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The map label for this gene is hdrA [H]

Identifier: 221632187

GI number: 221632187

Start: 162116

End: 163183

Strand: Reverse

Name: hdrA [H]

Synonym: trd_0153

Alternate gene names: 221632187

Gene position: 163183-162116 (Counterclockwise)

Preceding gene: 221632188

Following gene: 221632186

Centisome position: 8.15

GC content: 64.42

Gene sequence:

>1068_bases
GTGCAGGAGACGACCCGTCCCATTCTGGTCATCGGTGGCGGCCCCGGTGGGCTCGAGGCCGCCCGCACCGTTGCAGCGCT
CGGTCATCCAGTGCTCCTCGTCGAGCGCCGAGGTCGACTGGGTGGCACACCGGATGCCGAACGGTATGCCAAGCTGACGC
ACCACTTTCGCGATGCCGAAGAGGCGATCGGCGAGCTCGTCGCCGCGGTCACCGATCACCCCCTCATCGAAGTGCTGACC
CGGAGCGAGGTCACCGCCTGCGAGGGGGAGGCAGGCGATTTCCGAGTGACGGTGAGCACGCCCACTGGCAGCCGAGAGGC
TCGAGTCAGCGCGATCATCGTCGCCACCGGCTTCCAACACTTCGATCCGGGGCGCGAGACGCAACTGTACAACTACTACT
CGTTCCCTGATGTCGTGACCTTGAGCGACATGGAGGCGATGCTCAAGGCCCACCAGGTCGTCCGCCCCTCCAATGGGCAA
CCCCCGGAACGAGTGGCCTTCATCCAGTGCGTCGGATCCCGCGACCGGCAGATCGGGAACGAGTTTTGCTCCAAAGTCTG
CTGCGGTATCGCCTCCAAGCAAGCGATCGAGATCAAGGAACAGCTGCCCGACGCCCGTGTCTTCATCTTCTACATCGACA
TGCGCATGTACGGCTACTGGGAGAACGAGCTGTACTGGCCGGCTCAGGAACGCTACAAGGTCAACTACGTCAAAGGGATC
GTCAGCGAGATCCTGCCCAAGGGGGATCGCTTGCTGATCCGCGGGGAGGACACAACGATGGGTCGACCGATGGAGATCAC
GGTCGACCTGGTCGTCCTCTCCGTCGGTATGGAGCCGAGCAGCGGGACGCGGCAGATGGCCAAGTTGCTGGGCATCGCCC
AGAACAAGTACGGCTACATCGAGGCCGGCGGACCCTCCGGTCTCGACCCGGTCGCGACTTCCCGACCAGGAATCTACGTC
GTCGGTGCTGCGGCCCGACCAGCTGACCTGGACGATACCTTCGCTACTGCCGGTCTCGCTGCGGCACGAGCGGTCGCGAC
GGCGCGCCAAGCCTTGGTCGGAACGTGA

Upstream 100 bases:

>100_bases
GAGTTCGAAGAGGACTTGGCTGCGATCGAGCGCGGTGAGAAGCCGGGTCTGACCTGGCAAGACGCTGAACAGCCGATCGT
GACGCGGTGAGGGGGAAGCC

Downstream 100 bases:

>100_bases
TGAAGCTCCGCGGACGCACGGGTGCTTCACCGGATACAGGAAGGAGCAGCGGGATGGCACTGCCAGCCAAGCGCAATCCC
TTCGTCAGTTTCATGGCCAG

Product: CoB--CoM heterodisulfide reductase iron-sulfur subunit A 1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MQETTRPILVIGGGPGGLEAARTVAALGHPVLLVERRGRLGGTPDAERYAKLTHHFRDAEEAIGELVAAVTDHPLIEVLT
RSEVTACEGEAGDFRVTVSTPTGSREARVSAIIVATGFQHFDPGRETQLYNYYSFPDVVTLSDMEAMLKAHQVVRPSNGQ
PPERVAFIQCVGSRDRQIGNEFCSKVCCGIASKQAIEIKEQLPDARVFIFYIDMRMYGYWENELYWPAQERYKVNYVKGI
VSEILPKGDRLLIRGEDTTMGRPMEITVDLVVLSVGMEPSSGTRQMAKLLGIAQNKYGYIEAGGPSGLDPVATSRPGIYV
VGAAARPADLDDTFATAGLAAARAVATARQALVGT

Sequences:

>Translated_355_residues
MQETTRPILVIGGGPGGLEAARTVAALGHPVLLVERRGRLGGTPDAERYAKLTHHFRDAEEAIGELVAAVTDHPLIEVLT
RSEVTACEGEAGDFRVTVSTPTGSREARVSAIIVATGFQHFDPGRETQLYNYYSFPDVVTLSDMEAMLKAHQVVRPSNGQ
PPERVAFIQCVGSRDRQIGNEFCSKVCCGIASKQAIEIKEQLPDARVFIFYIDMRMYGYWENELYWPAQERYKVNYVKGI
VSEILPKGDRLLIRGEDTTMGRPMEITVDLVVLSVGMEPSSGTRQMAKLLGIAQNKYGYIEAGGPSGLDPVATSRPGIYV
VGAAARPADLDDTFATAGLAAARAVATARQALVGT
>Mature_355_residues
MQETTRPILVIGGGPGGLEAARTVAALGHPVLLVERRGRLGGTPDAERYAKLTHHFRDAEEAIGELVAAVTDHPLIEVLT
RSEVTACEGEAGDFRVTVSTPTGSREARVSAIIVATGFQHFDPGRETQLYNYYSFPDVVTLSDMEAMLKAHQVVRPSNGQ
PPERVAFIQCVGSRDRQIGNEFCSKVCCGIASKQAIEIKEQLPDARVFIFYIDMRMYGYWENELYWPAQERYKVNYVKGI
VSEILPKGDRLLIRGEDTTMGRPMEITVDLVVLSVGMEPSSGTRQMAKLLGIAQNKYGYIEAGGPSGLDPVATSRPGIYV
VGAAARPADLDDTFATAGLAAARAVATARQALVGT

Specific function: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). May act as the catalytic subunit [H]

COG id: COG1148

COG function: function code C; Heterodisulfide reductase, subunit A and related polyferredoxins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 4 4Fe-4S ferredoxin-type domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR013027 [H]

Pfam domain/function: PF00037 Fer4; PF07992 Pyr_redox_2 [H]

EC number: =1.8.98.1 [H]

Molecular weight: Translated: 38473; Mature: 38473

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQETTRPILVIGGGPGGLEAARTVAALGHPVLLVERRGRLGGTPDAERYAKLTHHFRDAE
CCCCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHH
EAIGELVAAVTDHPLIEVLTRSEVTACEGEAGDFRVTVSTPTGSREARVSAIIVATGFQH
HHHHHHHHHHCCCHHHHHHHHCCCEECCCCCCCEEEEEECCCCCCCCEEEEEEEEECCHH
FDPGRETQLYNYYSFPDVVTLSDMEAMLKAHQVVRPSNGQPPERVAFIQCVGSRDRQIGN
CCCCCCCEEEEEECCCCEEEHHHHHHHHHHHHHCCCCCCCCHHHEEEEEECCCCHHHHHH
EFCSKVCCGIASKQAIEIKEQLPDARVFIFYIDMRMYGYWENELYWPAQERYKVNYVKGI
HHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEEEEEEEEEECCCEECCHHHCEEHHHHHHH
VSEILPKGDRLLIRGEDTTMGRPMEITVDLVVLSVGMEPSSGTRQMAKLLGIAQNKYGYI
HHHHCCCCCEEEEECCCCCCCCCEEEEEEEEEEEECCCCCCCHHHHHHHHHHHCCCCEEE
EAGGPSGLDPVATSRPGIYVVGAAARPADLDDTFATAGLAAARAVATARQALVGT
ECCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQETTRPILVIGGGPGGLEAARTVAALGHPVLLVERRGRLGGTPDAERYAKLTHHFRDAE
CCCCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHH
EAIGELVAAVTDHPLIEVLTRSEVTACEGEAGDFRVTVSTPTGSREARVSAIIVATGFQH
HHHHHHHHHHCCCHHHHHHHHCCCEECCCCCCCEEEEEECCCCCCCCEEEEEEEEECCHH
FDPGRETQLYNYYSFPDVVTLSDMEAMLKAHQVVRPSNGQPPERVAFIQCVGSRDRQIGN
CCCCCCCEEEEEECCCCEEEHHHHHHHHHHHHHCCCCCCCCHHHEEEEEECCCCHHHHHH
EFCSKVCCGIASKQAIEIKEQLPDARVFIFYIDMRMYGYWENELYWPAQERYKVNYVKGI
HHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEEEEEEEEEECCCEECCHHHCEEHHHHHHH
VSEILPKGDRLLIRGEDTTMGRPMEITVDLVVLSVGMEPSSGTRQMAKLLGIAQNKYGYI
HHHHCCCCCEEEEECCCCCCCCCEEEEEEEEEEEECCCCCCCHHHHHHHHHHHCCCCEEE
EAGGPSGLDPVATSRPGIYVVGAAARPADLDDTFATAGLAAARAVATARQALVGT
ECCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]