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The map label for this gene is pbpA [H]

Identifier: 221632841

GI number: 221632841

Start: 815601

End: 817241

Strand: Reverse

Name: pbpA [H]

Synonym: trd_0835

Alternate gene names: 221632841

Gene position: 817241-815601 (Counterclockwise)

Preceding gene: 221632842

Following gene: 221632840

Centisome position: 40.8

GC content: 60.88

Gene sequence:

>1641_bases
ATGGTATGGAGAGTCGTCCCAGCAGCAGCATTTTTGGCCTCCCTCTGCGTCCTCGCCTACGGGATCGTACGGACGAACGA
TCGGACTGATCCGACCTGGTTCGCTCTACTTCTCGTCGCTGGCGTTCTTTGGGCGACCGCACTCGCGCCAGAGATTCGCC
GACTCGCTCGCCGGCGTGGGCACCCGCTCTTGCATGTCGCCTTGGTGCTTACGCTCGGCTTCGGTTTAGTCACTGTGCAG
ATTCTGCGGGCACAACTTTTCGACCGTGAGCGGATTCTCGCTCGAACGAGCGACCCGACGAGTGGTGTGATCGACGTGCG
ACGCTATGCCCTCGAGCGCTCCATAACCCGCGGGAAGATCCTCTTGTCCGATGGCTCGGTGATCGCAGAGGATACGTTGG
AGAATGGACGCAGAGTACGCCGTTACCTGACGAGTGCCGCGTATCTGGCCGGTTACTATTCTCCAGGTCTTTACGGTGCT
GCTGGCTTGGAAGCGCGGTACGACGCTGACCTTTCTGGCATAACAGCCACTACCTGGCAAGCTTGGCTTGACGGGGTTCT
CCACCGGAGGCGAAGCGGTAACGATATCGTTCTCACCATCGACCCTCGACTGCAGGAACTGGGGCAGTCGTTGCTGGGCG
ATCGTTCTGGAGGGATCGTCTTGCTCGATGCCGACACCGGGGCTGTCCTGGCACTGGTCACTGCACCGGCATTCGATCCC
AATTTGCTCAGCGTTCCACTCGGTGCCTCAGCAGACGAGGTGAGGCGAGCCGCGTCCTATCTCGATCGCTTGCGGGAGGA
CGGACGCGGCCCCCTTTTGCTCCGGCCGATCCAAGGGTTGTACGTACCAGGATCGACGTTCAAAACGATAACAGCTGCGG
CTGCTTTGCAGTCGGGTGTTGCGACGCCCGACACCGTTTATCGGGATGACGGTGCCCTGGTGATCGATTCGCGCGTGATC
ATCGAACAGAATCGCCCAGATCCCACACGTGTGAGCTATACCTTGCGAGAGGCATATGGCTACTCTTTGAATGTGGTCTA
CGCTCAGGTCGGCCTGGCTTTAGGAGCTTCTCGACTGGAGGAGACTGCACGCGCAGCTGGATTCGGTGAACGCATCCCTT
TCGATCTACCCGTCGCGGTCAGTCGATTGACCGACTCGCTTGATTTCCTCGGCGCACCGGCTGGACTGGCCGAGACAGCG
TTCGGGCAGGGACAGTTGCTCGTGACTCCGCTCCAGATGGCTCTGGTCGTTACTGGTGTCGTAAGAGATGGAACGCTTCC
GGAACCGTATCTCGTGCAGGAGACGCGTGACGCGGCTGGAGCAGTCGTTTGGCATCACGAGCCGCGCGTTTGGCGACGCG
CCTTTGACCAAGAAACAGCGAGAGCCCTGCATGAACTCATGACCTGGTCGGTCGAACATGGGTATGCCCAGGCAGCGCGC
ATCCCGGGAGTTACGGTCGGGGGTAAGACAGGTACAGCCGAGGTGGGAGAACGCGCACCGCACGCCTGGTTTATCGGCTT
CGCCGAGCGGGGTGACAGGCGCGTCGTCGTTGCCGTCGTCGTGGAGCATGGTGGATCAGGAGCGCAGGTCGCGCTGCCGA
TCGGTAGAACGCTTTTGGCAGCGGCGGTCGGGACGGGATGA

Upstream 100 bases:

>100_bases
CACCCTACCCTTCGTCAGTGCAGGTGGGAGCTCGCTGATCACGAATTTTCTCATCGTCGGACTGCTGCTCCGTGCCAGCG
AGCAGGCACGAGGATGAACG

Downstream 100 bases:

>100_bases
CGCTCACCGGTGAGGCCGATTCTGGTATACTTGTTCGGGTTTAGTGACAGGGTGTCGCATGCCGGTCGTCGTGACGCGCC
GCGAATTCGAGCACATGGTC

Product: PbpA

Products: NA

Alternate protein names: PBPA [H]

Number of amino acids: Translated: 546; Mature: 546

Protein sequence:

>546_residues
MVWRVVPAAAFLASLCVLAYGIVRTNDRTDPTWFALLLVAGVLWATALAPEIRRLARRRGHPLLHVALVLTLGFGLVTVQ
ILRAQLFDRERILARTSDPTSGVIDVRRYALERSITRGKILLSDGSVIAEDTLENGRRVRRYLTSAAYLAGYYSPGLYGA
AGLEARYDADLSGITATTWQAWLDGVLHRRRSGNDIVLTIDPRLQELGQSLLGDRSGGIVLLDADTGAVLALVTAPAFDP
NLLSVPLGASADEVRRAASYLDRLREDGRGPLLLRPIQGLYVPGSTFKTITAAAALQSGVATPDTVYRDDGALVIDSRVI
IEQNRPDPTRVSYTLREAYGYSLNVVYAQVGLALGASRLEETARAAGFGERIPFDLPVAVSRLTDSLDFLGAPAGLAETA
FGQGQLLVTPLQMALVVTGVVRDGTLPEPYLVQETRDAAGAVVWHHEPRVWRRAFDQETARALHELMTWSVEHGYAQAAR
IPGVTVGGKTGTAEVGERAPHAWFIGFAERGDRRVVVAVVVEHGGSGAQVALPIGRTLLAAAVGTG

Sequences:

>Translated_546_residues
MVWRVVPAAAFLASLCVLAYGIVRTNDRTDPTWFALLLVAGVLWATALAPEIRRLARRRGHPLLHVALVLTLGFGLVTVQ
ILRAQLFDRERILARTSDPTSGVIDVRRYALERSITRGKILLSDGSVIAEDTLENGRRVRRYLTSAAYLAGYYSPGLYGA
AGLEARYDADLSGITATTWQAWLDGVLHRRRSGNDIVLTIDPRLQELGQSLLGDRSGGIVLLDADTGAVLALVTAPAFDP
NLLSVPLGASADEVRRAASYLDRLREDGRGPLLLRPIQGLYVPGSTFKTITAAAALQSGVATPDTVYRDDGALVIDSRVI
IEQNRPDPTRVSYTLREAYGYSLNVVYAQVGLALGASRLEETARAAGFGERIPFDLPVAVSRLTDSLDFLGAPAGLAETA
FGQGQLLVTPLQMALVVTGVVRDGTLPEPYLVQETRDAAGAVVWHHEPRVWRRAFDQETARALHELMTWSVEHGYAQAAR
IPGVTVGGKTGTAEVGERAPHAWFIGFAERGDRRVVVAVVVEHGGSGAQVALPIGRTLLAAAVGTG
>Mature_546_residues
MVWRVVPAAAFLASLCVLAYGIVRTNDRTDPTWFALLLVAGVLWATALAPEIRRLARRRGHPLLHVALVLTLGFGLVTVQ
ILRAQLFDRERILARTSDPTSGVIDVRRYALERSITRGKILLSDGSVIAEDTLENGRRVRRYLTSAAYLAGYYSPGLYGA
AGLEARYDADLSGITATTWQAWLDGVLHRRRSGNDIVLTIDPRLQELGQSLLGDRSGGIVLLDADTGAVLALVTAPAFDP
NLLSVPLGASADEVRRAASYLDRLREDGRGPLLLRPIQGLYVPGSTFKTITAAAALQSGVATPDTVYRDDGALVIDSRVI
IEQNRPDPTRVSYTLREAYGYSLNVVYAQVGLALGASRLEETARAAGFGERIPFDLPVAVSRLTDSLDFLGAPAGLAETA
FGQGQLLVTPLQMALVVTGVVRDGTLPEPYLVQETRDAAGAVVWHHEPRVWRRAFDQETARALHELMTWSVEHGYAQAAR
IPGVTVGGKTGTAEVGERAPHAWFIGFAERGDRRVVVAVVVEHGGSGAQVALPIGRTLLAAAVGTG

Specific function: Cell wall formation. Plays an important role in cell division and cell shape maintenance by cross-linking adjacent peptidoglycan chains through transpeptidation [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Probable). Note=Localized to the division site (septum) along with newly synthesized peptidoglycan, between segregated nucleoids (Probable) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=441, Percent_Identity=28.5714285714286, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1786272, Length=401, Percent_Identity=25.9351620947631, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 58699; Mature: 58699

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVWRVVPAAAFLASLCVLAYGIVRTNDRTDPTWFALLLVAGVLWATALAPEIRRLARRRG
CCEEEHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
HPLLHVALVLTLGFGLVTVQILRAQLFDRERILARTSDPTSGVIDVRRYALERSITRGKI
CCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHEECCCCCCCHHHHHHHHHHHCCCCCEE
LLSDGSVIAEDTLENGRRVRRYLTSAAYLAGYYSPGLYGAAGLEARYDADLSGITATTWQ
EEECCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
AWLDGVLHRRRSGNDIVLTIDPRLQELGQSLLGDRSGGIVLLDADTGAVLALVTAPAFDP
HHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEEECCCCCC
NLLSVPLGASADEVRRAASYLDRLREDGRGPLLLRPIQGLYVPGSTFKTITAAAALQSGV
CEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEECCCCHHHHHHHHHHHCCC
ATPDTVYRDDGALVIDSRVIIEQNRPDPTRVSYTLREAYGYSLNVVYAQVGLALGASRLE
CCCCCEEECCCCEEEECEEEEECCCCCCCHHEEEEHHHCCCEEEEHHHHHHHHHHHHHHH
ETARAAGFGERIPFDLPVAVSRLTDSLDFLGAPAGLAETAFGQGQLLVTPLQMALVVTGV
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHCCCCCCEEEHHHHHHHHHHHH
VRDGTLPEPYLVQETRDAAGAVVWHHEPRVWRRAFDQETARALHELMTWSVEHGYAQAAR
HCCCCCCCCEEHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHC
IPGVTVGGKTGTAEVGERAPHAWFIGFAERGDRRVVVAVVVEHGGSGAQVALPIGRTLLA
CCCEEECCCCCCHHHHCCCCCEEEEEEECCCCCEEEEEEEEECCCCCCEEEECHHHHHHH
AAVGTG
HHHCCC
>Mature Secondary Structure
MVWRVVPAAAFLASLCVLAYGIVRTNDRTDPTWFALLLVAGVLWATALAPEIRRLARRRG
CCEEEHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
HPLLHVALVLTLGFGLVTVQILRAQLFDRERILARTSDPTSGVIDVRRYALERSITRGKI
CCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHEECCCCCCCHHHHHHHHHHHCCCCCEE
LLSDGSVIAEDTLENGRRVRRYLTSAAYLAGYYSPGLYGAAGLEARYDADLSGITATTWQ
EEECCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
AWLDGVLHRRRSGNDIVLTIDPRLQELGQSLLGDRSGGIVLLDADTGAVLALVTAPAFDP
HHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEEECCCCCC
NLLSVPLGASADEVRRAASYLDRLREDGRGPLLLRPIQGLYVPGSTFKTITAAAALQSGV
CEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEECCCCHHHHHHHHHHHCCC
ATPDTVYRDDGALVIDSRVIIEQNRPDPTRVSYTLREAYGYSLNVVYAQVGLALGASRLE
CCCCCEEECCCCEEEECEEEEECCCCCCCHHEEEEHHHCCCEEEEHHHHHHHHHHHHHHH
ETARAAGFGERIPFDLPVAVSRLTDSLDFLGAPAGLAETAFGQGQLLVTPLQMALVVTGV
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHCCCCCCEEEHHHHHHHHHHHH
VRDGTLPEPYLVQETRDAAGAVVWHHEPRVWRRAFDQETARALHELMTWSVEHGYAQAAR
HCCCCCCCCEEHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHC
IPGVTVGGKTGTAEVGERAPHAWFIGFAERGDRRVVVAVVVEHGGSGAQVALPIGRTLLA
CCCEEECCCCCCHHHHCCCCCEEEEEEECCCCCEEEEEEEEECCCCCCEEEECHHHHHHH
AAVGTG
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA