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The map label for this gene is purE [H]

Identifier: 220933140

GI number: 220933140

Start: 2520919

End: 2521422

Strand: Reverse

Name: purE [H]

Synonym: Hore_23080

Alternate gene names: 220933140

Gene position: 2521422-2520919 (Counterclockwise)

Preceding gene: 220933141

Following gene: 220933139

Centisome position: 97.8

GC content: 48.21

Gene sequence:

>504_bases
ATGCCTGATAAAAAAGTAGAAGTGGGAATAGTGATGGGCAGTGATTCTGATTTGCCGGTTATGGAAGATGCGGCAAAATT
CCTTGATGAGATGGGAATCGGATATGAAATGAGGGTTATCTCGGCCCACCGCACCCCTGATATAGCTAAGGAGTATGCTA
CCTCGGCTCTGGACAGGGGGTTAAAGGTAATCATTGCCGGGGCCGGTAAGGCCGCTCACCTGGCTGGTGTCCTGGCCAGC
TTTACCCCTTTACCTGTTATTGGAGTGCCGGTCCGGACTTCGACCCTGGGAGGGGCTGATTCTCTCTACTCCATGGTCCA
GATGCCATCCGGGGTTCCGGTAGCTACGGTGGCCTTGAACGGAGCCAAAAATGCCGCTATCCTGGCTCTGCAGATTATGG
CTACCGGTGACAGAGATAAAATGGATAAGATGATTGAGTTTAAAAAGAGGTTAAAAAAAGAAACGATCAATAAAGATAAA
AACCTGAAAAACAAAATGTCTTAA

Upstream 100 bases:

>100_bases
GGATGACTAAAACTAATTATAAGGAACCCACAAATCTATAAGTGAGTACAAAAAGTGAGTTCAAAAAAGTATATTTTTGA
AGAGAAGGGAGAATGTAATA

Downstream 100 bases:

>100_bases
GTATGACTTACCATAAAGCCCCGGCAAGAATCGCGGGAAATAGGTAACGAAAAACTGAGGGCTTAAACGGTGTTCTTGAT
GATCACACTTCATATATTGA

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 167; Mature: 166

Protein sequence:

>167_residues
MPDKKVEVGIVMGSDSDLPVMEDAAKFLDEMGIGYEMRVISAHRTPDIAKEYATSALDRGLKVIIAGAGKAAHLAGVLAS
FTPLPVIGVPVRTSTLGGADSLYSMVQMPSGVPVATVALNGAKNAAILALQIMATGDRDKMDKMIEFKKRLKKETINKDK
NLKNKMS

Sequences:

>Translated_167_residues
MPDKKVEVGIVMGSDSDLPVMEDAAKFLDEMGIGYEMRVISAHRTPDIAKEYATSALDRGLKVIIAGAGKAAHLAGVLAS
FTPLPVIGVPVRTSTLGGADSLYSMVQMPSGVPVATVALNGAKNAAILALQIMATGDRDKMDKMIEFKKRLKKETINKDK
NLKNKMS
>Mature_166_residues
PDKKVEVGIVMGSDSDLPVMEDAAKFLDEMGIGYEMRVISAHRTPDIAKEYATSALDRGLKVIIAGAGKAAHLAGVLASF
TPLPVIGVPVRTSTLGGADSLYSMVQMPSGVPVATVALNGAKNAAILALQIMATGDRDKMDKMIEFKKRLKKETINKDKN
LKNKMS

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=115, Percent_Identity=50.4347826086956, Blast_Score=119, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6324702, Length=156, Percent_Identity=53.8461538461538, Blast_Score=169, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17788; Mature: 17657

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.6 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDKKVEVGIVMGSDSDLPVMEDAAKFLDEMGIGYEMRVISAHRTPDIAKEYATSALDRG
CCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHCC
LKVIIAGAGKAAHLAGVLASFTPLPVIGVPVRTSTLGGADSLYSMVQMPSGVPVATVALN
EEEEEECCCCHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEC
GAKNAAILALQIMATGDRDKMDKMIEFKKRLKKETINKDKNLKNKMS
CCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHCCC
>Mature Secondary Structure 
PDKKVEVGIVMGSDSDLPVMEDAAKFLDEMGIGYEMRVISAHRTPDIAKEYATSALDRG
CCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHCC
LKVIIAGAGKAAHLAGVLASFTPLPVIGVPVRTSTLGGADSLYSMVQMPSGVPVATVALN
EEEEEECCCCHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEC
GAKNAAILALQIMATGDRDKMDKMIEFKKRLKKETINKDKNLKNKMS
CCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]