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The map label for this gene is gcvPB [H]

Identifier: 220933173

GI number: 220933173

Start: 2558667

End: 2560106

Strand: Reverse

Name: gcvPB [H]

Synonym: Hore_23410

Alternate gene names: 220933173

Gene position: 2560106-2558667 (Counterclockwise)

Preceding gene: 220933174

Following gene: 220933172

Centisome position: 99.3

GC content: 44.1

Gene sequence:

>1440_bases
GTGATTGAACCACTTATTAAAGATTACAGCAGTCAGGGCCGGAAGGGTTATTCCCTGCCCGAACTTGATGTACCCGATAT
AGATGTTAAAGAGTATTTAAAAGAGGGTTATTATCGGGAAGAGGCTCCGGACCTTCCTGAAGTCAGTGAAGTAGATGTGG
TCAGACATTATACGGCCCTGTCGGAAGAGAATTATGGGGTTGATTCCGGTATATATCCCTTAGGGTCCTGTACTATGAAG
TATAACCCCAAAATTAATGAAGAGATTGCCCGTCTTGATAAACTGGTGAAACTTCATCCCTACCAGGATGAAGATCAGAT
TCAGGGGACCCTGGAAATCATGTATGAATTAAAAGAGTATCTGGCAGAAATCAGTGGAATGGATGAGGTAACCCTGCAAC
CGGCTTCTGGAGCCCAGGGTGAATTGACCGGGTTATTGATTATTAAGAAGTATTTTGAGGAAAAAGGAGAAGAACGAACA
AAGGTAATTGTACCCGATTCTGCCCACGGTACCAACCCCGCCAGTGCTGCGATGGCCGGTTTTAAGGTTGTTGAAATTAA
ATCAAACGAACGGGGTATGGTTGACCTTGAAGCCCTTAAAGAAGCAGTTGATGAAAAAGTGGCAGCCCTGATGCTTACCA
ACCCCAATACCCTGGGTATATTTGAAGAAGAAATCCTTGATATTGCCAAAGTAGTCCATGATGCCGGTGGCCTGCTTTAT
TACGATGGAGCCAATATGAATGCTATTATGGGGTATGTCAGACCGGGTGATATGAATTTCGATGTTTTACACTTTAACCT
TCATAAGACTTTTTCTACGCCCCATGGGGGTGGGGGTCCCGGCTCCGGACCGGTCGGTGTTAAAGAATTTTTAAAACCAT
ATCTGCCCCGCCCTCTATTGAAAAAAGATAATGACCGGTATTACTGGGATTATGACCGTCCCTATTCTATTGGTAAGGTT
CATAGTTTTTATGGCAATTATGCCGTGATGTTGCGAGCATATACCTATATCAGGGCTCTGGGAGGGAAAGGCCTGAAAGA
GGTTACTGAAAATGCGGTGTTAAATGCCAATTACCTCAAGGTCAGATTAAAAGATATATATGAACTTCCCTATGAAGAAA
ATAGCCTTCATGAATTTGTTCTGTCGGGTAGCCGGCAGAAAAAGAAGGGGGTCAGTACCCTTAATATAGCCAAAAGGCTT
TTAGATTACGGACTGTATGCACCAACCATATATTTCCCGCTGATAGTTAAAGAAGCCTTAATGATTGAACCTACTGAAAC
CGAGAACCTGAAAACCCTGAATCAATTTGTCGAAACTATGAAGATTATTTCCCGGGAAATAGAAGAAAGTCCTGAATTGG
TGAAAGAGGCGCCCCGGAATACCCCGGTCAGGAAACTGGATGAGGCTCAGGCTGCCCGGAACCCGGACCTGAGATGGTAG

Upstream 100 bases:

>100_bases
TCCCGCTGGTATTCTTTTGATGGTTTTCTGGTATGTACGACTGAAAAAAGGACCAGGGAAGAAATAGATGGGTATCTGGA
GGCCCTGGAGGTGATATCCA

Downstream 100 bases:

>100_bases
GAATACAGTATAATTAAAAAAATAGTAGTAAATAAAATATTAGTAAATAAGGGTATAGATAAATAAACCCGCCGGCTTTA
AAAGTTGGCGGGTTTTTTAA

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MIEPLIKDYSSQGRKGYSLPELDVPDIDVKEYLKEGYYREEAPDLPEVSEVDVVRHYTALSEENYGVDSGIYPLGSCTMK
YNPKINEEIARLDKLVKLHPYQDEDQIQGTLEIMYELKEYLAEISGMDEVTLQPASGAQGELTGLLIIKKYFEEKGEERT
KVIVPDSAHGTNPASAAMAGFKVVEIKSNERGMVDLEALKEAVDEKVAALMLTNPNTLGIFEEEILDIAKVVHDAGGLLY
YDGANMNAIMGYVRPGDMNFDVLHFNLHKTFSTPHGGGGPGSGPVGVKEFLKPYLPRPLLKKDNDRYYWDYDRPYSIGKV
HSFYGNYAVMLRAYTYIRALGGKGLKEVTENAVLNANYLKVRLKDIYELPYEENSLHEFVLSGSRQKKKGVSTLNIAKRL
LDYGLYAPTIYFPLIVKEALMIEPTETENLKTLNQFVETMKIISREIEESPELVKEAPRNTPVRKLDEAQAARNPDLRW

Sequences:

>Translated_479_residues
MIEPLIKDYSSQGRKGYSLPELDVPDIDVKEYLKEGYYREEAPDLPEVSEVDVVRHYTALSEENYGVDSGIYPLGSCTMK
YNPKINEEIARLDKLVKLHPYQDEDQIQGTLEIMYELKEYLAEISGMDEVTLQPASGAQGELTGLLIIKKYFEEKGEERT
KVIVPDSAHGTNPASAAMAGFKVVEIKSNERGMVDLEALKEAVDEKVAALMLTNPNTLGIFEEEILDIAKVVHDAGGLLY
YDGANMNAIMGYVRPGDMNFDVLHFNLHKTFSTPHGGGGPGSGPVGVKEFLKPYLPRPLLKKDNDRYYWDYDRPYSIGKV
HSFYGNYAVMLRAYTYIRALGGKGLKEVTENAVLNANYLKVRLKDIYELPYEENSLHEFVLSGSRQKKKGVSTLNIAKRL
LDYGLYAPTIYFPLIVKEALMIEPTETENLKTLNQFVETMKIISREIEESPELVKEAPRNTPVRKLDEAQAARNPDLRW
>Mature_479_residues
MIEPLIKDYSSQGRKGYSLPELDVPDIDVKEYLKEGYYREEAPDLPEVSEVDVVRHYTALSEENYGVDSGIYPLGSCTMK
YNPKINEEIARLDKLVKLHPYQDEDQIQGTLEIMYELKEYLAEISGMDEVTLQPASGAQGELTGLLIIKKYFEEKGEERT
KVIVPDSAHGTNPASAAMAGFKVVEIKSNERGMVDLEALKEAVDEKVAALMLTNPNTLGIFEEEILDIAKVVHDAGGLLY
YDGANMNAIMGYVRPGDMNFDVLHFNLHKTFSTPHGGGGPGSGPVGVKEFLKPYLPRPLLKKDNDRYYWDYDRPYSIGKV
HSFYGNYAVMLRAYTYIRALGGKGLKEVTENAVLNANYLKVRLKDIYELPYEENSLHEFVLSGSRQKKKGVSTLNIAKRL
LDYGLYAPTIYFPLIVKEALMIEPTETENLKTLNQFVETMKIISREIEESPELVKEAPRNTPVRKLDEAQAARNPDLRW

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=428, Percent_Identity=42.2897196261682, Blast_Score=296, Evalue=4e-80,
Organism=Escherichia coli, GI1789269, Length=410, Percent_Identity=39.7560975609756, Blast_Score=273, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17535605, Length=409, Percent_Identity=42.5427872860636, Blast_Score=286, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI32564013, Length=363, Percent_Identity=44.0771349862259, Blast_Score=268, Evalue=4e-72,
Organism=Saccharomyces cerevisiae, GI6323843, Length=447, Percent_Identity=41.834451901566, Blast_Score=307, Evalue=2e-84,
Organism=Drosophila melanogaster, GI24645648, Length=412, Percent_Identity=41.9902912621359, Blast_Score=286, Evalue=2e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 54087; Mature: 54087

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEPLIKDYSSQGRKGYSLPELDVPDIDVKEYLKEGYYREEAPDLPEVSEVDVVRHYTAL
CCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
SEENYGVDSGIYPLGSCTMKYNPKINEEIARLDKLVKLHPYQDEDQIQGTLEIMYELKEY
CCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
LAEISGMDEVTLQPASGAQGELTGLLIIKKYFEEKGEERTKVIVPDSAHGTNPASAAMAG
HHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHC
FKVVEIKSNERGMVDLEALKEAVDEKVAALMLTNPNTLGIFEEEILDIAKVVHDAGGLLY
EEEEEEECCCCCCEEHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEE
YDGANMNAIMGYVRPGDMNFDVLHFNLHKTFSTPHGGGGPGSGPVGVKEFLKPYLPRPLL
ECCCCCCEEEEEECCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHH
KKDNDRYYWDYDRPYSIGKVHSFYGNYAVMLRAYTYIRALGGKGLKEVTENAVLNANYLK
CCCCCCEEECCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHEECCHHEE
VRLKDIYELPYEENSLHEFVLSGSRQKKKGVSTLNIAKRLLDYGLYAPTIYFPLIVKEAL
EEHHHHHHCCCCCCHHHHHHHCCCCHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
MIEPTETENLKTLNQFVETMKIISREIEESPELVKEAPRNTPVRKLDEAQAARNPDLRW
EECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIEPLIKDYSSQGRKGYSLPELDVPDIDVKEYLKEGYYREEAPDLPEVSEVDVVRHYTAL
CCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
SEENYGVDSGIYPLGSCTMKYNPKINEEIARLDKLVKLHPYQDEDQIQGTLEIMYELKEY
CCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
LAEISGMDEVTLQPASGAQGELTGLLIIKKYFEEKGEERTKVIVPDSAHGTNPASAAMAG
HHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHC
FKVVEIKSNERGMVDLEALKEAVDEKVAALMLTNPNTLGIFEEEILDIAKVVHDAGGLLY
EEEEEEECCCCCCEEHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEE
YDGANMNAIMGYVRPGDMNFDVLHFNLHKTFSTPHGGGGPGSGPVGVKEFLKPYLPRPLL
ECCCCCCEEEEEECCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHH
KKDNDRYYWDYDRPYSIGKVHSFYGNYAVMLRAYTYIRALGGKGLKEVTENAVLNANYLK
CCCCCCEEECCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHEECCHHEE
VRLKDIYELPYEENSLHEFVLSGSRQKKKGVSTLNIAKRLLDYGLYAPTIYFPLIVKEAL
EEHHHHHHCCCCCCHHHHHHHCCCCHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
MIEPTETENLKTLNQFVETMKIISREIEESPELVKEAPRNTPVRKLDEAQAARNPDLRW
EECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA