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The map label for this gene is dapE [H]

Identifier: 221632314

GI number: 221632314

Start: 286829

End: 288175

Strand: Reverse

Name: dapE [H]

Synonym: trd_0281

Alternate gene names: 221632314

Gene position: 288175-286829 (Counterclockwise)

Preceding gene: 221632315

Following gene: 221632313

Centisome position: 14.39

GC content: 64.59

Gene sequence:

>1347_bases
GTGACCGACTGTGGAATCGATTGGAATGCGCTTCAGGACGAAGTCACTCGCCACTTGCAAGCATTGATCCGCTTCGAGAC
GGTCAATCCGCCCGGCAACGAGACCCCATTCGCCGAGTATCTCGCGGGGGTACTCAGGCGTGAGGGGATAGCCGCTGAGG
TCGTCGAAAGTGCACCCGGTCGGGGCAACCTGGTCGCCCGCCTCCGCGGTCGGGGGCACGGTCGCCCGCTCCTGCTCATG
GCCCACAGCGATGTCGTCAGCGTGGAGCGCGACAAGTGGACACGTGACCCGTTCGGTGGGGAACTGGTCGACGGGAGAGT
CTGGGGACGAGGTGCCGTCGACACCAAGGGGCTGGTGGCTTGCGAACTGGGCGTGATGCTGACGATTCAGCGCCTGGGGC
TCCCGCTGGAGCGGGACCTCATTTTCGCTGTCTTCGCCGACGAGGAAGCCGGCGGTCAGTACGGGGCGTGCTGGATGTGG
GAGCATCGGCGCGACCTGATCGACGCCGAGTTTGCGATCAACGAAGGGGGTGGTATGGCGCTCACCCTCGGTGGCCAGCG
CTTCTATCTCTGCCAGACCGGCGAGAAGGGCGCAGCACGCTTGCGCCTGACGGCACGCGGCCAGCCAGGACACGCCTCCA
TGCCGATCCCCGATACTGCGATGCAGCATGCCGCTCGAGCTATCCTGACCCTCTCGACGCATACCTTCCCGACTGTCCTC
ACGCCAACCGTCACCCGCTTTCTGCACGAGATCGGTCGCGCCCTGGGCGGCTCAGTCCGTCAGCAGATCGAGTCAGCACT
CGCCGATCCGACATGGGAACGACTGGCTGCCTTGCCGCTCGGCCCGGGCGAACGCCGTCTCCTCTACGCGATGACCCGCA
ATACTGCTGTCCCGACCATCGTGCGCGGTGGTCACCGCATCAATGTCATCCCCTCCGAAGTCGTGGTCGAGGTCGATGGA
CGAATTCTCCCCGGCCAAGAACCCGAAGCGTTTGCCGCCGAAGTCCAGCGACTCGTGGGCCCGCACGTCGAGGTCGAATT
GACGACGCGCGGTCGAGGACTGGAGGCAGATCCTGATTCCCCACTCTTCCGCACGATCTCTGAGACGATGGCCGAGCTCG
ACCCAGGTGCGCGGGTGGTTCCCTACTTGATCCCTGGGGGAACCGATGCCAAGTGCCTGCCCGGGATCACGGTGTATGGC
TTCATGCCGATGCGAGATCATCCAGAGGAGTTCGAGCTGGCGCATGCCCACGACGAGCGCATTTCCGTTTCCACGCTCGG
CTTTGCCACCCGTGCGCTCTTCGAAATCGTCACACGTTTCTGCGCACCCCGATCCAGGAGCCGGTGA

Upstream 100 bases:

>100_bases
CGATGATGGTGCTCAGCGAGCAGCTGACGCTGGTACAGCTCGTTGGTGGGCTGCTGGTGCTGACTGCGGCTGCGGTGATC
AGTGGACAAGGAGGGAAACC

Downstream 100 bases:

>100_bases
TGCCGCTGCTCGTCCTCTTCGATATCGACGGCACGCTGTTGCGCGCCGGGGATCCCCTCCACGCCCAAGCCATGCGCGAA
GCGCTGCACGAGATCGTCGG

Product: peptidase, M20/M25/M40 family

Products: NA

Alternate protein names: SDAP desuccinylase [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MTDCGIDWNALQDEVTRHLQALIRFETVNPPGNETPFAEYLAGVLRREGIAAEVVESAPGRGNLVARLRGRGHGRPLLLM
AHSDVVSVERDKWTRDPFGGELVDGRVWGRGAVDTKGLVACELGVMLTIQRLGLPLERDLIFAVFADEEAGGQYGACWMW
EHRRDLIDAEFAINEGGGMALTLGGQRFYLCQTGEKGAARLRLTARGQPGHASMPIPDTAMQHAARAILTLSTHTFPTVL
TPTVTRFLHEIGRALGGSVRQQIESALADPTWERLAALPLGPGERRLLYAMTRNTAVPTIVRGGHRINVIPSEVVVEVDG
RILPGQEPEAFAAEVQRLVGPHVEVELTTRGRGLEADPDSPLFRTISETMAELDPGARVVPYLIPGGTDAKCLPGITVYG
FMPMRDHPEEFELAHAHDERISVSTLGFATRALFEIVTRFCAPRSRSR

Sequences:

>Translated_448_residues
MTDCGIDWNALQDEVTRHLQALIRFETVNPPGNETPFAEYLAGVLRREGIAAEVVESAPGRGNLVARLRGRGHGRPLLLM
AHSDVVSVERDKWTRDPFGGELVDGRVWGRGAVDTKGLVACELGVMLTIQRLGLPLERDLIFAVFADEEAGGQYGACWMW
EHRRDLIDAEFAINEGGGMALTLGGQRFYLCQTGEKGAARLRLTARGQPGHASMPIPDTAMQHAARAILTLSTHTFPTVL
TPTVTRFLHEIGRALGGSVRQQIESALADPTWERLAALPLGPGERRLLYAMTRNTAVPTIVRGGHRINVIPSEVVVEVDG
RILPGQEPEAFAAEVQRLVGPHVEVELTTRGRGLEADPDSPLFRTISETMAELDPGARVVPYLIPGGTDAKCLPGITVYG
FMPMRDHPEEFELAHAHDERISVSTLGFATRALFEIVTRFCAPRSRSR
>Mature_447_residues
TDCGIDWNALQDEVTRHLQALIRFETVNPPGNETPFAEYLAGVLRREGIAAEVVESAPGRGNLVARLRGRGHGRPLLLMA
HSDVVSVERDKWTRDPFGGELVDGRVWGRGAVDTKGLVACELGVMLTIQRLGLPLERDLIFAVFADEEAGGQYGACWMWE
HRRDLIDAEFAINEGGGMALTLGGQRFYLCQTGEKGAARLRLTARGQPGHASMPIPDTAMQHAARAILTLSTHTFPTVLT
PTVTRFLHEIGRALGGSVRQQIESALADPTWERLAALPLGPGERRLLYAMTRNTAVPTIVRGGHRINVIPSEVVVEVDGR
ILPGQEPEAFAAEVQRLVGPHVEVELTTRGRGLEADPDSPLFRTISETMAELDPGARVVPYLIPGGTDAKCLPGITVYGF
MPMRDHPEEFELAHAHDERISVSTLGFATRALFEIVTRFCAPRSRSR

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family [H]

Homologues:

Organism=Homo sapiens, GI269846968, Length=376, Percent_Identity=26.063829787234, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI4501901, Length=415, Percent_Identity=24.8192771084337, Blast_Score=93, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17538642, Length=422, Percent_Identity=25.5924170616114, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6322289, Length=261, Percent_Identity=26.8199233716475, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24649208, Length=427, Percent_Identity=23.1850117096019, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24649202, Length=429, Percent_Identity=23.7762237762238, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24649204, Length=429, Percent_Identity=23.7762237762238, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI21356353, Length=440, Percent_Identity=23.8636363636364, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24649206, Length=436, Percent_Identity=23.1651376146789, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24649210, Length=421, Percent_Identity=23.9904988123515, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24649212, Length=213, Percent_Identity=28.169014084507, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001261
- InterPro:   IPR010182
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.5.1.18 [H]

Molecular weight: Translated: 48990; Mature: 48858

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00758 ARGE_DAPE_CPG2_1 ; PS00759 ARGE_DAPE_CPG2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDCGIDWNALQDEVTRHLQALIRFETVNPPGNETPFAEYLAGVLRREGIAAEVVESAPG
CCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHCCCHHHHHHCCCC
RGNLVARLRGRGHGRPLLLMAHSDVVSVERDKWTRDPFGGELVDGRVWGRGAVDTKGLVA
CCCEEEEECCCCCCCEEEEEECCCEEEECCCCCCCCCCCCEEECCEEECCCCCCCCCEEE
CELGVMLTIQRLGLPLERDLIFAVFADEEAGGQYGACWMWEHRRDLIDAEFAINEGGGMA
EHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCEEEEEHHHHHHCCCEEEEECCCCEE
LTLGGQRFYLCQTGEKGAARLRLTARGQPGHASMPIPDTAMQHAARAILTLSTHTFPTVL
EEECCCEEEEEECCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHEEEEEECCCCCCHH
TPTVTRFLHEIGRALGGSVRQQIESALADPTWERLAALPLGPGERRLLYAMTRNTAVPTI
HHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHEECCCCCCCCEEEEEEECCCCCCCE
VRGGHRINVIPSEVVVEVDGRILPGQEPEAFAAEVQRLVGPHVEVELTTRGRGLEADPDS
ECCCEEEEEECCEEEEEECCEECCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCC
PLFRTISETMAELDPGARVVPYLIPGGTDAKCLPGITVYGFMPMRDHPEEFELAHAHDER
HHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCEEEEEEECCCCCCCHHHHHHCCCCE
ISVSTLGFATRALFEIVTRFCAPRSRSR
EEEHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TDCGIDWNALQDEVTRHLQALIRFETVNPPGNETPFAEYLAGVLRREGIAAEVVESAPG
CCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHCCCHHHHHHCCCC
RGNLVARLRGRGHGRPLLLMAHSDVVSVERDKWTRDPFGGELVDGRVWGRGAVDTKGLVA
CCCEEEEECCCCCCCEEEEEECCCEEEECCCCCCCCCCCCEEECCEEECCCCCCCCCEEE
CELGVMLTIQRLGLPLERDLIFAVFADEEAGGQYGACWMWEHRRDLIDAEFAINEGGGMA
EHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCEEEEEHHHHHHCCCEEEEECCCCEE
LTLGGQRFYLCQTGEKGAARLRLTARGQPGHASMPIPDTAMQHAARAILTLSTHTFPTVL
EEECCCEEEEEECCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHEEEEEECCCCCCHH
TPTVTRFLHEIGRALGGSVRQQIESALADPTWERLAALPLGPGERRLLYAMTRNTAVPTI
HHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHEECCCCCCCCEEEEEEECCCCCCCE
VRGGHRINVIPSEVVVEVDGRILPGQEPEAFAAEVQRLVGPHVEVELTTRGRGLEADPDS
ECCCEEEEEECCEEEEEECCEECCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCC
PLFRTISETMAELDPGARVVPYLIPGGTDAKCLPGITVYGFMPMRDHPEEFELAHAHDER
HHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCEEEEEEECCCCCCCHHHHHHCCCCE
ISVSTLGFATRALFEIVTRFCAPRSRSR
EEEHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA