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The map label for this gene is hisD [H]

Identifier: 221632654

GI number: 221632654

Start: 625154

End: 626500

Strand: Reverse

Name: hisD [H]

Synonym: trd_0637

Alternate gene names: 221632654

Gene position: 626500-625154 (Counterclockwise)

Preceding gene: 221632655

Following gene: 221632650

Centisome position: 31.28

GC content: 63.33

Gene sequence:

>1347_bases
ATGACGCGCACCATTCGCGTGATCGAGAGCATCGCTGAAGCCGAACGCTTCCTGTCCCGCTCCCGTCAAATGCCAACCCA
CCTCCCTGCCGCCGTGCAGGAACGCATCCGCGCCGTCTTCGGTGGCGATCTGACGCCGCTTCAGGTCGTCGAGCGAATCA
TCGACGATGTTCGTTCCCAGGGAGACGATGCTGTCCGCCGTTATACGCTCGCCTTCGATGGTGCTCATCTCGATACGTTT
CTCGCCACTCCGGAAGAGTTCCTGCGAGCACGTCGAGCGATCACGCCTGAGCTCGAGGCAGCGCTCCGCTTCGCCCGCGA
CCGCATCGTGGCGTTTCATCGGCGAGCGATCCCGCGCTCCTGGATCGAGTTCGACGAAACGGGCGCCTTCGGACAGCTCG
TGCGACCGGTCGATCGCGTCGGCATTTACGTGCCAGGCGGCCGAGCTCCGCTCCCCTCCTCGCTCCTCATGACCGCAATC
CCGGCCCAACTAGCTGGTGTTCGTGACATTGTCGTCTGCACGCCACCAGGCCGCGACGGGACGATCTCGCCTGCTGTACT
GGCCGCAGCGGAACTTCTCGGGATCGAACGCGTCTTCAAGATCGGCGGTGCCCAGGCGATCGCTGCACTGGCCTATGGCA
CACAGACGGTTCCAGCTGTCGATATCGTCGCCGGCCCGGGCAATCTCTTCGTCGTCCTCGCCAAAAGACTCGTGTACGGC
GACGTCGGGATCGATCAGCTACCAGGGCCAACAGAAACATTGCTGATCGCTGACGAGCAGGCTGATCCGGTGCTCTGTGC
GGCTGACTTGCTTGCCCAGGCTGAACACGATCCCCTGGCCTGCGCGATCTTGATCACTCCAGCGCGCACGCTTGCCCACA
AAGTGGCGCAGGAACTGGAACGGCAGCTCCAGCAGCTGGACCGGAGCGAGATCGCTCGTGCTGCCTTGGAAGCGAATGGA
GCCATCATCATCGTTCCTGATCTCGAGCGCGCCTTCGACCTGGCCAATCTCTTCGCGCCGGAACACCTCTGTCTGCTTGT
CCGCGATCCCTGGCGCTATCTCGACCGGGTCCGTCATGCTGGTGGTGTCTTTCTCGGCGAGACTTCACCCGAGGTCATCG
GCGATTACACCGCCGGCCCCAGTCACGTCATGCCGACCGGCCGGACCGCACGCTTCGCTTCACCTGTGACCGTACAGACG
TTTCTGAAGGTGACGAGTCTCGTCGCGGTCGCACCGAAGGCGCTGGAACAGCTCGGAAGCCCCGCTCTTCAACTGGCCAT
GAGCGAGGGGCTCACTGCACATGCAGCTGCCATCGAGCATCGCCTGGAGCGCACGCGGCCTGATTGA

Upstream 100 bases:

>100_bases
TGGCCGGAAGCTCGGGGATCACCGTGACTTCTCCCGAGTACGTTTTCGATTCCCGCTCCCATGCCTTCGCCCGCCTCTGC
CAGGCCTTGGAGGAGAAAGC

Downstream 100 bases:

>100_bases
TTCAGGGTGGTGCCAACTGACGGAGCGCAGCGACGATACGCTCCTCGAGGGACGGGGCACGCCGCACCTCGGGATGCGTT
GCGGCTTGCCGTGCCTCCTG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MTRTIRVIESIAEAERFLSRSRQMPTHLPAAVQERIRAVFGGDLTPLQVVERIIDDVRSQGDDAVRRYTLAFDGAHLDTF
LATPEEFLRARRAITPELEAALRFARDRIVAFHRRAIPRSWIEFDETGAFGQLVRPVDRVGIYVPGGRAPLPSSLLMTAI
PAQLAGVRDIVVCTPPGRDGTISPAVLAAAELLGIERVFKIGGAQAIAALAYGTQTVPAVDIVAGPGNLFVVLAKRLVYG
DVGIDQLPGPTETLLIADEQADPVLCAADLLAQAEHDPLACAILITPARTLAHKVAQELERQLQQLDRSEIARAALEANG
AIIIVPDLERAFDLANLFAPEHLCLLVRDPWRYLDRVRHAGGVFLGETSPEVIGDYTAGPSHVMPTGRTARFASPVTVQT
FLKVTSLVAVAPKALEQLGSPALQLAMSEGLTAHAAAIEHRLERTRPD

Sequences:

>Translated_448_residues
MTRTIRVIESIAEAERFLSRSRQMPTHLPAAVQERIRAVFGGDLTPLQVVERIIDDVRSQGDDAVRRYTLAFDGAHLDTF
LATPEEFLRARRAITPELEAALRFARDRIVAFHRRAIPRSWIEFDETGAFGQLVRPVDRVGIYVPGGRAPLPSSLLMTAI
PAQLAGVRDIVVCTPPGRDGTISPAVLAAAELLGIERVFKIGGAQAIAALAYGTQTVPAVDIVAGPGNLFVVLAKRLVYG
DVGIDQLPGPTETLLIADEQADPVLCAADLLAQAEHDPLACAILITPARTLAHKVAQELERQLQQLDRSEIARAALEANG
AIIIVPDLERAFDLANLFAPEHLCLLVRDPWRYLDRVRHAGGVFLGETSPEVIGDYTAGPSHVMPTGRTARFASPVTVQT
FLKVTSLVAVAPKALEQLGSPALQLAMSEGLTAHAAAIEHRLERTRPD
>Mature_447_residues
TRTIRVIESIAEAERFLSRSRQMPTHLPAAVQERIRAVFGGDLTPLQVVERIIDDVRSQGDDAVRRYTLAFDGAHLDTFL
ATPEEFLRARRAITPELEAALRFARDRIVAFHRRAIPRSWIEFDETGAFGQLVRPVDRVGIYVPGGRAPLPSSLLMTAIP
AQLAGVRDIVVCTPPGRDGTISPAVLAAAELLGIERVFKIGGAQAIAALAYGTQTVPAVDIVAGPGNLFVVLAKRLVYGD
VGIDQLPGPTETLLIADEQADPVLCAADLLAQAEHDPLACAILITPARTLAHKVAQELERQLQQLDRSEIARAALEANGA
IIIVPDLERAFDLANLFAPEHLCLLVRDPWRYLDRVRHAGGVFLGETSPEVIGDYTAGPSHVMPTGRTARFASPVTVQTF
LKVTSLVAVAPKALEQLGSPALQLAMSEGLTAHAAAIEHRLERTRPD

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=400, Percent_Identity=40.75, Blast_Score=289, Evalue=3e-79,
Organism=Saccharomyces cerevisiae, GI6319819, Length=412, Percent_Identity=37.8640776699029, Blast_Score=272, Evalue=6e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 48451; Mature: 48320

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRTIRVIESIAEAERFLSRSRQMPTHLPAAVQERIRAVFGGDLTPLQVVERIIDDVRSQ
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
GDDAVRRYTLAFDGAHLDTFLATPEEFLRARRAITPELEAALRFARDRIVAFHRRAIPRS
CCHHHHEEEEEECCCHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHH
WIEFDETGAFGQLVRPVDRVGIYVPGGRAPLPSSLLMTAIPAQLAGVRDIVVCTPPGRDG
HHCCCCCCCHHHHHHHHHHCEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCC
TISPAVLAAAELLGIERVFKIGGAQAIAALAYGTQTVPAVDIVAGPGNLFVVLAKRLVYG
CCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHC
DVGIDQLPGPTETLLIADEQADPVLCAADLLAQAEHDPLACAILITPARTLAHKVAQELE
CCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHH
RQLQQLDRSEIARAALEANGAIIIVPDLERAFDLANLFAPEHLCLLVRDPWRYLDRVRHA
HHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHC
GGVFLGETSPEVIGDYTAGPSHVMPTGRTARFASPVTVQTFLKVTSLVAVAPKALEQLGS
CCEEECCCCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
PALQLAMSEGLTAHAAAIEHRLERTRPD
HHHHHHHHCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TRTIRVIESIAEAERFLSRSRQMPTHLPAAVQERIRAVFGGDLTPLQVVERIIDDVRSQ
CHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
GDDAVRRYTLAFDGAHLDTFLATPEEFLRARRAITPELEAALRFARDRIVAFHRRAIPRS
CCHHHHEEEEEECCCHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHH
WIEFDETGAFGQLVRPVDRVGIYVPGGRAPLPSSLLMTAIPAQLAGVRDIVVCTPPGRDG
HHCCCCCCCHHHHHHHHHHCEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCC
TISPAVLAAAELLGIERVFKIGGAQAIAALAYGTQTVPAVDIVAGPGNLFVVLAKRLVYG
CCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHC
DVGIDQLPGPTETLLIADEQADPVLCAADLLAQAEHDPLACAILITPARTLAHKVAQELE
CCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHH
RQLQQLDRSEIARAALEANGAIIIVPDLERAFDLANLFAPEHLCLLVRDPWRYLDRVRHA
HHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHC
GGVFLGETSPEVIGDYTAGPSHVMPTGRTARFASPVTVQTFLKVTSLVAVAPKALEQLGS
CCEEECCCCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
PALQLAMSEGLTAHAAAIEHRLERTRPD
HHHHHHHHCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]