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The map label for this gene is ltrA [H]

Identifier: 221232061

GI number: 221232061

Start: 1246260

End: 1248071

Strand: Reverse

Name: ltrA [H]

Synonym: SPN23F_12790

Alternate gene names: 221232061

Gene position: 1248071-1246260 (Counterclockwise)

Preceding gene: 221232062

Following gene: 221232060

Centisome position: 56.19

GC content: 36.98

Gene sequence:

>1812_bases
ATGAGAAATCCTCAAAATGTGTTAAACAATCTAACAAAACACAGTAAAGATAAAAACTATCAATTTGAGCGACTGTATCG
TTTGCTTTATAACAAAGAAATGTACTTAGTTGCCTATCAAACGATTTACGCTAACCCAGGACACTTGACACCTGGAGTAG
ACGAGTTGACGATTGATGGTATGAGTATAGCTAGAATTGACCAATTGATTGATTCCCTGAAAGATGAATCCTATCAGCCA
CACCCATCAAGACGAACCTATATTCCTAAAAAGAATGGGAAGCTACGTCCACTAGGTATTCCATCATTTGATGATAAGCT
CTTACAACAGGTTATTAAAATGATTTTGGAAGCTATCTACGAGGGACAATTTGAACCCTCTTCCCATGGTTTTCGTCCGA
ATAAAAGTTGCCATACAGCACTTACTCAGATTCAGAAGACCTACACTGGAACAAAATGGTTTATTGAAGGAGATATCAAG
TCATTCTTTGATAATATCAATCATGATGTGATGATTCACATTCTCCGAGAAAGAATTACTGATGAGCGGTTCTTACGCTT
GATTCGTAAATTCCTCAATGCGGGATACGTGGAAGATTGGAAATTCTACAAAACCTACTCAGGAACTCCACAAGGAGGGA
TAATCAGTCCCATTCTAGCCAATATCTATTTGGATAAGTTTGATAAATATATGACGGATTATGTGAAGAACTTCTGCCAA
GGGAAATACCGGAAACGTACCCCAGAATATCGCCAAAATGAGATAGCGTTGGGAAAAGCAAGAAGAGCATTAGAATGTGT
TTCAACGGAAAATCAACGACAAGAAGTTATCCAGCGTATTCGTCAATTGGAAAAGGAAAGAGTGTTAATTCCTCATAGTG
ATCCTATGGATAGTAGTTTTAAACGTCTAACCTATACCCGATACGCAGATGATTTTATCTGCGGTGTGATTGGCAGTAAA
GAGGACGCTCATCGCATTAAAGCAGATATTAAGGACTATTTGGAAGCGGTTCTCAAATTGGAACTCTCTGTGGAGAAAAC
CTTGATTACCAATGCGAGAGATAAAGCTAAGTTTCTGGGATATCATCTGTATATTCGCCAATCGAATTTAGCTAAGCGTG
ATTCGGCAGGACGATTGGTAAGAAATTATACAGGTAGATTAGTCCTAGAGGTTTCTATTGAAACGATTCGAGACAGATTA
CTGTCTTACGGAGCTATGAAAATGACTTATCATAGAGGCTACGAAGTTTGGAAACCAACGGCCCGTTATTTCATGAAAGA
TTGCGATGATTTAGAGATTTTAGAACGCTACAATGCAGAAATAAGAGGTTTTTATAACTATTATTGTATCGCTAATAACA
GCTCTATCCTTCATCGCTTTAAGTACATCATGGAATATAGCATGTATAAAACTTATGCGACTAAATATCGTACGACTAAA
TCCCACATCATCCGTAAATATAAAAAGGATGGTCAATTTAGTGTACAGTATATTGGACGTAAAGGGGATACAATGACCCG
TTATTTATATAACGGAGGATTTAAACGTCAAAAGAAATCTTTCCTTGAAAATGATAATTTGCCAAATACGGCGAAATATT
TTAGTCGAACAAATTTAATTGATAGATTAAAAGCAAGCCGTTGTGAGTATTGTCAAGCGACCGACAGTTCCCTAGAAATC
CATCATGTGAGAAAACTAAAGGATTTAAAGGGAAAGACTTTTTGGGAACGTTTGATGATTTCTAGACAACGGAAAACAAT
AGCACTGTGTAAAGATTGCCATAAGAAATTACATCATGGCAAGTTAGATTGA

Upstream 100 bases:

>100_bases
GGAGTTCCCATAGTAGTCCGAGCGTGTTAATGGCACGTACATGGCGAAGGGGAACAGTTTATAACATTAACATTATGGAA
AGGAAGGTGTGTGAGACACC

Downstream 100 bases:

>100_bases
GTTTATAAACGGAGAGCCGTATACATTGAAAGGTGTACGTACGGTTCGGGGGCGAGTATTTGGAAACCTGACGTAGTAAT
ATGGTAAGGCGCTGGGTACT

Product: group II intron reverse transcriptase/maturase

Products: NA

Alternate protein names: Reverse-transcriptase; RNA maturase; DNA endonuclease [H]

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MRNPQNVLNNLTKHSKDKNYQFERLYRLLYNKEMYLVAYQTIYANPGHLTPGVDELTIDGMSIARIDQLIDSLKDESYQP
HPSRRTYIPKKNGKLRPLGIPSFDDKLLQQVIKMILEAIYEGQFEPSSHGFRPNKSCHTALTQIQKTYTGTKWFIEGDIK
SFFDNINHDVMIHILRERITDERFLRLIRKFLNAGYVEDWKFYKTYSGTPQGGIISPILANIYLDKFDKYMTDYVKNFCQ
GKYRKRTPEYRQNEIALGKARRALECVSTENQRQEVIQRIRQLEKERVLIPHSDPMDSSFKRLTYTRYADDFICGVIGSK
EDAHRIKADIKDYLEAVLKLELSVEKTLITNARDKAKFLGYHLYIRQSNLAKRDSAGRLVRNYTGRLVLEVSIETIRDRL
LSYGAMKMTYHRGYEVWKPTARYFMKDCDDLEILERYNAEIRGFYNYYCIANNSSILHRFKYIMEYSMYKTYATKYRTTK
SHIIRKYKKDGQFSVQYIGRKGDTMTRYLYNGGFKRQKKSFLENDNLPNTAKYFSRTNLIDRLKASRCEYCQATDSSLEI
HHVRKLKDLKGKTFWERLMISRQRKTIALCKDCHKKLHHGKLD

Sequences:

>Translated_603_residues
MRNPQNVLNNLTKHSKDKNYQFERLYRLLYNKEMYLVAYQTIYANPGHLTPGVDELTIDGMSIARIDQLIDSLKDESYQP
HPSRRTYIPKKNGKLRPLGIPSFDDKLLQQVIKMILEAIYEGQFEPSSHGFRPNKSCHTALTQIQKTYTGTKWFIEGDIK
SFFDNINHDVMIHILRERITDERFLRLIRKFLNAGYVEDWKFYKTYSGTPQGGIISPILANIYLDKFDKYMTDYVKNFCQ
GKYRKRTPEYRQNEIALGKARRALECVSTENQRQEVIQRIRQLEKERVLIPHSDPMDSSFKRLTYTRYADDFICGVIGSK
EDAHRIKADIKDYLEAVLKLELSVEKTLITNARDKAKFLGYHLYIRQSNLAKRDSAGRLVRNYTGRLVLEVSIETIRDRL
LSYGAMKMTYHRGYEVWKPTARYFMKDCDDLEILERYNAEIRGFYNYYCIANNSSILHRFKYIMEYSMYKTYATKYRTTK
SHIIRKYKKDGQFSVQYIGRKGDTMTRYLYNGGFKRQKKSFLENDNLPNTAKYFSRTNLIDRLKASRCEYCQATDSSLEI
HHVRKLKDLKGKTFWERLMISRQRKTIALCKDCHKKLHHGKLD
>Mature_603_residues
MRNPQNVLNNLTKHSKDKNYQFERLYRLLYNKEMYLVAYQTIYANPGHLTPGVDELTIDGMSIARIDQLIDSLKDESYQP
HPSRRTYIPKKNGKLRPLGIPSFDDKLLQQVIKMILEAIYEGQFEPSSHGFRPNKSCHTALTQIQKTYTGTKWFIEGDIK
SFFDNINHDVMIHILRERITDERFLRLIRKFLNAGYVEDWKFYKTYSGTPQGGIISPILANIYLDKFDKYMTDYVKNFCQ
GKYRKRTPEYRQNEIALGKARRALECVSTENQRQEVIQRIRQLEKERVLIPHSDPMDSSFKRLTYTRYADDFICGVIGSK
EDAHRIKADIKDYLEAVLKLELSVEKTLITNARDKAKFLGYHLYIRQSNLAKRDSAGRLVRNYTGRLVLEVSIETIRDRL
LSYGAMKMTYHRGYEVWKPTARYFMKDCDDLEILERYNAEIRGFYNYYCIANNSSILHRFKYIMEYSMYKTYATKYRTTK
SHIIRKYKKDGQFSVQYIGRKGDTMTRYLYNGGFKRQKKSFLENDNLPNTAKYFSRTNLIDRLKASRCEYCQATDSSLEI
HHVRKLKDLKGKTFWERLMISRQRKTIALCKDCHKKLHHGKLD

Specific function: Multifunctional protein that promotes group II intron splicing and mobility by acting both on RNA and DNA. It has three activities:reverse transcriptase (RT) for intron duplication, maturase to promote splicing, and DNA endonuclease for site- specific cle

COG id: COG3344

COG function: function code L; Retron-type reverse transcriptase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 reverse transcriptase domain [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6226520, Length=599, Percent_Identity=33.7228714524207, Blast_Score=288, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6226521, Length=612, Percent_Identity=32.3529411764706, Blast_Score=270, Evalue=4e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003615
- InterPro:   IPR002866
- InterPro:   IPR000477 [H]

Pfam domain/function: PF01348 Intron_maturas2; PF00078 RVT_1 [H]

EC number: =2.7.7.49 [H]

Molecular weight: Translated: 71413; Mature: 71413

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: PS50878 RT_POL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNPQNVLNNLTKHSKDKNYQFERLYRLLYNKEMYLVAYQTIYANPGHLTPGVDELTIDG
CCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEEEEHCCCCCCCCCCCCCEEECC
MSIARIDQLIDSLKDESYQPHPSRRTYIPKKNGKLRPLGIPSFDDKLLQQVIKMILEAIY
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
EGQFEPSSHGFRPNKSCHTALTQIQKTYTGTKWFIEGDIKSFFDNINHDVMIHILRERIT
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHCCCHHHHHHHHHHHHC
DERFLRLIRKFLNAGYVEDWKFYKTYSGTPQGGIISPILANIYLDKFDKYMTDYVKNFCQ
HHHHHHHHHHHHCCCCCCCCHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
GKYRKRTPEYRQNEIALGKARRALECVSTENQRQEVIQRIRQLEKERVLIPHSDPMDSSF
CCHHCCCCCHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEECCCCCCCCCHH
KRLTYTRYADDFICGVIGSKEDAHRIKADIKDYLEAVLKLELSVEKTLITNARDKAKFLG
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHEE
YHLYIRQSNLAKRDSAGRLVRNYTGRLVLEVSIETIRDRLLSYGAMKMTYHRGYEVWKPT
EEEEEECCCCCCCCHHHHHHHHCCCCEEEEEEHHHHHHHHHHHCHHHHHHHCCCHHCCHH
ARYFMKDCDDLEILERYNAEIRGFYNYYCIANNSSILHRFKYIMEYSMYKTYATKYRTTK
HHHHHHCCCHHHHHHHHCCCEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHIIRKYKKDGQFSVQYIGRKGDTMTRYLYNGGFKRQKKSFLENDNLPNTAKYFSRTNLI
HHHHHHHHCCCCEEEEEECCCCCHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHH
DRLKASRCEYCQATDSSLEIHHVRKLKDLKGKTFWERLMISRQRKTIALCKDCHKKLHHG
HHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KLD
CCC
>Mature Secondary Structure
MRNPQNVLNNLTKHSKDKNYQFERLYRLLYNKEMYLVAYQTIYANPGHLTPGVDELTIDG
CCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEEEEHCCCCCCCCCCCCCEEECC
MSIARIDQLIDSLKDESYQPHPSRRTYIPKKNGKLRPLGIPSFDDKLLQQVIKMILEAIY
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
EGQFEPSSHGFRPNKSCHTALTQIQKTYTGTKWFIEGDIKSFFDNINHDVMIHILRERIT
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHCCCHHHHHHHHHHHHC
DERFLRLIRKFLNAGYVEDWKFYKTYSGTPQGGIISPILANIYLDKFDKYMTDYVKNFCQ
HHHHHHHHHHHHCCCCCCCCHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
GKYRKRTPEYRQNEIALGKARRALECVSTENQRQEVIQRIRQLEKERVLIPHSDPMDSSF
CCHHCCCCCHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEECCCCCCCCCHH
KRLTYTRYADDFICGVIGSKEDAHRIKADIKDYLEAVLKLELSVEKTLITNARDKAKFLG
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHEE
YHLYIRQSNLAKRDSAGRLVRNYTGRLVLEVSIETIRDRLLSYGAMKMTYHRGYEVWKPT
EEEEEECCCCCCCCHHHHHHHHCCCCEEEEEEHHHHHHHHHHHCHHHHHHHCCCHHCCHH
ARYFMKDCDDLEILERYNAEIRGFYNYYCIANNSSILHRFKYIMEYSMYKTYATKYRTTK
HHHHHHCCCHHHHHHHHCCCEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHIIRKYKKDGQFSVQYIGRKGDTMTRYLYNGGFKRQKKSFLENDNLPNTAKYFSRTNLI
HHHHHHHHCCCCEEEEEECCCCCHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHH
DRLKASRCEYCQATDSSLEIHHVRKLKDLKGKTFWERLMISRQRKTIALCKDCHKKLHHG
HHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KLD
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655550; 11157264; 10488339; 9353259; 10413481; 11731786 [H]