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The map label for this gene is mrdA [H]

Identifier: 220932257

GI number: 220932257

Start: 1508417

End: 1510432

Strand: Reverse

Name: mrdA [H]

Synonym: Hore_14210

Alternate gene names: 220932257

Gene position: 1510432-1508417 (Counterclockwise)

Preceding gene: 220932258

Following gene: 220932256

Centisome position: 58.59

GC content: 41.96

Gene sequence:

>2016_bases
ATGGTTAAACGGATACTGGTTCTGAAGGTTGTATTTTTGCTGGCATTAATTATAGTTGTTGCCAGAGCGGCCCAGCTTCA
GCTGGTGATGGGTGATTATTATTACCAGCTGTCGGAGGGTAACCGGATATCCCTGAGGCCTATTAATGCTCCCCGGGGAA
AAATATATGATAAAAATGGAAAAATTCTGGTATCCAATAAACTCGCCTATGACCTGTATTTACTCCCCAATGAAGTCCCT
CCAGACATTTCTGTAAAAGAGATACTTCACCGCCTCAGTAAATATACCAATTTACCTATCAGCCAACTTGAAAAAAATTA
TCAGGAACATGAGGGTGATAGTTCACCCTCTCCTATTATCCTGAAAAGGAATATAACACCGGAAACAATGGTCATTATCC
AGGAAAATGCAGAAAGCCTTCCTGGTATTTTTATTAAGGAATCAGCAATACGTTACTATGTCTATGGTGATTTAGCCCCA
CATGTGGTTGGTTATGTAGGGGAAATTAGTACAGAGGAATTAAGAAACCTGACCAGTCAGGGTTACGATTACCGCGGTGG
GGATATTGTAGGTAAGGCAGGACTGGAACGTCAGTATGAAATCTATCTGAAAGGGACTGACGGGATTGAACAGATTGAGG
TTAACAGCCTTCGGGAAAAGGTCAGGACCCTGGGGATAAAACCACCCAGACCAGGTAATAACCTTATTCTAAATTTAGAC
TATGAATTACAGAAAGAGACAGAGCGTTTGCTTGAAGAACATTTTTATAAACTCAGGGAGGAATTCCTGGATGATCCGGA
AATGTACAGCCCGACAGGGGCTGCAGCAATTGTAATGGACCCCGACACCGGAGAAATACTGGCCATGGCCAGTATTCCTG
ATTATAATTTAAATGAATTTGCCGAAGGCCTGTCTCTTAAGGAGTATAAAGAACTTTTAAATGATCCCTTAAAACCCTTA
TTAAACCGGACTATTATGGCGGCTGTTCCTCCTGGTTCCATATTCAAACTTGTTACCGGTACGGCGGCTATAGAGGAACT
GGGGATCAGGGCTGATACCAAATTTGTTGATGAAAACGGGATGTTTTTTGTACCCAACTGGTCAAGACCCTATAAAAACT
GGCACCCCGGTGGTGAAGGTGAATTAAGCTTCACCAGGGCCATTGCCCGGTCCAATAACGTTGTTTTTTATGAGTTGGGT
TACAGGCTTTACAAAAAATATAGAGGGAAGAAATTAAAATGGTATGCCCATCAGTATGGACTCGGTTCTCCAACGGGTAT
TGACCTTCCCGGTGAAAAAGAAGGGCTGGTACCTGATGAAAAATGGAAGAGGAAAGTTTTCAATGAAGGCTGGTATCCTG
GTGATTCTGTAAACCTGTCAATTGGCCAGGGTGGACTTTTAACCACTCCACTACAGCTTGCGGTTATGGTCAGTTCTATT
GCCAATGGAGGAATTATATATGAACCTCATCTGGTGGATAAAGTTATTAGTCCTGATGGTGAGGTTGTCCTGGATGTTAA
ACCCCGCATTAAAAAGAGATTACCATTTAGAAGGCAGACCCTGAATATTCTGGAAAAAGGAATGGTGGAGGTTACTTCAA
CTTCTTATGGAACTGCCAGGTCTGTTTTTGCTGATTTTCCCATAAAAGTGGCCGGTAAGACCGGTACTGCCCAGACCGGG
ACAAGCAGACCCAATCACGGTTGGTTTGCTGGATATGCCCCTGTTGAGGACCCTGAAATTACTGTGCTGGTGTTTTTAGA
GAATGGTAATTCCAGTAGCTATACTTTACCGATTGTAGCCGGTATTTTAAGAACTTATTTTGGGATAGAAGAACCTGTTG
AAGAAGAACAAAATAATGAGGGTTCAAGTAGTAGTCTGGATGAAAATGTCCAGGAGGTTGAAGACAAAACAGGGGATAAA
AAAGACAAGGAACAGGAAATAGAAAAAGAGAGAGAAATACAAGATGATGATAAGAAACTTCTGGAATATCTTGAAGAGGT
TTTTTCTAAAGAATAG

Upstream 100 bases:

>100_bases
TTAAGACAGACAATTTTACCTGAGGCGTTTTTTAATAGTATAGCCGGAATTATTATCTACTACATTGTTTATCGCCTTGA
AAGAGGTGGCGAGTTATATT

Downstream 100 bases:

>100_bases
GTATTATTTAAAGTAATTAATTAGATAATGCAGGAAATAAAAGCATAAGTGTAGAAATAATACAAAGAAACAAGAAGGGA
CAAGGGTAGATGACAATGAG

Product: Peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 671; Mature: 671

Protein sequence:

>671_residues
MVKRILVLKVVFLLALIIVVARAAQLQLVMGDYYYQLSEGNRISLRPINAPRGKIYDKNGKILVSNKLAYDLYLLPNEVP
PDISVKEILHRLSKYTNLPISQLEKNYQEHEGDSSPSPIILKRNITPETMVIIQENAESLPGIFIKESAIRYYVYGDLAP
HVVGYVGEISTEELRNLTSQGYDYRGGDIVGKAGLERQYEIYLKGTDGIEQIEVNSLREKVRTLGIKPPRPGNNLILNLD
YELQKETERLLEEHFYKLREEFLDDPEMYSPTGAAAIVMDPDTGEILAMASIPDYNLNEFAEGLSLKEYKELLNDPLKPL
LNRTIMAAVPPGSIFKLVTGTAAIEELGIRADTKFVDENGMFFVPNWSRPYKNWHPGGEGELSFTRAIARSNNVVFYELG
YRLYKKYRGKKLKWYAHQYGLGSPTGIDLPGEKEGLVPDEKWKRKVFNEGWYPGDSVNLSIGQGGLLTTPLQLAVMVSSI
ANGGIIYEPHLVDKVISPDGEVVLDVKPRIKKRLPFRRQTLNILEKGMVEVTSTSYGTARSVFADFPIKVAGKTGTAQTG
TSRPNHGWFAGYAPVEDPEITVLVFLENGNSSSYTLPIVAGILRTYFGIEEPVEEEQNNEGSSSSLDENVQEVEDKTGDK
KDKEQEIEKEREIQDDDKKLLEYLEEVFSKE

Sequences:

>Translated_671_residues
MVKRILVLKVVFLLALIIVVARAAQLQLVMGDYYYQLSEGNRISLRPINAPRGKIYDKNGKILVSNKLAYDLYLLPNEVP
PDISVKEILHRLSKYTNLPISQLEKNYQEHEGDSSPSPIILKRNITPETMVIIQENAESLPGIFIKESAIRYYVYGDLAP
HVVGYVGEISTEELRNLTSQGYDYRGGDIVGKAGLERQYEIYLKGTDGIEQIEVNSLREKVRTLGIKPPRPGNNLILNLD
YELQKETERLLEEHFYKLREEFLDDPEMYSPTGAAAIVMDPDTGEILAMASIPDYNLNEFAEGLSLKEYKELLNDPLKPL
LNRTIMAAVPPGSIFKLVTGTAAIEELGIRADTKFVDENGMFFVPNWSRPYKNWHPGGEGELSFTRAIARSNNVVFYELG
YRLYKKYRGKKLKWYAHQYGLGSPTGIDLPGEKEGLVPDEKWKRKVFNEGWYPGDSVNLSIGQGGLLTTPLQLAVMVSSI
ANGGIIYEPHLVDKVISPDGEVVLDVKPRIKKRLPFRRQTLNILEKGMVEVTSTSYGTARSVFADFPIKVAGKTGTAQTG
TSRPNHGWFAGYAPVEDPEITVLVFLENGNSSSYTLPIVAGILRTYFGIEEPVEEEQNNEGSSSSLDENVQEVEDKTGDK
KDKEQEIEKEREIQDDDKKLLEYLEEVFSKE
>Mature_671_residues
MVKRILVLKVVFLLALIIVVARAAQLQLVMGDYYYQLSEGNRISLRPINAPRGKIYDKNGKILVSNKLAYDLYLLPNEVP
PDISVKEILHRLSKYTNLPISQLEKNYQEHEGDSSPSPIILKRNITPETMVIIQENAESLPGIFIKESAIRYYVYGDLAP
HVVGYVGEISTEELRNLTSQGYDYRGGDIVGKAGLERQYEIYLKGTDGIEQIEVNSLREKVRTLGIKPPRPGNNLILNLD
YELQKETERLLEEHFYKLREEFLDDPEMYSPTGAAAIVMDPDTGEILAMASIPDYNLNEFAEGLSLKEYKELLNDPLKPL
LNRTIMAAVPPGSIFKLVTGTAAIEELGIRADTKFVDENGMFFVPNWSRPYKNWHPGGEGELSFTRAIARSNNVVFYELG
YRLYKKYRGKKLKWYAHQYGLGSPTGIDLPGEKEGLVPDEKWKRKVFNEGWYPGDSVNLSIGQGGLLTTPLQLAVMVSSI
ANGGIIYEPHLVDKVISPDGEVVLDVKPRIKKRLPFRRQTLNILEKGMVEVTSTSYGTARSVFADFPIKVAGKTGTAQTG
TSRPNHGWFAGYAPVEDPEITVLVFLENGNSSSYTLPIVAGILRTYFGIEEPVEEEQNNEGSSSSLDENVQEVEDKTGDK
KDKEQEIEKEREIQDDDKKLLEYLEEVFSKE

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=620, Percent_Identity=31.9354838709677, Blast_Score=300, Evalue=2e-82,
Organism=Escherichia coli, GI1786272, Length=628, Percent_Identity=25, Blast_Score=132, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 75517; Mature: 75517

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00191 CYTOCHROME_B5_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKRILVLKVVFLLALIIVVARAAQLQLVMGDYYYQLSEGNRISLRPINAPRGKIYDKNG
CCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCEEEEECCCCEEEEEECCCCCCCEECCCC
KILVSNKLAYDLYLLPNEVPPDISVKEILHRLSKYTNLPISQLEKNYQEHEGDSSPSPII
CEEEECCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCEE
LKRNITPETMVIIQENAESLPGIFIKESAIRYYVYGDLAPHVVGYVGEISTEELRNLTSQ
EECCCCCCEEEEECCCCCCCCCEEEECCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHC
GYDYRGGDIVGKAGLERQYEIYLKGTDGIEQIEVNSLREKVRTLGIKPPRPGNNLILNLD
CCCCCCCCEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEC
YELQKETERLLEEHFYKLREEFLDDPEMYSPTGAAAIVMDPDTGEILAMASIPDYNLNEF
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCEEEEECCCCCCHHHH
AEGLSLKEYKELLNDPLKPLLNRTIMAAVPPGSIFKLVTGTAAIEELGIRADTKFVDENG
HCCCCHHHHHHHHHCHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEECCCC
MFFVPNWSRPYKNWHPGGEGELSFTRAIARSNNVVFYELGYRLYKKYRGKKLKWYAHQYG
EEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEHHHHHHHHHHCCCEEEEEEECCC
LGSPTGIDLPGEKEGLVPDEKWKRKVFNEGWYPGDSVNLSIGQGGLLTTPLQLAVMVSSI
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHH
ANGGIIYEPHLVDKVISPDGEVVLDVKPRIKKRLPFRRQTLNILEKGMVEVTSTSYGTAR
CCCCEEECCHHHHHHHCCCCCEEEECCHHHHHCCCHHHHHHHHHHHCCEEEECCCCCCHH
SVFADFPIKVAGKTGTAQTGTSRPNHGWFAGYAPVEDPEITVLVFLENGNSSSYTLPIVA
HHHHCCCEEEECCCCCCCCCCCCCCCCEEECCCCCCCCCEEEEEEEECCCCCCEEHHHHH
GILRTYFGIEEPVEEEQNNEGSSSSLDENVQEVEDKTGDKKDKEQEIEKEREIQDDDKKL
HHHHHHCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHH
LEYLEEVFSKE
HHHHHHHHCCC
>Mature Secondary Structure
MVKRILVLKVVFLLALIIVVARAAQLQLVMGDYYYQLSEGNRISLRPINAPRGKIYDKNG
CCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCEEEEECCCCEEEEEECCCCCCCEECCCC
KILVSNKLAYDLYLLPNEVPPDISVKEILHRLSKYTNLPISQLEKNYQEHEGDSSPSPII
CEEEECCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCEE
LKRNITPETMVIIQENAESLPGIFIKESAIRYYVYGDLAPHVVGYVGEISTEELRNLTSQ
EECCCCCCEEEEECCCCCCCCCEEEECCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHC
GYDYRGGDIVGKAGLERQYEIYLKGTDGIEQIEVNSLREKVRTLGIKPPRPGNNLILNLD
CCCCCCCCEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEC
YELQKETERLLEEHFYKLREEFLDDPEMYSPTGAAAIVMDPDTGEILAMASIPDYNLNEF
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCEEEEECCCCCCHHHH
AEGLSLKEYKELLNDPLKPLLNRTIMAAVPPGSIFKLVTGTAAIEELGIRADTKFVDENG
HCCCCHHHHHHHHHCHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEECCCC
MFFVPNWSRPYKNWHPGGEGELSFTRAIARSNNVVFYELGYRLYKKYRGKKLKWYAHQYG
EEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEHHHHHHHHHHCCCEEEEEEECCC
LGSPTGIDLPGEKEGLVPDEKWKRKVFNEGWYPGDSVNLSIGQGGLLTTPLQLAVMVSSI
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHH
ANGGIIYEPHLVDKVISPDGEVVLDVKPRIKKRLPFRRQTLNILEKGMVEVTSTSYGTAR
CCCCEEECCHHHHHHHCCCCCEEEECCHHHHHCCCHHHHHHHHHHHCCEEEECCCCCCHH
SVFADFPIKVAGKTGTAQTGTSRPNHGWFAGYAPVEDPEITVLVFLENGNSSSYTLPIVA
HHHHCCCEEEECCCCCCCCCCCCCCCCEEECCCCCCCCCEEEEEEEECCCCCCEEHHHHH
GILRTYFGIEEPVEEEQNNEGSSSSLDENVQEVEDKTGDKKDKEQEIEKEREIQDDDKKL
HHHHHHCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHH
LEYLEEVFSKE
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]