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The map label for this gene is galE [H]

Identifier: 221633720

GI number: 221633720

Start: 1755038

End: 1756027

Strand: Reverse

Name: galE [H]

Synonym: trd_1747

Alternate gene names: 221633720

Gene position: 1756027-1755038 (Counterclockwise)

Preceding gene: 221633721

Following gene: 221633719

Centisome position: 87.67

GC content: 63.64

Gene sequence:

>990_bases
ATGGCTGCAGCGCTCACCGTGCTGGTTACCGGAGGAGCTGGGTACGTCGGTTCTTTTACGGTGCGCGCGCTCCAACAAGC
TGGTCATGAGGTGGTCGTCTTCGACAACCTGCGGCAAGGGCATCGCTCAGCCGTCTGCGTTCCCCTGGTTGTCGGTGAGT
TGATCGATCGCGAGGCTGTCGCAACCTGCTTCCGTCGCTGGCGTTTCGACGCGGTCATCCATCTCGCGGCGTACACCTCC
GTACGCGAGTCGGTCACCGACCCGAACAAGTACGTGGTGCACAATGTGGGCGGAACGATCGTGCTCCTCGAGGCCTGTTT
GCGGCACGATGTTCCCTATCTGGTCTTTTCCTCTTCCTCGGAAGTGTACGGCGAAGCACGGTATCTCCCGCTCGACGAAG
CGCATCCGACGGAGCCGACCAATCCGTATGGAGCGACCAAGCTCCAGGTCGAGCACTATCTGCGCTGGTACGACGCAGCC
TACGGCTTGCGCTCCATCAGCCTCCGCTACTTCAACGCAGCGGGTGCCGCGCTCGACGGTTCGATGGGTGAAGATCATCG
ACCCGAAGAGCACTTGATTCCGAATGCCATCCGGGGAGCGCTCGGCCTGCAGGCGTTTCGCCTCACCTCCCCGGTCGTCG
CGACACCGGACGGGACGACGATCCGGGATTACGTGCACGTGCTCGATCTCGCGGAGGCCCATGTGCTGGCGCTCGAGGCA
CTCCGGCAGGGGCACCCGACTGACGTGATCAATCTCGGGAGCGGTGTCGGCTATTCCACGCGGCAGATCATCGAACTCGT
CCAGGAGCTGACCGGTGTGCGTTTCCCGGTCGAGCGCGGCGAGGCGCGTCCGGGCGAGCCGCCGATCAAGTACGCGAGCT
ACGCCAAGGCCGAACGCGTCCTCGGCTGGCGACCACGTTACGGAATCGAGGAAATCATCGCTTCGGCGGTGCGTTGGCAC
ACGCGCTTTCCGCACGGCTATCCGGACTGA

Upstream 100 bases:

>100_bases
GGTGGTTCACCGAATGGGAGACCGCACCGGAAATCGCTGACGAGGAAGCAGCGTGGGCCGCGATCCACGCCGCACGTCGT
TCCTGAGGAGGAGATTGTCC

Downstream 100 bases:

>100_bases
CGAGGTCGCAGGCCATGGGTGTCCGGCTCCTCCGCCTGGCGCTGCTCGGCTTCAAGAGCTTTGCCGATCCTGTCGAACTC
GTCTTCGACCGTGGCATCAC

Product: UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MAAALTVLVTGGAGYVGSFTVRALQQAGHEVVVFDNLRQGHRSAVCVPLVVGELIDREAVATCFRRWRFDAVIHLAAYTS
VRESVTDPNKYVVHNVGGTIVLLEACLRHDVPYLVFSSSSEVYGEARYLPLDEAHPTEPTNPYGATKLQVEHYLRWYDAA
YGLRSISLRYFNAAGAALDGSMGEDHRPEEHLIPNAIRGALGLQAFRLTSPVVATPDGTTIRDYVHVLDLAEAHVLALEA
LRQGHPTDVINLGSGVGYSTRQIIELVQELTGVRFPVERGEARPGEPPIKYASYAKAERVLGWRPRYGIEEIIASAVRWH
TRFPHGYPD

Sequences:

>Translated_329_residues
MAAALTVLVTGGAGYVGSFTVRALQQAGHEVVVFDNLRQGHRSAVCVPLVVGELIDREAVATCFRRWRFDAVIHLAAYTS
VRESVTDPNKYVVHNVGGTIVLLEACLRHDVPYLVFSSSSEVYGEARYLPLDEAHPTEPTNPYGATKLQVEHYLRWYDAA
YGLRSISLRYFNAAGAALDGSMGEDHRPEEHLIPNAIRGALGLQAFRLTSPVVATPDGTTIRDYVHVLDLAEAHVLALEA
LRQGHPTDVINLGSGVGYSTRQIIELVQELTGVRFPVERGEARPGEPPIKYASYAKAERVLGWRPRYGIEEIIASAVRWH
TRFPHGYPD
>Mature_328_residues
AAALTVLVTGGAGYVGSFTVRALQQAGHEVVVFDNLRQGHRSAVCVPLVVGELIDREAVATCFRRWRFDAVIHLAAYTSV
RESVTDPNKYVVHNVGGTIVLLEACLRHDVPYLVFSSSSEVYGEARYLPLDEAHPTEPTNPYGATKLQVEHYLRWYDAAY
GLRSISLRYFNAAGAALDGSMGEDHRPEEHLIPNAIRGALGLQAFRLTSPVVATPDGTTIRDYVHVLDLAEAHVLALEAL
RQGHPTDVINLGSGVGYSTRQIIELVQELTGVRFPVERGEARPGEPPIKYASYAKAERVLGWRPRYGIEEIIASAVRWHT
RFPHGYPD

Specific function: Galactose metabolism; third step. [C]

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=343, Percent_Identity=37.9008746355685, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI56118217, Length=343, Percent_Identity=37.9008746355685, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI189083684, Length=343, Percent_Identity=37.9008746355685, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI7657641, Length=349, Percent_Identity=25.5014326647564, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI42516563, Length=323, Percent_Identity=26.625386996904, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI239745448, Length=243, Percent_Identity=27.5720164609054, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI310132178, Length=243, Percent_Identity=27.5720164609054, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI310113012, Length=243, Percent_Identity=27.5720164609054, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1786974, Length=338, Percent_Identity=37.8698224852071, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1788353, Length=355, Percent_Identity=28.7323943661972, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI48994969, Length=350, Percent_Identity=29.7142857142857, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1790049, Length=262, Percent_Identity=27.4809160305344, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788365, Length=329, Percent_Identity=26.4437689969605, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1788366, Length=362, Percent_Identity=25.1381215469613, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71982035, Length=345, Percent_Identity=36.231884057971, Blast_Score=207, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI71982038, Length=345, Percent_Identity=36.231884057971, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17568069, Length=346, Percent_Identity=25.4335260115607, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17539532, Length=321, Percent_Identity=23.98753894081, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI115532424, Length=350, Percent_Identity=25.1428571428571, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319493, Length=347, Percent_Identity=34.0057636887608, Blast_Score=180, Evalue=3e-46,
Organism=Drosophila melanogaster, GI19923002, Length=347, Percent_Identity=37.1757925072046, Blast_Score=211, Evalue=8e-55,
Organism=Drosophila melanogaster, GI21356223, Length=311, Percent_Identity=27.6527331189711, Blast_Score=89, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 36265; Mature: 36133

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAALTVLVTGGAGYVGSFTVRALQQAGHEVVVFDNLRQGHRSAVCVPLVVGELIDREAV
CCCEEEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
ATCFRRWRFDAVIHLAAYTSVRESVTDPNKYVVHNVGGTIVLLEACLRHDVPYLVFSSSS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCCCEEEECCCC
EVYGEARYLPLDEAHPTEPTNPYGATKLQVEHYLRWYDAAYGLRSISLRYFNAAGAALDG
CCCCCEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCC
SMGEDHRPEEHLIPNAIRGALGLQAFRLTSPVVATPDGTTIRDYVHVLDLAEAHVLALEA
CCCCCCCCHHHCCCHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHH
LRQGHPTDVINLGSGVGYSTRQIIELVQELTGVRFPVERGEARPGEPPIKYASYAKAERV
HHCCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCHHHHHHHHHHH
LGWRPRYGIEEIIASAVRWHTRFPHGYPD
HCCCCCCCHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AAALTVLVTGGAGYVGSFTVRALQQAGHEVVVFDNLRQGHRSAVCVPLVVGELIDREAV
CCEEEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
ATCFRRWRFDAVIHLAAYTSVRESVTDPNKYVVHNVGGTIVLLEACLRHDVPYLVFSSSS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCCCEEEECCCC
EVYGEARYLPLDEAHPTEPTNPYGATKLQVEHYLRWYDAAYGLRSISLRYFNAAGAALDG
CCCCCEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCC
SMGEDHRPEEHLIPNAIRGALGLQAFRLTSPVVATPDGTTIRDYVHVLDLAEAHVLALEA
CCCCCCCCHHHCCCHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHH
LRQGHPTDVINLGSGVGYSTRQIIELVQELTGVRFPVERGEARPGEPPIKYASYAKAERV
HHCCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCHHHHHHHHHHH
LGWRPRYGIEEIIASAVRWHTRFPHGYPD
HCCCCCCCHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8973358; 12397186 [H]