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The map label for this gene is serS [H]

Identifier: 221231277

GI number: 221231277

Start: 374487

End: 375761

Strand: Reverse

Name: serS [H]

Synonym: SPN23F_03870

Alternate gene names: 221231277

Gene position: 375761-374487 (Counterclockwise)

Preceding gene: 221231278

Following gene: 221231270

Centisome position: 16.92

GC content: 44.16

Gene sequence:

>1275_bases
ATGTTAGATATCAAACGTATTCGTACAGATTTTGAAGCTGTCACAGAAAAATTAGCTACACGTGGTGTAGATGCTGCTGT
CTTGAATGAAATGAAAGAAATCGATGCTAAACGTCGTAACATCTTGGTCAAGGTTGAAACTCTCAAAGCAGAACGTAACA
CAGTTTCTGCTGAGATTGCCCAAGCTAAGCGCAACAAGGAAAATACAGATGACAAGATTGCTGCCATGCAAAATCTATCT
GCTGAGGTTAAAGCCTTGGATGCTGAATTGGCAGAAATCGATGCTAAATTGACAGAATTTACAACGACTCTTCCAAATAT
CCCAGCTGACAGCGTTCCTGTTGGGGCTGATGAAGACGACAATGTGGAAGTTCGCCGTTGGGGTACTCCACGCGAGTTTG
ACTTCGAACCTAAAGCTCACTGGGATCTCGGTGAAGACCTTGGTATCCTTGACTGGGAACGCGGTGGTAAGGTAACAGGC
GCTCGCTTCCTCTTCTATAAAGGCCTCGGTGCTCGTTTGGAACGTGCTATCTACAACTTTATGTTGGATGAACATGGAAA
AGAAGGCTATACTGAAGTCATCACACCTTACATAGTCAACCATGATTCTATGTTTGGTACTGGTCAGTATCCAAAATTTA
AGGAAGATACTTTTGAACTCAGCGATACCAACTTTGTCTTGATTCCAACTGCTGAAGTTCCTCTGGCAAACTACTACCGT
GATGAAATCTTAGACGGCAAAGATCTTCCAATCTACTTCACTGCTATGAGTCCGTCATTCCGTTCTGAGGCTGGTTCTGC
CGGTCGTGATACGCGTGGCTTGATCCGTTTGCACCAATTCCACAAGGTTGAAATGGTCAAATTTGCCAAACCAGAAGAAT
CTTACGAAGAATTGGAAAAAATGACAGCCAACGCTGAAAACATTCTTCAAAAACTCAACCTTCCATACCGTGTCGTTGCT
CTCTCTACTGGAGATATGGGCTTCTCAGCTGCGAAGACTTACGACTTGGAAGTGTGGATTCCAGCACAAAACAATTACCG
TGAAATCTCAAGCTGTTCAAACACAGAAGATTTCCAAGCCCGTCGTGCCCAAATCCGTTACCGTGATGAAGCAGATGGCA
AGGTGAAACTCCTTCATACCTTGAACGGTTCTGGACTTGCAGTTGGACGTACAGTGGCTGCAATTCTTGAAAATTACCAA
AATGAAGATGGTTCTGTGACCATCCCAGAAGCACTTCGTCCATACATGGGTGGAGCTGAAGTCATCAAACCATAA

Upstream 100 bases:

>100_bases
TTACATACACAATCAAGTGCACACCTGTGAAGTTGGATGGAACCGTGGCCCTGCCACTCCAACGTTTTGTCAGGCGTGCT
TTTTTCATAAAGGAGTTCTT

Downstream 100 bases:

>100_bases
AAAATAAGGTTTAGCTATTTCTAGCTAGACCTTTTTTCGTAACCAAATCAGATAATCACCTAGTACAAAGAATAAAATAG
TTAGGCATATAATGGTTTCA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MLDIKRIRTDFEAVTEKLATRGVDAAVLNEMKEIDAKRRNILVKVETLKAERNTVSAEIAQAKRNKENTDDKIAAMQNLS
AEVKALDAELAEIDAKLTEFTTTLPNIPADSVPVGADEDDNVEVRRWGTPREFDFEPKAHWDLGEDLGILDWERGGKVTG
ARFLFYKGLGARLERAIYNFMLDEHGKEGYTEVITPYIVNHDSMFGTGQYPKFKEDTFELSDTNFVLIPTAEVPLANYYR
DEILDGKDLPIYFTAMSPSFRSEAGSAGRDTRGLIRLHQFHKVEMVKFAKPEESYEELEKMTANAENILQKLNLPYRVVA
LSTGDMGFSAAKTYDLEVWIPAQNNYREISSCSNTEDFQARRAQIRYRDEADGKVKLLHTLNGSGLAVGRTVAAILENYQ
NEDGSVTIPEALRPYMGGAEVIKP

Sequences:

>Translated_424_residues
MLDIKRIRTDFEAVTEKLATRGVDAAVLNEMKEIDAKRRNILVKVETLKAERNTVSAEIAQAKRNKENTDDKIAAMQNLS
AEVKALDAELAEIDAKLTEFTTTLPNIPADSVPVGADEDDNVEVRRWGTPREFDFEPKAHWDLGEDLGILDWERGGKVTG
ARFLFYKGLGARLERAIYNFMLDEHGKEGYTEVITPYIVNHDSMFGTGQYPKFKEDTFELSDTNFVLIPTAEVPLANYYR
DEILDGKDLPIYFTAMSPSFRSEAGSAGRDTRGLIRLHQFHKVEMVKFAKPEESYEELEKMTANAENILQKLNLPYRVVA
LSTGDMGFSAAKTYDLEVWIPAQNNYREISSCSNTEDFQARRAQIRYRDEADGKVKLLHTLNGSGLAVGRTVAAILENYQ
NEDGSVTIPEALRPYMGGAEVIKP
>Mature_424_residues
MLDIKRIRTDFEAVTEKLATRGVDAAVLNEMKEIDAKRRNILVKVETLKAERNTVSAEIAQAKRNKENTDDKIAAMQNLS
AEVKALDAELAEIDAKLTEFTTTLPNIPADSVPVGADEDDNVEVRRWGTPREFDFEPKAHWDLGEDLGILDWERGGKVTG
ARFLFYKGLGARLERAIYNFMLDEHGKEGYTEVITPYIVNHDSMFGTGQYPKFKEDTFELSDTNFVLIPTAEVPLANYYR
DEILDGKDLPIYFTAMSPSFRSEAGSAGRDTRGLIRLHQFHKVEMVKFAKPEESYEELEKMTANAENILQKLNLPYRVVA
LSTGDMGFSAAKTYDLEVWIPAQNNYREISSCSNTEDFQARRAQIRYRDEADGKVKLLHTLNGSGLAVGRTVAAILENYQ
NEDGSVTIPEALRPYMGGAEVIKP

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=461, Percent_Identity=33.4056399132321, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI8923421, Length=441, Percent_Identity=30.8390022675737, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI225579074, Length=329, Percent_Identity=34.6504559270517, Blast_Score=200, Evalue=2e-51,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=55.1162790697674, Blast_Score=470, Evalue=1e-134,
Organism=Escherichia coli, GI1786392, Length=195, Percent_Identity=26.6666666666667, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17539260, Length=466, Percent_Identity=32.4034334763949, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17542084, Length=317, Percent_Identity=30.2839116719243, Blast_Score=150, Evalue=9e-37,
Organism=Saccharomyces cerevisiae, GI6320226, Length=443, Percent_Identity=32.0541760722348, Blast_Score=226, Evalue=7e-60,
Organism=Saccharomyces cerevisiae, GI6321799, Length=386, Percent_Identity=31.3471502590674, Blast_Score=223, Evalue=4e-59,
Organism=Drosophila melanogaster, GI24581334, Length=470, Percent_Identity=32.1276595744681, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI17737985, Length=374, Percent_Identity=31.0160427807487, Blast_Score=168, Evalue=6e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 47694; Mature: 47694

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIKRIRTDFEAVTEKLATRGVDAAVLNEMKEIDAKRRNILVKVETLKAERNTVSAEIA
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCEEEEEEEEECCCHHHHHHHHH
QAKRNKENTDDKIAAMQNLSAEVKALDAELAEIDAKLTEFTTTLPNIPADSVPVGADEDD
HHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NVEVRRWGTPREFDFEPKAHWDLGEDLGILDWERGGKVTGARFLFYKGLGARLERAIYNF
CEEEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEEEEEECCHHHHHHHHHHHH
MLDEHGKEGYTEVITPYIVNHDSMFGTGQYPKFKEDTFELSDTNFVLIPTAEVPLANYYR
HHHHCCCCCCHHHCCCEEECCCCCCCCCCCCCCCCCCEEECCCCEEEEECCCCCHHHHHH
DEILDGKDLPIYFTAMSPSFRSEAGSAGRDTRGLIRLHQFHKVEMVKFAKPEESYEELEK
HHHCCCCCCCEEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHHEEECCCHHHHHHHHH
MTANAENILQKLNLPYRVVALSTGDMGFSAAKTYDLEVWIPAQNNYREISSCSNTEDFQA
HHCCHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEEEECCCCCCHHHHCCCCCHHHHH
RRAQIRYRDEADGKVKLLHTLNGSGLAVGRTVAAILENYQNEDGSVTIPEALRPYMGGAE
HHHHEEECCCCCCEEEEEEEECCCCEEHHHHHHHHHHHHCCCCCCEECHHHHCCCCCCCC
VIKP
CCCC
>Mature Secondary Structure
MLDIKRIRTDFEAVTEKLATRGVDAAVLNEMKEIDAKRRNILVKVETLKAERNTVSAEIA
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCEEEEEEEEECCCHHHHHHHHH
QAKRNKENTDDKIAAMQNLSAEVKALDAELAEIDAKLTEFTTTLPNIPADSVPVGADEDD
HHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NVEVRRWGTPREFDFEPKAHWDLGEDLGILDWERGGKVTGARFLFYKGLGARLERAIYNF
CEEEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEEEEEECCHHHHHHHHHHHH
MLDEHGKEGYTEVITPYIVNHDSMFGTGQYPKFKEDTFELSDTNFVLIPTAEVPLANYYR
HHHHCCCCCCHHHCCCEEECCCCCCCCCCCCCCCCCCEEECCCCEEEEECCCCCHHHHHH
DEILDGKDLPIYFTAMSPSFRSEAGSAGRDTRGLIRLHQFHKVEMVKFAKPEESYEELEK
HHHCCCCCCCEEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHHEEECCCHHHHHHHHH
MTANAENILQKLNLPYRVVALSTGDMGFSAAKTYDLEVWIPAQNNYREISSCSNTEDFQA
HHCCHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEEEECCCCCCHHHHCCCCCHHHHH
RRAQIRYRDEADGKVKLLHTLNGSGLAVGRTVAAILENYQNEDGSVTIPEALRPYMGGAE
HHHHEEECCCCCCEEEEEEEECCCCEEHHHHHHHHHHHHCCCCCCEECHHHHCCCCCCCC
VIKP
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA