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The map label for this gene is prsA [H]

Identifier: 220932946

GI number: 220932946

Start: 2295158

End: 2296156

Strand: Reverse

Name: prsA [H]

Synonym: Hore_21140

Alternate gene names: 220932946

Gene position: 2296156-2295158 (Counterclockwise)

Preceding gene: 220932947

Following gene: 220932945

Centisome position: 89.06

GC content: 36.14

Gene sequence:

>999_bases
ATGAGGTTTAGGAGAAGTGTTTTTTTATTTCTGGCTTTAGTATTAGTTATATCTTTTTCAGTGCTGGCAGAGGATAAAGT
AGAAAAGACAGACAATATTGCAGCAGTAGTTGATGGTAAGGAAATTACGATTTCTGAAGTTGATGAATATGCCCGGACCC
GGGATGTTATTATGCAATTATATCAGGCTAATGGTGAGTTTACTCAGTTGATTTTATCTACAGAGGCTGGTAATGAGTTA
ATTAATGAGTACCGTAAACTTAAACTGGATGAATTGATTACCAGGGAACTTTTAATAAAGGAAGCCAAAAATCAGGGGAT
CAATGTTTCCAAAGAGGAAATGGATAAGATATTTAATGAGCAGATAGAAATGGTTAAACAGAAGAATAATATTAACGAAG
AGCAGTTACTTCAGGCTTTAAATCAGCAGGGAATTGAATCCCTTGATCAATATAAAAACCTCTTTTTTGAACAAAATGGT
GACCTCCTTTTAATTAATAAGTTACGGGAAAAGGTTATGGAAGATGTTAGTGTAGAGGAATCTGCTGTCAGAGAATATTA
CGATAATAACAAGGAAAACTTTAAACATGGAACCCAGATTAAGGCCAGACATATTTTAGTTGAAACTGAAAAAGAAGCCC
GGGAGATATTAAATGAGCTGGAAAATGGGGCTGATTTTGGGGAAATGGCCAAAGAGTATTCTACTGGTCCTTCCAGTAAA
AATGGAGGGGATTTAGGTTATTTTGGCAAGGGGCGTATGGTCCCGGAATTTGAAGAGGCTGCTTTTGCCCTCAAGGTTGG
GCAGATAAGTGACCCGGTCAAAACCCAGTACGGCTACCATATTATAAAAGTAGAAGATAAAGTTGAAGAGGGAATTACTC
CTTTTGATGAGGTAAAAGATAAGATTAAAAATAACCTCCTTCAACAAAAACAACAGACAGCCTGGAATAACTTCCTGAAG
GAATTAAGGGATAAAGCTGAAATTGAAATTAAATTATAG

Upstream 100 bases:

>100_bases
AAATTTTGGTAGGCAGGCAGGTATTTCAGTAATGATATAGAATTATAAAAGAGAGCTAATTAAAGACTAAAAGTTAAGTT
AAAGGAGAGTTGATAAGTTT

Downstream 100 bases:

>100_bases
GTCTGGCATGAGTGCAATAAAATTAATCCCCACCCACTTTTTGGGTTGGGGATTAATTTTTTTTTCTCTTAAAACAGGCA
GTTGCATATTTACTTTTAAA

Product: peptidil-prolyl cis-trans isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MRFRRSVFLFLALVLVISFSVLAEDKVEKTDNIAAVVDGKEITISEVDEYARTRDVIMQLYQANGEFTQLILSTEAGNEL
INEYRKLKLDELITRELLIKEAKNQGINVSKEEMDKIFNEQIEMVKQKNNINEEQLLQALNQQGIESLDQYKNLFFEQNG
DLLLINKLREKVMEDVSVEESAVREYYDNNKENFKHGTQIKARHILVETEKEAREILNELENGADFGEMAKEYSTGPSSK
NGGDLGYFGKGRMVPEFEEAAFALKVGQISDPVKTQYGYHIIKVEDKVEEGITPFDEVKDKIKNNLLQQKQQTAWNNFLK
ELRDKAEIEIKL

Sequences:

>Translated_332_residues
MRFRRSVFLFLALVLVISFSVLAEDKVEKTDNIAAVVDGKEITISEVDEYARTRDVIMQLYQANGEFTQLILSTEAGNEL
INEYRKLKLDELITRELLIKEAKNQGINVSKEEMDKIFNEQIEMVKQKNNINEEQLLQALNQQGIESLDQYKNLFFEQNG
DLLLINKLREKVMEDVSVEESAVREYYDNNKENFKHGTQIKARHILVETEKEAREILNELENGADFGEMAKEYSTGPSSK
NGGDLGYFGKGRMVPEFEEAAFALKVGQISDPVKTQYGYHIIKVEDKVEEGITPFDEVKDKIKNNLLQQKQQTAWNNFLK
ELRDKAEIEIKL
>Mature_332_residues
MRFRRSVFLFLALVLVISFSVLAEDKVEKTDNIAAVVDGKEITISEVDEYARTRDVIMQLYQANGEFTQLILSTEAGNEL
INEYRKLKLDELITRELLIKEAKNQGINVSKEEMDKIFNEQIEMVKQKNNINEEQLLQALNQQGIESLDQYKNLFFEQNG
DLLLINKLREKVMEDVSVEESAVREYYDNNKENFKHGTQIKARHILVETEKEAREILNELENGADFGEMAKEYSTGPSSK
NGGDLGYFGKGRMVPEFEEAAFALKVGQISDPVKTQYGYHIIKVEDKVEEGITPFDEVKDKIKNNLLQQKQQTAWNNFLK
ELRDKAEIEIKL

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Homo sapiens, GI38679892, Length=97, Percent_Identity=43.298969072165, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1790211, Length=83, Percent_Identity=53.0120481927711, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786645, Length=161, Percent_Identity=29.8136645962733, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1786238, Length=212, Percent_Identity=25, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17537235, Length=103, Percent_Identity=42.7184466019417, Blast_Score=81, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6322478, Length=58, Percent_Identity=56.8965517241379, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21356303, Length=99, Percent_Identity=42.4242424242424, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 38287; Mature: 38287

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFRRSVFLFLALVLVISFSVLAEDKVEKTDNIAAVVDGKEITISEVDEYARTRDVIMQL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEHHHHHHHHHHHHHHHHH
YQANGEFTQLILSTEAGNELINEYRKLKLDELITRELLIKEAKNQGINVSKEEMDKIFNE
HHCCCHHHHHEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
QIEMVKQKNNINEEQLLQALNQQGIESLDQYKNLFFEQNGDLLLINKLREKVMEDVSVEE
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCHHH
SAVREYYDNNKENFKHGTQIKARHILVETEKEAREILNELENGADFGEMAKEYSTGPSSK
HHHHHHHHCCHHHHCCCCCHHHHHHEEECHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCC
NGGDLGYFGKGRMVPEFEEAAFALKVGQISDPVKTQYGYHIIKVEDKVEEGITPFDEVKD
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHCCEEEEEECCHHHHCCCCHHHHHH
KIKNNLLQQKQQTAWNNFLKELRDKAEIEIKL
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEC
>Mature Secondary Structure
MRFRRSVFLFLALVLVISFSVLAEDKVEKTDNIAAVVDGKEITISEVDEYARTRDVIMQL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEHHHHHHHHHHHHHHHHH
YQANGEFTQLILSTEAGNELINEYRKLKLDELITRELLIKEAKNQGINVSKEEMDKIFNE
HHCCCHHHHHEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
QIEMVKQKNNINEEQLLQALNQQGIESLDQYKNLFFEQNGDLLLINKLREKVMEDVSVEE
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCHHH
SAVREYYDNNKENFKHGTQIKARHILVETEKEAREILNELENGADFGEMAKEYSTGPSSK
HHHHHHHHCCHHHHCCCCCHHHHHHEEECHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCC
NGGDLGYFGKGRMVPEFEEAAFALKVGQISDPVKTQYGYHIIKVEDKVEEGITPFDEVKD
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHCCEEEEEECCHHHHCCCCHHHHHH
KIKNNLLQQKQQTAWNNFLKELRDKAEIEIKL
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]