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The map label for this gene is 221231917

Identifier: 221231917

GI number: 221231917

Start: 1092854

End: 1093627

Strand: Reverse

Name: 221231917

Synonym: SPN23F_11180

Alternate gene names: NA

Gene position: 1093627-1092854 (Counterclockwise)

Preceding gene: 221231918

Following gene: 221231915

Centisome position: 49.23

GC content: 30.88

Gene sequence:

>774_bases
TTGAAGAAAAAATGGTTTTTTGTAGATTATTATGATACAACAATTATTTTACTTGCTTTAATCTCTGTTATTCTGGTATT
ACTTGGATTTGCTGAGATGATTGATTTGGACAATCCGCCTTATAGTATTATTGATTTAGTAATCTGGGGTGTTTTTGTAA
TTGATTATAGTTGGCGCTTTTTTATTACTAAAAGAAAATGGCGCTTTATTCTTGAAAATATTTTTGATTTATTGGCTATT
CTCCCTTTAAATGCTATTTTTACAGTGTTTCGATTAGGGCGTATCTTTCGTTTAGCTAAACTAACAAAATTACTGAAACT
GACTCGTTTACTTAGAATAATTGGACTTACAGGTAAATTAGAAAGAAAAATTAGTAGATTCTTACGGACAAATGGCCTGA
TTTATATCTTGTATGTTAATATCTTTATTGTTCTAGTAGGGAGTTCGATTTTATCCGTTGTTGAAGAAAAATCCTTCTCA
GATAGTCTTTGGTGGGCTCTTGTGACAGTAACTACTGTTGGATATGGGGATATTGTTCCTGCTTCCATTTTTGGGAAATG
GCTAGCAGTTTTACTGATGCTTGTCGGTATTGGAACAATAGGGATGTTAACAAGTGCTTTGACGAACTTTTTTGTAAAGG
ATAATCCAGATGAACAGATAAAACTTGATAAACTCCAAGATGAATTATCTAGTCAGAGAATATTACTAGAGAAACAATCT
AAAAAGATAGAAGAACTACATAAAATGATACAAGATTTGATTGAAAAAACATAA

Upstream 100 bases:

>100_bases
GATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGGAGAGATATTTATTAAATTAAAGCTGAGTAATAACAGTATAG
AAAGTAAGGAGAGTAAAAAT

Downstream 100 bases:

>100_bases
TAAAAATAAAGATGAGACAAAGTTTGAGCTGAGGAGAAATCAAGTAAGTTTTGACACAATAGAACGCATATTATCAGGTA
TAAAAACTTGATACTATGCG

Product: ion channel transport protein

Products: NA

Alternate protein names: KvAP [H]

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MKKKWFFVDYYDTTIILLALISVILVLLGFAEMIDLDNPPYSIIDLVIWGVFVIDYSWRFFITKRKWRFILENIFDLLAI
LPLNAIFTVFRLGRIFRLAKLTKLLKLTRLLRIIGLTGKLERKISRFLRTNGLIYILYVNIFIVLVGSSILSVVEEKSFS
DSLWWALVTVTTVGYGDIVPASIFGKWLAVLLMLVGIGTIGMLTSALTNFFVKDNPDEQIKLDKLQDELSSQRILLEKQS
KKIEELHKMIQDLIEKT

Sequences:

>Translated_257_residues
MKKKWFFVDYYDTTIILLALISVILVLLGFAEMIDLDNPPYSIIDLVIWGVFVIDYSWRFFITKRKWRFILENIFDLLAI
LPLNAIFTVFRLGRIFRLAKLTKLLKLTRLLRIIGLTGKLERKISRFLRTNGLIYILYVNIFIVLVGSSILSVVEEKSFS
DSLWWALVTVTTVGYGDIVPASIFGKWLAVLLMLVGIGTIGMLTSALTNFFVKDNPDEQIKLDKLQDELSSQRILLEKQS
KKIEELHKMIQDLIEKT
>Mature_257_residues
MKKKWFFVDYYDTTIILLALISVILVLLGFAEMIDLDNPPYSIIDLVIWGVFVIDYSWRFFITKRKWRFILENIFDLLAI
LPLNAIFTVFRLGRIFRLAKLTKLLKLTRLLRIIGLTGKLERKISRFLRTNGLIYILYVNIFIVLVGSSILSVVEEKSFS
DSLWWALVTVTTVGYGDIVPASIFGKWLAVLLMLVGIGTIGMLTSALTNFFVKDNPDEQIKLDKLQDELSSQRILLEKQS
KKIEELHKMIQDLIEKT

Specific function: Mediates a strong voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassi

COG id: COG1226

COG function: function code P; Kef-type K+ transport systems, predicted NAD-binding component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the potassium channel family [H]

Homologues:

Organism=Homo sapiens, GI4826784, Length=281, Percent_Identity=28.8256227758007, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI20070166, Length=223, Percent_Identity=31.390134529148, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI27436974, Length=281, Percent_Identity=27.4021352313167, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4826782, Length=217, Percent_Identity=29.4930875576037, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI119395748, Length=216, Percent_Identity=29.6296296296296, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI27436984, Length=231, Percent_Identity=25.5411255411255, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI27436986, Length=231, Percent_Identity=25.5411255411255, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI27436996, Length=253, Percent_Identity=26.4822134387352, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI25952087, Length=244, Percent_Identity=27.0491803278689, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI4504817, Length=218, Percent_Identity=27.0642201834862, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI88758565, Length=214, Percent_Identity=28.9719626168224, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI26051262, Length=232, Percent_Identity=25.4310344827586, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI26051260, Length=232, Percent_Identity=25.4310344827586, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI26051266, Length=232, Percent_Identity=25.4310344827586, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI26051264, Length=232, Percent_Identity=25.4310344827586, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI5031819, Length=145, Percent_Identity=32.4137931034483, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71989361, Length=232, Percent_Identity=26.2931034482759, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71989369, Length=232, Percent_Identity=26.2931034482759, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71989376, Length=232, Percent_Identity=26.2931034482759, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71989381, Length=232, Percent_Identity=26.2931034482759, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI193206869, Length=198, Percent_Identity=26.2626262626263, Blast_Score=64, Evalue=1e-10,
Organism=Drosophila melanogaster, GI281365536, Length=226, Percent_Identity=27.8761061946903, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI116007764, Length=226, Percent_Identity=27.8761061946903, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24656289, Length=226, Percent_Identity=27.8761061946903, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24656294, Length=226, Percent_Identity=27.8761061946903, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24642916, Length=247, Percent_Identity=28.7449392712551, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24642914, Length=247, Percent_Identity=28.7449392712551, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45555859, Length=247, Percent_Identity=29.1497975708502, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI45549143, Length=247, Percent_Identity=29.1497975708502, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24642910, Length=247, Percent_Identity=29.1497975708502, Blast_Score=71, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013099 [H]

Pfam domain/function: PF07885 Ion_trans_2 [H]

EC number: NA

Molecular weight: Translated: 29728; Mature: 29728

Theoretical pI: Translated: 10.02; Mature: 10.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKWFFVDYYDTTIILLALISVILVLLGFAEMIDLDNPPYSIIDLVIWGVFVIDYSWRF
CCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHE
FITKRKWRFILENIFDLLAILPLNAIFTVFRLGRIFRLAKLTKLLKLTRLLRIIGLTGKL
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
ERKISRFLRTNGLIYILYVNIFIVLVGSSILSVVEEKSFSDSLWWALVTVTTVGYGDIVP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCH
ASIFGKWLAVLLMLVGIGTIGMLTSALTNFFVKDNPDEQIKLDKLQDELSSQRILLEKQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KKIEELHKMIQDLIEKT
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKKWFFVDYYDTTIILLALISVILVLLGFAEMIDLDNPPYSIIDLVIWGVFVIDYSWRF
CCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHE
FITKRKWRFILENIFDLLAILPLNAIFTVFRLGRIFRLAKLTKLLKLTRLLRIIGLTGKL
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
ERKISRFLRTNGLIYILYVNIFIVLVGSSILSVVEEKSFSDSLWWALVTVTTVGYGDIVP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCH
ASIFGKWLAVLLMLVGIGTIGMLTSALTNFFVKDNPDEQIKLDKLQDELSSQRILLEKQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KKIEELHKMIQDLIEKT
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]