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The map label for this gene is ltaE [H]

Identifier: 220932828

GI number: 220932828

Start: 2150575

End: 2151606

Strand: Reverse

Name: ltaE [H]

Synonym: Hore_19940

Alternate gene names: 220932828

Gene position: 2151606-2150575 (Counterclockwise)

Preceding gene: 220932829

Following gene: 220932825

Centisome position: 83.46

GC content: 45.06

Gene sequence:

>1032_bases
TTGAAGCTTAAAGTCGATTTATTCAGTGATACTGGAACCAGACCTTCTAAGGAAATGAGAGAATTTATGGCTAAAGCCGA
GGTTGGCGATGAGCAACTGGGGGAAGATCCATCTGTTAATCGCCTGAATGAAATGGTAGCAGAATTACTGGGAAAAGAAG
ACGCTATCTATTTACCATCGGGATTAATGGCCAATCAGATTTCCTTTGCCGTACACTGCCGGCCGGGTGATGAAATTATC
ATGGATAAAACAGCCCACCCCATTCATTTTGAGGGGGGAGCGGTCAGTGTTATCAGTGGTGCATCAATTAACCCTTTAGA
TGGTGAGAATGGTATATTTACCACTGAACAGGTTATAAAGGCCATCAGGACATCTGATTACCACCACCCCAGGACACGGC
TTATTTCCATTGAGCAGACTTCAAATCTGGGAGGAGGTACCATCTGGCCCCTGGATGTAATTGAAGATATTTGCCAGCTG
GCCCGGGAGCATAATCTAAAGACCCATATGGATGGAGCTCGTCTTTTAAATGCTGTTGCCGCTACCGGTATTCCAGCTTC
GAAGTATGCTGAACACTTTGATTCTATCTGGATTGATCTCAGTAAAGGGTTAGGGGCTCCGGTTGGTTCAGTACTGGCCA
GTTCCAGGGATTTTATAGAAGAGGCAAGATACTGGAAACAGAGGCTGGGAGGGGCTATGCGTCAGGCGGGGATAATTGCT
GCCGGAGGTATTTATGCCCTGAAGCATAACCTTGAGCGTTTACAGGAAGATAATGATAATGCCAGGTATCTGGCCGAAGA
GATGGCCCGGCTTAAAAATATAGAGATTGATCCGGAGACAGTTGAGACCAATATCGTTATCTTTAAGGTTAAGGGCCTGA
CAGCAGAACAATTTTCTAAAGAATTGATTAAGAGAGGGGTCAGGGTCAGTATAATCGCTAAAGATACCCTCCGGGCGGTT
ACTCACCTGGATGTTAATCGTCAGGATATTGATTATGCTTTAACGGTAATTAAAGAAGTGACCGGTAGTTAA

Upstream 100 bases:

>100_bases
TAAACAATAAAAAAAGTTATAATTGAGAACAAATAGATAGCAAAATTTTTGTCTGGAGAAAATATATGTAAGAACTTTAT
TTCATAAAGGAGGTAATTCA

Downstream 100 bases:

>100_bases
TAAAGGTCTTTCATTTGAGACCTTCGAGTTTATAAATGAAGCTTAATATTTCAGCAATTACTTTATATAATTCTTGAGGA
ATTTCAGTTCCGATATTGAG

Product: threonine aldolase

Products: NA

Alternate protein names: Low-specificity L-TA [H]

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MKLKVDLFSDTGTRPSKEMREFMAKAEVGDEQLGEDPSVNRLNEMVAELLGKEDAIYLPSGLMANQISFAVHCRPGDEII
MDKTAHPIHFEGGAVSVISGASINPLDGENGIFTTEQVIKAIRTSDYHHPRTRLISIEQTSNLGGGTIWPLDVIEDICQL
AREHNLKTHMDGARLLNAVAATGIPASKYAEHFDSIWIDLSKGLGAPVGSVLASSRDFIEEARYWKQRLGGAMRQAGIIA
AGGIYALKHNLERLQEDNDNARYLAEEMARLKNIEIDPETVETNIVIFKVKGLTAEQFSKELIKRGVRVSIIAKDTLRAV
THLDVNRQDIDYALTVIKEVTGS

Sequences:

>Translated_343_residues
MKLKVDLFSDTGTRPSKEMREFMAKAEVGDEQLGEDPSVNRLNEMVAELLGKEDAIYLPSGLMANQISFAVHCRPGDEII
MDKTAHPIHFEGGAVSVISGASINPLDGENGIFTTEQVIKAIRTSDYHHPRTRLISIEQTSNLGGGTIWPLDVIEDICQL
AREHNLKTHMDGARLLNAVAATGIPASKYAEHFDSIWIDLSKGLGAPVGSVLASSRDFIEEARYWKQRLGGAMRQAGIIA
AGGIYALKHNLERLQEDNDNARYLAEEMARLKNIEIDPETVETNIVIFKVKGLTAEQFSKELIKRGVRVSIIAKDTLRAV
THLDVNRQDIDYALTVIKEVTGS
>Mature_343_residues
MKLKVDLFSDTGTRPSKEMREFMAKAEVGDEQLGEDPSVNRLNEMVAELLGKEDAIYLPSGLMANQISFAVHCRPGDEII
MDKTAHPIHFEGGAVSVISGASINPLDGENGIFTTEQVIKAIRTSDYHHPRTRLISIEQTSNLGGGTIWPLDVIEDICQL
AREHNLKTHMDGARLLNAVAATGIPASKYAEHFDSIWIDLSKGLGAPVGSVLASSRDFIEEARYWKQRLGGAMRQAGIIA
AGGIYALKHNLERLQEDNDNARYLAEEMARLKNIEIDPETVETNIVIFKVKGLTAEQFSKELIKRGVRVSIIAKDTLRAV
THLDVNRQDIDYALTVIKEVTGS

Specific function: Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. L-threo-phenylserine and L- erythro-phenylserine are also good substrates [H]

COG id: COG2008

COG function: function code E; Threonine aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1787095, Length=327, Percent_Identity=42.2018348623853, Blast_Score=256, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI193206520, Length=344, Percent_Identity=36.3372093023256, Blast_Score=199, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI193206522, Length=344, Percent_Identity=36.3372093023256, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI193206524, Length=344, Percent_Identity=36.3372093023256, Blast_Score=199, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6320789, Length=339, Percent_Identity=33.9233038348083, Blast_Score=170, Evalue=3e-43,
Organism=Drosophila melanogaster, GI21355439, Length=368, Percent_Identity=36.6847826086957, Blast_Score=224, Evalue=6e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001597
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01212 Beta_elim_lyase [H]

EC number: =4.1.2.5 [H]

Molecular weight: Translated: 37817; Mature: 37817

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLKVDLFSDTGTRPSKEMREFMAKAEVGDEQLGEDPSVNRLNEMVAELLGKEDAIYLPS
CEEEEEECCCCCCCCHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHCCCCCEECCC
GLMANQISFAVHCRPGDEIIMDKTAHPIHFEGGAVSVISGASINPLDGENGIFTTEQVIK
CCHHCCEEEEEEECCCCCEEECCCCCCEEECCCEEEEECCCCCCCCCCCCCCCCHHHHHH
AIRTSDYHHPRTRLISIEQTSNLGGGTIWPLDVIEDICQLAREHNLKTHMDGARLLNAVA
HHHHCCCCCCCCEEEEEECCCCCCCCEECHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHH
ATGIPASKYAEHFDSIWIDLSKGLGAPVGSVLASSRDFIEEARYWKQRLGGAMRQAGIIA
HCCCCHHHHHHHHHHHEEEHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
AGGIYALKHNLERLQEDNDNARYLAEEMARLKNIEIDPETVETNIVIFKVKGLTAEQFSK
ECHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEEECEEEEEEECCCCHHHHHH
ELIKRGVRVSIIAKDTLRAVTHLDVNRQDIDYALTVIKEVTGS
HHHHCCCEEEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLKVDLFSDTGTRPSKEMREFMAKAEVGDEQLGEDPSVNRLNEMVAELLGKEDAIYLPS
CEEEEEECCCCCCCCHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHCCCCCEECCC
GLMANQISFAVHCRPGDEIIMDKTAHPIHFEGGAVSVISGASINPLDGENGIFTTEQVIK
CCHHCCEEEEEEECCCCCEEECCCCCCEEECCCEEEEECCCCCCCCCCCCCCCCHHHHHH
AIRTSDYHHPRTRLISIEQTSNLGGGTIWPLDVIEDICQLAREHNLKTHMDGARLLNAVA
HHHHCCCCCCCCEEEEEECCCCCCCCEECHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHH
ATGIPASKYAEHFDSIWIDLSKGLGAPVGSVLASSRDFIEEARYWKQRLGGAMRQAGIIA
HCCCCHHHHHHHHHHHEEEHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
AGGIYALKHNLERLQEDNDNARYLAEEMARLKNIEIDPETVETNIVIFKVKGLTAEQFSK
ECHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEEECEEEEEEECCCCHHHHHH
ELIKRGVRVSIIAKDTLRAVTHLDVNRQDIDYALTVIKEVTGS
HHHHCCCEEEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]