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The map label for this gene is ilvC

Identifier: 221632642

GI number: 221632642

Start: 615925

End: 616932

Strand: Reverse

Name: ilvC

Synonym: trd_0625

Alternate gene names: 221632642

Gene position: 616932-615925 (Counterclockwise)

Preceding gene: 221632643

Following gene: 221632641

Centisome position: 30.8

GC content: 60.02

Gene sequence:

>1008_bases
ATGGCGACAATCTATTACGACTCGGATGCCGATCTCGCGTACCTCGCTGGCAAGACTGTCGCCGTTTTGGGTTATGGAAG
TCAGGGTCACGCCCATGCCCAGAACTTACGTGACAGTGGCGTCCAGGTGGTGGTCGGCCTGCACGAGGGAAGCCGCAGCC
GCGAGCGAGCAAAGTCCGACGGCTTCGAGGTTCTCACTCCACGCGAAGCGGCCGCTCGTGGCGACATTATCTCCATGCTG
ATGCCTGACCACGTCCAGAAGGGCGTCTACGAGGAGAGCGTTGCGCCGGAGCTCCGTCCAGGAAAACTCCTCATGTTCGC
TCATGGTTTTAACATTCACTATGGGCGCATCGTGCCGCCGCCGGACGTCGATGTCGCGATGGTCGCACCGAAGAGCCCAG
GGCACATCTTGCGCGATCTGTATGTCCAGGGGATCGGCGTACCCGCACTCGTTGCCGTCCACCAGGACGCCAGTGGCCAG
GCCAAGCAGATCGCGCTGGCGTATGCGAAGGGGCTCGGCTGCACCAAAGCAGGTGTCATCGAGACAACGTTCAAAGAAGA
GACGGAGACTGACCTCTTCGGCGAACAAGCGGTACTCTGTGGTGGCGTCAGTCACCTGATCCAAGCCGGCTTCGAGACGC
TGGTCGAAGCAGGATACCAGCCGGAGGTGGCCTACTTCGAGGTCCTGAACGAACTCAAGCTGATCGTCGATCTGATCTAC
GAGGGCGGCCTCAAGTTCATGCGCTACTCGGTCAGCGATACCGCGGAGTATGGTGACTACGTGAGCGGCCCCAAAGTCAT
CGACGACCATGTGCGCGAAACGATGCACAAGCTCCTGCAGGATATCCAGACGGGACGTTTCGCTCAGCAATGGATCGCCG
AGAACGAGGCTGGTCGTCCTAACTTCTACCGAATGCGCCAGGAGCATCTGCAACACCCGATCGAGGAAGTGGGTGACCGC
CTCCGAGCGATGATGCCCTGGCTCAAGCGACGCGAAATTCCGTCCTGA

Upstream 100 bases:

>100_bases
CATGGCCCGCGGTGCGCGAGTGGTTGCGACAACTCCACAGCCCGTTGTAGCATGAGACATGGAGACTCGGTTATCGAGCA
GTTGGAGGGTAAAGAGACCG

Downstream 100 bases:

>100_bases
CAACCGAACCCACCGGAAACAGGAAGGGGTATTCGGCGAGCGGTCGAATACCCCATGCCCTTCTCCGTGGGTATCATTTG
CTATACTGTCGGTGTTGTGC

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MATIYYDSDADLAYLAGKTVAVLGYGSQGHAHAQNLRDSGVQVVVGLHEGSRSRERAKSDGFEVLTPREAAARGDIISML
MPDHVQKGVYEESVAPELRPGKLLMFAHGFNIHYGRIVPPPDVDVAMVAPKSPGHILRDLYVQGIGVPALVAVHQDASGQ
AKQIALAYAKGLGCTKAGVIETTFKEETETDLFGEQAVLCGGVSHLIQAGFETLVEAGYQPEVAYFEVLNELKLIVDLIY
EGGLKFMRYSVSDTAEYGDYVSGPKVIDDHVRETMHKLLQDIQTGRFAQQWIAENEAGRPNFYRMRQEHLQHPIEEVGDR
LRAMMPWLKRREIPS

Sequences:

>Translated_335_residues
MATIYYDSDADLAYLAGKTVAVLGYGSQGHAHAQNLRDSGVQVVVGLHEGSRSRERAKSDGFEVLTPREAAARGDIISML
MPDHVQKGVYEESVAPELRPGKLLMFAHGFNIHYGRIVPPPDVDVAMVAPKSPGHILRDLYVQGIGVPALVAVHQDASGQ
AKQIALAYAKGLGCTKAGVIETTFKEETETDLFGEQAVLCGGVSHLIQAGFETLVEAGYQPEVAYFEVLNELKLIVDLIY
EGGLKFMRYSVSDTAEYGDYVSGPKVIDDHVRETMHKLLQDIQTGRFAQQWIAENEAGRPNFYRMRQEHLQHPIEEVGDR
LRAMMPWLKRREIPS
>Mature_334_residues
ATIYYDSDADLAYLAGKTVAVLGYGSQGHAHAQNLRDSGVQVVVGLHEGSRSRERAKSDGFEVLTPREAAARGDIISMLM
PDHVQKGVYEESVAPELRPGKLLMFAHGFNIHYGRIVPPPDVDVAMVAPKSPGHILRDLYVQGIGVPALVAVHQDASGQA
KQIALAYAKGLGCTKAGVIETTFKEETETDLFGEQAVLCGGVSHLIQAGFETLVEAGYQPEVAYFEVLNELKLIVDLIYE
GGLKFMRYSVSDTAEYGDYVSGPKVIDDHVRETMHKLLQDIQTGRFAQQWIAENEAGRPNFYRMRQEHLQHPIEEVGDRL
RAMMPWLKRREIPS

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=314, Percent_Identity=34.7133757961783, Blast_Score=145, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6323387, Length=327, Percent_Identity=30.2752293577982, Blast_Score=134, Evalue=2e-32,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_THERP (B9KYS1)

Other databases:

- EMBL:   CP001275
- RefSeq:   YP_002521863.1
- ProteinModelPortal:   B9KYS1
- GeneID:   7355769
- GenomeReviews:   CP001275_GR
- KEGG:   tro:trd_0625
- OMA:   AMKQCLK
- ProtClustDB:   CLSK2807606
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 37019; Mature: 36887

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIYYDSDADLAYLAGKTVAVLGYGSQGHAHAQNLRDSGVQVVVGLHEGSRSRERAKSD
CEEEEECCCCCEEEECCCEEEEEECCCCCCHHHHHHHCCCCEEEEEECCCCCHHHHHHCC
GFEVLTPREAAARGDIISMLMPDHVQKGVYEESVAPELRPGKLLMFAHGFNIHYGRIVPP
CCEEECCHHHHHCCCHHHHHCCHHHHHCCHHHHCCCCCCCCEEEEEEECCCEEECCCCCC
PDVDVAMVAPKSPGHILRDLYVQGIGVPALVAVHQDASGQAKQIALAYAKGLGCTKAGVI
CCCCEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCE
ETTFKEETETDLFGEQAVLCGGVSHLIQAGFETLVEAGYQPEVAYFEVLNELKLIVDLIY
EHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EGGLKFMRYSVSDTAEYGDYVSGPKVIDDHVRETMHKLLQDIQTGRFAQQWIAENEAGRP
HCCHHHEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
NFYRMRQEHLQHPIEEVGDRLRAMMPWLKRREIPS
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ATIYYDSDADLAYLAGKTVAVLGYGSQGHAHAQNLRDSGVQVVVGLHEGSRSRERAKSD
EEEEECCCCCEEEECCCEEEEEECCCCCCHHHHHHHCCCCEEEEEECCCCCHHHHHHCC
GFEVLTPREAAARGDIISMLMPDHVQKGVYEESVAPELRPGKLLMFAHGFNIHYGRIVPP
CCEEECCHHHHHCCCHHHHHCCHHHHHCCHHHHCCCCCCCCEEEEEEECCCEEECCCCCC
PDVDVAMVAPKSPGHILRDLYVQGIGVPALVAVHQDASGQAKQIALAYAKGLGCTKAGVI
CCCCEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCE
ETTFKEETETDLFGEQAVLCGGVSHLIQAGFETLVEAGYQPEVAYFEVLNELKLIVDLIY
EHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EGGLKFMRYSVSDTAEYGDYVSGPKVIDDHVRETMHKLLQDIQTGRFAQQWIAENEAGRP
HCCHHHEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
NFYRMRQEHLQHPIEEVGDRLRAMMPWLKRREIPS
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA