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The map label for this gene is lepB2 [H]

Identifier: 220932064

GI number: 220932064

Start: 1321709

End: 1322230

Strand: Reverse

Name: lepB2 [H]

Synonym: Hore_12270

Alternate gene names: 220932064

Gene position: 1322230-1321709 (Counterclockwise)

Preceding gene: 220932065

Following gene: 220932063

Centisome position: 51.29

GC content: 40.42

Gene sequence:

>522_bases
GTGGATAGTACAGATATAAAAGAGTTTTTCCAATCATTTGTCATTGCAGCCATACTGGCTTTTTTTATAATTACCTTTAT
AGCCCAGTCTTTTGTTGTTGATGGAGAGTCTATGGAGCCTACCCTGCATGATGGGGAGAGGCTTTTTGTAAATAAATTCA
TTTACAGATTTCATCCCCCGGAACGCTATGATATAGTTGTTTTTCGTCCCTATCAGGGGCAGAGTAAACGCTTTATTAAA
AGGGTTATAGGTTTGCCAGGTGAGACTATATTTATAAGGGATGGTGTTACCTATATAAATGGTGAGCCTCTAAAAGAAGA
TTTTATTAATGGGCCCATGAGGAGAAAATTTGGCCCTTTTTACGTGCCTGAAAACAGTGTTTTTGTGATGGGGGATAACC
GTAATAACAGTATGGACAGCCGGCACTTTGGCTGTGTGCCATTTGAATCAATAGAAGGCAGGGCTTTCTGGGTTTACTGG
CCAGTTACCAAAATGAGGCTCATTGGTCACAAGGTGGAATAG

Upstream 100 bases:

>100_bases
GGATATTGATTTTGTCAAAAATGCAATTGCCCGCCTGGATAATACAGAAGATGAAGAATAATCTTTATTGTATTTACCTG
TGGTTGTAGGGGGGAAAAAG

Downstream 100 bases:

>100_bases
ACTTTCTGATAATTATGTTGTTATTGATGTTCAAATATTTTGAAGGAAAGGCAGGAGGTCAGGTATGAGATATAAACAGA
AGAGGATTTTAAATGCCATC

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I-2; Leader peptidase I-2 [H]

Number of amino acids: Translated: 173; Mature: 173

Protein sequence:

>173_residues
MDSTDIKEFFQSFVIAAILAFFIITFIAQSFVVDGESMEPTLHDGERLFVNKFIYRFHPPERYDIVVFRPYQGQSKRFIK
RVIGLPGETIFIRDGVTYINGEPLKEDFINGPMRRKFGPFYVPENSVFVMGDNRNNSMDSRHFGCVPFESIEGRAFWVYW
PVTKMRLIGHKVE

Sequences:

>Translated_173_residues
MDSTDIKEFFQSFVIAAILAFFIITFIAQSFVVDGESMEPTLHDGERLFVNKFIYRFHPPERYDIVVFRPYQGQSKRFIK
RVIGLPGETIFIRDGVTYINGEPLKEDFINGPMRRKFGPFYVPENSVFVMGDNRNNSMDSRHFGCVPFESIEGRAFWVYW
PVTKMRLIGHKVE
>Mature_173_residues
MDSTDIKEFFQSFVIAAILAFFIITFIAQSFVVDGESMEPTLHDGERLFVNKFIYRFHPPERYDIVVFRPYQGQSKRFIK
RVIGLPGETIFIRDGVTYINGEPLKEDFINGPMRRKFGPFYVPENSVFVMGDNRNNSMDSRHFGCVPFESIEGRAFWVYW
PVTKMRLIGHKVE

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Homo sapiens, GI21450679, Length=147, Percent_Identity=27.891156462585, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24642241, Length=155, Percent_Identity=27.0967741935484, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 20237; Mature: 20237

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSTDIKEFFQSFVIAAILAFFIITFIAQSFVVDGESMEPTLHDGERLFVNKFIYRFHPP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHCCCC
ERYDIVVFRPYQGQSKRFIKRVIGLPGETIFIRDGVTYINGEPLKEDFINGPMRRKFGPF
CCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEECCEEEECCCCCHHHHCCCCHHHCCCCE
YVPENSVFVMGDNRNNSMDSRHFGCVPFESIEGRAFWVYWPVTKMRLIGHKVE
ECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHCCCCC
>Mature Secondary Structure
MDSTDIKEFFQSFVIAAILAFFIITFIAQSFVVDGESMEPTLHDGERLFVNKFIYRFHPP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHCCCC
ERYDIVVFRPYQGQSKRFIKRVIGLPGETIFIRDGVTYINGEPLKEDFINGPMRRKFGPF
CCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEECCEEEECCCCCHHHHCCCCHHHCCCCE
YVPENSVFVMGDNRNNSMDSRHFGCVPFESIEGRAFWVYWPVTKMRLIGHKVE
ECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]