGCCAACAGGGCCGTTTCATCGGCATCGGATTGGTCACCTA
TACCGAGATCTGTGGCTTCGGCCCCTACGAGAGTGCCTCGATCCGCGTCGAGCCGACCGGTGCAGTGATCGCCTACACCG
GTACCTCGCCGCACGGTCAGGGGCTGGAGACAGCACTGGCCCAGATCATCGCCGACGAGATCGGTGCCGACTTCGACCAG
ATCGTCGTTCTCCACGGCGATACGCAGAGTGTCCCCGAAGGCGTGGGAACGATGGGCAGCCGCAGCTTGGCGGTCGGCGG
GGGGGCGATGCTTCTGGCCGCTCAGCGGATTCGCGAGAAGGCGCTCCGCATCGCGGCTCATCTCCTGGAGGCGGCTATCG
AGGATGTCGAGTACGCGGATGGGAAGTACCGCGTCAAGGGTGCTCCCGACCGTGCCGTCACGCTGGCCGAGATCGCACGA
GCAGCCTATAGCCCCGGTTTGCCACCGGATATCGAACCGGGCTTGGTCGCGACGGACTACTACGCGCCGTCGGGTGTGCT
GTTCCCCTTCGGGACGCATGTGGCAGTGGTCGAAGTCTTCCCCGAGACAGGCGAGGTCGAGATCCTCGAGTACTACGCGG
TCGATGACTGTGGCCCCCGCATCAACCCGCTCCTCGTCGAGGGCCAGGTGCACGGCGGCTTGGCCCAGGGGATCGCCCAG
GCCCTCTGGGAAGAGGTCCGCTACGACGAGAACGGCCAGCTCCTCACCGGCACGCTCATGGACTACGCCATCCCCAAGGC
GAGCATGCTGCCGAGTTTCGTGACCGACGAGACGGTGACACCGAGCCCGCTCAACCCGCTGGGTGCCAAGGGGATCGGCG
AGGCAGCCACGATCGGCTCCACCCCGACCATCGCCAACGCGGTCATGGATGCCCTGGCCCCCTTCGGGATCGAGCACCTC
GACATCCCGCTCACCCCGCAGAAGATCTGGCGGGCGATTCGAGAGGCGCAGCGAGCGTAG

Upstream 100 bases:

>100_bases
AACTCGTCACCACCATCGGCATCGACGACTTCCGCATCGCAGCAGGTGATCTGGCACAAGCGATCGATCTCGTCGCGATC
GCACGTGACGAGAGAGACGA

Downstream 100 bases:

>100_bases
CACATCGTTCACGAGAAAGATGCCTTCGAGGGTCCCACGACACACGGGGCCCTCGATTTTTCCTTTTCCCCTTGACGACA
GTGTCAAACACGTTCACGCT

Product: carbon monoxide dehydrogenase large chain

Products: NA

Alternate protein names: CO dehydrogenase subunit L; CO-DH L [H]

Number of amino acids: Translated: 819; Mature: 818

Protein sequence:

>819_residues
MTVRQSRPSLLTNGYFRTDNETERFARRRTVGRREQQSGRGSVMVLTRMVGARVRRKEDPRLITGSSQYVDDLQLGGMLY
AAFVRSAYPHAIIKRIDPSPALALPGVVAVITHKELEQWLKGAVQLGAGEGEAEAPAQQEDQAGPPQHELLAIDRVRYVG
QPIAVVLATERYRAYDAAAAVEIEYEPLPAVVDPEETMKEGAPQLHATVKNNIAMHTSHQHGDIEKAFAEADVIVKQRFY
QQRLVSVPMEPRAVVAAPDPLTRGVTVWSSTQAPHNNRNSLAQALGLSHGQVRVIAPEVGGGFGAKIGAYPEDIILAALA
LHLHRPVKWYETRSEHFMATNQGRGQVAYYELAATKEGRILGLRAKVIQDLGAYPKLLLLAGLTAMMSVGVYDIPNLSIE
TYSVLTNTTPVGAYRGAGRPEAAYYIERMMDLLARKLGKDPAEVRRLNYIPPEKFPCQTPAGARYDSAEYEKNLNKALEI
SRYHEWRQKQQELCQQGRFIGIGLVTYTEICGFGPYESASIRVEPTGAVIAYTGTSPHGQGLETALAQIIADEIGADFDQ
IVVLHGDTQSVPEGVGTMGSRSLAVGGGAMLLAAQRIREKALRIAAHLLEAAIEDVEYADGKYRVKGAPDRAVTLAEIAR
AAYSPGLPPDIEPGLVATDYYAPSGVLFPFGTHVAVVEVFPETGEVEILEYYAVDDCGPRINPLLVEGQVHGGLAQGIAQ
ALWEEVRYDENGQLLTGTLMDYAIPKASMLPSFVTDETVTPSPLNPLGAKGIGEAATIGSTPTIANAVMDALAPFGIEHL
DIPLTPQKIWRAIREAQRA

Sequences:

>Translated_819_residues
MTVRQSRPSLLTNGYFRTDNETERFARRRTVGRREQQSGRGSVMVLTRMVGARVRRKEDPRLITGSSQYVDDLQLGGMLY
AAFVRSAYPHAIIKRIDPSPALALPGVVAVITHKELEQWLKGAVQLGAGEGEAEAPAQQEDQAGPPQHELLAIDRVRYVG
QPIAVVLATERYRAYDAAAAVEIEYEPLPAVVDPEETMKEGAPQLHATVKNNIAMHTSHQHGDIEKAFAEADVIVKQRFY
QQRLVSVPMEPRAVVAAPDPLTRGVTVWSSTQAPHNNRNSLAQALGLSHGQVRVIAPEVGGGFGAKIGAYPEDIILAALA
LHLHRPVKWYETRSEHFMATNQGRGQVAYYELAATKEGRILGLRAKVIQDLGAYPKLLLLAGLTAMMSVGVYDIPNLSIE
TYSVLTNTTPVGAYRGAGRPEAAYYIERMMDLLARKLGKDPAEVRRLNYIPPEKFPCQTPAGARYDSAEYEKNLNKALEI
SRYHEWRQKQQELCQQGRFIGIGLVTYTEICGFGPYESASIRVEPTGAVIAYTGTSPHGQGLETALAQIIADEIGADFDQ
IVVLHGDTQSVPEGVGTMGSRSLAVGGGAMLLAAQRIREKALRIAAHLLEAAIEDVEYADGKYRVKGAPDRAVTLAEIAR
AAYSPGLPPDIEPGLVATDYYAPSGVLFPFGTHVAVVEVFPETGEVEILEYYAVDDCGPRINPLLVEGQVHGGLAQGIAQ
ALWEEVRYDENGQLLTGTLMDYAIPKASMLPSFVTDETVTPSPLNPLGAKGIGEAATIGSTPTIANAVMDALAPFGIEHL
DIPLTPQKIWRAIREAQRA
>Mature_818_residues
TVRQSRPSLLTNGYFRTDNETERFARRRTVGRREQQSGRGSVMVLTRMVGARVRRKEDPRLITGSSQYVDDLQLGGMLYA
AFVRSAYPHAIIKRIDPSPALALPGVVAVITHKELEQWLKGAVQLGAGEGEAEAPAQQEDQAGPPQHELLAIDRVRYVGQ
PIAVVLATERYRAYDAAAAVEIEYEPLPAVVDPEETMKEGAPQLHATVKNNIAMHTSHQHGDIEKAFAEADVIVKQRFYQ
QRLVSVPMEPRAVVAAPDPLTRGVTVWSSTQAPHNNRNSLAQALGLSHGQVRVIAPEVGGGFGAKIGAYPEDIILAALAL
HLHRPVKWYETRSEHFMATNQGRGQVAYYELAATKEGRILGLRAKVIQDLGAYPKLLLLAGLTAMMSVGVYDIPNLSIET
YSVLTNTTPVGAYRGAGRPEAAYYIERMMDLLARKLGKDPAEVRRLNYIPPEKFPCQTPAGARYDSAEYEKNLNKALEIS
RYHEWRQKQQELCQQGRFIGIGLVTYTEICGFGPYESASIRVEPTGAVIAYTGTSPHGQGLETALAQIIADEIGADFDQI
VVLHGDTQSVPEGVGTMGSRSLAVGGGAMLLAAQRIREKALRIAAHLLEAAIEDVEYADGKYRVKGAPDRAVTLAEIARA
AYSPGLPPDIEPGLVATDYYAPSGVLFPFGTHVAVVEVFPETGEVEILEYYAVDDCGPRINPLLVEGQVHGGLAQGIAQA
LWEEVRYDENGQLLTGTLMDYAIPKASMLPSFVTDETVTPSPLNPLGAKGIGEAATIGSTPTIANAVMDALAPFGIEHLD
IPLTPQKIWRAIREAQRA

Specific function: Catalyzes the oxidation of carbon monoxide to carbon dioxide [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI71773480, Length=773, Percent_Identity=25.8732212160414, Blast_Score=171, Evalue=3e-42,
Organism=Homo sapiens, GI91823271, Length=781, Percent_Identity=25.6081946222791, Blast_Score=158, Evalue=2e-38,
Organism=Escherichia coli, GI1789246, Length=821, Percent_Identity=27.2838002436054, Blast_Score=252, Evalue=7e-68,
Organism=Escherichia coli, GI1789230, Length=769, Percent_Identity=28.0884265279584, Blast_Score=232, Evalue=7e-62,
Organism=Escherichia coli, GI1786478, Length=780, Percent_Identity=25.8974358974359, Blast_Score=123, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17540638, Length=803, Percent_Identity=24.2839352428394, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI32566215, Length=576, Percent_Identity=23.7847222222222, Blast_Score=114, Evalue=3e-25,
Organism=Drosophila melanogaster, GI17737937, Length=737, Percent_Identity=26.4586160108548, Blast_Score=174, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24647193, Length=811, Percent_Identity=25.0308261405672, Blast_Score=167, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24647199, Length=741, Percent_Identity=25.3711201079622, Blast_Score=149, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24647201, Length=783, Percent_Identity=24.3933588761175, Blast_Score=138, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24647195, Length=820, Percent_Identity=24.5121951219512, Blast_Score=125, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24647197, Length=778, Percent_Identity=24.5501285347044, Blast_Score=124, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR012780 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.2.99.2 [H]

Molecular weight: Translated: 89035; Mature: 88903

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVRQSRPSLLTNGYFRTDNETERFARRRTVGRREQQSGRGSVMVLTRMVGARVRRKEDP
CCCCCCCCCHHHCCEEECCCHHHHHHHHHHHCCHHHHCCCCCEEHHHHHHHHHHHCCCCC
RLITGSSQYVDDLQLGGMLYAAFVRSAYPHAIIKRIDPSPALALPGVVAVITHKELEQWL
CEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHH
KGAVQLGAGEGEAEAPAQQEDQAGPPQHELLAIDRVRYVGQPIAVVLATERYRAYDAAAA
HHHHEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECHHHHHHCCEEE
VEIEYEPLPAVVDPEETMKEGAPQLHATVKNNIAMHTSHQHGDIEKAFAEADVIVKQRFY
EEEEECCCCCCCCCHHHHHCCCCCEEHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHH
QQRLVSVPMEPRAVVAAPDPLTRGVTVWSSTQAPHNNRNSLAQALGLSHGQVRVIAPEVG
HHHHHCCCCCCCEEEECCCCCCCCEEEEECCCCCCCCHHHHHHHHCCCCCEEEEEECCCC
GGFGAKIGAYPEDIILAALALHLHRPVKWYETRSEHFMATNQGRGQVAYYELAATKEGRI
CCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHCCCCCEEEECCCCCEEEEEEEEECCCCCE
LGLRAKVIQDLGAYPKLLLLAGLTAMMSVGVYDIPNLSIETYSVLTNTTPVGAYRGAGRP
EEHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEECCCCCEEEEEEEECCCCCCCCCCCCCC
EAAYYIERMMDLLARKLGKDPAEVRRLNYIPPEKFPCQTPAGARYDSAEYEKNLNKALEI
HHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
SRYHEWRQKQQELCQQGRFIGIGLVTYTEICGFGPYESASIRVEPTGAVIAYTGTSPHGQ
HHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCCCCCEEEEECCCEEEEEECCCCCCC
GLETALAQIIADEIGADFDQIVVLHGDTQSVPEGVGTMGSRSLAVGGGAMLLAAQRIREK
CHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHCCCCCCEEEECCHHHHHHHHHHHHH
ALRIAAHLLEAAIEDVEYADGKYRVKGAPDRAVTLAEIARAAYSPGLPPDIEPGLVATDY
HHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEECC
YAPSGVLFPFGTHVAVVEVFPETGEVEILEYYAVDDCGPRINPLLVEGQVHGGLAQGIAQ
CCCCCCEEECCCCEEEEEEECCCCCEEEEEEEEECCCCCCCCCEEEECCCCCHHHHHHHH
ALWEEVRYDENGQLLTGTLMDYAIPKASMLPSFVTDETVTPSPLNPLGAKGIGEAATIGS
HHHHHHCCCCCCCEEEEHHHHHHCCCHHHCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCC
TPTIANAVMDALAPFGIEHLDIPLTPQKIWRAIREAQRA
CCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TVRQSRPSLLTNGYFRTDNETERFARRRTVGRREQQSGRGSVMVLTRMVGARVRRKEDP
CCCCCCCCHHHCCEEECCCHHHHHHHHHHHCCHHHHCCCCCEEHHHHHHHHHHHCCCCC
RLITGSSQYVDDLQLGGMLYAAFVRSAYPHAIIKRIDPSPALALPGVVAVITHKELEQWL
CEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHH
KGAVQLGAGEGEAEAPAQQEDQAGPPQHELLAIDRVRYVGQPIAVVLATERYRAYDAAAA
HHHHEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECHHHHHHCCEEE
VEIEYEPLPAVVDPEETMKEGAPQLHATVKNNIAMHTSHQHGDIEKAFAEADVIVKQRFY
EEEEECCCCCCCCCHHHHHCCCCCEEHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHH
QQRLVSVPMEPRAVVAAPDPLTRGVTVWSSTQAPHNNRNSLAQALGLSHGQVRVIAPEVG
HHHHHCCCCCCCEEEECCCCCCCCEEEEECCCCCCCCHHHHHHHHCCCCCEEEEEECCCC
GGFGAKIGAYPEDIILAALALHLHRPVKWYETRSEHFMATNQGRGQVAYYELAATKEGRI
CCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHCCCCCEEEECCCCCEEEEEEEEECCCCCE
LGLRAKVIQDLGAYPKLLLLAGLTAMMSVGVYDIPNLSIETYSVLTNTTPVGAYRGAGRP
EEHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEECCCCCEEEEEEEECCCCCCCCCCCCCC
EAAYYIERMMDLLARKLGKDPAEVRRLNYIPPEKFPCQTPAGARYDSAEYEKNLNKALEI
HHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
SRYHEWRQKQQELCQQGRFIGIGLVTYTEICGFGPYESASIRVEPTGAVIAYTGTSPHGQ
HHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCCCCCEEEEECCCEEEEEECCCCCCC
GLETALAQIIADEIGADFDQIVVLHGDTQSVPEGVGTMGSRSLAVGGGAMLLAAQRIREK
CHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHCCCCCCEEEECCHHHHHHHHHHHHH
ALRIAAHLLEAAIEDVEYADGKYRVKGAPDRAVTLAEIARAAYSPGLPPDIEPGLVATDY
HHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEECC
YAPSGVLFPFGTHVAVVEVFPETGEVEILEYYAVDDCGPRINPLLVEGQVHGGLAQGIAQ
CCCCCCEEECCCCEEEEEEECCCCCEEEEEEEEECCCCCCCCCEEEECCCCCHHHHHHHH
ALWEEVRYDENGQLLTGTLMDYAIPKASMLPSFVTDETVTPSPLNPLGAKGIGEAATIGS
HHHHHHCCCCCCCEEEEHHHHHHCCCHHHCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCC
TPTIANAVMDALAPFGIEHLDIPLTPQKIWRAIREAQRA
CCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10482497; 2818128; 10966817; 11076018 [H]