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The map label for this gene is coaA [H]

Identifier: 221231624

GI number: 221231624

Start: 740480

End: 741400

Strand: Reverse

Name: coaA [H]

Synonym: SPN23F_07600

Alternate gene names: 221231624

Gene position: 741400-740480 (Counterclockwise)

Preceding gene: 221231634

Following gene: 221231623

Centisome position: 33.38

GC content: 38.76

Gene sequence:

>921_bases
ATGACCAACGAATTTTTACATTTTGAAAAAATCAGCCGCCAGACTTGGCAATCTTTACATCGAAAGACAACACCTCCTTT
GACAGAAGAAGAATTGGAATCTATCAAGAGTTTTAATGACCAAATCAGTCTCCAAGACGTTACAGATATCTATCTCCCCT
TGGCTCATCTGATTCAGATTTACAAGCGAACTAAGGAAGATTTAGCCTTTTCAAAAGGAATTTTCCTCCAACGTGAAAGT
AAATCTCAACCTTTTATTATTGGGGTTTCTGGGAGTGTTGCCGTTGGAAAATCCACAACCAGTCGCCTACTTCAAATCCT
ACTGTCCCGTACGTTTACAGATGCTACGGTTGAGTTGGTTACAACTGATGGTTTTCTCTATCCCAATCAAACCTTGATTG
AGCAGGGGATTTTAAATCGTAAAGGATTTCCTGAAAGCTATGATATGGAAGCTCTTCTCAACTTCTTGGACCGCATCAAA
AATGGACAAGATGTAGATATTCCTGTCTATTCTCATGAAGTTTACGACATCGTACCCGAAAAGAAACAAAGTGTCAAAGC
TGCTGATTTTGTAATTGTTGAGGGAATTAATGTCTTTCAAAATCCACAAAACGATCGTCTCTATATCACTGACTTCTTTG
ACTTTTCCATCTATGTAGATGCTGGAGTGGATGATATTGAAAGTTGGTATCTGGACCGTTTCTTGAAGATGCTGAGCCTA
GCCCAAAACGACCCTGATAGCTACTATTATCGTTTTACTCAGATGCCGATTGGGGAAGTGGAGTCCTTTGCCCATCAGGT
CTGGATCAGTATCAATCTCACAAATCTGCAAAATTATATTGAACCAACCAGAAATCGTGCAGAAGTGATTCTTCATAAAA
GCAAGAACCATGAAATCGATGAAATTTACTTAAAAAAGTAA

Upstream 100 bases:

>100_bases
ATCACTTATACTATATACCATTGACTTACCACATTCAAGAAACCGCTTTATTTTTTTAGCTTTTTATGGTATGATAGACA
AAATATCTAGGGGAAAACAA

Downstream 100 bases:

>100_bases
TTTTCCCTTGTCAAAACGTAAGTTTTCATATATAATGGTATAGTTAGTAAATATGGAGGTAAGAACATTGGCAAACATTA
AATCAGCTATCAAACGCGCT

Product: pantothenate kinase

Products: NA

Alternate protein names: Pantothenic acid kinase [H]

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MTNEFLHFEKISRQTWQSLHRKTTPPLTEEELESIKSFNDQISLQDVTDIYLPLAHLIQIYKRTKEDLAFSKGIFLQRES
KSQPFIIGVSGSVAVGKSTTSRLLQILLSRTFTDATVELVTTDGFLYPNQTLIEQGILNRKGFPESYDMEALLNFLDRIK
NGQDVDIPVYSHEVYDIVPEKKQSVKAADFVIVEGINVFQNPQNDRLYITDFFDFSIYVDAGVDDIESWYLDRFLKMLSL
AQNDPDSYYYRFTQMPIGEVESFAHQVWISINLTNLQNYIEPTRNRAEVILHKSKNHEIDEIYLKK

Sequences:

>Translated_306_residues
MTNEFLHFEKISRQTWQSLHRKTTPPLTEEELESIKSFNDQISLQDVTDIYLPLAHLIQIYKRTKEDLAFSKGIFLQRES
KSQPFIIGVSGSVAVGKSTTSRLLQILLSRTFTDATVELVTTDGFLYPNQTLIEQGILNRKGFPESYDMEALLNFLDRIK
NGQDVDIPVYSHEVYDIVPEKKQSVKAADFVIVEGINVFQNPQNDRLYITDFFDFSIYVDAGVDDIESWYLDRFLKMLSL
AQNDPDSYYYRFTQMPIGEVESFAHQVWISINLTNLQNYIEPTRNRAEVILHKSKNHEIDEIYLKK
>Mature_305_residues
TNEFLHFEKISRQTWQSLHRKTTPPLTEEELESIKSFNDQISLQDVTDIYLPLAHLIQIYKRTKEDLAFSKGIFLQRESK
SQPFIIGVSGSVAVGKSTTSRLLQILLSRTFTDATVELVTTDGFLYPNQTLIEQGILNRKGFPESYDMEALLNFLDRIKN
GQDVDIPVYSHEVYDIVPEKKQSVKAADFVIVEGINVFQNPQNDRLYITDFFDFSIYVDAGVDDIESWYLDRFLKMLSLA
QNDPDSYYYRFTQMPIGEVESFAHQVWISINLTNLQNYIEPTRNRAEVILHKSKNHEIDEIYLKK

Specific function: Coenzyme A (CoA) biosynthesis; first step. [C]

COG id: COG1072

COG function: function code H; Panthothenate kinase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic pantothenate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1790409, Length=312, Percent_Identity=42.3076923076923, Blast_Score=256, Evalue=1e-69,
Organism=Drosophila melanogaster, GI45550449, Length=220, Percent_Identity=26.3636363636364, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28573516, Length=223, Percent_Identity=25.1121076233184, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28573514, Length=223, Percent_Identity=25.1121076233184, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28573512, Length=223, Percent_Identity=25.1121076233184, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004566
- InterPro:   IPR006083 [H]

Pfam domain/function: PF00485 PRK [H]

EC number: =2.7.1.33 [H]

Molecular weight: Translated: 35556; Mature: 35424

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNEFLHFEKISRQTWQSLHRKTTPPLTEEELESIKSFNDQISLQDVTDIYLPLAHLIQI
CCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHH
YKRTKEDLAFSKGIFLQRESKSQPFIIGVSGSVAVGKSTTSRLLQILLSRTFTDATVELV
HHHHHHHHHHHCCEEEEECCCCCCEEEECCCCEEECCHHHHHHHHHHHHHCCCCCEEEEE
TTDGFLYPNQTLIEQGILNRKGFPESYDMEALLNFLDRIKNGQDVDIPVYSHEVYDIVPE
EECCEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCHHHHCCCC
KKQSVKAADFVIVEGINVFQNPQNDRLYITDFFDFSIYVDAGVDDIESWYLDRFLKMLSL
HHHCCHHHCEEEEECCHHHCCCCCCEEEEEEEEEEEEEEECCCHHHHHHHHHHHHHHHHH
AQNDPDSYYYRFTQMPIGEVESFAHQVWISINLTNLQNYIEPTRNRAEVILHKSKNHEID
HCCCCCHHEEEEECCCHHHHHHHHEEEEEEEEHHHHHHHHHCCCCCEEEEEECCCCCCCC
EIYLKK
EEEECC
>Mature Secondary Structure 
TNEFLHFEKISRQTWQSLHRKTTPPLTEEELESIKSFNDQISLQDVTDIYLPLAHLIQI
CCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHH
YKRTKEDLAFSKGIFLQRESKSQPFIIGVSGSVAVGKSTTSRLLQILLSRTFTDATVELV
HHHHHHHHHHHCCEEEEECCCCCCEEEECCCCEEECCHHHHHHHHHHHHHCCCCCEEEEE
TTDGFLYPNQTLIEQGILNRKGFPESYDMEALLNFLDRIKNGQDVDIPVYSHEVYDIVPE
EECCEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCHHHHCCCC
KKQSVKAADFVIVEGINVFQNPQNDRLYITDFFDFSIYVDAGVDDIESWYLDRFLKMLSL
HHHCCHHHCEEEEECCHHHCCCCCCEEEEEEEEEEEEEEECCCHHHHHHHHHHHHHHHHH
AQNDPDSYYYRFTQMPIGEVESFAHQVWISINLTNLQNYIEPTRNRAEVILHKSKNHEID
HCCCCCHHEEEEECCCHHHHHHHHEEEEEEEEHHHHHHHHHCCCCCEEEEEECCCCCCCC
EIYLKK
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA