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The map label for this gene is serS

Identifier: 220932938

GI number: 220932938

Start: 2285245

End: 2286513

Strand: Reverse

Name: serS

Synonym: Hore_21060

Alternate gene names: 220932938

Gene position: 2286513-2285245 (Counterclockwise)

Preceding gene: 220932939

Following gene: 220932937

Centisome position: 88.69

GC content: 43.66

Gene sequence:

>1269_bases
ATGTTAGATATGAAGTTCATCAGGGAAAATCTTGAAACCGTGGCTGATATGCTTAAAAGAAGAGGGACTGAAGCCCCCCT
CGATGAATTTAAGGAACTGGATGAGAAAAGGAGGGAAATTATTCAGGAAGTAGAACAGTTAAAACACAAACGGAATGTTG
TTTCCAGTAAAATTGGGGAGTTAAAAAGGGCCGGTGAAGATGCCAGTGATATTATTGCAGAGATGAAAGAGGTTTCGGCC
ACTATTAAGAAATATGATGAGGAATTAAGAGGGATAGAAGAGAGATTACAGCAGGTTGTTTTATCTATACCAAATATGCC
CCATGACAGCGTTCCTGTGGGAGAAGATGAAGATGATAATGTAGAGGTTCGGCGCTGGGGTGAACCCCGCAAGTTTGATT
TTGAGTTTAAACCCCACTGGGACCTTGGAGAAGCACTGGATATTCTCGACTTTGAAAGGGGTAGCAAGGTATCTGGAGCC
AGGTTTACCTTCCTTAAGGGAGCCGGTGCCCGTCTGGAAAGAAGCCTGATTAGTTTTATGATTGACCACCATACCCAAAA
TGGTTATACGGAGATATTTCCACCTTTTATGGTAAACAGTGATAGCTGTATCGGAACCGGACAGTTACCAAAATTTGCCG
GCGATATGTTTAAGGTTGAGGGAACCGATTATTACCTTATTCCAACAGCAGAAGTGCCTGTAACCAATCTTTACCGGGAT
GAAATATTGAATGCTGAAGACCTTCCAGTATATCATGTTGCTTACAGTGCCTGTTTCAGAGCAGAAGCCGGAGCCCATGG
ACGGGATACAAGGGGAATTATCAGACAGCATCAGTTTAATAAGGTAGAACTGGTTAAATTTGTTCATCCTGATAAATCTT
TTGAGGAATTAGAAAAGCTGACCCGTAATGCTGAGGAAATATTACAGATGCTAGAGCTTCCCTACCGGGTAGTTACTCTC
TGCACCGGTGATTTAACCTTCTCCTCGGCCAAAACCTATGATATTGAGGTCTGGATGCCGGCCTATGATACCTATCGGGA
GATTTCTTCCTGCAGTAACTTTAAAGACTTTCAGGCCAGGCGGGCTGGAATCAGATTCAGGCCTGAGCCAGGGGCTAAAG
CCGAGTATGTCCACACTCTGAATGGTTCGGGGCTTGCTATTGGCAGAACGGTGGCTGCCATTATGGAAAATTACCAGAAT
GAAGACGGGAGTATTACTGTACCTGAAGTGTTAAGACCCTATATGGGTATGGATGTAATTAAACCTTAA

Upstream 100 bases:

>100_bases
AGATTAGTTTAGCCATCAGGGTGGCACCGCGGAAATAATTAAACTTCCGTCCCTGTTCAGGGATGGAAGTTTTTTTGATT
TAAAAAAGGAGGGTGGTAAA

Downstream 100 bases:

>100_bases
CTTTAAACCTTAAAGTCAGTTAATATTATTACAGGCAGGAAATGAATATATTTTGACTTTAAACCAGCTCTGTTATAGAG
TAGAAATTGTGAGATAAGAA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MLDMKFIRENLETVADMLKRRGTEAPLDEFKELDEKRREIIQEVEQLKHKRNVVSSKIGELKRAGEDASDIIAEMKEVSA
TIKKYDEELRGIEERLQQVVLSIPNMPHDSVPVGEDEDDNVEVRRWGEPRKFDFEFKPHWDLGEALDILDFERGSKVSGA
RFTFLKGAGARLERSLISFMIDHHTQNGYTEIFPPFMVNSDSCIGTGQLPKFAGDMFKVEGTDYYLIPTAEVPVTNLYRD
EILNAEDLPVYHVAYSACFRAEAGAHGRDTRGIIRQHQFNKVELVKFVHPDKSFEELEKLTRNAEEILQMLELPYRVVTL
CTGDLTFSSAKTYDIEVWMPAYDTYREISSCSNFKDFQARRAGIRFRPEPGAKAEYVHTLNGSGLAIGRTVAAIMENYQN
EDGSITVPEVLRPYMGMDVIKP

Sequences:

>Translated_422_residues
MLDMKFIRENLETVADMLKRRGTEAPLDEFKELDEKRREIIQEVEQLKHKRNVVSSKIGELKRAGEDASDIIAEMKEVSA
TIKKYDEELRGIEERLQQVVLSIPNMPHDSVPVGEDEDDNVEVRRWGEPRKFDFEFKPHWDLGEALDILDFERGSKVSGA
RFTFLKGAGARLERSLISFMIDHHTQNGYTEIFPPFMVNSDSCIGTGQLPKFAGDMFKVEGTDYYLIPTAEVPVTNLYRD
EILNAEDLPVYHVAYSACFRAEAGAHGRDTRGIIRQHQFNKVELVKFVHPDKSFEELEKLTRNAEEILQMLELPYRVVTL
CTGDLTFSSAKTYDIEVWMPAYDTYREISSCSNFKDFQARRAGIRFRPEPGAKAEYVHTLNGSGLAIGRTVAAIMENYQN
EDGSITVPEVLRPYMGMDVIKP
>Mature_422_residues
MLDMKFIRENLETVADMLKRRGTEAPLDEFKELDEKRREIIQEVEQLKHKRNVVSSKIGELKRAGEDASDIIAEMKEVSA
TIKKYDEELRGIEERLQQVVLSIPNMPHDSVPVGEDEDDNVEVRRWGEPRKFDFEFKPHWDLGEALDILDFERGSKVSGA
RFTFLKGAGARLERSLISFMIDHHTQNGYTEIFPPFMVNSDSCIGTGQLPKFAGDMFKVEGTDYYLIPTAEVPVTNLYRD
EILNAEDLPVYHVAYSACFRAEAGAHGRDTRGIIRQHQFNKVELVKFVHPDKSFEELEKLTRNAEEILQMLELPYRVVTL
CTGDLTFSSAKTYDIEVWMPAYDTYREISSCSNFKDFQARRAGIRFRPEPGAKAEYVHTLNGSGLAIGRTVAAIMENYQN
EDGSITVPEVLRPYMGMDVIKP

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=460, Percent_Identity=35.6521739130435, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI8923421, Length=397, Percent_Identity=31.4861460957179, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI225579074, Length=335, Percent_Identity=34.6268656716418, Blast_Score=196, Evalue=4e-50,
Organism=Escherichia coli, GI1787120, Length=429, Percent_Identity=50.8158508158508, Blast_Score=450, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI17539260, Length=434, Percent_Identity=32.7188940092166, Blast_Score=227, Evalue=8e-60,
Organism=Caenorhabditis elegans, GI17542084, Length=391, Percent_Identity=28.1329923273657, Blast_Score=146, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6320226, Length=394, Percent_Identity=35.7868020304569, Blast_Score=243, Evalue=5e-65,
Organism=Saccharomyces cerevisiae, GI6321799, Length=410, Percent_Identity=31.4634146341463, Blast_Score=213, Evalue=6e-56,
Organism=Drosophila melanogaster, GI24581334, Length=427, Percent_Identity=34.192037470726, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI17737985, Length=380, Percent_Identity=30.2631578947368, Blast_Score=156, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_HALOH (B8CZZ9)

Other databases:

- EMBL:   CP001098
- RefSeq:   YP_002509846.1
- ProteinModelPortal:   B8CZZ9
- SMR:   B8CZZ9
- GeneID:   7313340
- GenomeReviews:   CP001098_GR
- KEGG:   hor:Hore_21060
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- ProtClustDB:   CLSK2806603
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48248; Mature: 48248

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 283-283 BINDING 383-383

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDMKFIRENLETVADMLKRRGTEAPLDEFKELDEKRREIIQEVEQLKHKRNVVSSKIGE
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKRAGEDASDIIAEMKEVSATIKKYDEELRGIEERLQQVVLSIPNMPHDSVPVGEDEDDN
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VEVRRWGEPRKFDFEFKPHWDLGEALDILDFERGSKVSGARFTFLKGAGARLERSLISFM
EEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHH
IDHHTQNGYTEIFPPFMVNSDSCIGTGQLPKFAGDMFKVEGTDYYLIPTAEVPVTNLYRD
HHHCCCCCCCCCCCCEEECCCCCCCCCCCCHHCCCEEEECCCCEEEEECCCCCHHHHHHH
EILNAEDLPVYHVAYSACFRAEAGAHGRDTRGIIRQHQFNKVELVKFVHPDKSFEELEKL
HHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCHHHHHHH
TRNAEEILQMLELPYRVVTLCTGDLTFSSAKTYDIEVWMPAYDTYREISSCSNFKDFQAR
HHCHHHHHHHHHCCHHEEHEEECCCEECCCCEEEEEEEECCHHHHHHHHHHCCCHHHHHH
RAGIRFRPEPGAKAEYVHTLNGSGLAIGRTVAAIMENYQNEDGSITVPEVLRPYMGMDVI
HCCCEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHCCCCC
KP
CC
>Mature Secondary Structure
MLDMKFIRENLETVADMLKRRGTEAPLDEFKELDEKRREIIQEVEQLKHKRNVVSSKIGE
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKRAGEDASDIIAEMKEVSATIKKYDEELRGIEERLQQVVLSIPNMPHDSVPVGEDEDDN
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VEVRRWGEPRKFDFEFKPHWDLGEALDILDFERGSKVSGARFTFLKGAGARLERSLISFM
EEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHH
IDHHTQNGYTEIFPPFMVNSDSCIGTGQLPKFAGDMFKVEGTDYYLIPTAEVPVTNLYRD
HHHCCCCCCCCCCCCEEECCCCCCCCCCCCHHCCCEEEECCCCEEEEECCCCCHHHHHHH
EILNAEDLPVYHVAYSACFRAEAGAHGRDTRGIIRQHQFNKVELVKFVHPDKSFEELEKL
HHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCHHHHHHH
TRNAEEILQMLELPYRVVTLCTGDLTFSSAKTYDIEVWMPAYDTYREISSCSNFKDFQAR
HHCHHHHHHHHHCCHHEEHEEECCCEECCCCEEEEEEEECCHHHHHHHHHHCCCHHHHHH
RAGIRFRPEPGAKAEYVHTLNGSGLAIGRTVAAIMENYQNEDGSITVPEVLRPYMGMDVI
HCCCEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHCCCCC
KP
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA