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The map label for this gene is dapA

Identifier: 221632442

GI number: 221632442

Start: 412797

End: 413705

Strand: Reverse

Name: dapA

Synonym: trd_0414

Alternate gene names: 221632442

Gene position: 413705-412797 (Counterclockwise)

Preceding gene: 221632444

Following gene: 221632441

Centisome position: 20.65

GC content: 64.91

Gene sequence:

>909_bases
ATGCTCCGCGGAACGTTCGTTGCCTTGATCACGCCCTTCGCTGGTGAGGAGATCGACGAGCCGCGACTGCGCGACCTCGT
CGACTGGCTCATCGCCAACCGGGTCGATGGACTGGTCCCCTGCGGAACGACCGGCGAGACGCCGAGTTTGTCCGATACCG
AATGGCAGCGCGTCGCGGCGGTCGTGATCGAGCAGGCGGCGGGCCGCGTCCCGGTGATCGTCGGCACGGGAACAAATTCC
ACGATGGTCACGATTCAACGAACCCGCGTGGCGCGCGAGTTGGGTGCGACCGCTGCCATGGTCGTCACGCCTTACTACAA
CAAGCCACAGCAAGACGGTTTATACCGTCATGTCGCCGCGATCGCCGATGCGGTCGACCTCCCGCTCGTCATCTATAACG
TCCCGAGTCGGACCGGCGTCAATCTCGCTCCCGAGACGGCACGTCGCCTGCTGGATATCGCACCGGTCATCGCCTTCAAG
GACTCGAGTGGGTCGCTCGACCAGGTGAGCGAACTCGTCCTGGCGGTGGGTGATCGAAGCTCGGTGTTGAGCGGCGACGA
TTCGCTCACGTTACCGATCATTGCTGTTGGCGGCCAAGGGGTCGTCTCTGTCCTGGCGAATATCGCCCCTGCGGCCACGG
CAACGATGGTTCGCGCAGCACTCGACGGCGACCTCGCCCGTGCACGCCAACTCCACGGTGAACTCTTCCCGCTGGCTCGC
GCACTGTTCATCGAGACCAACCCGGTGCCGGTCAAGACGGCAGCGGAACTGTTGGGGTTGTGCAGCGCGACTGTTCGTCT
CCCTCTCGCACCGCTGGCTCCGGCCAACCGCGAGCGGCTGCTCGCTGCGCTGGCCAGCTGTCCACACACTGCTTCGCTTC
TCGCACGACCGATGGGGGAGGCTGCGTGA

Upstream 100 bases:

>100_bases
GCGATGAGCGGGCAGGTATGTCCCGGGAAACAGCGCACTCATCGCGGTGCTGCGGCGCGGACTCGAGTCGTTTTGCGTGA
TGCAACGAGGAGGGAACAGC

Downstream 100 bases:

>100_bases
TGCTCCGCCTCGCGCTCACCGGTGTCACCGGACGAATGGGACGCGCTGTCCTCGAACTGGCCGCGAGCGCTCCGGATATT
CAGCTCGTATGTGGGCTCAT

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MLRGTFVALITPFAGEEIDEPRLRDLVDWLIANRVDGLVPCGTTGETPSLSDTEWQRVAAVVIEQAAGRVPVIVGTGTNS
TMVTIQRTRVARELGATAAMVVTPYYNKPQQDGLYRHVAAIADAVDLPLVIYNVPSRTGVNLAPETARRLLDIAPVIAFK
DSSGSLDQVSELVLAVGDRSSVLSGDDSLTLPIIAVGGQGVVSVLANIAPAATATMVRAALDGDLARARQLHGELFPLAR
ALFIETNPVPVKTAAELLGLCSATVRLPLAPLAPANRERLLAALASCPHTASLLARPMGEAA

Sequences:

>Translated_302_residues
MLRGTFVALITPFAGEEIDEPRLRDLVDWLIANRVDGLVPCGTTGETPSLSDTEWQRVAAVVIEQAAGRVPVIVGTGTNS
TMVTIQRTRVARELGATAAMVVTPYYNKPQQDGLYRHVAAIADAVDLPLVIYNVPSRTGVNLAPETARRLLDIAPVIAFK
DSSGSLDQVSELVLAVGDRSSVLSGDDSLTLPIIAVGGQGVVSVLANIAPAATATMVRAALDGDLARARQLHGELFPLAR
ALFIETNPVPVKTAAELLGLCSATVRLPLAPLAPANRERLLAALASCPHTASLLARPMGEAA
>Mature_302_residues
MLRGTFVALITPFAGEEIDEPRLRDLVDWLIANRVDGLVPCGTTGETPSLSDTEWQRVAAVVIEQAAGRVPVIVGTGTNS
TMVTIQRTRVARELGATAAMVVTPYYNKPQQDGLYRHVAAIADAVDLPLVIYNVPSRTGVNLAPETARRLLDIAPVIAFK
DSSGSLDQVSELVLAVGDRSSVLSGDDSLTLPIIAVGGQGVVSVLANIAPAATATMVRAALDGDLARARQLHGELFPLAR
ALFIETNPVPVKTAAELLGLCSATVRLPLAPLAPANRERLLAALASCPHTASLLARPMGEAA

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=281, Percent_Identity=28.4697508896797, Blast_Score=102, Evalue=5e-22,
Organism=Escherichia coli, GI1788823, Length=286, Percent_Identity=41.6083916083916, Blast_Score=230, Evalue=9e-62,
Organism=Escherichia coli, GI1786463, Length=284, Percent_Identity=32.0422535211268, Blast_Score=131, Evalue=5e-32,
Organism=Escherichia coli, GI87082415, Length=266, Percent_Identity=33.4586466165414, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1789620, Length=290, Percent_Identity=31.3793103448276, Blast_Score=109, Evalue=2e-25,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_THERP (B9KY71)

Other databases:

- EMBL:   CP001275
- RefSeq:   YP_002521663.1
- ProteinModelPortal:   B9KY71
- GeneID:   7355460
- GenomeReviews:   CP001275_GR
- KEGG:   tro:trd_0414
- OMA:   QKGLIEH
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 31674; Mature: 31674

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 160-160 BINDING 105-105

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRGTFVALITPFAGEEIDEPRLRDLVDWLIANRVDGLVPCGTTGETPSLSDTEWQRVAA
CCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHH
VVIEQAAGRVPVIVGTGTNSTMVTIQRTRVARELGATAAMVVTPYYNKPQQDGLYRHVAA
HHHHHHCCCCCEEEECCCCCEEEEEHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHH
IADAVDLPLVIYNVPSRTGVNLAPETARRLLDIAPVIAFKDSSGSLDQVSELVLAVGDRS
HHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHCCCCC
SVLSGDDSLTLPIIAVGGQGVVSVLANIAPAATATMVRAALDGDLARARQLHGELFPLAR
CEECCCCCEEEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
ALFIETNPVPVKTAAELLGLCSATVRLPLAPLAPANRERLLAALASCPHTASLLARPMGE
HHEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCC
AA
CC
>Mature Secondary Structure
MLRGTFVALITPFAGEEIDEPRLRDLVDWLIANRVDGLVPCGTTGETPSLSDTEWQRVAA
CCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHH
VVIEQAAGRVPVIVGTGTNSTMVTIQRTRVARELGATAAMVVTPYYNKPQQDGLYRHVAA
HHHHHHCCCCCEEEECCCCCEEEEEHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHH
IADAVDLPLVIYNVPSRTGVNLAPETARRLLDIAPVIAFKDSSGSLDQVSELVLAVGDRS
HHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHCCCCC
SVLSGDDSLTLPIIAVGGQGVVSVLANIAPAATATMVRAALDGDLARARQLHGELFPLAR
CEECCCCCEEEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
ALFIETNPVPVKTAAELLGLCSATVRLPLAPLAPANRERLLAALASCPHTASLLARPMGE
HHEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCC
AA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA