Click here to switch to the map view.

The map label for this gene is lip2 [H]

Identifier: 221633661

GI number: 221633661

Start: 1689092

End: 1690060

Strand: Reverse

Name: lip2 [H]

Synonym: trd_1687

Alternate gene names: 221633661

Gene position: 1690060-1689092 (Counterclockwise)

Preceding gene: 221633662

Following gene: 221633654

Centisome position: 84.38

GC content: 65.33

Gene sequence:

>969_bases
ATGTCCGTGTTCGCGCGACTCGATCCAGAGCTCGCTGCCGCACTCCGAGAGATTCCCGAGGAGTTCCTCCTCGACCTCCG
CGATATCTCGCTAGCCCGCCGGCGACTCCAGATTCTGCGCGAGGCACTCGCCAGCCTGTTGCCCCCGCTGCCCAGCGATG
TCGCGGTGACCGATGAGCTCGCTCCCAATTCCTTCGATGGGACGATGGTACGGGTTCGCCTCTACCGGCCGAGCGAGGTA
ACGGGTCCGCTCCCGGTACTCTTGTGGATCCATGGGGGCGGGTACGTCATGGGCGCCCCGGAAATGAACGACCAGCAGTG
TGCGGAGTTGGCCCAGCGCATTCCGGCGCTGGTTGCCTCGGTCGATTACCGGTTGGCCCCTGAACATCCCTACCCGGCAC
CGCTCGAAGATTGTTATGCCGCGCTCCGCTGGGTCGCTGAGCGCGCCGAGCAACTCGGAGTCGATCGCGAGCGACTCGCC
ATCGCTGGCGCGAGTGCGGGAGGAGGTCTGGCTGCTGGTCTGGCGCTCCTGGCGCGCGATCGCGGCGAGGTGCCTGTCCG
TTTCCAACTTCTCATCTATCCCATGCTCGATGACCGGAACCAAACCCCCTCGAGCTACGAGATCACTGATCCGCGCCTGA
TCTGGACGCGGGACTGGAATCTGATCGGCTGGCGTGCCTACCTCGGTCGAGAGCCGGGGAGTCCGGACGTGCCGCCCTAT
GCAGCCCCCGCCCGGGCGGACGATCTGGCCGGACTTCCGCCAGCCTATGTGCTCGTCGGTACAGCGGATCTCTTCCGCGA
CGAAGACATCGCCTACGCGCAGCGCTTAATGCAGGCTGGTGTGCCGACCGAGTTGCATGTCTTCGCGGGAGCCTTCCACG
GTTTCGATGTCTTCGCGCCGACCGCTTGGGTCAGTCAGCGAGCCAATGCCGAAGTGCTCGCGGTCCTGCAACGGGCACTC
GCAGCGTAA

Upstream 100 bases:

>100_bases
GCCGTGTCAGCCGAATGAACCACCTCCTCGTTCGGATACGCTCGTCATGGTAGGGTGTGGTTTTTACACCCGGGCAACGA
AAGGAAGAGGAGGCTGAGCG

Downstream 100 bases:

>100_bases
GAGTGGGCTAACCGAGAGTCCCGGAGACGGGGCTGGCTCCGCGGCTCGGGGTCACGCTCAGGCGAGCAGCTTCGCCAGTG
GGTGGACAGAGCGTGTCGTG

Product: lipase

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MSVFARLDPELAAALREIPEEFLLDLRDISLARRRLQILREALASLLPPLPSDVAVTDELAPNSFDGTMVRVRLYRPSEV
TGPLPVLLWIHGGGYVMGAPEMNDQQCAELAQRIPALVASVDYRLAPEHPYPAPLEDCYAALRWVAERAEQLGVDRERLA
IAGASAGGGLAAGLALLARDRGEVPVRFQLLIYPMLDDRNQTPSSYEITDPRLIWTRDWNLIGWRAYLGREPGSPDVPPY
AAPARADDLAGLPPAYVLVGTADLFRDEDIAYAQRLMQAGVPTELHVFAGAFHGFDVFAPTAWVSQRANAEVLAVLQRAL
AA

Sequences:

>Translated_322_residues
MSVFARLDPELAAALREIPEEFLLDLRDISLARRRLQILREALASLLPPLPSDVAVTDELAPNSFDGTMVRVRLYRPSEV
TGPLPVLLWIHGGGYVMGAPEMNDQQCAELAQRIPALVASVDYRLAPEHPYPAPLEDCYAALRWVAERAEQLGVDRERLA
IAGASAGGGLAAGLALLARDRGEVPVRFQLLIYPMLDDRNQTPSSYEITDPRLIWTRDWNLIGWRAYLGREPGSPDVPPY
AAPARADDLAGLPPAYVLVGTADLFRDEDIAYAQRLMQAGVPTELHVFAGAFHGFDVFAPTAWVSQRANAEVLAVLQRAL
AA
>Mature_321_residues
SVFARLDPELAAALREIPEEFLLDLRDISLARRRLQILREALASLLPPLPSDVAVTDELAPNSFDGTMVRVRLYRPSEVT
GPLPVLLWIHGGGYVMGAPEMNDQQCAELAQRIPALVASVDYRLAPEHPYPAPLEDCYAALRWVAERAEQLGVDRERLAI
AGASAGGGLAAGLALLARDRGEVPVRFQLLIYPMLDDRNQTPSSYEITDPRLIWTRDWNLIGWRAYLGREPGSPDVPPYA
APARADDLAGLPPAYVLVGTADLFRDEDIAYAQRLMQAGVPTELHVFAGAFHGFDVFAPTAWVSQRANAEVLAVLQRALA
A

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI68299767, Length=311, Percent_Identity=29.5819935691318, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI157041239, Length=307, Percent_Identity=28.6644951140065, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI68051721, Length=317, Percent_Identity=29.3375394321767, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI206597554, Length=327, Percent_Identity=26.2996941896024, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI226423947, Length=325, Percent_Identity=28.6153846153846, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI61966717, Length=298, Percent_Identity=26.8456375838926, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI157041237, Length=250, Percent_Identity=26.4, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI21328446, Length=103, Percent_Identity=36.8932038834951, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI1786682, Length=236, Percent_Identity=27.5423728813559, Blast_Score=68, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17567059, Length=269, Percent_Identity=30.8550185873606, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI72001146, Length=147, Percent_Identity=34.0136054421769, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17540028, Length=145, Percent_Identity=35.8620689655172, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71996133, Length=145, Percent_Identity=35.1724137931034, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24656084, Length=119, Percent_Identity=36.1344537815126, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24656076, Length=119, Percent_Identity=36.1344537815126, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI20130169, Length=119, Percent_Identity=36.1344537815126, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 35280; Mature: 35149

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVFARLDPELAAALREIPEEFLLDLRDISLARRRLQILREALASLLPPLPSDVAVTDEL
CCCHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCC
APNSFDGTMVRVRLYRPSEVTGPLPVLLWIHGGGYVMGAPEMNDQQCAELAQRIPALVAS
CCCCCCCEEEEEEEECCCCCCCCCEEEEEEECCCEEECCCCCCHHHHHHHHHHHHHHHHH
VDYRLAPEHPYPAPLEDCYAALRWVAERAEQLGVDRERLAIAGASAGGGLAAGLALLARD
CCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHEEECCCCCCHHHHHHHHHHHC
RGEVPVRFQLLIYPMLDDRNQTPSSYEITDPRLIWTRDWNLIGWRAYLGREPGSPDVPPY
CCCCCEEEEEEEEEEECCCCCCCCCEECCCCEEEEEECCCEEEEHHHHCCCCCCCCCCCC
AAPARADDLAGLPPAYVLVGTADLFRDEDIAYAQRLMQAGVPTELHVFAGAFHGFDVFAP
CCCCCCCCCCCCCCCEEEEECHHHHCCCHHHHHHHHHHCCCCCEEHHHHHHHCCCHHHCC
TAWVSQRANAEVLAVLQRALAA
HHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SVFARLDPELAAALREIPEEFLLDLRDISLARRRLQILREALASLLPPLPSDVAVTDEL
CCHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCC
APNSFDGTMVRVRLYRPSEVTGPLPVLLWIHGGGYVMGAPEMNDQQCAELAQRIPALVAS
CCCCCCCEEEEEEEECCCCCCCCCEEEEEEECCCEEECCCCCCHHHHHHHHHHHHHHHHH
VDYRLAPEHPYPAPLEDCYAALRWVAERAEQLGVDRERLAIAGASAGGGLAAGLALLARD
CCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHEEECCCCCCHHHHHHHHHHHC
RGEVPVRFQLLIYPMLDDRNQTPSSYEITDPRLIWTRDWNLIGWRAYLGREPGSPDVPPY
CCCCCEEEEEEEEEEECCCCCCCCCEECCCCEEEEEECCCEEEEHHHHCCCCCCCCCCCC
AAPARADDLAGLPPAYVLVGTADLFRDEDIAYAQRLMQAGVPTELHVFAGAFHGFDVFAP
CCCCCCCCCCCCCCCEEEEECHHHHCCCHHHHHHHHHHCCCCCEEHHHHHHHCCCHHHCC
TAWVSQRANAEVLAVLQRALAA
HHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]