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The map label for this gene is groL [H]

Identifier: 221633280

GI number: 221633280

Start: 1291492

End: 1293138

Strand: Reverse

Name: groL [H]

Synonym: trd_1300

Alternate gene names: 221633280

Gene position: 1293138-1291492 (Counterclockwise)

Preceding gene: 221633281

Following gene: 221633279

Centisome position: 64.56

GC content: 63.45

Gene sequence:

>1647_bases
TTGACGAGTGACGGGAGGGTAGCGATGCCGGCCAAAATGATCCGTTTCCACGAGCAGGCTCGACAGTCCTTGAAAGAAGG
CGTCGATATTCTGGCCAATGCAGTCAAGACCACGCTGGGACCGAAGGGACGCAACGTCGCGCTGGACAAGAAGTACGGTG
CTCCGACCGTCAGCCATGACGGTGTGACGGTCGCCAAGGAAATCGAGCTGGAGGATCCCTTCGCCAATATGGGGGCCCAG
CTTCTGAAAGAGGCGGCGACCAAGACGAACGATGTCGCCGGTGACGGTACGACGACGGCGACCGTTCTGGCACAGGCGAT
CGTCCACGAGGGGCTGCGGAACGTCGCTGCTGGAGCCAACCCGATGCTGCTCAAGCGCGGTATCGAGCTGGCCACCAAGG
CGGTCGTGGAGCGCCTCAAGTCGATGGCCAAGGAGGTCCGCGGGCGCGAGGATATCGCCCATGTCGCTACTATCTCGGCG
GCTGATCCCGAGATCGGGAACCTGATCGCCGAGGTCATGGAGAAGGTCGGCAAGGACGGTGTCATCACCGTCGAGGAATC
GAAGGGGCTGGCCTTCGAGGTCGAGTACACCGAGGGGATGGAGATCGACCGCGGGTACATCTCCCCCTACTTCGTCACGA
ACCCGGAGCGCATGGAGGCGGTGGTCGAGGAACCCTTCATCCTGATTACCGACAAGAAGGTTTCGGCCGTCTCCGACATC
CTGCCCATCCTCGAGAAGGTTTTGCAGGTCAGCAAGAACTTCGTGATTATCGCTGAGGACGTCGAAGGCGAAGCGCTGGC
GACGCTGGTCGTCAACAAGCTGCGCGGCACGCTGAATGCGCTGGCCGTCAAGGCGCCGGGCTTCGGTGACCGCCGCAAGG
AGATGCTGCGCGACATCGCCATTCTGACTGGCGGTACGGTCATCTCGGAGGAGCTCGGGCGCAAGCTGGAGACTGCGCGC
CTGGAGGATCTGGGTCGTGCCCGCCGCGTCGTCGCGACCAAGGACAAGACGACGATCGTCGAAGGGTACGGCCGCGAGGA
GGACATCAAGGCGCGCATCGAGCAGATCAAGGCCCAGATCGAGCAGACGACCAGCGACTTCGATCGCGAGAAGCTCCAGG
AGCGACTGGCGAAGCTCGCCGGCGGCGTCGCGGTCATCAAGGTCGGTGCGGCGACCGAAGTCGAGCTGAAGGAGAAGAAG
CACCGCGTCGAGGACGCGCTGAGCGCGACCCGCGCTGCGGTCGAAGAGGGTATCGTCCCGGGTGGTGGTGTGGCGTTGCT
CAATGCGATCGCCGCACTCGATGAGGTCCAGGCCGAGGGCGACATCAAGACCGGTGTGATGATCGTCAAGCGGGCGCTCG
AAGAGCCGCTCCGCGGCATCGTCGAGAACGCTGGCCTGGATGGCTCGGTGGTCATCGAGACGGTGCGGCGGCTCCAGAAG
GAGCAGAACAACCCGAACATCGGATACGACGTCATCCGCGAGGAGTACGGTGACCTTCTGGAGTGGGGCGTCATCGACCC
GGTCAAGGTGACGCGCTCGGCAGTGGAGAACGCGGCCTCTGTGGCGGCCATGATCCTCACGACCGAGGCGTTGATCACCG
AGAAGCCGGAGAAGGAGAAGACCCCGGCTCCGAGCATGGAGTACTGA

Upstream 100 bases:

>100_bases
GCTCAAGATCGATGACGAAGAGTACCTGATCCTGAGCGAAAAGGATATCCTGGCTGTTCTGTCCGAATGAGTGGATGAGT
CGAGCGGTACGACGGAATAG

Downstream 100 bases:

>100_bases
TCCGACGCGTCGATCGGATGCCGATCCGGGCGCACGAGCAGTGCGCCCGGATTTCTTTTCTCCCTCGTTCCCGAGGGACG
AGTACACTGCTGCCGATGGC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2 [H]

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MTSDGRVAMPAKMIRFHEQARQSLKEGVDILANAVKTTLGPKGRNVALDKKYGAPTVSHDGVTVAKEIELEDPFANMGAQ
LLKEAATKTNDVAGDGTTTATVLAQAIVHEGLRNVAAGANPMLLKRGIELATKAVVERLKSMAKEVRGREDIAHVATISA
ADPEIGNLIAEVMEKVGKDGVITVEESKGLAFEVEYTEGMEIDRGYISPYFVTNPERMEAVVEEPFILITDKKVSAVSDI
LPILEKVLQVSKNFVIIAEDVEGEALATLVVNKLRGTLNALAVKAPGFGDRRKEMLRDIAILTGGTVISEELGRKLETAR
LEDLGRARRVVATKDKTTIVEGYGREEDIKARIEQIKAQIEQTTSDFDREKLQERLAKLAGGVAVIKVGAATEVELKEKK
HRVEDALSATRAAVEEGIVPGGGVALLNAIAALDEVQAEGDIKTGVMIVKRALEEPLRGIVENAGLDGSVVIETVRRLQK
EQNNPNIGYDVIREEYGDLLEWGVIDPVKVTRSAVENAASVAAMILTTEALITEKPEKEKTPAPSMEY

Sequences:

>Translated_548_residues
MTSDGRVAMPAKMIRFHEQARQSLKEGVDILANAVKTTLGPKGRNVALDKKYGAPTVSHDGVTVAKEIELEDPFANMGAQ
LLKEAATKTNDVAGDGTTTATVLAQAIVHEGLRNVAAGANPMLLKRGIELATKAVVERLKSMAKEVRGREDIAHVATISA
ADPEIGNLIAEVMEKVGKDGVITVEESKGLAFEVEYTEGMEIDRGYISPYFVTNPERMEAVVEEPFILITDKKVSAVSDI
LPILEKVLQVSKNFVIIAEDVEGEALATLVVNKLRGTLNALAVKAPGFGDRRKEMLRDIAILTGGTVISEELGRKLETAR
LEDLGRARRVVATKDKTTIVEGYGREEDIKARIEQIKAQIEQTTSDFDREKLQERLAKLAGGVAVIKVGAATEVELKEKK
HRVEDALSATRAAVEEGIVPGGGVALLNAIAALDEVQAEGDIKTGVMIVKRALEEPLRGIVENAGLDGSVVIETVRRLQK
EQNNPNIGYDVIREEYGDLLEWGVIDPVKVTRSAVENAASVAAMILTTEALITEKPEKEKTPAPSMEY
>Mature_547_residues
TSDGRVAMPAKMIRFHEQARQSLKEGVDILANAVKTTLGPKGRNVALDKKYGAPTVSHDGVTVAKEIELEDPFANMGAQL
LKEAATKTNDVAGDGTTTATVLAQAIVHEGLRNVAAGANPMLLKRGIELATKAVVERLKSMAKEVRGREDIAHVATISAA
DPEIGNLIAEVMEKVGKDGVITVEESKGLAFEVEYTEGMEIDRGYISPYFVTNPERMEAVVEEPFILITDKKVSAVSDIL
PILEKVLQVSKNFVIIAEDVEGEALATLVVNKLRGTLNALAVKAPGFGDRRKEMLRDIAILTGGTVISEELGRKLETARL
EDLGRARRVVATKDKTTIVEGYGREEDIKARIEQIKAQIEQTTSDFDREKLQERLAKLAGGVAVIKVGAATEVELKEKKH
RVEDALSATRAAVEEGIVPGGGVALLNAIAALDEVQAEGDIKTGVMIVKRALEEPLRGIVENAGLDGSVVIETVRRLQKE
QNNPNIGYDVIREEYGDLLEWGVIDPVKVTRSAVENAASVAAMILTTEALITEKPEKEKTPAPSMEY

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=535, Percent_Identity=49.1588785046729, Blast_Score=497, Evalue=1e-140,
Organism=Homo sapiens, GI31542947, Length=535, Percent_Identity=49.1588785046729, Blast_Score=497, Evalue=1e-140,
Organism=Homo sapiens, GI24307939, Length=547, Percent_Identity=23.217550274223, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1790586, Length=533, Percent_Identity=59.4746716697936, Blast_Score=613, Evalue=1e-177,
Organism=Caenorhabditis elegans, GI17555558, Length=532, Percent_Identity=49.0601503759398, Blast_Score=495, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI193210679, Length=214, Percent_Identity=50.4672897196262, Blast_Score=204, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI25147750, Length=557, Percent_Identity=25.1346499102334, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25144674, Length=173, Percent_Identity=29.4797687861272, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6323288, Length=532, Percent_Identity=52.2556390977444, Blast_Score=524, Evalue=1e-149,
Organism=Saccharomyces cerevisiae, GI6322350, Length=561, Percent_Identity=23.3511586452763, Blast_Score=68, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322524, Length=121, Percent_Identity=30.5785123966942, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24641193, Length=532, Percent_Identity=51.3157894736842, Blast_Score=520, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24641191, Length=532, Percent_Identity=51.3157894736842, Blast_Score=520, Evalue=1e-147,
Organism=Drosophila melanogaster, GI45550936, Length=532, Percent_Identity=47.5563909774436, Blast_Score=491, Evalue=1e-139,
Organism=Drosophila melanogaster, GI45550132, Length=532, Percent_Identity=47.5563909774436, Blast_Score=491, Evalue=1e-139,
Organism=Drosophila melanogaster, GI45550935, Length=532, Percent_Identity=47.5563909774436, Blast_Score=491, Evalue=1e-139,
Organism=Drosophila melanogaster, GI17864606, Length=530, Percent_Identity=44.3396226415094, Blast_Score=433, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24584129, Length=537, Percent_Identity=38.1750465549348, Blast_Score=329, Evalue=3e-90,
Organism=Drosophila melanogaster, GI19921262, Length=537, Percent_Identity=38.1750465549348, Blast_Score=329, Evalue=3e-90,
Organism=Drosophila melanogaster, GI28571140, Length=572, Percent_Identity=25, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI18858175, Length=572, Percent_Identity=25, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24652903, Length=562, Percent_Identity=23.8434163701068, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17647245, Length=540, Percent_Identity=23.8888888888889, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 59192; Mature: 59061

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSDGRVAMPAKMIRFHEQARQSLKEGVDILANAVKTTLGPKGRNVALDKKYGAPTVSHD
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCC
GVTVAKEIELEDPFANMGAQLLKEAATKTNDVAGDGTTTATVLAQAIVHEGLRNVAAGAN
CCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
PMLLKRGIELATKAVVERLKSMAKEVRGREDIAHVATISAADPEIGNLIAEVMEKVGKDG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEECCCCCHHHHHHHHHHHHHCCCC
VITVEESKGLAFEVEYTEGMEIDRGYISPYFVTNPERMEAVVEEPFILITDKKVSAVSDI
EEEEECCCCCEEEEEECCCCCCCCCCCCCEEECCHHHHHHHHHCCEEEEECCHHHHHHHH
LPILEKVLQVSKNFVIIAEDVEGEALATLVVNKLRGTLNALAVKAPGFGDRRKEMLRDIA
HHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHH
ILTGGTVISEELGRKLETARLEDLGRARRVVATKDKTTIVEGYGREEDIKARIEQIKAQI
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHH
EQTTSDFDREKLQERLAKLAGGVAVIKVGAATEVELKEKKHRVEDALSATRAAVEEGIVP
HHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
GGGVALLNAIAALDEVQAEGDIKTGVMIVKRALEEPLRGIVENAGLDGSVVIETVRRLQK
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
EQNNPNIGYDVIREEYGDLLEWGVIDPVKVTRSAVENAASVAAMILTTEALITEKPEKEK
HCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TPAPSMEY
CCCCCCCC
>Mature Secondary Structure 
TSDGRVAMPAKMIRFHEQARQSLKEGVDILANAVKTTLGPKGRNVALDKKYGAPTVSHD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCC
GVTVAKEIELEDPFANMGAQLLKEAATKTNDVAGDGTTTATVLAQAIVHEGLRNVAAGAN
CCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
PMLLKRGIELATKAVVERLKSMAKEVRGREDIAHVATISAADPEIGNLIAEVMEKVGKDG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEECCCCCHHHHHHHHHHHHHCCCC
VITVEESKGLAFEVEYTEGMEIDRGYISPYFVTNPERMEAVVEEPFILITDKKVSAVSDI
EEEEECCCCCEEEEEECCCCCCCCCCCCCEEECCHHHHHHHHHCCEEEEECCHHHHHHHH
LPILEKVLQVSKNFVIIAEDVEGEALATLVVNKLRGTLNALAVKAPGFGDRRKEMLRDIA
HHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHH
ILTGGTVISEELGRKLETARLEDLGRARRVVATKDKTTIVEGYGREEDIKARIEQIKAQI
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHH
EQTTSDFDREKLQERLAKLAGGVAVIKVGAATEVELKEKKHRVEDALSATRAAVEEGIVP
HHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
GGGVALLNAIAALDEVQAEGDIKTGVMIVKRALEEPLRGIVENAGLDGSVVIETVRRLQK
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
EQNNPNIGYDVIREEYGDLLEWGVIDPVKVTRSAVENAASVAAMILTTEALITEKPEKEK
HCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TPAPSMEY
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA