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The map label for this gene is hemH [H]

Identifier: 221633363

GI number: 221633363

Start: 1373112

End: 1374068

Strand: Reverse

Name: hemH [H]

Synonym: trd_1383

Alternate gene names: 221633363

Gene position: 1374068-1373112 (Counterclockwise)

Preceding gene: 221633364

Following gene: 221633362

Centisome position: 68.6

GC content: 64.89

Gene sequence:

>957_bases
GTGACACGCGAGCGCGTCGCTGTCTTGCTCATGGCCTACGGAGGACCCGATCGTTTGGACGATCTTCCGGCCTTCCTCCT
GGACGTCCGACACGGGCGGCCGTATTCGCCCGAACTCTTGGCTGATCTCACGGAGCGTTACCGGGCGATCGGTGGTCGTT
CCCCGATCCTCGAGCGCACCCGGGCCGAGGCGCTCGGGATCGAACGAGCGTTGCAGGAGTACGCGACCGAGGATGGGGTT
GACTACCGCATCTACGTGGCGATGCGACACTGGCATCCCTTCATTCGCGAGGTGGTTCCAGAGATCCTGCGCGACGGCGT
CGACCGGCTCGTCGCGGTCGTGATGGCGCCTCATTACTCTCGGATGAGCGTGGGTGCTTATCTGGCACGACTGGACGAGG
CGCTCCGCGACCATCAGGCGACGGTTCCTGTCCATGCGGTCGAGAGCTGGAAGGACGAGCCGGAGTTCATCGCCGCTTGG
GTCGACCGGATCGCTGCGGCGCTCCGAGCCGTCCCCGAGACGGAGCGATCTCGGACGCTCTTGCTGTTCACCGCGCATAG
TTTGCCGACGCGGATACTGGACTGGGGGGATCCGTACCGGGAGGAGATTCTCACCTCCGTCCGGCTGGTCGCGGCGCACT
TCCCAGAATACGAGTGGCGTTTCGCTTTCCAGAGTCAGGGAGCGAGCGAGGAACCGTGGTTGGGGCCGACGGTCGAGGAG
ACGCTCGACGAGTTGGCGGCTGCGGGTGTTGCGCGAGTCTTGCTGGTACCGATCGGGTTCGTCTGCGACCACGTGGAAGT
GCTCTACGACGTCGATATCGCACACAAGGAGTACGCGTTGTCCCGGGGAATCGTGCTCGAGCGGCCAGCGATGTTGAACG
ATCATCCCCTGCTTTGCCGAGCGATCGCGAATGCGGTGCGGCGGACGCTGCGCGCGGCGCGCGTTGGGGTAGGATGA

Upstream 100 bases:

>100_bases
GCTGCCGGAGACATCGCCCGATGCGGTCGCGATCCTCGTCGAGTTCGTGCACGAGTACAGCGCCCGTGTCCGAGACTGAG
TATGAGAAGGGAGGAAAACC

Downstream 100 bases:

>100_bases
GCGAGGTGCACGCTCATGTGGTCGTCATCGGCGGGGGGATCGCTGGTCTCGCTGCGGCCTGGCGCCTCGAACAGCTGAGT
CCGGCGATCAGCGTCACGCT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MTRERVAVLLMAYGGPDRLDDLPAFLLDVRHGRPYSPELLADLTERYRAIGGRSPILERTRAEALGIERALQEYATEDGV
DYRIYVAMRHWHPFIREVVPEILRDGVDRLVAVVMAPHYSRMSVGAYLARLDEALRDHQATVPVHAVESWKDEPEFIAAW
VDRIAAALRAVPETERSRTLLLFTAHSLPTRILDWGDPYREEILTSVRLVAAHFPEYEWRFAFQSQGASEEPWLGPTVEE
TLDELAAAGVARVLLVPIGFVCDHVEVLYDVDIAHKEYALSRGIVLERPAMLNDHPLLCRAIANAVRRTLRAARVGVG

Sequences:

>Translated_318_residues
MTRERVAVLLMAYGGPDRLDDLPAFLLDVRHGRPYSPELLADLTERYRAIGGRSPILERTRAEALGIERALQEYATEDGV
DYRIYVAMRHWHPFIREVVPEILRDGVDRLVAVVMAPHYSRMSVGAYLARLDEALRDHQATVPVHAVESWKDEPEFIAAW
VDRIAAALRAVPETERSRTLLLFTAHSLPTRILDWGDPYREEILTSVRLVAAHFPEYEWRFAFQSQGASEEPWLGPTVEE
TLDELAAAGVARVLLVPIGFVCDHVEVLYDVDIAHKEYALSRGIVLERPAMLNDHPLLCRAIANAVRRTLRAARVGVG
>Mature_317_residues
TRERVAVLLMAYGGPDRLDDLPAFLLDVRHGRPYSPELLADLTERYRAIGGRSPILERTRAEALGIERALQEYATEDGVD
YRIYVAMRHWHPFIREVVPEILRDGVDRLVAVVMAPHYSRMSVGAYLARLDEALRDHQATVPVHAVESWKDEPEFIAAWV
DRIAAALRAVPETERSRTLLLFTAHSLPTRILDWGDPYREEILTSVRLVAAHFPEYEWRFAFQSQGASEEPWLGPTVEET
LDELAAAGVARVLLVPIGFVCDHVEVLYDVDIAHKEYALSRGIVLERPAMLNDHPLLCRAIANAVRRTLRAARVGVG

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=329, Percent_Identity=28.8753799392097, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI60499025, Length=329, Percent_Identity=28.8753799392097, Blast_Score=149, Evalue=4e-36,
Organism=Escherichia coli, GI1786681, Length=227, Percent_Identity=28.1938325991189, Blast_Score=80, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324750, Length=334, Percent_Identity=25.4491017964072, Blast_Score=129, Evalue=4e-31,
Organism=Drosophila melanogaster, GI17864156, Length=330, Percent_Identity=28.4848484848485, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24651774, Length=256, Percent_Identity=26.5625, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI45552018, Length=171, Percent_Identity=33.9181286549708, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 35929; Mature: 35797

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRERVAVLLMAYGGPDRLDDLPAFLLDVRHGRPYSPELLADLTERYRAIGGRSPILERT
CCCHHEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHH
RAEALGIERALQEYATEDGVDYRIYVAMRHWHPFIREVVPEILRDGVDRLVAVVMAPHYS
HHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
RMSVGAYLARLDEALRDHQATVPVHAVESWKDEPEFIAAWVDRIAAALRAVPETERSRTL
HHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEE
LLFTAHSLPTRILDWGDPYREEILTSVRLVAAHFPEYEWRFAFQSQGASEEPWLGPTVEE
EEEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHH
TLDELAAAGVARVLLVPIGFVCDHVEVLYDVDIAHKEYALSRGIVLERPAMLNDHPLLCR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHH
AIANAVRRTLRAARVGVG
HHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TRERVAVLLMAYGGPDRLDDLPAFLLDVRHGRPYSPELLADLTERYRAIGGRSPILERT
CCHHEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHH
RAEALGIERALQEYATEDGVDYRIYVAMRHWHPFIREVVPEILRDGVDRLVAVVMAPHYS
HHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
RMSVGAYLARLDEALRDHQATVPVHAVESWKDEPEFIAAWVDRIAAALRAVPETERSRTL
HHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEE
LLFTAHSLPTRILDWGDPYREEILTSVRLVAAHFPEYEWRFAFQSQGASEEPWLGPTVEE
EEEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHH
TLDELAAAGVARVLLVPIGFVCDHVEVLYDVDIAHKEYALSRGIVLERPAMLNDHPLLCR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHH
AIANAVRRTLRAARVGVG
HHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA