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The map label for this gene is rnc [H]

Identifier: 221633356

GI number: 221633356

Start: 1368235

End: 1368993

Strand: Reverse

Name: rnc [H]

Synonym: trd_1376

Alternate gene names: 221633356

Gene position: 1368993-1368235 (Counterclockwise)

Preceding gene: 221633357

Following gene: 221633355

Centisome position: 68.35

GC content: 66.93

Gene sequence:

>759_bases
ATGGAGGACCAGCAGACGAACCGAGCGCAGTCGAGCGGGCGCGACGAGCGAGTCGTGCAGGCGATGGAGGCCCTGGGGAT
CGCGTTCCGTCGACCGGACCTCCTGCGCCAGGCCTTGACGCACCTTTCGTACGTCTACGAACGGAGCCGGAGCACGCAGG
CCGCGGTCGAGGAGGCGAACGAGCGCTTGGAGTTTCTCGGCGACGCAGTTCTCGAACTCTTGGTGAGCGAGTTCCTCTAC
CGGCGCTTTCCCACCGCGAGCGAGGGGGAACTCACCGCGTACCGCGCGGCTTTGGTGCGTACGCCGACGTTGGCACGCTG
GGCACGCCGTTTCCGACTCGACGAGTTCTTGTATCTCGGTCGTAGCGAGGTGCCCCGACCGGGGCGACCGGTCCGCGAAC
GGATTCTCGCAGGAGCCTTCGAGGCGGTGCTCGGTGCGCTCTACCTGGATCGTGGTATTCGGGTCGTGCGGCGGTTCCTG
CACCGGCTCTTGCTCGAAGAGGCCGAGGGACTGATCGCGATCGGCCAGAACGAGAACTACAAGGGACGGCTCCAGGAACT
GATTCAAGACCGGTTGCGGATCACGCCGGTCTATCGCACCATTGCAGTGACGGGGCCGGCGCACCAGCGTACGTTCACGG
CGGAAGTGCTGATCGGCGAGCGCCCATACGGAGTGGGCCACGGCCCGAGCAAGCGGGCAGCGGAGCAAGAGGCAGCACGG
CGCGCACTCGAGCGGCTGCGGGCGGAGGGGATCGGCTGA

Upstream 100 bases:

>100_bases
GCATTACCTGTACATCATCTCGATCGATTGGGAAGCCTTGGAGCGGGTGGCGCGCGACGCGCAGGTGGATCTCGCGAGCG
TGCTCGAGGCTCATTGATCG

Downstream 100 bases:

>100_bases
GGCGATGGGCGGGCTCTACGACCAACTGACGATTTTCGGTGGTAATTCCAATCCGGAACTCACCAAGGCGATCTGCGCCT
ATATCGACATCCCACCCGGA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MEDQQTNRAQSSGRDERVVQAMEALGIAFRRPDLLRQALTHLSYVYERSRSTQAAVEEANERLEFLGDAVLELLVSEFLY
RRFPTASEGELTAYRAALVRTPTLARWARRFRLDEFLYLGRSEVPRPGRPVRERILAGAFEAVLGALYLDRGIRVVRRFL
HRLLLEEAEGLIAIGQNENYKGRLQELIQDRLRITPVYRTIAVTGPAHQRTFTAEVLIGERPYGVGHGPSKRAAEQEAAR
RALERLRAEGIG

Sequences:

>Translated_252_residues
MEDQQTNRAQSSGRDERVVQAMEALGIAFRRPDLLRQALTHLSYVYERSRSTQAAVEEANERLEFLGDAVLELLVSEFLY
RRFPTASEGELTAYRAALVRTPTLARWARRFRLDEFLYLGRSEVPRPGRPVRERILAGAFEAVLGALYLDRGIRVVRRFL
HRLLLEEAEGLIAIGQNENYKGRLQELIQDRLRITPVYRTIAVTGPAHQRTFTAEVLIGERPYGVGHGPSKRAAEQEAAR
RALERLRAEGIG
>Mature_252_residues
MEDQQTNRAQSSGRDERVVQAMEALGIAFRRPDLLRQALTHLSYVYERSRSTQAAVEEANERLEFLGDAVLELLVSEFLY
RRFPTASEGELTAYRAALVRTPTLARWARRFRLDEFLYLGRSEVPRPGRPVRERILAGAFEAVLGALYLDRGIRVVRRFL
HRLLLEEAEGLIAIGQNENYKGRLQELIQDRLRITPVYRTIAVTGPAHQRTFTAEVLIGERPYGVGHGPSKRAAEQEAAR
RALERLRAEGIG

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=252, Percent_Identity=28.968253968254, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI155030236, Length=252, Percent_Identity=28.968253968254, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1788920, Length=226, Percent_Identity=38.9380530973451, Blast_Score=123, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI193202651, Length=232, Percent_Identity=30.6034482758621, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17506883, Length=232, Percent_Identity=30.6034482758621, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17137682, Length=232, Percent_Identity=31.0344827586207, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 28681; Mature: 28681

Theoretical pI: Translated: 10.11; Mature: 10.11

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDQQTNRAQSSGRDERVVQAMEALGIAFRRPDLLRQALTHLSYVYERSRSTQAAVEEAN
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
ERLEFLGDAVLELLVSEFLYRRFPTASEGELTAYRAALVRTPTLARWARRFRLDEFLYLG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
RSEVPRPGRPVRERILAGAFEAVLGALYLDRGIRVVRRFLHRLLLEEAEGLIAIGQNENY
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCH
KGRLQELIQDRLRITPVYRTIAVTGPAHQRTFTAEVLIGERPYGVGHGPSKRAAEQEAAR
HHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHH
RALERLRAEGIG
HHHHHHHHCCCC
>Mature Secondary Structure
MEDQQTNRAQSSGRDERVVQAMEALGIAFRRPDLLRQALTHLSYVYERSRSTQAAVEEAN
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
ERLEFLGDAVLELLVSEFLYRRFPTASEGELTAYRAALVRTPTLARWARRFRLDEFLYLG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
RSEVPRPGRPVRERILAGAFEAVLGALYLDRGIRVVRRFLHRLLLEEAEGLIAIGQNENY
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCH
KGRLQELIQDRLRITPVYRTIAVTGPAHQRTFTAEVLIGERPYGVGHGPSKRAAEQEAAR
HHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHH
RALERLRAEGIG
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA