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The map label for this gene is ldh [H]

Identifier: 220932450

GI number: 220932450

Start: 1730260

End: 1731228

Strand: Reverse

Name: ldh [H]

Synonym: Hore_16140

Alternate gene names: 220932450

Gene position: 1731228-1730260 (Counterclockwise)

Preceding gene: 220932451

Following gene: 220932449

Centisome position: 67.15

GC content: 40.45

Gene sequence:

>969_bases
TTGAAAGATAAAGTAGTTGTTGTCGGAGCAGGGTTTGTCGGTTCAACGTCGGCTTATGCTATAATGAACTGGGGCCTGGC
CTCAGAAATAGTGTTAATTGATATAGATAAGGACAGGGCTGAAGGAGAGGCCATGGATTTAAACCATGGGGCATCTTTTG
TTAAGCCTGTTAGAATAAGAAGTGGCGATTACGAAGAATGTAAGGATGCCAGAATAGTAATAATTAGTGCCGGGGCTAAC
CAAAAGCCCGGTGAGACGAGACTGGATCTTGTTAAGAAAAATACTGAAATCTTTAAGGAGATAATCCCCAGAATACTCAA
GTATACAAGAGAAGCTATAATCCTTGTGGTTACCAATCCGGTAGACGTCTTAACCTATGTAACCTGGAAAATCTCCGGTC
TTCCCAGAAATCAGGTCCTCGGCTCAGGGACGGTCCTCGATACCTCACGCTTCAGGTATTTACTCAGTGAACATTGTCGG
GTTAATCCCAAAAATATTCATGCCTATATTATAGGTGAACACGGTGACCATGAAGTTGCAGCCTGGAGTTTAACAAATGT
GGCCGGGGTCAATTTTGATGATTATTGTCTTGTTTGTGGCAAGGATTGTTGTACTAAAGAATTTAGAAAAGATATATATA
ATAAGGTTAAAAATGCTGCCTATGATATTATTGAAAGAAAGGATGCTACATATTATGCGGTGGGGCTGGCAGTAGCCCGA
ATTGTTGAGAGTATTTTCAGGGATGAGAGTTCTATTTTAACGGTATCCAGTGTACTACAGGGTGAATATAATCTTGATGG
TCTGGCTTTAAGCCTTCCCAGTATAGTTGGAGAAAAAGGGATTAAAAAAGTTTTGACCCTTGAGTTCTCTGCTAAAGAAG
AAGAAGATTTATATGAATCGGCCCGGATATTAAAAGATGTAATAAAGGACCTGGATATAACGCGGTCTCCCCAGGATATA
TTAGTTTAG

Upstream 100 bases:

>100_bases
ATATCCACTAATAATGAACCACCTACCCATACTGAAGAAACAAATTGTATGAGTTTTGAATCTAAATTATATTAATTCAC
CCCGGGGGAGTGGATTTTAT

Downstream 100 bases:

>100_bases
GATTTTTGATAACCTGTTTTTCTGGTTCATAACCGGGCGATAAACTTAAAATTAAATATTAATTTTTATTAATAGATTCA
GTTAATAAGCTATTTTATAC

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: L-LDH [H]

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MKDKVVVVGAGFVGSTSAYAIMNWGLASEIVLIDIDKDRAEGEAMDLNHGASFVKPVRIRSGDYEECKDARIVIISAGAN
QKPGETRLDLVKKNTEIFKEIIPRILKYTREAIILVVTNPVDVLTYVTWKISGLPRNQVLGSGTVLDTSRFRYLLSEHCR
VNPKNIHAYIIGEHGDHEVAAWSLTNVAGVNFDDYCLVCGKDCCTKEFRKDIYNKVKNAAYDIIERKDATYYAVGLAVAR
IVESIFRDESSILTVSSVLQGEYNLDGLALSLPSIVGEKGIKKVLTLEFSAKEEEDLYESARILKDVIKDLDITRSPQDI
LV

Sequences:

>Translated_322_residues
MKDKVVVVGAGFVGSTSAYAIMNWGLASEIVLIDIDKDRAEGEAMDLNHGASFVKPVRIRSGDYEECKDARIVIISAGAN
QKPGETRLDLVKKNTEIFKEIIPRILKYTREAIILVVTNPVDVLTYVTWKISGLPRNQVLGSGTVLDTSRFRYLLSEHCR
VNPKNIHAYIIGEHGDHEVAAWSLTNVAGVNFDDYCLVCGKDCCTKEFRKDIYNKVKNAAYDIIERKDATYYAVGLAVAR
IVESIFRDESSILTVSSVLQGEYNLDGLALSLPSIVGEKGIKKVLTLEFSAKEEEDLYESARILKDVIKDLDITRSPQDI
LV
>Mature_322_residues
MKDKVVVVGAGFVGSTSAYAIMNWGLASEIVLIDIDKDRAEGEAMDLNHGASFVKPVRIRSGDYEECKDARIVIISAGAN
QKPGETRLDLVKKNTEIFKEIIPRILKYTREAIILVVTNPVDVLTYVTWKISGLPRNQVLGSGTVLDTSRFRYLLSEHCR
VNPKNIHAYIIGEHGDHEVAAWSLTNVAGVNFDDYCLVCGKDCCTKEFRKDIYNKVKNAAYDIIERKDATYYAVGLAVAR
IVESIFRDESSILTVSSVLQGEYNLDGLALSLPSIVGEKGIKKVLTLEFSAKEEEDLYESARILKDVIKDLDITRSPQDI
LV

Specific function: Catalyzes The Reversible Oxidation Of Malate To Oxaloacetate. [C]

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. LDH family [H]

Homologues:

Organism=Homo sapiens, GI291575128, Length=311, Percent_Identity=42.443729903537, Blast_Score=265, Evalue=4e-71,
Organism=Homo sapiens, GI4557032, Length=311, Percent_Identity=42.443729903537, Blast_Score=265, Evalue=4e-71,
Organism=Homo sapiens, GI260099723, Length=314, Percent_Identity=42.6751592356688, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI5031857, Length=314, Percent_Identity=42.6751592356688, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI9257228, Length=310, Percent_Identity=44.1935483870968, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI4504973, Length=310, Percent_Identity=44.1935483870968, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI15082234, Length=313, Percent_Identity=40.5750798722045, Blast_Score=253, Evalue=1e-67,
Organism=Homo sapiens, GI47059044, Length=313, Percent_Identity=40.5750798722045, Blast_Score=252, Evalue=3e-67,
Organism=Homo sapiens, GI221136809, Length=313, Percent_Identity=40.5750798722045, Blast_Score=252, Evalue=3e-67,
Organism=Homo sapiens, GI260099727, Length=216, Percent_Identity=46.7592592592593, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI260099725, Length=192, Percent_Identity=49.4791666666667, Blast_Score=204, Evalue=6e-53,
Organism=Homo sapiens, GI207028494, Length=199, Percent_Identity=40.7035175879397, Blast_Score=158, Evalue=7e-39,
Organism=Homo sapiens, GI103472011, Length=318, Percent_Identity=28.6163522012579, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI103472015, Length=184, Percent_Identity=32.6086956521739, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI21735621, Length=325, Percent_Identity=25.5384615384615, Blast_Score=68, Evalue=9e-12,
Organism=Escherichia coli, GI1789632, Length=273, Percent_Identity=28.2051282051282, Blast_Score=75, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17535107, Length=292, Percent_Identity=43.4931506849315, Blast_Score=262, Evalue=2e-70,
Organism=Drosophila melanogaster, GI17136226, Length=308, Percent_Identity=42.5324675324675, Blast_Score=265, Evalue=3e-71,
Organism=Drosophila melanogaster, GI45550422, Length=318, Percent_Identity=33.0188679245283, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24647881, Length=335, Percent_Identity=23.8805970149254, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: 2640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 260 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2380 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). 260 Molecules/Cell In: Stationary Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001557
- InterPro:   IPR011304
- InterPro:   IPR018177
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N [H]

EC number: =1.1.1.27 [H]

Molecular weight: Translated: 35794; Mature: 35794

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDKVVVVGAGFVGSTSAYAIMNWGLASEIVLIDIDKDRAEGEAMDLNHGASFVKPVRIR
CCCCEEEEECCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCEEECCCCCCCCCEEEEC
SGDYEECKDARIVIISAGANQKPGETRLDLVKKNTEIFKEIIPRILKYTREAIILVVTNP
CCCHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECC
VDVLTYVTWKISGLPRNQVLGSGTVLDTSRFRYLLSEHCRVNPKNIHAYIIGEHGDHEVA
HHEEEEEEEEECCCCHHHCCCCCCEECHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCEE
AWSLTNVAGVNFDDYCLVCGKDCCTKEFRKDIYNKVKNAAYDIIERKDATYYAVGLAVAR
EEEECCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
IVESIFRDESSILTVSSVLQGEYNLDGLALSLPSIVGEKGIKKVLTLEFSAKEEEDLYES
HHHHHHCCCCCEEEHHHHHCCCCCCCCCEEEHHHHHHHHHHHEEEEEEECCCCHHHHHHH
ARILKDVIKDLDITRSPQDILV
HHHHHHHHHHCCCCCCCHHHCC
>Mature Secondary Structure
MKDKVVVVGAGFVGSTSAYAIMNWGLASEIVLIDIDKDRAEGEAMDLNHGASFVKPVRIR
CCCCEEEEECCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCEEECCCCCCCCCEEEEC
SGDYEECKDARIVIISAGANQKPGETRLDLVKKNTEIFKEIIPRILKYTREAIILVVTNP
CCCHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECC
VDVLTYVTWKISGLPRNQVLGSGTVLDTSRFRYLLSEHCRVNPKNIHAYIIGEHGDHEVA
HHEEEEEEEEECCCCHHHCCCCCCEECHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCEE
AWSLTNVAGVNFDDYCLVCGKDCCTKEFRKDIYNKVKNAAYDIIERKDATYYAVGLAVAR
EEEECCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
IVESIFRDESSILTVSSVLQGEYNLDGLALSLPSIVGEKGIKKVLTLEFSAKEEEDLYES
HHHHHHCCCCCEEEHHHHHCCCCCCCCCEEEHHHHHHHHHHHEEEEEEECCCCHHHHHHH
ARILKDVIKDLDITRSPQDILV
HHHHHHHHHHCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA