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The map label for this gene is yhxA [H]

Identifier: 221633087

GI number: 221633087

Start: 1078647

End: 1080041

Strand: Reverse

Name: yhxA [H]

Synonym: trd_1103

Alternate gene names: 221633087

Gene position: 1080041-1078647 (Counterclockwise)

Preceding gene: 221633090

Following gene: 221633081

Centisome position: 53.92

GC content: 60.79

Gene sequence:

>1395_bases
ATGACTGAGGTCGCGGCGGTGCATCCGGAGCCACGCACCGCACCGGATTTCGAGCAGGAAGCGCTCAAGCATGTCTGGAT
CCACTCCGCCGAGTGGATCCGTCTCGCGGAGGAGCGAGGTTTTCGCGTCTTCGAACGTGCGTACGGGAGCACGCTGGTCG
ACGTCTACGGTCGGGAATTCATCGACGGGTTGTCCGGGCTTTGGGTGGTGAATGCTGGACACGGTCGCAAGGAGATCGCC
GAAGCGATGGCGGAGCAGGCGTCCAAGCTCGCCTACGTCTCGTCCGCCAACCATACGACAGTCCCGACGGTGCGCTTGGC
ACACGAGCTTGCGCTCCGTTTGCCTGGCGATCTAAATCGCGTCTTCTTCTGCTCCGGTGGCTCGGAGGCGGTGGAGAGCG
CCATCAAGATCGCCAAGCAAGTCCAGGCGATGCGCGGATTTCCCAAGCGGTACAAGATCATCGCTCGGCGAGGCAGCTAC
CACGGCATGACGTATGGGGCGATGTCGTTGACGCAGTCGCGCAACGAGAAGTTCTTCGGGCCCTTTATGTATGGGGTGTA
CTATGTCCCCTCGCCTAACCGGTACCGCAACGACTTCGGGCTGGAAGGCGAGGAAGGCGATCTGATGTGTGCCAACTACG
TCGAGCAGGAGATCCTCTATCAGGATCCGGAGACGGTCGCGGCGGTGATCGGCGAGCCGATCTCGACCTCGAATGGCGTC
CACGTACCCTCGCCCAAGTATTGGCAGCGTTTGCGTGAGATCTGTGACAAATACGGTGTTCTCTTGATCATGGACGAAGT
GATCAACGGTTTTGGGCGCACCGGGAAGCTGTTCGCGGCTGAGCACTTCGGGGTCGTTCCTGATCTGATGACGATGGCCA
AAGGCATTACTTCCGGATATGCCCCGATGGGCGCAGTGGCAGTTCGCGACAGTGTCTTCCAAATCTTCCAGGAGCAGAAG
GAAGTTCCGCTCGGTCACCTGCTCACCTTCGGTGGGCATGCCGTTGCGGCAGCAGCCGCGCTGAAGAATCTCGAGATCTT
CGAGCGGGAAGGGTTAGTGCAGCAGAGCGCCGAGAAGGGTGCGTATTTGCTCGAGAGGCTCAAGGAGCTGCTCCGGCACC
CCACCGTCGGTGACGTGCGTGGCCTGGGCCTGATGTGCGGGATCGAACTAGTCAAGAGCAAGGCGACCAAGGAGAAATGG
CCGCGCAACAGCGCTTTCATCAAGGCGCTCGAACGGCGTATGAACGAGAAGGGGTTGCTCACGCGCGTCTGGGAGATCGT
GCACGTCGCTCCGCCGCTGGTCGTCACGTACGAGGAACTCGATCGCATCGTGACGATCATCGACGAGGCGCTGACCGAGA
CGGAGAACGAGTTCGCCAGCGAGATCGCGGAGTGA

Upstream 100 bases:

>100_bases
GGAACGGTGGAGACAGGGTTCTCGGACTGTCCCTGTTCGCGTCCGCAACGTTGGAGACGACGGCTGGTCGGCCGTCACGA
TGGATTTCAGGGGGTGTCGT

Downstream 100 bases:

>100_bases
TCGGTCACGCGCTCGCGGCGACCTGACCGTCGAGCGCGGTTTCCGATCGGTCACGGGACTCGAATCATCGGACGAGGCGC
TCGAGGAGCTCGGCGAGGCG

Product: taurine--pyruvate aminotransferase

Products: L-Glutamate; L-Glutamate 5-semialdehyde [C]

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MTEVAAVHPEPRTAPDFEQEALKHVWIHSAEWIRLAEERGFRVFERAYGSTLVDVYGREFIDGLSGLWVVNAGHGRKEIA
EAMAEQASKLAYVSSANHTTVPTVRLAHELALRLPGDLNRVFFCSGGSEAVESAIKIAKQVQAMRGFPKRYKIIARRGSY
HGMTYGAMSLTQSRNEKFFGPFMYGVYYVPSPNRYRNDFGLEGEEGDLMCANYVEQEILYQDPETVAAVIGEPISTSNGV
HVPSPKYWQRLREICDKYGVLLIMDEVINGFGRTGKLFAAEHFGVVPDLMTMAKGITSGYAPMGAVAVRDSVFQIFQEQK
EVPLGHLLTFGGHAVAAAAALKNLEIFEREGLVQQSAEKGAYLLERLKELLRHPTVGDVRGLGLMCGIELVKSKATKEKW
PRNSAFIKALERRMNEKGLLTRVWEIVHVAPPLVVTYEELDRIVTIIDEALTETENEFASEIAE

Sequences:

>Translated_464_residues
MTEVAAVHPEPRTAPDFEQEALKHVWIHSAEWIRLAEERGFRVFERAYGSTLVDVYGREFIDGLSGLWVVNAGHGRKEIA
EAMAEQASKLAYVSSANHTTVPTVRLAHELALRLPGDLNRVFFCSGGSEAVESAIKIAKQVQAMRGFPKRYKIIARRGSY
HGMTYGAMSLTQSRNEKFFGPFMYGVYYVPSPNRYRNDFGLEGEEGDLMCANYVEQEILYQDPETVAAVIGEPISTSNGV
HVPSPKYWQRLREICDKYGVLLIMDEVINGFGRTGKLFAAEHFGVVPDLMTMAKGITSGYAPMGAVAVRDSVFQIFQEQK
EVPLGHLLTFGGHAVAAAAALKNLEIFEREGLVQQSAEKGAYLLERLKELLRHPTVGDVRGLGLMCGIELVKSKATKEKW
PRNSAFIKALERRMNEKGLLTRVWEIVHVAPPLVVTYEELDRIVTIIDEALTETENEFASEIAE
>Mature_463_residues
TEVAAVHPEPRTAPDFEQEALKHVWIHSAEWIRLAEERGFRVFERAYGSTLVDVYGREFIDGLSGLWVVNAGHGRKEIAE
AMAEQASKLAYVSSANHTTVPTVRLAHELALRLPGDLNRVFFCSGGSEAVESAIKIAKQVQAMRGFPKRYKIIARRGSYH
GMTYGAMSLTQSRNEKFFGPFMYGVYYVPSPNRYRNDFGLEGEEGDLMCANYVEQEILYQDPETVAAVIGEPISTSNGVH
VPSPKYWQRLREICDKYGVLLIMDEVINGFGRTGKLFAAEHFGVVPDLMTMAKGITSGYAPMGAVAVRDSVFQIFQEQKE
VPLGHLLTFGGHAVAAAAALKNLEIFEREGLVQQSAEKGAYLLERLKELLRHPTVGDVRGLGLMCGIELVKSKATKEKWP
RNSAFIKALERRMNEKGLLTRVWEIVHVAPPLVVTYEELDRIVTIIDEALTETENEFASEIAE

Specific function: Essential for glycerol catabolism [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=415, Percent_Identity=30.8433734939759, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI24119277, Length=425, Percent_Identity=28, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI13994255, Length=430, Percent_Identity=30.4651162790698, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI37574042, Length=429, Percent_Identity=28.4382284382284, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI226442705, Length=429, Percent_Identity=28.4382284382284, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI226442709, Length=402, Percent_Identity=28.8557213930348, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI284507298, Length=332, Percent_Identity=31.0240963855422, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI188536080, Length=414, Percent_Identity=25.3623188405797, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI38679950, Length=414, Percent_Identity=25.3623188405797, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI38679946, Length=414, Percent_Identity=25.3623188405797, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI145693181, Length=407, Percent_Identity=34.6437346437346, Blast_Score=212, Evalue=4e-56,
Organism=Escherichia coli, GI1789016, Length=422, Percent_Identity=33.6492890995261, Blast_Score=201, Evalue=7e-53,
Organism=Escherichia coli, GI1786991, Length=411, Percent_Identity=30.1703163017032, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1788044, Length=405, Percent_Identity=31.8518518518519, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1787560, Length=425, Percent_Identity=30.5882352941176, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1789759, Length=398, Percent_Identity=29.6482412060301, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1786349, Length=333, Percent_Identity=29.1291291291291, Blast_Score=104, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI32564660, Length=428, Percent_Identity=30.607476635514, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI25144271, Length=415, Percent_Identity=30.1204819277108, Blast_Score=164, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI71992977, Length=440, Percent_Identity=28.6363636363636, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI25144274, Length=304, Percent_Identity=31.25, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17541228, Length=445, Percent_Identity=24.7191011235955, Blast_Score=98, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6323470, Length=426, Percent_Identity=31.924882629108, Blast_Score=173, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6324386, Length=513, Percent_Identity=28.6549707602339, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6324432, Length=348, Percent_Identity=31.6091954022989, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6321456, Length=375, Percent_Identity=24.8, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28574759, Length=431, Percent_Identity=30.6264501160093, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI161085790, Length=428, Percent_Identity=30.3738317757009, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI21357415, Length=403, Percent_Identity=31.5136476426799, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI21356575, Length=428, Percent_Identity=29.2056074766355, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI281366494, Length=289, Percent_Identity=25.9515570934256, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24667139, Length=289, Percent_Identity=25.9515570934256, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24667143, Length=289, Percent_Identity=25.9515570934256, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.13 [C]

Molecular weight: Translated: 51772; Mature: 51641

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEVAAVHPEPRTAPDFEQEALKHVWIHSAEWIRLAEERGFRVFERAYGSTLVDVYGREF
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHH
IDGLSGLWVVNAGHGRKEIAEAMAEQASKLAYVSSANHTTVPTVRLAHELALRLPGDLNR
HHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHCCCCCCE
VFFCSGGSEAVESAIKIAKQVQAMRGFPKRYKIIARRGSYHGMTYGAMSLTQSRNEKFFG
EEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCC
PFMYGVYYVPSPNRYRNDFGLEGEEGDLMCANYVEQEILYQDPETVAAVIGEPISTSNGV
CHHHCEEECCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCC
HVPSPKYWQRLREICDKYGVLLIMDEVINGFGRTGKLFAAEHFGVVPDLMTMAKGITSGY
CCCCHHHHHHHHHHHHHCCCEEEHHHHHHCCCCCCCEEEHHHCCCHHHHHHHHHHHHCCC
APMGAVAVRDSVFQIFQEQKEVPLGHLLTFGGHAVAAAAALKNLEIFEREGLVQQSAEKG
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHH
AYLLERLKELLRHPTVGDVRGLGLMCGIELVKSKATKEKWPRNSAFIKALERRMNEKGLL
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHH
TRVWEIVHVAPPLVVTYEELDRIVTIIDEALTETENEFASEIAE
HHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TEVAAVHPEPRTAPDFEQEALKHVWIHSAEWIRLAEERGFRVFERAYGSTLVDVYGREF
CCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHH
IDGLSGLWVVNAGHGRKEIAEAMAEQASKLAYVSSANHTTVPTVRLAHELALRLPGDLNR
HHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHCCCCCCE
VFFCSGGSEAVESAIKIAKQVQAMRGFPKRYKIIARRGSYHGMTYGAMSLTQSRNEKFFG
EEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCC
PFMYGVYYVPSPNRYRNDFGLEGEEGDLMCANYVEQEILYQDPETVAAVIGEPISTSNGV
CHHHCEEECCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCC
HVPSPKYWQRLREICDKYGVLLIMDEVINGFGRTGKLFAAEHFGVVPDLMTMAKGITSGY
CCCCHHHHHHHHHHHHHCCCEEEHHHHHHCCCCCCCEEEHHHCCCHHHHHHHHHHHHCCC
APMGAVAVRDSVFQIFQEQKEVPLGHLLTFGGHAVAAAAALKNLEIFEREGLVQQSAEKG
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHH
AYLLERLKELLRHPTVGDVRGLGLMCGIELVKSKATKEKWPRNSAFIKALERRMNEKGLL
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHH
TRVWEIVHVAPPLVVTYEELDRIVTIIDEALTETENEFASEIAE
HHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-Oxoglutarate; Ornithine [C]

Specific reaction: 2-Oxoglutarate + Ornithine --> L-Glutamate + L-Glutamate 5-semialdehyde [C]

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 8969498; 8436953 [H]