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The map label for this gene is pbp1A [H]

Identifier: 221231242

GI number: 221231242

Start: 331533

End: 333692

Strand: Reverse

Name: pbp1A [H]

Synonym: SPN23F_03410

Alternate gene names: 221231242

Gene position: 333692-331533 (Counterclockwise)

Preceding gene: 221231243

Following gene: 221231220

Centisome position: 15.02

GC content: 41.53

Gene sequence:

>2160_bases
ATGAACAAACCAACGATTCTGCGCCTAATCAAGTATCTGAGCATTAGCTTCTTAAGCTTGGTTATCGCAGCCATTGTCTT
AGGCGGAGGAGTTTTTTTCTACTACGTTAGCAAGGCTCCTAGCCTATCCGAGAGTAAACTAGTTGCAACAACTTCTAGTA
AAATCTACGACAATAAAAATCAACTCATTGCTGACTTGGGTTCTGAACGCCGCGTCAATGCCCAAGCTAATGATATTCCC
ACAGATTTGGTTAAGGCAATCGTTTCTATCGAAGACCATCGCTTCTTCGACCACAGGGGGATTGATTCCATCCGTATCCT
GGGAGCTTTCTTGCGCAATCTGCAAAGTAATTCCCTCCAAGGTGGATCAACTCTCACCCAACAGTTGATTAAGTTGACTT
ACTTTTCAACCTCGACTTCCGACCAGACTATTTCTCGTAAGGCTCAGGAAGCTTGGTTAGCGATTCAGTTAGAACAAAAA
GCAACCAAACAGGAAATCTTGACCTACTATATAAATAAGGTCTACATGTCTAATGGCAACTATGGAATGCAGACAGCAGC
TCAAAACTACTATGGTAAAGACCTCAATAATTTAAGTTTACCTCAGTTAGCCTTGCTGGCTGGAATGCCTCAGGCACCAA
ACCAATATGACCCCTATTCACATCCAGAAGCAGCCCAAGACCGCCGAAACTTGGTCTTATCTGAAATGAAAAATCAAGGT
TACATCTCTGCTGAACAGTATGAGAAAGCAGTCAATACACCAATTACTGATGGACTACAAAGTCTCAAATCAGCAAGTAA
TTACCCTGCTTACATGGATAATTACCTCAAGGAGGTCATCAATCAAGTAGAACAAGAAACTGGCTATAACCTTCTAACTA
CTGGGATGGATGTTTACACAAATGTAGACCAAGAAGCTCAAAAACATCTGTGGGATATCTACAACTCCGATCAATACGTC
TCTTACCCTGACGATGATTTGCAAGTCGCATCTACGGTCGTAGATGTTTCAAATGGTAAAGTCATCGCCCAACTTGGAGC
TCGTCACCAAGCAAGTAACGTTTCATTTGGTACCAACCAAGCTGTGGAAACCAATCGTGACTGGGGTTCTGCTATGAAAC
CAATCACCGATTATGCACCTGCCATAGAATACGGTGTTTATGATTCCACTGCAACTATGGTTAATGATATTCCTTATAAC
TATCCGGGAACAAGCACACCTGTCTACAACTGGGATAGAGCATATTTCGGTAATATTACTCTGCAATATGCTCTTCAACA
ATCACGAAATGTCACAGCCGTTGAGACTTTGAATAAGGTCGGTCTAGATAGAGCTAAAACCTTCCTTAATGGTCTTGGTA
TCGACTATCCAAGCATGCATTATGCAAACGCCATTTCAAGTAATACAACAGAATCTAATAAACAATACGGAGCAAGTAGT
GAAAAAATGGCTGCTGCTTATGCTGCCTTTGCAAATGGTGGCACTTACTATAAACCAATGTATATCCATAAAGTCGTCTT
CAGTGATGGAAGTAAAAAAGAGTTCTCTAATGTCGGAACTCGTGCCATGAAGGAAACGACAGCCTATATGATGACCGACA
TGATGAAAACAGTCTTGACTTATGGAACTGGGCGTGGAGCCTATCTTCCTTGGCTTCCTCAAGCTGGTAAAACAGGAACC
TCTAACTATACAGATGAGGAAGTTGAAAACCACATCAAGAACACTGGCTATGTAGCTCCAGATGAAATGTTTGTTGGTTA
TACTCGTAAGTATTCTATGGCTGTATGGACAGGTTATTCGAATCGTTTAACTCCTATCGTTGGAGATGGTTTCCTAGTTG
CAGCTAAAGTTTATCGCTCAATGATAACGTATCTATCAGAAGATACTCATCCAGAAGACTGGACGATGCCAGACGGACTT
TTCAGAAACGGGGAATTTGTATTCAAAAATGGAGCTCGCCCAATATGGACTGAACCCTCTACTCAACAATCCTCAACAGC
TGAAAGTTCAAGCTCATCATCAGATAGTTCAACTTCACAGTCTAGCTCAACCACTCCAAGCACAAATAATAGTACGACTA
CCAATCCTAACAATAATACGCAACAATCAAATACAACCCCTGATCAACAAAATCAGAATCCTCAACCAGCACAACCATAA

Upstream 100 bases:

>100_bases
GATATATTCGAGAATATGGATATGAAATCAAGGCTGGTGCCTTCCCTCAAATTCCTTATCTCAATGTTATCAAAGAACAT
TTATTAGGTGGTAAAACAAG

Downstream 100 bases:

>100_bases
CATTTATCATCCAGATTTTTCTGGGTGATTTTTTCATAGCACTATTGTATTTATGTGCTTAACAAAAGCCTGAGAAGACA
TCTTCTCAGGCTTTTTCTGT

Product: penicillin-binding protein 1A

Products: NA

Alternate protein names: PBP-1A [H]

Number of amino acids: Translated: 719; Mature: 719

Protein sequence:

>719_residues
MNKPTILRLIKYLSISFLSLVIAAIVLGGGVFFYYVSKAPSLSESKLVATTSSKIYDNKNQLIADLGSERRVNAQANDIP
TDLVKAIVSIEDHRFFDHRGIDSIRILGAFLRNLQSNSLQGGSTLTQQLIKLTYFSTSTSDQTISRKAQEAWLAIQLEQK
ATKQEILTYYINKVYMSNGNYGMQTAAQNYYGKDLNNLSLPQLALLAGMPQAPNQYDPYSHPEAAQDRRNLVLSEMKNQG
YISAEQYEKAVNTPITDGLQSLKSASNYPAYMDNYLKEVINQVEQETGYNLLTTGMDVYTNVDQEAQKHLWDIYNSDQYV
SYPDDDLQVASTVVDVSNGKVIAQLGARHQASNVSFGTNQAVETNRDWGSAMKPITDYAPAIEYGVYDSTATMVNDIPYN
YPGTSTPVYNWDRAYFGNITLQYALQQSRNVTAVETLNKVGLDRAKTFLNGLGIDYPSMHYANAISSNTTESNKQYGASS
EKMAAAYAAFANGGTYYKPMYIHKVVFSDGSKKEFSNVGTRAMKETTAYMMTDMMKTVLTYGTGRGAYLPWLPQAGKTGT
SNYTDEEVENHIKNTGYVAPDEMFVGYTRKYSMAVWTGYSNRLTPIVGDGFLVAAKVYRSMITYLSEDTHPEDWTMPDGL
FRNGEFVFKNGARPIWTEPSTQQSSTAESSSSSSDSSTSQSSSTTPSTNNSTTTNPNNNTQQSNTTPDQQNQNPQPAQP

Sequences:

>Translated_719_residues
MNKPTILRLIKYLSISFLSLVIAAIVLGGGVFFYYVSKAPSLSESKLVATTSSKIYDNKNQLIADLGSERRVNAQANDIP
TDLVKAIVSIEDHRFFDHRGIDSIRILGAFLRNLQSNSLQGGSTLTQQLIKLTYFSTSTSDQTISRKAQEAWLAIQLEQK
ATKQEILTYYINKVYMSNGNYGMQTAAQNYYGKDLNNLSLPQLALLAGMPQAPNQYDPYSHPEAAQDRRNLVLSEMKNQG
YISAEQYEKAVNTPITDGLQSLKSASNYPAYMDNYLKEVINQVEQETGYNLLTTGMDVYTNVDQEAQKHLWDIYNSDQYV
SYPDDDLQVASTVVDVSNGKVIAQLGARHQASNVSFGTNQAVETNRDWGSAMKPITDYAPAIEYGVYDSTATMVNDIPYN
YPGTSTPVYNWDRAYFGNITLQYALQQSRNVTAVETLNKVGLDRAKTFLNGLGIDYPSMHYANAISSNTTESNKQYGASS
EKMAAAYAAFANGGTYYKPMYIHKVVFSDGSKKEFSNVGTRAMKETTAYMMTDMMKTVLTYGTGRGAYLPWLPQAGKTGT
SNYTDEEVENHIKNTGYVAPDEMFVGYTRKYSMAVWTGYSNRLTPIVGDGFLVAAKVYRSMITYLSEDTHPEDWTMPDGL
FRNGEFVFKNGARPIWTEPSTQQSSTAESSSSSSDSSTSQSSSTTPSTNNSTTTNPNNNTQQSNTTPDQQNQNPQPAQP
>Mature_719_residues
MNKPTILRLIKYLSISFLSLVIAAIVLGGGVFFYYVSKAPSLSESKLVATTSSKIYDNKNQLIADLGSERRVNAQANDIP
TDLVKAIVSIEDHRFFDHRGIDSIRILGAFLRNLQSNSLQGGSTLTQQLIKLTYFSTSTSDQTISRKAQEAWLAIQLEQK
ATKQEILTYYINKVYMSNGNYGMQTAAQNYYGKDLNNLSLPQLALLAGMPQAPNQYDPYSHPEAAQDRRNLVLSEMKNQG
YISAEQYEKAVNTPITDGLQSLKSASNYPAYMDNYLKEVINQVEQETGYNLLTTGMDVYTNVDQEAQKHLWDIYNSDQYV
SYPDDDLQVASTVVDVSNGKVIAQLGARHQASNVSFGTNQAVETNRDWGSAMKPITDYAPAIEYGVYDSTATMVNDIPYN
YPGTSTPVYNWDRAYFGNITLQYALQQSRNVTAVETLNKVGLDRAKTFLNGLGIDYPSMHYANAISSNTTESNKQYGASS
EKMAAAYAAFANGGTYYKPMYIHKVVFSDGSKKEFSNVGTRAMKETTAYMMTDMMKTVLTYGTGRGAYLPWLPQAGKTGT
SNYTDEEVENHIKNTGYVAPDEMFVGYTRKYSMAVWTGYSNRLTPIVGDGFLVAAKVYRSMITYLSEDTHPEDWTMPDGL
FRNGEFVFKNGARPIWTEPSTQQSSTAESSSSSSDSSTSQSSSTTPSTNNSTTTNPNNNTQQSNTTPDQQNQNPQPAQP

Specific function: Cell wall formation [H]

COG id: COG0744

COG function: function code M; Membrane carboxypeptidase (penicillin-binding protein)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI87082258, Length=313, Percent_Identity=33.5463258785943, Blast_Score=178, Evalue=1e-45,
Organism=Escherichia coli, GI1786343, Length=641, Percent_Identity=29.6411856474259, Blast_Score=162, Evalue=8e-41,
Organism=Escherichia coli, GI1788867, Length=575, Percent_Identity=27.1304347826087, Blast_Score=159, Evalue=6e-40,
Organism=Escherichia coli, GI1789601, Length=227, Percent_Identity=26.8722466960352, Blast_Score=78, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011816
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-; 3.4.-.-

Molecular weight: Translated: 79737; Mature: 79737

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKPTILRLIKYLSISFLSLVIAAIVLGGGVFFYYVSKAPSLSESKLVATTSSKIYDNKN
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEECCHHHHCCHH
QLIADLGSERRVNAQANDIPTDLVKAIVSIEDHRFFDHRGIDSIRILGAFLRNLQSNSLQ
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHCCCCC
GGSTLTQQLIKLTYFSTSTSDQTISRKAQEAWLAIQLEQKATKQEILTYYINKVYMSNGN
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHEECCCC
YGMQTAAQNYYGKDLNNLSLPQLALLAGMPQAPNQYDPYSHPEAAQDRRNLVLSEMKNQG
CCHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
YISAEQYEKAVNTPITDGLQSLKSASNYPAYMDNYLKEVINQVEQETGYNLLTTGMDVYT
CCCHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCHHHC
NVDQEAQKHLWDIYNSDQYVSYPDDDLQVASTVVDVSNGKVIAQLGARHQASNVSFGTNQ
CCHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHEECCCCEEEEECCCCCCCCCCCCCCCC
AVETNRDWGSAMKPITDYAPAIEYGVYDSTATMVNDIPYNYPGTSTPVYNWDRAYFGNIT
CCCCCCCHHHHHCCHHHHCCHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCEECCEE
LQYALQQSRNVTAVETLNKVGLDRAKTFLNGLGIDYPSMHYANAISSNTTESNKQYGASS
EEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCHHCCCCH
EKMAAAYAAFANGGTYYKPMYIHKVVFSDGSKKEFSNVGTRAMKETTAYMMTDMMKTVLT
HHHHHHHHHHHCCCCEECHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGTGRGAYLPWLPQAGKTGTSNYTDEEVENHIKNTGYVAPDEMFVGYTRKYSMAVWTGYS
HCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHCCCCCEEEEEEEECCC
NRLTPIVGDGFLVAAKVYRSMITYLSEDTHPEDWTMPDGLFRNGEFVFKNGARPIWTEPS
CCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCC
TQQSSTAESSSSSSDSSTSQSSSTTPSTNNSTTTNPNNNTQQSNTTPDQQNQNPQPAQP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNKPTILRLIKYLSISFLSLVIAAIVLGGGVFFYYVSKAPSLSESKLVATTSSKIYDNKN
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEECCHHHHCCHH
QLIADLGSERRVNAQANDIPTDLVKAIVSIEDHRFFDHRGIDSIRILGAFLRNLQSNSLQ
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHCCCCC
GGSTLTQQLIKLTYFSTSTSDQTISRKAQEAWLAIQLEQKATKQEILTYYINKVYMSNGN
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHEECCCC
YGMQTAAQNYYGKDLNNLSLPQLALLAGMPQAPNQYDPYSHPEAAQDRRNLVLSEMKNQG
CCHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
YISAEQYEKAVNTPITDGLQSLKSASNYPAYMDNYLKEVINQVEQETGYNLLTTGMDVYT
CCCHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCHHHC
NVDQEAQKHLWDIYNSDQYVSYPDDDLQVASTVVDVSNGKVIAQLGARHQASNVSFGTNQ
CCHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHEECCCCEEEEECCCCCCCCCCCCCCCC
AVETNRDWGSAMKPITDYAPAIEYGVYDSTATMVNDIPYNYPGTSTPVYNWDRAYFGNIT
CCCCCCCHHHHHCCHHHHCCHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCEECCEE
LQYALQQSRNVTAVETLNKVGLDRAKTFLNGLGIDYPSMHYANAISSNTTESNKQYGASS
EEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCHHCCCCH
EKMAAAYAAFANGGTYYKPMYIHKVVFSDGSKKEFSNVGTRAMKETTAYMMTDMMKTVLT
HHHHHHHHHHHCCCCEECHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGTGRGAYLPWLPQAGKTGTSNYTDEEVENHIKNTGYVAPDEMFVGYTRKYSMAVWTGYS
HCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHCCCCCEEEEEEEECCC
NRLTPIVGDGFLVAAKVYRSMITYLSEDTHPEDWTMPDGLFRNGEFVFKNGARPIWTEPS
CCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCC
TQQSSTAESSSSSSDSSTSQSSSTTPSTNNSTTTNPNNNTQQSNTTPDQQNQNPQPAQP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1396576; 11463916 [H]