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The map label for this gene is guaB [H]

Identifier: 220932880

GI number: 220932880

Start: 2209844

End: 2211304

Strand: Reverse

Name: guaB [H]

Synonym: Hore_20480

Alternate gene names: 220932880

Gene position: 2211304-2209844 (Counterclockwise)

Preceding gene: 220932881

Following gene: 220932879

Centisome position: 85.77

GC content: 42.57

Gene sequence:

>1461_bases
GTGCATAAACTGGTTAAAGAGGGATTGACTTTTGATGATGTTCTACTGATTCCGGCCAGGTCTGAAGTTTTGCCCCGTGA
TGTTGAGACCAGGACCAGGCTAACAAAGAATATTAACCTCAATATACCGATAATGAGTGCCGGTATGGATACAGTTACTG
AGGCCAGATTGGCCATTGCTATGGCAAGACAGGGTGGTATCGGTATAATCCATAAGAATATGAGTATTGGGAGACAGGCT
GAGGAAGTAGATCGGGTTAAAAGGTCTGAAAGTGGTGTTATTGTAGACCCCTTTTATTTAAAACCAGATAATTTAATCGT
TGAAGCCGAGGCATTGATGTCCAAGTTTAAAATATCAGGGGTACCTATTGTTGATGAGAATAGAAAACTGGTAGGGATTA
TAACCAACCGTGATTTGCGATTCGTTAAAGACTATAATCGACCCATCCATGAGGTTATGACAGATGAAGACCTGGTTACA
GCTCCAGTGGGAACCACCATCGAACAGGCCAAGGAGATTCTCCAGGAGCATAAAATTGAAAAACTACCTCTGGTGGATGA
AAATAATATCCTTAAAGGTTTAATAACAATTAAAGATATTGAAAAAGCAGAAGAATTTCCCCATGCTGCCAAAGATGAAA
GAGGAAGGTTAATAGTAGGAGCTGCCGTGGGTATCAGTGACGATACTGATGACAGAGTCGCAGCCCTTGTTAAAGCAGGG
GTTGATGTTATTGTTATTGATACTGCCCATGGTCATTCCGTTGGTGTCTTAAAGACAGTAGAAAGAATTAAAGGAAATTA
CCCAGATGTACCTGTAATTGCAGGTAATGTGGCTACAGCAGAAGCAACTGAAGATTTAATTAAAGCTGGTGCAGATGTAG
TCAAAGTAGGGGTAGGACCTGGCTCTATCTGTACAACCCGTGTTATTGCCGGGGTTGGTGTACCGCAGATTACTGCAATT
TATGATTGTGCTGAAAAAGCCAAAGAATATGGTATTCCTGTGATTGCTGATGGTGGTATCAAATATTCGGGTGATATTGT
TAAGGCCCTGGTAGCCGGGGCAGATGTTGTTATGATTGGAAGTCTTTTAGCCGGTACTGAAGAAAGCCCTGGAGAACTTG
AGATATATAAAGGCAGGAGTTATAAGGTATACCGGGGTATGGGCTCCCTGGGGGCCATGCAGCAAGGTAGTAAAGACCGT
TATTTCCAGAATGAATCAGATGTTAAAAAACTGGTCCCTGAAGGTATAGAGGGACGCGTCCCCTATCGTGGGCCTTTATC
TGAAACCATTTATCAGTTAGTTGGAGGGCTCAGGGCCGGTATGGGTTATTGTGGTGCCAGAACCATATCTGAGCTACAGG
AAAAAGGCAAATTTGTTAGAATCACCAGTGCCGGTTTAAGAGAAAGCCATCCCCATGATGTAACTATAACTAAAGAAGCC
CCCAACTATTCTGTTAATTAA

Upstream 100 bases:

>100_bases
TTTTGAAATGGGAAATTTTAATACATGCGTTATATAACAGGTGCTTTTTGTAAATGTAATACCACTGTATCACCAAAATT
AAACCAAGGGGTGAGTAATA

Downstream 100 bases:

>100_bases
AGACTTTAAAGTTAAACAAGTTTGTTAACAGTGAGCCCCATCTTTTAAAAGATGGGGTTATTTTTATGCTCAGGAATAAT
ATCAGTAACCTGGTTATTAA

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MHKLVKEGLTFDDVLLIPARSEVLPRDVETRTRLTKNINLNIPIMSAGMDTVTEARLAIAMARQGGIGIIHKNMSIGRQA
EEVDRVKRSESGVIVDPFYLKPDNLIVEAEALMSKFKISGVPIVDENRKLVGIITNRDLRFVKDYNRPIHEVMTDEDLVT
APVGTTIEQAKEILQEHKIEKLPLVDENNILKGLITIKDIEKAEEFPHAAKDERGRLIVGAAVGISDDTDDRVAALVKAG
VDVIVIDTAHGHSVGVLKTVERIKGNYPDVPVIAGNVATAEATEDLIKAGADVVKVGVGPGSICTTRVIAGVGVPQITAI
YDCAEKAKEYGIPVIADGGIKYSGDIVKALVAGADVVMIGSLLAGTEESPGELEIYKGRSYKVYRGMGSLGAMQQGSKDR
YFQNESDVKKLVPEGIEGRVPYRGPLSETIYQLVGGLRAGMGYCGARTISELQEKGKFVRITSAGLRESHPHDVTITKEA
PNYSVN

Sequences:

>Translated_486_residues
MHKLVKEGLTFDDVLLIPARSEVLPRDVETRTRLTKNINLNIPIMSAGMDTVTEARLAIAMARQGGIGIIHKNMSIGRQA
EEVDRVKRSESGVIVDPFYLKPDNLIVEAEALMSKFKISGVPIVDENRKLVGIITNRDLRFVKDYNRPIHEVMTDEDLVT
APVGTTIEQAKEILQEHKIEKLPLVDENNILKGLITIKDIEKAEEFPHAAKDERGRLIVGAAVGISDDTDDRVAALVKAG
VDVIVIDTAHGHSVGVLKTVERIKGNYPDVPVIAGNVATAEATEDLIKAGADVVKVGVGPGSICTTRVIAGVGVPQITAI
YDCAEKAKEYGIPVIADGGIKYSGDIVKALVAGADVVMIGSLLAGTEESPGELEIYKGRSYKVYRGMGSLGAMQQGSKDR
YFQNESDVKKLVPEGIEGRVPYRGPLSETIYQLVGGLRAGMGYCGARTISELQEKGKFVRITSAGLRESHPHDVTITKEA
PNYSVN
>Mature_486_residues
MHKLVKEGLTFDDVLLIPARSEVLPRDVETRTRLTKNINLNIPIMSAGMDTVTEARLAIAMARQGGIGIIHKNMSIGRQA
EEVDRVKRSESGVIVDPFYLKPDNLIVEAEALMSKFKISGVPIVDENRKLVGIITNRDLRFVKDYNRPIHEVMTDEDLVT
APVGTTIEQAKEILQEHKIEKLPLVDENNILKGLITIKDIEKAEEFPHAAKDERGRLIVGAAVGISDDTDDRVAALVKAG
VDVIVIDTAHGHSVGVLKTVERIKGNYPDVPVIAGNVATAEATEDLIKAGADVVKVGVGPGSICTTRVIAGVGVPQITAI
YDCAEKAKEYGIPVIADGGIKYSGDIVKALVAGADVVMIGSLLAGTEESPGELEIYKGRSYKVYRGMGSLGAMQQGSKDR
YFQNESDVKKLVPEGIEGRVPYRGPLSETIYQLVGGLRAGMGYCGARTISELQEKGKFVRITSAGLRESHPHDVTITKEA
PNYSVN

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=481, Percent_Identity=41.1642411642412, Blast_Score=356, Evalue=2e-98,
Organism=Homo sapiens, GI217035146, Length=456, Percent_Identity=43.2017543859649, Blast_Score=353, Evalue=2e-97,
Organism=Homo sapiens, GI34328930, Length=456, Percent_Identity=43.2017543859649, Blast_Score=353, Evalue=3e-97,
Organism=Homo sapiens, GI156616279, Length=455, Percent_Identity=43.2967032967033, Blast_Score=352, Evalue=3e-97,
Organism=Homo sapiens, GI34328928, Length=455, Percent_Identity=43.2967032967033, Blast_Score=352, Evalue=3e-97,
Organism=Homo sapiens, GI217035152, Length=449, Percent_Identity=43.2071269487751, Blast_Score=345, Evalue=7e-95,
Organism=Homo sapiens, GI217035148, Length=456, Percent_Identity=42.5438596491228, Blast_Score=343, Evalue=3e-94,
Organism=Homo sapiens, GI217035150, Length=456, Percent_Identity=40.3508771929825, Blast_Score=318, Evalue=1e-86,
Organism=Homo sapiens, GI50541956, Length=263, Percent_Identity=37.2623574144487, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI50541954, Length=263, Percent_Identity=37.2623574144487, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI50541952, Length=263, Percent_Identity=37.2623574144487, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI50541948, Length=263, Percent_Identity=37.2623574144487, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI156104880, Length=224, Percent_Identity=40.1785714285714, Blast_Score=170, Evalue=2e-42,
Organism=Escherichia coli, GI1788855, Length=486, Percent_Identity=58.8477366255144, Blast_Score=532, Evalue=1e-152,
Organism=Escherichia coli, GI1786293, Length=221, Percent_Identity=39.3665158371041, Blast_Score=169, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI71994385, Length=475, Percent_Identity=38.7368421052632, Blast_Score=298, Evalue=5e-81,
Organism=Caenorhabditis elegans, GI71994389, Length=422, Percent_Identity=39.5734597156398, Blast_Score=275, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI17560440, Length=256, Percent_Identity=37.890625, Blast_Score=181, Evalue=8e-46,
Organism=Saccharomyces cerevisiae, GI6322012, Length=489, Percent_Identity=38.8548057259714, Blast_Score=341, Evalue=1e-94,
Organism=Saccharomyces cerevisiae, GI6323585, Length=464, Percent_Identity=39.8706896551724, Blast_Score=338, Evalue=2e-93,
Organism=Saccharomyces cerevisiae, GI6323464, Length=465, Percent_Identity=40.8602150537634, Blast_Score=336, Evalue=4e-93,
Organism=Saccharomyces cerevisiae, GI6319352, Length=345, Percent_Identity=39.4202898550725, Blast_Score=265, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6319353, Length=115, Percent_Identity=40.8695652173913, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24641071, Length=482, Percent_Identity=40.0414937759336, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI24641073, Length=482, Percent_Identity=40.0414937759336, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI28571163, Length=440, Percent_Identity=40.6818181818182, Blast_Score=306, Evalue=2e-83,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52523; Mature: 52523

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKLVKEGLTFDDVLLIPARSEVLPRDVETRTRLTKNINLNIPIMSAGMDTVTEARLAIA
CCCHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCEEEEEEEECCCHHHHHHHHHHH
MARQGGIGIIHKNMSIGRQAEEVDRVKRSESGVIVDPFYLKPDNLIVEAEALMSKFKISG
HHCCCCEEEEECCCCCCCHHHHHHHHHHCCCCEEEECEEECCCCEEEEHHHHHHHHHCCC
VPIVDENRKLVGIITNRDLRFVKDYNRPIHEVMTDEDLVTAPVGTTIEQAKEILQEHKIE
CCEECCCCEEEEEEECCCCHHHHHCCCCHHHHCCCCCEEECCCCCHHHHHHHHHHHCCCC
KLPLVDENNILKGLITIKDIEKAEEFPHAAKDERGRLIVGAAVGISDDTDDRVAALVKAG
CCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHCC
VDVIVIDTAHGHSVGVLKTVERIKGNYPDVPVIAGNVATAEATEDLIKAGADVVKVGVGP
CCEEEEECCCCCCHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHCCCCEEEECCCC
GSICTTRVIAGVGVPQITAIYDCAEKAKEYGIPVIADGGIKYSGDIVKALVAGADVVMIG
CHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECHHHHHHHHCCCCCEEHH
SLLAGTEESPGELEIYKGRSYKVYRGMGSLGAMQQGSKDRYFQNESDVKKLVPEGIEGRV
HHHCCCCCCCCCEEEEECCCEEEEECCCCCCHHCCCCCCCCCCCHHHHHHHCCCCCCCCC
PYRGPLSETIYQLVGGLRAGMGYCGARTISELQEKGKFVRITSAGLRESHPHDVTITKEA
CCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEECC
PNYSVN
CCCCCC
>Mature Secondary Structure
MHKLVKEGLTFDDVLLIPARSEVLPRDVETRTRLTKNINLNIPIMSAGMDTVTEARLAIA
CCCHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCEEEEEEEECCCHHHHHHHHHHH
MARQGGIGIIHKNMSIGRQAEEVDRVKRSESGVIVDPFYLKPDNLIVEAEALMSKFKISG
HHCCCCEEEEECCCCCCCHHHHHHHHHHCCCCEEEECEEECCCCEEEEHHHHHHHHHCCC
VPIVDENRKLVGIITNRDLRFVKDYNRPIHEVMTDEDLVTAPVGTTIEQAKEILQEHKIE
CCEECCCCEEEEEEECCCCHHHHHCCCCHHHHCCCCCEEECCCCCHHHHHHHHHHHCCCC
KLPLVDENNILKGLITIKDIEKAEEFPHAAKDERGRLIVGAAVGISDDTDDRVAALVKAG
CCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHCC
VDVIVIDTAHGHSVGVLKTVERIKGNYPDVPVIAGNVATAEATEDLIKAGADVVKVGVGP
CCEEEEECCCCCCHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHCCCCEEEECCCC
GSICTTRVIAGVGVPQITAIYDCAEKAKEYGIPVIADGGIKYSGDIVKALVAGADVVMIG
CHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECHHHHHHHHCCCCCEEHH
SLLAGTEESPGELEIYKGRSYKVYRGMGSLGAMQQGSKDRYFQNESDVKKLVPEGIEGRV
HHHCCCCCCCCCEEEEECCCEEEEECCCCCCHHCCCCCCCCCCCHHHHHHHCCCCCCCCC
PYRGPLSETIYQLVGGLRAGMGYCGARTISELQEKGKFVRITSAGLRESHPHDVTITKEA
CCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEECC
PNYSVN
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]