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The map label for this gene is moeA [H]

Identifier: 221633682

GI number: 221633682

Start: 1711015

End: 1712241

Strand: Reverse

Name: moeA [H]

Synonym: trd_1709

Alternate gene names: 221633682

Gene position: 1712241-1711015 (Counterclockwise)

Preceding gene: 221633683

Following gene: 221633662

Centisome position: 85.48

GC content: 66.91

Gene sequence:

>1227_bases
ATGCAGCGAACGAGCCGGATGTTGACTCCACAGGAAGCGCTCGACATCATTCTCGCTCACGTCCAGCGCCTCCCGAGCGA
AGAGGTCGGGCTGATGGATGCGGCTGGGCGCGTGCTGGCCGAACCGCTGTATGCACCGGAGGACCATCCCCCGTTTCCTG
CCGCGACCATGGATGGCTACGCAGTGATCCACGACGATACCTCACCGTGGCGCGAAGTGATCGGCGAACAGTTCGCTGGT
CATGTCACGGACGTCACCGTGACTCCGGGGACAGCCGTGCGGATCACGACTGGGGCGCCTTTGCCGGCGGGCGCGGACGC
AGTCGTCCCGGTGGAAGACGTCGAGCTCGTGGACGATCATATCGTGATTCGGCGGGAGGAGGTCCGTCCAGGCGAGAACG
TGCGGCCGGTCGGGGCGGACGTGCACCGTGGCGAACTGATCGTGCCGGCCGGGACGGTACTCGGCCCGGCGGAGATCGGC
CTCGCGGCGAGCTTGGGCATCGCCAGTGTCCCCGTCTCACGCCGACCGCGAGTTTCCGTGTTGAGTACCGGCGACGAGCT
GGTCGATCCCGGACAGCCGCTCGGTCCCGGCCAGATCCGCGATTCGAACCGCTTCATGCTGGTCGCAGCGTTGCAGCAGG
CCGGTGCCGAGGTGGTTTGGGCGGGGCGAGGACCCGACGATGTGGAGCGCTTGACCGAACTGCTGCGAGAGCGAATCGCG
GAGAGTGACGTCGTGATTTCCTCCGGCGGTGTGTCGGTCGGGGAACGCGACTTGATCAGTGCGGCACTCCGCACGCTCGG
AACCGTTCACATCGAGCGGCTCTTCATGAAGCCAGGCAAGCCTTTTCACTTCGTGACGGTTGGCCGGACGCTCCTTTTCG
GCTTGCCCGGTAACCCCGTCTCGGCGCTCGTCGGTTTCGAGATCTTCGTCATGGCGGCGTTGCGGGCGATGACCGGACAG
CAGCCGGTCATCCCGGAGCCGGTTACCGTGGTGCTCGCGCATCCGATCGAGCCGGGTGACCGTATCGAGTACCAGCGGGC
GATCGTCTGGTGTGACGAGACGGGGACCCTGTTCGCTCGCAATACCGGGCCGCAGTCGTCGGCCCGCTTGCTCTCGGCCG
TCGGAGCGAATGCCTACCTGATCGTGCCGCCGCGGGCCGAGCCATACCGTCCCGGCGAGCGACTCCGTGCGATCCTGCGG
CGTCCGGTGCACGGACAGGCGCGCTGA

Upstream 100 bases:

>100_bases
GCGGAGAGGCCGGCCTGCAGCGGTGGAGCCGCCTTCGCTCCCTGGGGAGGTGTAGGATAGAATCGCTTTCGTGCCGATAG
CGGTCGGCGAGGAGTACGGT

Downstream 100 bases:

>100_bases
GATGCCTCATCACTCGGCTGGAGGCGAAGGTTCCGAGGCGCGACGAGCGAAGAGTTCCTGGTAGAGCGCTTCGCTCCCGA
TCCAGATCTCGCCGTCCTCG

Product: putative molybdopterin biosynthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MQRTSRMLTPQEALDIILAHVQRLPSEEVGLMDAAGRVLAEPLYAPEDHPPFPAATMDGYAVIHDDTSPWREVIGEQFAG
HVTDVTVTPGTAVRITTGAPLPAGADAVVPVEDVELVDDHIVIRREEVRPGENVRPVGADVHRGELIVPAGTVLGPAEIG
LAASLGIASVPVSRRPRVSVLSTGDELVDPGQPLGPGQIRDSNRFMLVAALQQAGAEVVWAGRGPDDVERLTELLRERIA
ESDVVISSGGVSVGERDLISAALRTLGTVHIERLFMKPGKPFHFVTVGRTLLFGLPGNPVSALVGFEIFVMAALRAMTGQ
QPVIPEPVTVVLAHPIEPGDRIEYQRAIVWCDETGTLFARNTGPQSSARLLSAVGANAYLIVPPRAEPYRPGERLRAILR
RPVHGQAR

Sequences:

>Translated_408_residues
MQRTSRMLTPQEALDIILAHVQRLPSEEVGLMDAAGRVLAEPLYAPEDHPPFPAATMDGYAVIHDDTSPWREVIGEQFAG
HVTDVTVTPGTAVRITTGAPLPAGADAVVPVEDVELVDDHIVIRREEVRPGENVRPVGADVHRGELIVPAGTVLGPAEIG
LAASLGIASVPVSRRPRVSVLSTGDELVDPGQPLGPGQIRDSNRFMLVAALQQAGAEVVWAGRGPDDVERLTELLRERIA
ESDVVISSGGVSVGERDLISAALRTLGTVHIERLFMKPGKPFHFVTVGRTLLFGLPGNPVSALVGFEIFVMAALRAMTGQ
QPVIPEPVTVVLAHPIEPGDRIEYQRAIVWCDETGTLFARNTGPQSSARLLSAVGANAYLIVPPRAEPYRPGERLRAILR
RPVHGQAR
>Mature_408_residues
MQRTSRMLTPQEALDIILAHVQRLPSEEVGLMDAAGRVLAEPLYAPEDHPPFPAATMDGYAVIHDDTSPWREVIGEQFAG
HVTDVTVTPGTAVRITTGAPLPAGADAVVPVEDVELVDDHIVIRREEVRPGENVRPVGADVHRGELIVPAGTVLGPAEIG
LAASLGIASVPVSRRPRVSVLSTGDELVDPGQPLGPGQIRDSNRFMLVAALQQAGAEVVWAGRGPDDVERLTELLRERIA
ESDVVISSGGVSVGERDLISAALRTLGTVHIERLFMKPGKPFHFVTVGRTLLFGLPGNPVSALVGFEIFVMAALRAMTGQ
QPVIPEPVTVVLAHPIEPGDRIEYQRAIVWCDETGTLFARNTGPQSSARLLSAVGANAYLIVPPRAEPYRPGERLRAILR
RPVHGQAR

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=392, Percent_Identity=42.6020408163265, Blast_Score=285, Evalue=7e-77,
Organism=Homo sapiens, GI10880983, Length=392, Percent_Identity=42.6020408163265, Blast_Score=285, Evalue=7e-77,
Organism=Escherichia coli, GI1787049, Length=388, Percent_Identity=39.9484536082474, Blast_Score=235, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI25147659, Length=364, Percent_Identity=38.7362637362637, Blast_Score=211, Evalue=8e-55,
Organism=Caenorhabditis elegans, GI17562606, Length=320, Percent_Identity=29.375, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI17136978, Length=393, Percent_Identity=35.6234096692112, Blast_Score=187, Evalue=9e-48,
Organism=Drosophila melanogaster, GI24638841, Length=393, Percent_Identity=35.6234096692112, Blast_Score=187, Evalue=9e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43710; Mature: 43710

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRTSRMLTPQEALDIILAHVQRLPSEEVGLMDAAGRVLAEPLYAPEDHPPFPAATMDGY
CCCCCCCCCHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCE
AVIHDDTSPWREVIGEQFAGHVTDVTVTPGTAVRITTGAPLPAGADAVVPVEDVELVDDH
EEEECCCHHHHHHHHHHHCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHCCE
IVIRREEVRPGENVRPVGADVHRGELIVPAGTVLGPAEIGLAASLGIASVPVSRRPRVSV
EEEEECCCCCCCCCCCCCCCCCCCEEEEECCCEECHHHHCHHHHCCCEECCCCCCCCEEE
LSTGDELVDPGQPLGPGQIRDSNRFMLVAALQQAGAEVVWAGRGPDDVERLTELLRERIA
EECCHHHCCCCCCCCCCCCCCCCCEEEEEEHHHCCCEEEEECCCHHHHHHHHHHHHHHHC
ESDVVISSGGVSVGERDLISAALRTLGTVHIERLFMKPGKPFHFVTVGRTLLFGLPGNPV
CCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCEEEEECCCCHH
SALVGFEIFVMAALRAMTGQQPVIPEPVTVVLAHPIEPGDRIEYQRAIVWCDETGTLFAR
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCEEEEEEEEEECCCCCEEEE
NTGPQSSARLLSAVGANAYLIVPPRAEPYRPGERLRAILRRPVHGQAR
CCCCCHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MQRTSRMLTPQEALDIILAHVQRLPSEEVGLMDAAGRVLAEPLYAPEDHPPFPAATMDGY
CCCCCCCCCHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCE
AVIHDDTSPWREVIGEQFAGHVTDVTVTPGTAVRITTGAPLPAGADAVVPVEDVELVDDH
EEEECCCHHHHHHHHHHHCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHCCE
IVIRREEVRPGENVRPVGADVHRGELIVPAGTVLGPAEIGLAASLGIASVPVSRRPRVSV
EEEEECCCCCCCCCCCCCCCCCCCEEEEECCCEECHHHHCHHHHCCCEECCCCCCCCEEE
LSTGDELVDPGQPLGPGQIRDSNRFMLVAALQQAGAEVVWAGRGPDDVERLTELLRERIA
EECCHHHCCCCCCCCCCCCCCCCCEEEEEEHHHCCCEEEEECCCHHHHHHHHHHHHHHHC
ESDVVISSGGVSVGERDLISAALRTLGTVHIERLFMKPGKPFHFVTVGRTLLFGLPGNPV
CCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCEEEEECCCCHH
SALVGFEIFVMAALRAMTGQQPVIPEPVTVVLAHPIEPGDRIEYQRAIVWCDETGTLFAR
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCEEEEEEEEEECCCCCEEEE
NTGPQSSARLLSAVGANAYLIVPPRAEPYRPGERLRAILRRPVHGQAR
CCCCCHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]