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The map label for this gene is glyS

Identifier: 221633039

GI number: 221633039

Start: 1024134

End: 1025540

Strand: Reverse

Name: glyS

Synonym: trd_1053

Alternate gene names: 221633039

Gene position: 1025540-1024134 (Counterclockwise)

Preceding gene: 221633040

Following gene: 221633037

Centisome position: 51.2

GC content: 57.64

Gene sequence:

>1407_bases
ATGGACGCGCGTCACGCTGCCACCGTCCGACTGGAGACGATCGTCTCGCTCGCCAAGCGTCGCGGTTTCGTGTATCCGGG
AAGCGAGATCTACGGTGGTCTGGCGAATACCTGGGACTTCGGACCGTTAGGTGCCGAGTTGAAGCGGAACCTCAAGAACG
CATGGTGGGAATACTTCATTCAACGTCGCGAGGACATGGTTGGCCTGGATGGTGGAATCCTCTTGCATCCCCGGGTCTGG
GAGGCATCCGGGCATGTGGAAGAGTTCAACGACCCGCTGATCGACTGCCGGCGTTGCAAGAGTCGCTTCCGAGCGGACAC
GCTCATCGAGGAGCGGCTCCATCGCTCGACGGAAGGCTTATCCCTCGACGAGATGACCAGACTCGTTCAGGAAGCGAATC
TGGCTTGCCCGGTTTGCGGTGTTCGTGACTGGACACCGGTTCGCAAATTCAACCTGATGTTCCGGACTTTCATCGGCCCC
GTGGAAACGGAGTCGACACCGGTCTATCTGCGTCCGGAGACGGCCCAGGCGATCTTCGTCAATTTCAAGAACGTCGTGCA
AACGAGTCGCGTCAAAATTCCATTCGGAATCGGCCAAATCGGCAAAGCTTTTCGCAACGAGATCACACCGGGGAACTTCA
TTTTTCGCCTGCTCGAGTTCGAGCAGATGGAGATCGAGTACTTCATTCGGCCGGAGATGTGGGAGGAGTATTTCGATCAC
TGGTTGAACGAGATGGGTCAGTTCCTACGTTGGATCGGATTCAAGCCCGATCGCCTGCGGACTCGCGAGCACGGTCCGCA
GGAACTCTCGCACTATTCCCGCAAGACGGTGGATTTCGAATACTTTTTCCCCTTCGGCTGGAAGGAACTGTGTGGTCTGG
CCTATCGTACTGATTACGACTTGCGTCGACATCAGGAATACAGTGGTGAGGACCTCACCTACTTCGATCAGGAGCGTAAC
GAGCGCTATATCCCGCATGTGATCGAGCCGACGATGGGTGTGGAACGGCTCTTCTTGGCCTTGCTGTGCGATGCGTACGA
CGAGGAACCGGCGGTCGACGTGAACGGTAATCCCTACACGCGCGTCGTCCTTCGCTTTCACCCGCGAGTTGCCCCGTACA
AGGTAGCAGTACTGCCGCTTCTGCGGAAACCAGAACTCGTCACCGTGGCACGCGAGGTCGCACAAGAGCTTCGCCAGTAC
TTCCGGATCGAGTATGACGAAACACAGAGCATCGGCCGGCGCTATCGTCGCCAGGACGAGATCGGGACGCCGTATTGCGT
GACGATCGATTATCAGACACTCGAGGATCGTACCGTGACGATCCGGGACCGTGACACGATGCAACAAGTGCGGGTCCCGA
TTTCAGGACTTGTCGAGGAGATCGAGGCGCGCCTGCGATCAGCCTAG

Upstream 100 bases:

>100_bases
TGCTCGAGACCGAGCAGGTGAGCTGTAATTCGACTGGTGATCGCTCGACAGCCCCTCGCCAGAACGAGGGGCTGTGTTTG
TCTTCAGGAGGGGACCGTCC

Downstream 100 bases:

>100_bases
TTCTACGAGGTGATCGTTGTGGGCCTGCCTGAGGAGTTCATCGATGAGTCGCGCGAGTTCCTCGGCGGAATAGTAGTGAA
TGATCAGCCGGCCGCCGCGC

Product: glycyl-tRNA synthetase

Products: NA

Alternate protein names: Glycine--tRNA ligase; GlyRS

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MDARHAATVRLETIVSLAKRRGFVYPGSEIYGGLANTWDFGPLGAELKRNLKNAWWEYFIQRREDMVGLDGGILLHPRVW
EASGHVEEFNDPLIDCRRCKSRFRADTLIEERLHRSTEGLSLDEMTRLVQEANLACPVCGVRDWTPVRKFNLMFRTFIGP
VETESTPVYLRPETAQAIFVNFKNVVQTSRVKIPFGIGQIGKAFRNEITPGNFIFRLLEFEQMEIEYFIRPEMWEEYFDH
WLNEMGQFLRWIGFKPDRLRTREHGPQELSHYSRKTVDFEYFFPFGWKELCGLAYRTDYDLRRHQEYSGEDLTYFDQERN
ERYIPHVIEPTMGVERLFLALLCDAYDEEPAVDVNGNPYTRVVLRFHPRVAPYKVAVLPLLRKPELVTVAREVAQELRQY
FRIEYDETQSIGRRYRRQDEIGTPYCVTIDYQTLEDRTVTIRDRDTMQQVRVPISGLVEEIEARLRSA

Sequences:

>Translated_468_residues
MDARHAATVRLETIVSLAKRRGFVYPGSEIYGGLANTWDFGPLGAELKRNLKNAWWEYFIQRREDMVGLDGGILLHPRVW
EASGHVEEFNDPLIDCRRCKSRFRADTLIEERLHRSTEGLSLDEMTRLVQEANLACPVCGVRDWTPVRKFNLMFRTFIGP
VETESTPVYLRPETAQAIFVNFKNVVQTSRVKIPFGIGQIGKAFRNEITPGNFIFRLLEFEQMEIEYFIRPEMWEEYFDH
WLNEMGQFLRWIGFKPDRLRTREHGPQELSHYSRKTVDFEYFFPFGWKELCGLAYRTDYDLRRHQEYSGEDLTYFDQERN
ERYIPHVIEPTMGVERLFLALLCDAYDEEPAVDVNGNPYTRVVLRFHPRVAPYKVAVLPLLRKPELVTVAREVAQELRQY
FRIEYDETQSIGRRYRRQDEIGTPYCVTIDYQTLEDRTVTIRDRDTMQQVRVPISGLVEEIEARLRSA
>Mature_468_residues
MDARHAATVRLETIVSLAKRRGFVYPGSEIYGGLANTWDFGPLGAELKRNLKNAWWEYFIQRREDMVGLDGGILLHPRVW
EASGHVEEFNDPLIDCRRCKSRFRADTLIEERLHRSTEGLSLDEMTRLVQEANLACPVCGVRDWTPVRKFNLMFRTFIGP
VETESTPVYLRPETAQAIFVNFKNVVQTSRVKIPFGIGQIGKAFRNEITPGNFIFRLLEFEQMEIEYFIRPEMWEEYFDH
WLNEMGQFLRWIGFKPDRLRTREHGPQELSHYSRKTVDFEYFFPFGWKELCGLAYRTDYDLRRHQEYSGEDLTYFDQERN
ERYIPHVIEPTMGVERLFLALLCDAYDEEPAVDVNGNPYTRVVLRFHPRVAPYKVAVLPLLRKPELVTVAREVAQELRQY
FRIEYDETQSIGRRYRRQDEIGTPYCVTIDYQTLEDRTVTIRDRDTMQQVRVPISGLVEEIEARLRSA

Specific function: Catalyzes the attachment of glycine to tRNA(Gly)

COG id: COG0423

COG function: function code J; Glycyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI116805340, Length=348, Percent_Identity=33.0459770114943, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI70887790, Length=316, Percent_Identity=25.3164556962025, Blast_Score=76, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI32564541, Length=395, Percent_Identity=30.6329113924051, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17554996, Length=395, Percent_Identity=30.6329113924051, Blast_Score=176, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6325338, Length=365, Percent_Identity=33.4246575342466, Blast_Score=175, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6319597, Length=409, Percent_Identity=28.8508557457213, Blast_Score=158, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24664462, Length=355, Percent_Identity=33.5211267605634, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI21357965, Length=355, Percent_Identity=33.5211267605634, Blast_Score=189, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYG_THERP (B9L0I4)

Other databases:

- EMBL:   CP001275
- RefSeq:   YP_002522264.1
- GeneID:   7355539
- GenomeReviews:   CP001275_GR
- KEGG:   tro:trd_1053
- OMA:   GSEWGEL
- ProtClustDB:   CLSK2807828
- GO:   GO:0005737
- HAMAP:   MF_00253_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR022961
- InterPro:   IPR002315
- Gene3D:   G3DSA:3.40.50.800
- PANTHER:   PTHR10745
- PRINTS:   PR01043
- TIGRFAMs:   TIGR00389

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd

EC number: =6.1.1.14

Molecular weight: Translated: 55242; Mature: 55242

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 104-104 BINDING 173-173

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDARHAATVRLETIVSLAKRRGFVYPGSEIYGGLANTWDFGPLGAELKRNLKNAWWEYFI
CCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
QRREDMVGLDGGILLHPRVWEASGHVEEFNDPLIDCRRCKSRFRADTLIEERLHRSTEGL
HHHHHCCCCCCCEEECCEEECCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SLDEMTRLVQEANLACPVCGVRDWTPVRKFNLMFRTFIGPVETESTPVYLRPETAQAIFV
CHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCEEEH
NFKNVVQTSRVKIPFGIGQIGKAFRNEITPGNFIFRLLEFEQMEIEYFIRPEMWEEYFDH
HHHHHHHHCCEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEECHHHHHHHHHH
WLNEMGQFLRWIGFKPDRLRTREHGPQELSHYSRKTVDFEYFFPFGWKELCGLAYRTDYD
HHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHCCCEEEECCCCHHHHCCHHHCCCCH
LRRHQEYSGEDLTYFDQERNERYIPHVIEPTMGVERLFLALLCDAYDEEPAVDVNGNPYT
HHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEECCCCCEE
RVVLRFHPRVAPYKVAVLPLLRKPELVTVAREVAQELRQYFRIEYDETQSIGRRYRRQDE
EEEEEECCCCCCCCEEEEHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
IGTPYCVTIDYQTLEDRTVTIRDRDTMQQVRVPISGLVEEIEARLRSA
CCCCEEEEEEEEECCCCEEEEECHHHHHHHHCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDARHAATVRLETIVSLAKRRGFVYPGSEIYGGLANTWDFGPLGAELKRNLKNAWWEYFI
CCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
QRREDMVGLDGGILLHPRVWEASGHVEEFNDPLIDCRRCKSRFRADTLIEERLHRSTEGL
HHHHHCCCCCCCEEECCEEECCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SLDEMTRLVQEANLACPVCGVRDWTPVRKFNLMFRTFIGPVETESTPVYLRPETAQAIFV
CHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCEEEH
NFKNVVQTSRVKIPFGIGQIGKAFRNEITPGNFIFRLLEFEQMEIEYFIRPEMWEEYFDH
HHHHHHHHCCEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEECHHHHHHHHHH
WLNEMGQFLRWIGFKPDRLRTREHGPQELSHYSRKTVDFEYFFPFGWKELCGLAYRTDYD
HHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHCCCEEEECCCCHHHHCCHHHCCCCH
LRRHQEYSGEDLTYFDQERNERYIPHVIEPTMGVERLFLALLCDAYDEEPAVDVNGNPYT
HHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEECCCCCEE
RVVLRFHPRVAPYKVAVLPLLRKPELVTVAREVAQELRQYFRIEYDETQSIGRRYRRQDE
EEEEEECCCCCCCCEEEEHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
IGTPYCVTIDYQTLEDRTVTIRDRDTMQQVRVPISGLVEEIEARLRSA
CCCCEEEEEEEEECCCCEEEEECHHHHHHHHCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA