Click here to switch to the map view.

The map label for this gene is aroA [H]

Identifier: 221632269

GI number: 221632269

Start: 245911

End: 247215

Strand: Reverse

Name: aroA [H]

Synonym: trd_0235

Alternate gene names: 221632269

Gene position: 247215-245911 (Counterclockwise)

Preceding gene: 221632270

Following gene: 221632262

Centisome position: 12.34

GC content: 65.67

Gene sequence:

>1305_bases
GTGACACTGCATCGCACCTATCCGCCTCGCTTGCCCATTCGACCCGCCGAGCAGCCGGTCGACGCCATCGTCCGGCTCCC
GGGTTCGAAGAGCTTGACCAACCGGGCACTCGTCCTCGCCGCCTTGGCCGATGGCGTCAGCGTGCTCGAAGGTGCCCTCC
TCAGCGAGGACAGCTGGGTGATGGTCGATTCGCTGCGCCGTCTCGGCATTCCGGTAGACGTCGACGAGCCCGCGGAACGC
ATGATCGTGCAGGGGAAGGGTGGCACGCTGCCAGCGACGCGGGCCGAGCTGTTCGTCGGCAATTCGGGCACGACGGCTCG
TTTCCTCACTGCGATGACGGCGCTCGGTCACGGCGAATACCTGATCGACGGCGTGCCGCGCATGCGCGAGCGACCGATCC
AACCGCTCCTCGACGCACTGGCGCAATTGGGTGTGCAGGCGGAATCGCTGCTCGGCACCGGTTGTCCGCCGGTCCGGGTG
CGGAGTTATGGGCTCGCCGGAGGAACCATCCGCCTGCGGGGCGACATCTCCAGTCAGTATCTCAGCGCGCTCCTCATGAT
CGGCCCGTGCACGCGCGATGGTCTCCGCATCGAACTCGAGAGCCCGCTCGTCTCCGTGCCCTATGTAGAGATGACGCTAG
CCGTGATGGCTGATTTCGGGGCGATCGCCACGCACGAACATGCCCAGGTCTTCCACGTCCCAGGGAACCAGCGCTACCGA
TCCCGCACCTACGCCATCGAGCCGGATGCCTCGGCCGCATCCTACTTTTTCGCCCTCGCAGCCGCAACAGCCGGTCGTAT
CCGCGTCGTCAATCTCGGCACGCGATCTCGCCAGGGTGACGTCCAGTTCGTGGACCTCCTGGAGCGCATGGGCTGTACCG
TCATTCGCGAGCCCGATGCTCTCACGGTCATCGGGAAACGACCGCTTCGCGGCATCGAGGCGGACATGAACGCGATTTCC
GATACGGTTCCGACGCTCGCCGCTCTCGCGCCGCTCGCCGACGGTCCGGTCATCATTCGCAATGTGCAGCACATCCGGTA
CAAGGAAACCGATCGCATCGCAGCGGTCGCGAACGAACTCCGCCGCTTGGGAATCACCGTCGAGGAGTTTCCCGACGGAC
TGCGCATCGAGCCCGGTCCCGTCCAGCCGGCCGTGATCCGAACCTATGGGGATCACCGCATGGCGATGAGCTTCGCGATC
CTCGGCTGCGCCGTCCCCGGCTTGGAGATCGATGACCCAGGATGCGTGGCCAAGACCTTCCCGGACTTCTTCGAGAGACT
GGAGGCAGCGCTCGGTCGCCGCTGA

Upstream 100 bases:

>100_bases
GAGCCCTACGATGCGGACGATCCGGACGAATATCGCTTGCCCTACGACACACCGGAAATCCCGTACTCGTGGGAGATCAA
GTATCGCTGAAGGAGCTGCT

Downstream 100 bases:

>100_bases
GTCGTCAGACGCGAGCCGCGCGGTTCATCAAATAACAGTCGGCCAGGACCAAGAGGAGCATTGCCTCGGCCACCGGAACC
ACACGAGGGCAGATCGACGG

Product: 3-phosphoshikimate 1-carboxyvinyltransferase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS [H]

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MTLHRTYPPRLPIRPAEQPVDAIVRLPGSKSLTNRALVLAALADGVSVLEGALLSEDSWVMVDSLRRLGIPVDVDEPAER
MIVQGKGGTLPATRAELFVGNSGTTARFLTAMTALGHGEYLIDGVPRMRERPIQPLLDALAQLGVQAESLLGTGCPPVRV
RSYGLAGGTIRLRGDISSQYLSALLMIGPCTRDGLRIELESPLVSVPYVEMTLAVMADFGAIATHEHAQVFHVPGNQRYR
SRTYAIEPDASAASYFFALAAATAGRIRVVNLGTRSRQGDVQFVDLLERMGCTVIREPDALTVIGKRPLRGIEADMNAIS
DTVPTLAALAPLADGPVIIRNVQHIRYKETDRIAAVANELRRLGITVEEFPDGLRIEPGPVQPAVIRTYGDHRMAMSFAI
LGCAVPGLEIDDPGCVAKTFPDFFERLEAALGRR

Sequences:

>Translated_434_residues
MTLHRTYPPRLPIRPAEQPVDAIVRLPGSKSLTNRALVLAALADGVSVLEGALLSEDSWVMVDSLRRLGIPVDVDEPAER
MIVQGKGGTLPATRAELFVGNSGTTARFLTAMTALGHGEYLIDGVPRMRERPIQPLLDALAQLGVQAESLLGTGCPPVRV
RSYGLAGGTIRLRGDISSQYLSALLMIGPCTRDGLRIELESPLVSVPYVEMTLAVMADFGAIATHEHAQVFHVPGNQRYR
SRTYAIEPDASAASYFFALAAATAGRIRVVNLGTRSRQGDVQFVDLLERMGCTVIREPDALTVIGKRPLRGIEADMNAIS
DTVPTLAALAPLADGPVIIRNVQHIRYKETDRIAAVANELRRLGITVEEFPDGLRIEPGPVQPAVIRTYGDHRMAMSFAI
LGCAVPGLEIDDPGCVAKTFPDFFERLEAALGRR
>Mature_433_residues
TLHRTYPPRLPIRPAEQPVDAIVRLPGSKSLTNRALVLAALADGVSVLEGALLSEDSWVMVDSLRRLGIPVDVDEPAERM
IVQGKGGTLPATRAELFVGNSGTTARFLTAMTALGHGEYLIDGVPRMRERPIQPLLDALAQLGVQAESLLGTGCPPVRVR
SYGLAGGTIRLRGDISSQYLSALLMIGPCTRDGLRIELESPLVSVPYVEMTLAVMADFGAIATHEHAQVFHVPGNQRYRS
RTYAIEPDASAASYFFALAAATAGRIRVVNLGTRSRQGDVQFVDLLERMGCTVIREPDALTVIGKRPLRGIEADMNAISD
TVPTLAALAPLADGPVIIRNVQHIRYKETDRIAAVANELRRLGITVEEFPDGLRIEPGPVQPAVIRTYGDHRMAMSFAIL
GCAVPGLEIDDPGCVAKTFPDFFERLEAALGRR

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family [H]

Homologues:

Organism=Escherichia coli, GI1787137, Length=411, Percent_Identity=43.7956204379562, Blast_Score=301, Evalue=8e-83,
Organism=Saccharomyces cerevisiae, GI6320332, Length=466, Percent_Identity=33.6909871244635, Blast_Score=224, Evalue=1e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792 [H]

Pfam domain/function: PF00275 EPSP_synthase [H]

EC number: =2.5.1.19 [H]

Molecular weight: Translated: 46897; Mature: 46766

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00104 EPSP_SYNTHASE_1 ; PS00885 EPSP_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLHRTYPPRLPIRPAEQPVDAIVRLPGSKSLTNRALVLAALADGVSVLEGALLSEDSWV
CCCCCCCCCCCCCCCCCCCHHHHEECCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCEE
MVDSLRRLGIPVDVDEPAERMIVQGKGGTLPATRAELFVGNSGTTARFLTAMTALGHGEY
HHHHHHHCCCCCCCCCCHHHEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCE
LIDGVPRMRERPIQPLLDALAQLGVQAESLLGTGCPPVRVRSYGLAGGTIRLRGDISSQY
EECCCCHHHHCCHHHHHHHHHHCCCCHHHHHCCCCCCCEEEEECCCCCEEEEECCCHHHH
LSALLMIGPCTRDGLRIELESPLVSVPYVEMTLAVMADFGAIATHEHAQVFHVPGNQRYR
HHHHHHHCCCCCCCEEEEECCCEEECCHHHHHHHHHHHHCCCEECCCCEEEECCCCCCCC
SRTYAIEPDASAASYFFALAAATAGRIRVVNLGTRSRQGDVQFVDLLERMGCTVIREPDA
CCEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHCCCEEEECCCE
LTVIGKRPLRGIEADMNAISDTVPTLAALAPLADGPVIIRNVQHIRYKETDRIAAVANEL
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHCCHHHHHHHHHHH
RRLGITVEEFPDGLRIEPGPVQPAVIRTYGDHRMAMSFAILGCAVPGLEIDDPGCVAKTF
HHHCCCHHHCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCEECCCCCHHHHH
PDFFERLEAALGRR
HHHHHHHHHHHCCC
>Mature Secondary Structure 
TLHRTYPPRLPIRPAEQPVDAIVRLPGSKSLTNRALVLAALADGVSVLEGALLSEDSWV
CCCCCCCCCCCCCCCCCCHHHHEECCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCEE
MVDSLRRLGIPVDVDEPAERMIVQGKGGTLPATRAELFVGNSGTTARFLTAMTALGHGEY
HHHHHHHCCCCCCCCCCHHHEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCE
LIDGVPRMRERPIQPLLDALAQLGVQAESLLGTGCPPVRVRSYGLAGGTIRLRGDISSQY
EECCCCHHHHCCHHHHHHHHHHCCCCHHHHHCCCCCCCEEEEECCCCCEEEEECCCHHHH
LSALLMIGPCTRDGLRIELESPLVSVPYVEMTLAVMADFGAIATHEHAQVFHVPGNQRYR
HHHHHHHCCCCCCCEEEEECCCEEECCHHHHHHHHHHHHCCCEECCCCEEEECCCCCCCC
SRTYAIEPDASAASYFFALAAATAGRIRVVNLGTRSRQGDVQFVDLLERMGCTVIREPDA
CCEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHCCCEEEECCCE
LTVIGKRPLRGIEADMNAISDTVPTLAALAPLADGPVIIRNVQHIRYKETDRIAAVANEL
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHCCHHHHHHHHHHH
RRLGITVEEFPDGLRIEPGPVQPAVIRTYGDHRMAMSFAILGCAVPGLEIDDPGCVAKTF
HHHCCCHHHCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCEECCCCCHHHHH
PDFFERLEAALGRR
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA