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The map label for this gene is tmk

Identifier: 220932870

GI number: 220932870

Start: 2197155

End: 2197778

Strand: Reverse

Name: tmk

Synonym: Hore_20380

Alternate gene names: 220932870

Gene position: 2197778-2197155 (Counterclockwise)

Preceding gene: 220932871

Following gene: 220932869

Centisome position: 85.25

GC content: 41.99

Gene sequence:

>624_bases
GTGAGAGGGTTATTTATTACCCTGGAAGGTATAGAGGGTTCCGGGAAATCTACTCAGATAGAAATGCTTTATAAGAGGTT
AAAAAAGGACGGTTTTGATGTTATTATAACCAGGGAGCCAGGTGGCACCCCAATTGGGAAAGAAATAAGGAAGCTTTTAT
TAGATCCTGATAACATTATGGGGGCTAAAGCTGAATTTTTATTATATGCTGCTGACAGGGCTCAGCATGTAGTAGAGCTG
ATAAAGCCAGCCCTGGAGAGTGGAAAGGTTGTCCTTGCTGATAGGTTTATCGATTCAAGTATTGCCTATCAGGGTTATGG
AAGAGGGCTCGATATAGATGTAGTTAAAACTGTAAATGAATGGGTAATTGATGGGTGCTGGCCTGACCTTACTTTTGTTC
TGGATCTGGATGTAGAGAAGGGATTAGAGAGAGCCAGGGGTTATTCTCCAGACAACCAGGGAGACAGGCTGGAAAGGGAA
TTAGTAACGTTTCATAGAAGGGTAAGACAGGCCTATCATCAGCTTGCAGAGGATAGGAGATTTATTATGCTGGATGCAGA
TCGTTCCCGTGAAGAAATACACCGGGAAATATATCATAAGGTAAAGGGGTGTTTAATTAAATGA

Upstream 100 bases:

>100_bases
CCTGGAATTGTTGATGGTTACCCCTTCAGTGGGGGATGAAAAAAGGATTTAAATAGATTTTGTAGAATATACACTATATA
ATACAGAAAGGAGAACAACA

Downstream 100 bases:

>100_bases
GAGAAGGGAGAAGCGAGAATATGAAAATGGTTATTGCGGTGGTTAATGACCATGATGCTCATGATTTAATAGATTAGTTA
ACTACAGCTGGCTATAAATT

Product: dTMP kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MRGLFITLEGIEGSGKSTQIEMLYKRLKKDGFDVIITREPGGTPIGKEIRKLLLDPDNIMGAKAEFLLYAADRAQHVVEL
IKPALESGKVVLADRFIDSSIAYQGYGRGLDIDVVKTVNEWVIDGCWPDLTFVLDLDVEKGLERARGYSPDNQGDRLERE
LVTFHRRVRQAYHQLAEDRRFIMLDADRSREEIHREIYHKVKGCLIK

Sequences:

>Translated_207_residues
MRGLFITLEGIEGSGKSTQIEMLYKRLKKDGFDVIITREPGGTPIGKEIRKLLLDPDNIMGAKAEFLLYAADRAQHVVEL
IKPALESGKVVLADRFIDSSIAYQGYGRGLDIDVVKTVNEWVIDGCWPDLTFVLDLDVEKGLERARGYSPDNQGDRLERE
LVTFHRRVRQAYHQLAEDRRFIMLDADRSREEIHREIYHKVKGCLIK
>Mature_207_residues
MRGLFITLEGIEGSGKSTQIEMLYKRLKKDGFDVIITREPGGTPIGKEIRKLLLDPDNIMGAKAEFLLYAADRAQHVVEL
IKPALESGKVVLADRFIDSSIAYQGYGRGLDIDVVKTVNEWVIDGCWPDLTFVLDLDVEKGLERARGYSPDNQGDRLERE
LVTFHRRVRQAYHQLAEDRRFIMLDADRSREEIHREIYHKVKGCLIK

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Homo sapiens, GI42544174, Length=200, Percent_Identity=30, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1787340, Length=207, Percent_Identity=39.1304347826087, Blast_Score=128, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6322517, Length=177, Percent_Identity=31.0734463276836, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_HALOH (B8CZT1)

Other databases:

- EMBL:   CP001098
- RefSeq:   YP_002509778.1
- ProteinModelPortal:   B8CZT1
- SMR:   B8CZT1
- GeneID:   7314362
- GenomeReviews:   CP001098_GR
- KEGG:   hor:Hore_20380
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- ProtClustDB:   CLSK2480635
- HAMAP:   MF_00165
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23701; Mature: 23701

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGLFITLEGIEGSGKSTQIEMLYKRLKKDGFDVIITREPGGTPIGKEIRKLLLDPDNIM
CCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCHHC
GAKAEFLLYAADRAQHVVELIKPALESGKVVLADRFIDSSIAYQGYGRGLDIDVVKTVNE
CCCHHEEEEEHHHHHHHHHHHHHHHHCCCEEEEEHHHCCHHHHCCCCCCCCHHHHHHHHH
WVIDGCWPDLTFVLDLDVEKGLERARGYSPDNQGDRLERELVTFHRRVRQAYHQLAEDRR
HHHCCCCCCEEEEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCE
FIMLDADRSREEIHREIYHKVKGCLIK
EEEEECCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRGLFITLEGIEGSGKSTQIEMLYKRLKKDGFDVIITREPGGTPIGKEIRKLLLDPDNIM
CCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCHHC
GAKAEFLLYAADRAQHVVELIKPALESGKVVLADRFIDSSIAYQGYGRGLDIDVVKTVNE
CCCHHEEEEEHHHHHHHHHHHHHHHHCCCEEEEEHHHCCHHHHCCCCCCCCHHHHHHHHH
WVIDGCWPDLTFVLDLDVEKGLERARGYSPDNQGDRLERELVTFHRRVRQAYHQLAEDRR
HHHCCCCCCEEEEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCE
FIMLDADRSREEIHREIYHKVKGCLIK
EEEEECCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA