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The map label for this gene is tlpA [H]

Identifier: 220932931

GI number: 220932931

Start: 2273613

End: 2275577

Strand: Reverse

Name: tlpA [H]

Synonym: Hore_20990

Alternate gene names: 220932931

Gene position: 2275577-2273613 (Counterclockwise)

Preceding gene: 220932933

Following gene: 220932930

Centisome position: 88.26

GC content: 41.42

Gene sequence:

>1965_bases
ATGAATCTAAATAAGAAATTCAAGGTAAAATTAATGCTATTTATTATTGTATTAATGCTTATACCAATGGCTATTTTCGG
GTACATATCTGTTACTGAAAAGATAGACATCCTGGAAGACAGGACATATAATACCAATATGCAACTCGCCGAAAGCCTGG
CTAAAGAGGTTGTTAATGTTGTCAAGACCAGTGAAGATATTATAAAGATAGTGTCAAAAACAGATGCTGTTAAAAGTATG
GACCCGGAATTAATGGAAGATATTTTAATGAAAACAGTCAACGAAAATGAGTATTTAGCCAATGTATATGTAATGGATAA
GACAGGAATGCAAATATTTAAGACAGAAGGTTCACTCGGAAACAGGTCTGATAGAAGTTATTTTCAGAAGGCTATCAGGG
GCGAGAGTGATTTCTCTGAGGTTATGATATCCCGCAGCCGGGGTGTTCCGATAGTTGTATACGCCCGTCCGATTACAAAT
AATGGGGAGATAGTGGGAGTTATTGGAGCCAGTGTTGAGCTCGGTATCTTAAGTGAAATTGCCTCCCAGGTAACTCCAGG
TGAAAATGGATATGGTTTTATTGTTGAAAACACTGGAAAGATAATTGGCCATCCTGATCAAAAATTTGCCGAAGATATGT
ATGATGCCTCTGAATTAGAACCGGTTAAAAATGTTATTAAGGGTAAAAAAGATGTCGGGGAATATACTTATGAAGGGGAA
GATAAACTTGCTGCTTATGTCCCTATTGAAAGGACAGGCTGGGGTACAGTTGTCCAGTTACCGGCTGATGAGGCTTTTTC
TGAGGTGGGTACTGCAATCCGTTCTTCATTAACTATAATTGCTGTAGCCATTTTGGTTGGAGCAATAGCGGCGTATTTAA
TGGCCCGTTTTATAACAACCCCGGTTCTGGAAGCTGTAAAATTTGCCAGTCAGATCGAGAAGGGAAACCTTAAGCTTGAT
ACCCTGAAAGTTAAGAGCGGGGATGAAATCGGACAGCTTTCCCGGGCCTTAAACAATATGTATAAAGGGTTAAAGAATAT
TATTTTAAAAATTATGGATATTTCAGAACAGCTGGCTTCATCCAGTGAGGAGCTTTCCGCTTCAGGTGACCAGGTTGGGG
AAACTGCCGGGCAGGTAGGAAGTGCTATCCAGAATGTGGCCTCCGGGGCCGAAGAACAGAGTGCCCAGATTGAAGAGGTA
AACAATAAGATGAATGACCTGAAGAACCTTGTCGACAGGATGGAAAAAATGTCATTTAGTATGAAGGATGCCTCAGATGA
GGTTGTTTTAAGTATAAACAAAGGTAATGAATCTGTTTCTGAAGCCATTGATAAGGCCAATAATGTAAAGGATACGTCCC
TTGAAGTTGCTCAACTGATTAATAAACTTGGTAAATTTTCAGAGGAAATAGGAAATATTGTAGAATTAATTAATGGTATT
TCAGCCCAGACTAATTTACTTGCTTTAAATGCTGCTATTGAAGCAGCCCGGGCTGGAGAAGCCGGCCGGGGTTTCAGTGT
TGTAGCTGAAGAAATCAGAGAGCTGGCTGAAGAATCCGGGGAGGCTACTGAAAAGATATCAAATATAATTGGCCAGATAA
GGGATAGTGTCGCCGAGGCTGTCAACAAAATGGAGGAGAGTGCCCGGGTAGTAGATGACAATGTTGCTACCATAGAACAG
ACCGGTAAGGCCTTTAACGAAATTGAGGGGTCTGCCGATAAACTTAATCAGTTTATTGAGACTGTAGCTAAAAATGCTAC
CGAAGTTACTACCATTAGTCAGCAGGTCAGTGAGGCTATAGATGATGTAGCTGCTGTAAGCCAGGAAGCTGCCGGCAATT
CAGAAGAAGTTGCTGCCTCCAGTGAAGAACAGATTGCGGCTACTGAGGAGATTGTGTCCGGGGCTAAACGACTGGCAGAC
CTGGCAGAAGATTTAGCCGAGGCCGTAAGTCAGTTTGATGTTTAA

Upstream 100 bases:

>100_bases
ATTTATCAGGACTATAAATATATTGAAATTATTACAGTATACAGAAAATTATATGCAGTATAAATTAAAAAATATTTTAG
TTACATAGGAGGGATAATAT

Downstream 100 bases:

>100_bases
TTTAAAATAGTATAATTTCAGTATCCAGAGAAAGATACACAGGGCTTTTGCCCTGTGTTTTTTAATGTACAGACATTTTA
CACCAGTGTTTATTATAATG

Product: methyl-accepting chemotaxis sensory transducer

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 654; Mature: 654

Protein sequence:

>654_residues
MNLNKKFKVKLMLFIIVLMLIPMAIFGYISVTEKIDILEDRTYNTNMQLAESLAKEVVNVVKTSEDIIKIVSKTDAVKSM
DPELMEDILMKTVNENEYLANVYVMDKTGMQIFKTEGSLGNRSDRSYFQKAIRGESDFSEVMISRSRGVPIVVYARPITN
NGEIVGVIGASVELGILSEIASQVTPGENGYGFIVENTGKIIGHPDQKFAEDMYDASELEPVKNVIKGKKDVGEYTYEGE
DKLAAYVPIERTGWGTVVQLPADEAFSEVGTAIRSSLTIIAVAILVGAIAAYLMARFITTPVLEAVKFASQIEKGNLKLD
TLKVKSGDEIGQLSRALNNMYKGLKNIILKIMDISEQLASSSEELSASGDQVGETAGQVGSAIQNVASGAEEQSAQIEEV
NNKMNDLKNLVDRMEKMSFSMKDASDEVVLSINKGNESVSEAIDKANNVKDTSLEVAQLINKLGKFSEEIGNIVELINGI
SAQTNLLALNAAIEAARAGEAGRGFSVVAEEIRELAEESGEATEKISNIIGQIRDSVAEAVNKMEESARVVDDNVATIEQ
TGKAFNEIEGSADKLNQFIETVAKNATEVTTISQQVSEAIDDVAAVSQEAAGNSEEVAASSEEQIAATEEIVSGAKRLAD
LAEDLAEAVSQFDV

Sequences:

>Translated_654_residues
MNLNKKFKVKLMLFIIVLMLIPMAIFGYISVTEKIDILEDRTYNTNMQLAESLAKEVVNVVKTSEDIIKIVSKTDAVKSM
DPELMEDILMKTVNENEYLANVYVMDKTGMQIFKTEGSLGNRSDRSYFQKAIRGESDFSEVMISRSRGVPIVVYARPITN
NGEIVGVIGASVELGILSEIASQVTPGENGYGFIVENTGKIIGHPDQKFAEDMYDASELEPVKNVIKGKKDVGEYTYEGE
DKLAAYVPIERTGWGTVVQLPADEAFSEVGTAIRSSLTIIAVAILVGAIAAYLMARFITTPVLEAVKFASQIEKGNLKLD
TLKVKSGDEIGQLSRALNNMYKGLKNIILKIMDISEQLASSSEELSASGDQVGETAGQVGSAIQNVASGAEEQSAQIEEV
NNKMNDLKNLVDRMEKMSFSMKDASDEVVLSINKGNESVSEAIDKANNVKDTSLEVAQLINKLGKFSEEIGNIVELINGI
SAQTNLLALNAAIEAARAGEAGRGFSVVAEEIRELAEESGEATEKISNIIGQIRDSVAEAVNKMEESARVVDDNVATIEQ
TGKAFNEIEGSADKLNQFIETVAKNATEVTTISQQVSEAIDDVAAVSQEAAGNSEEVAASSEEQIAATEEIVSGAKRLAD
LAEDLAEAVSQFDV
>Mature_654_residues
MNLNKKFKVKLMLFIIVLMLIPMAIFGYISVTEKIDILEDRTYNTNMQLAESLAKEVVNVVKTSEDIIKIVSKTDAVKSM
DPELMEDILMKTVNENEYLANVYVMDKTGMQIFKTEGSLGNRSDRSYFQKAIRGESDFSEVMISRSRGVPIVVYARPITN
NGEIVGVIGASVELGILSEIASQVTPGENGYGFIVENTGKIIGHPDQKFAEDMYDASELEPVKNVIKGKKDVGEYTYEGE
DKLAAYVPIERTGWGTVVQLPADEAFSEVGTAIRSSLTIIAVAILVGAIAAYLMARFITTPVLEAVKFASQIEKGNLKLD
TLKVKSGDEIGQLSRALNNMYKGLKNIILKIMDISEQLASSSEELSASGDQVGETAGQVGSAIQNVASGAEEQSAQIEEV
NNKMNDLKNLVDRMEKMSFSMKDASDEVVLSINKGNESVSEAIDKANNVKDTSLEVAQLINKLGKFSEEIGNIVELINGI
SAQTNLLALNAAIEAARAGEAGRGFSVVAEEIRELAEESGEATEKISNIIGQIRDSVAEAVNKMEESARVVDDNVATIEQ
TGKAFNEIEGSADKLNQFIETVAKNATEVTTISQQVSEAIDDVAAVSQEAAGNSEEVAASSEEQIAATEEIVSGAKRLAD
LAEDLAEAVSQFDV

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1787690, Length=357, Percent_Identity=29.9719887955182, Blast_Score=115, Evalue=1e-26,
Organism=Escherichia coli, GI1788195, Length=320, Percent_Identity=26.875, Blast_Score=109, Evalue=6e-25,
Organism=Escherichia coli, GI1789453, Length=472, Percent_Identity=24.5762711864407, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788194, Length=254, Percent_Identity=27.5590551181102, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI2367378, Length=327, Percent_Identity=27.82874617737, Blast_Score=97, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 70613; Mature: 70613

Theoretical pI: Translated: 4.21; Mature: 4.21

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLNKKFKVKLMLFIIVLMLIPMAIFGYISVTEKIDILEDRTYNTNMQLAESLAKEVVNV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
VKTSEDIIKIVSKTDAVKSMDPELMEDILMKTVNENEYLANVYVMDKTGMQIFKTEGSLG
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEEEEECCCCEEEECCCCCC
NRSDRSYFQKAIRGESDFSEVMISRSRGVPIVVYARPITNNGEIVGVIGASVELGILSEI
CCCHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEECCCHHHHHHHHH
ASQVTPGENGYGFIVENTGKIIGHPDQKFAEDMYDASELEPVKNVIKGKKDVGEYTYEGE
HHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHCCHHHHHHHHHHHCCCHHHCCCCCCCC
DKLAAYVPIERTGWGTVVQLPADEAFSEVGTAIRSSLTIIAVAILVGAIAAYLMARFITT
CCEEEEECCEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PVLEAVKFASQIEKGNLKLDTLKVKSGDEIGQLSRALNNMYKGLKNIILKIMDISEQLAS
HHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SSEELSASGDQVGETAGQVGSAIQNVASGAEEQSAQIEEVNNKMNDLKNLVDRMEKMSFS
CHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKDASDEVVLSINKGNESVSEAIDKANNVKDTSLEVAQLINKLGKFSEEIGNIVELINGI
HCCCCCCEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SAQTNLLALNAAIEAARAGEAGRGFSVVAEEIRELAEESGEATEKISNIIGQIRDSVAEA
CCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
VNKMEESARVVDDNVATIEQTGKAFNEIEGSADKLNQFIETVAKNATEVTTISQQVSEAI
HHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
DDVAAVSQEAAGNSEEVAASSEEQIAATEEIVSGAKRLADLAEDLAEAVSQFDV
HHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNLNKKFKVKLMLFIIVLMLIPMAIFGYISVTEKIDILEDRTYNTNMQLAESLAKEVVNV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
VKTSEDIIKIVSKTDAVKSMDPELMEDILMKTVNENEYLANVYVMDKTGMQIFKTEGSLG
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEEEEECCCCEEEECCCCCC
NRSDRSYFQKAIRGESDFSEVMISRSRGVPIVVYARPITNNGEIVGVIGASVELGILSEI
CCCHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEECCCHHHHHHHHH
ASQVTPGENGYGFIVENTGKIIGHPDQKFAEDMYDASELEPVKNVIKGKKDVGEYTYEGE
HHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHCCHHHHHHHHHHHCCCHHHCCCCCCCC
DKLAAYVPIERTGWGTVVQLPADEAFSEVGTAIRSSLTIIAVAILVGAIAAYLMARFITT
CCEEEEECCEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PVLEAVKFASQIEKGNLKLDTLKVKSGDEIGQLSRALNNMYKGLKNIILKIMDISEQLAS
HHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SSEELSASGDQVGETAGQVGSAIQNVASGAEEQSAQIEEVNNKMNDLKNLVDRMEKMSFS
CHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKDASDEVVLSINKGNESVSEAIDKANNVKDTSLEVAQLINKLGKFSEEIGNIVELINGI
HCCCCCCEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SAQTNLLALNAAIEAARAGEAGRGFSVVAEEIRELAEESGEATEKISNIIGQIRDSVAEA
CCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
VNKMEESARVVDDNVATIEQTGKAFNEIEGSADKLNQFIETVAKNATEVTTISQQVSEAI
HHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
DDVAAVSQEAAGNSEEVAASSEEQIAATEEIVSGAKRLADLAEDLAEAVSQFDV
HHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]