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The map label for this gene is ald [H]

Identifier: 220932945

GI number: 220932945

Start: 2293797

End: 2294822

Strand: Reverse

Name: ald [H]

Synonym: Hore_21130

Alternate gene names: 220932945

Gene position: 2294822-2293797 (Counterclockwise)

Preceding gene: 220932946

Following gene: 220932944

Centisome position: 89.01

GC content: 45.03

Gene sequence:

>1026_bases
GTGATTATAGAGCAGGGAGCAGGCCTGGGTAGTGGGATTAAAGATAGTGAGTATGAAGAGGCCGGAGCAGAAATAGGGGA
AACTGCCCAGCAGGTCTTCGAAGAAGCAGAAATGATTATGAAAGTTAAAGAACCCCTTCCCGAAGAATATAATTATTTAA
AACCCGACCAGATCCTGTTTACTTATCTTCATTTAGCTGCTGAAGAACGCTTAACAAAGGCTCTTATGGAAAAAAGGGTA
GTAGGTATTGCCTATGAGACTATTCAGCTTAATGATGGCTCCTTACCTTTATTAACCCCCATGAGTGAAGTGGCAGGTAG
GCTGGCTACCCAGGTGGGAGCTCATTTCCTGGAAAAGGCCCATGGTGGAAAGGGATTATTACTGGGTGGAGTACCCGGGG
TTAATCCCGGTAAGGTTGTTATTATAGGAGGAGGAACGGTTGGAATTAATGCTGCCAAGATGGCCGTTGGATTGGGAGCT
GATGTTACTATTCTGGACATCAGTGCTCCCCAGCTGAGATATGTTGATGATATTTTCAGGGGACGGGTAAAAACAGTTAT
GTCCAATGCATATAATATAGAAAGGGAAATTAAAGATGCCGACCTGGTAGTTGGTGGTGTCCTCATTCCCGGAGCTAAAG
CTCCGCATCTGGTGACAGAAGAGATGATAAAACAGATGAAGAAGGGGTCTGTTATCGTAGATGTGGCTATTGACCAGGGG
GGATGTGTGGAGACAACTTATCCAACGACCCATGATGACCCGGTCTTTGAAAAACATGGCGTTATTCACTACTCTGTTGC
CAATATGCCAGGGGCAGTGCCAATGACTTCAACATATGCCCTGACCAATGTAACCCTTCCCTATGCCCTGGAACTGGCCA
ACAAAGGATATAAAAAGGCCCTCAAAGAAAACCGGGCCCTGGCTTTAGGTTTAAATGTCTATGATGGTAAGATTATTTAT
AAAGCGGTTGCCGATGCTTTCTCCCTGGATCATTATCCATTAGACAGGGTATTAAAGGGCTTTTAG

Upstream 100 bases:

>100_bases
GGCCTATGATAGTAGGAGTACTAAAGAAATTAAAAATAATGAGAACAGAGTAGCGATTACTGCCGCCGGAGTTCAGGCTT
TAACAAAAGCAGGTCATCAG

Downstream 100 bases:

>100_bases
AACAGATTAAAGACTGGTATTAACAAAGGGGTCTTCCGGGCCCCTTTAAAAATGTATAATATTATACATTTGTGTATAAA
TATAAGCAATTTAATATTTA

Product: alanine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MIIEQGAGLGSGIKDSEYEEAGAEIGETAQQVFEEAEMIMKVKEPLPEEYNYLKPDQILFTYLHLAAEERLTKALMEKRV
VGIAYETIQLNDGSLPLLTPMSEVAGRLATQVGAHFLEKAHGGKGLLLGGVPGVNPGKVVIIGGGTVGINAAKMAVGLGA
DVTILDISAPQLRYVDDIFRGRVKTVMSNAYNIEREIKDADLVVGGVLIPGAKAPHLVTEEMIKQMKKGSVIVDVAIDQG
GCVETTYPTTHDDPVFEKHGVIHYSVANMPGAVPMTSTYALTNVTLPYALELANKGYKKALKENRALALGLNVYDGKIIY
KAVADAFSLDHYPLDRVLKGF

Sequences:

>Translated_341_residues
MIIEQGAGLGSGIKDSEYEEAGAEIGETAQQVFEEAEMIMKVKEPLPEEYNYLKPDQILFTYLHLAAEERLTKALMEKRV
VGIAYETIQLNDGSLPLLTPMSEVAGRLATQVGAHFLEKAHGGKGLLLGGVPGVNPGKVVIIGGGTVGINAAKMAVGLGA
DVTILDISAPQLRYVDDIFRGRVKTVMSNAYNIEREIKDADLVVGGVLIPGAKAPHLVTEEMIKQMKKGSVIVDVAIDQG
GCVETTYPTTHDDPVFEKHGVIHYSVANMPGAVPMTSTYALTNVTLPYALELANKGYKKALKENRALALGLNVYDGKIIY
KAVADAFSLDHYPLDRVLKGF
>Mature_341_residues
MIIEQGAGLGSGIKDSEYEEAGAEIGETAQQVFEEAEMIMKVKEPLPEEYNYLKPDQILFTYLHLAAEERLTKALMEKRV
VGIAYETIQLNDGSLPLLTPMSEVAGRLATQVGAHFLEKAHGGKGLLLGGVPGVNPGKVVIIGGGTVGINAAKMAVGLGA
DVTILDISAPQLRYVDDIFRGRVKTVMSNAYNIEREIKDADLVVGGVLIPGAKAPHLVTEEMIKQMKKGSVIVDVAIDQG
GCVETTYPTTHDDPVFEKHGVIHYSVANMPGAVPMTSTYALTNVTLPYALELANKGYKKALKENRALALGLNVYDGKIIY
KAVADAFSLDHYPLDRVLKGF

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=319, Percent_Identity=28.5266457680251, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI122939153, Length=319, Percent_Identity=28.5266457680251, Blast_Score=102, Evalue=6e-22,
Organism=Escherichia coli, GI1787887, Length=299, Percent_Identity=32.1070234113712, Blast_Score=116, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17550456, Length=346, Percent_Identity=29.1907514450867, Blast_Score=128, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 36681; Mature: 36681

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIEQGAGLGSGIKDSEYEEAGAEIGETAQQVFEEAEMIMKVKEPLPEEYNYLKPDQILF
CEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHH
TYLHLAAEERLTKALMEKRVVGIAYETIQLNDGSLPLLTPMSEVAGRLATQVGAHFLEKA
HHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCEECCHHHHHHHHHHHHHHHHHHHC
HGGKGLLLGGVPGVNPGKVVIIGGGTVGINAAKMAVGLGADVTILDISAPQLRYVDDIFR
CCCCEEEEECCCCCCCCEEEEECCCEECCCHHHHEEECCCCEEEEECCCCCHHHHHHHHH
GRVKTVMSNAYNIEREIKDADLVVGGVLIPGAKAPHLVTEEMIKQMKKGSVIVDVAIDQG
HHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEECCC
GCVETTYPTTHDDPVFEKHGVIHYSVANMPGAVPMTSTYALTNVTLPYALELANKGYKKA
CEEECCCCCCCCCCCHHHCCEEEEEECCCCCCCCCCCEEEEEECCHHHHHHHHCCHHHHH
LKENRALALGLNVYDGKIIYKAVADAFSLDHYPLDRVLKGF
HHCCCEEEEEEEEECCHHHHHHHHHHHCCCCCCHHHHHCCC
>Mature Secondary Structure
MIIEQGAGLGSGIKDSEYEEAGAEIGETAQQVFEEAEMIMKVKEPLPEEYNYLKPDQILF
CEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHH
TYLHLAAEERLTKALMEKRVVGIAYETIQLNDGSLPLLTPMSEVAGRLATQVGAHFLEKA
HHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCEECCHHHHHHHHHHHHHHHHHHHC
HGGKGLLLGGVPGVNPGKVVIIGGGTVGINAAKMAVGLGADVTILDISAPQLRYVDDIFR
CCCCEEEEECCCCCCCCEEEEECCCEECCCHHHHEEECCCCEEEEECCCCCHHHHHHHHH
GRVKTVMSNAYNIEREIKDADLVVGGVLIPGAKAPHLVTEEMIKQMKKGSVIVDVAIDQG
HHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEECCC
GCVETTYPTTHDDPVFEKHGVIHYSVANMPGAVPMTSTYALTNVTLPYALELANKGYKKA
CEEECCCCCCCCCCCHHHCCEEEEEECCCCCCCCCCCEEEEEECCHHHHHHHHCCHHHHH
LKENRALALGLNVYDGKIIYKAVADAFSLDHYPLDRVLKGF
HHCCCEEEEEEEEECCHHHHHHHHHHHCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA