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The map label for this gene is rsmH

Identifier: 220931744

GI number: 220931744

Start: 972444

End: 973379

Strand: Direct

Name: rsmH

Synonym: Hore_09010

Alternate gene names: 220931744

Gene position: 972444-973379 (Clockwise)

Preceding gene: 220931743

Following gene: 220931745

Centisome position: 37.72

GC content: 37.5

Gene sequence:

>936_bases
TTGTTGGAACATAAACCTGTATTATTAAAAGAATCACTTGACTATTTAAAGTGTAAAGAAAATGGAATATATATTGATGC
CACCCTGGGTCGGGGTGGCCATACTGAAGAAATCATAAAGGCTATAAATGACAGGGGCCTTGTAATCGGGATTGACCGTG
ATCATGAGGCCATTGAGTCGGTTAAAAAGAGATTAAAAAAGTATTCAAGTTTAAGGACTGTACATGATAATTTTACAAAT
ATACCATTTATATTAGAACAATTTAATATCAAAGCCGTGGATGGAATGTTGTTTGACCTGGGGGTATCATCACCACAGTT
TGATAATCCGGAAAGGGGTTTCAGTTATCGTAAAGAGGGTCCCCTTGATATGAGAATGGATAAGAATCAGGAACTGACTG
CAGAATATATAGTAAATAACTTTTCCCATGAAGAGTTAACAAATATATTTAAAGAATATGGGGAAGAACGATGGGCTTCC
CGGATTGCCAACTTTATCATTAAGTCCCGCCAACATAAACCAATTAAAACCACATTGCAGCTTACCACAATTATAAAAGA
CGCTATTCCTGCTTCTGCCAGACGAAAGGGTGGACATCCTGCCCGTCGCACTTTTCAGGCCCTGAGAATTGCAACCAATG
ATGAATTAAATATTTTAAAAAAGACCATAAACCATGTTGTAAAATTTTTGAAACCAGGTGGTAGAATTTGTATCATTAGT
TTTCATTCTCTGGAAGATAGAATTGTTAAAAAAACCTTCAGAGAACTGGCCCGGGATTGTGTTTGCCCCCCTGATTTCCC
GGAATGTGTTTGTGACCATAAAAGGAAACTTAAAATAATTACTAAAAAACCGGTTAAACCAGGGGAAAATGAAGTTGAAA
ATAATCCAAGGGCCCGAAGTGCCCGGCTCAGGGTTGCTGAAAGAGTTCTAAATTAA

Upstream 100 bases:

>100_bases
GTCTTCCAAGAGATGGGGAGGATACCTGGATTCTGCCGAAGAGTCATATGAAGAAATTGCCGCTGCCATGGAAGACTTAG
GTATTTAAATGGGAGTGTTT

Downstream 100 bases:

>100_bases
GAGGTGGGTGAATAAATTGTTACAGACGAGTTATAAGTATGACTATAACTATAATAATTTAAAAAATGAAGATAAGAAAA
GTAAAAATAATCGTTCTGTA

Product: S-adenosyl-methyltransferase MraW

Products: NA

Alternate protein names: 16S rRNA m(4)C1402 methyltransferase; rRNA (cytosine-N(4)-)-methyltransferase RsmH

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MLEHKPVLLKESLDYLKCKENGIYIDATLGRGGHTEEIIKAINDRGLVIGIDRDHEAIESVKKRLKKYSSLRTVHDNFTN
IPFILEQFNIKAVDGMLFDLGVSSPQFDNPERGFSYRKEGPLDMRMDKNQELTAEYIVNNFSHEELTNIFKEYGEERWAS
RIANFIIKSRQHKPIKTTLQLTTIIKDAIPASARRKGGHPARRTFQALRIATNDELNILKKTINHVVKFLKPGGRICIIS
FHSLEDRIVKKTFRELARDCVCPPDFPECVCDHKRKLKIITKKPVKPGENEVENNPRARSARLRVAERVLN

Sequences:

>Translated_311_residues
MLEHKPVLLKESLDYLKCKENGIYIDATLGRGGHTEEIIKAINDRGLVIGIDRDHEAIESVKKRLKKYSSLRTVHDNFTN
IPFILEQFNIKAVDGMLFDLGVSSPQFDNPERGFSYRKEGPLDMRMDKNQELTAEYIVNNFSHEELTNIFKEYGEERWAS
RIANFIIKSRQHKPIKTTLQLTTIIKDAIPASARRKGGHPARRTFQALRIATNDELNILKKTINHVVKFLKPGGRICIIS
FHSLEDRIVKKTFRELARDCVCPPDFPECVCDHKRKLKIITKKPVKPGENEVENNPRARSARLRVAERVLN
>Mature_311_residues
MLEHKPVLLKESLDYLKCKENGIYIDATLGRGGHTEEIIKAINDRGLVIGIDRDHEAIESVKKRLKKYSSLRTVHDNFTN
IPFILEQFNIKAVDGMLFDLGVSSPQFDNPERGFSYRKEGPLDMRMDKNQELTAEYIVNNFSHEELTNIFKEYGEERWAS
RIANFIIKSRQHKPIKTTLQLTTIIKDAIPASARRKGGHPARRTFQALRIATNDELNILKKTINHVVKFLKPGGRICIIS
FHSLEDRIVKKTFRELARDCVCPPDFPECVCDHKRKLKIITKKPVKPGENEVENNPRARSARLRVAERVLN

Specific function: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA

COG id: COG0275

COG function: function code M; Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RsmH family

Homologues:

Organism=Homo sapiens, GI165377209, Length=336, Percent_Identity=37.202380952381, Blast_Score=199, Evalue=2e-51,
Organism=Homo sapiens, GI165377202, Length=190, Percent_Identity=36.8421052631579, Blast_Score=123, Evalue=2e-28,
Organism=Escherichia coli, GI1786270, Length=311, Percent_Identity=41.8006430868167, Blast_Score=238, Evalue=4e-64,
Organism=Drosophila melanogaster, GI62472493, Length=329, Percent_Identity=33.7386018237082, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI28571637, Length=329, Percent_Identity=33.7386018237082, Blast_Score=169, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RSMH_HALOH (B8CWI8)

Other databases:

- EMBL:   CP001098
- RefSeq:   YP_002508652.1
- ProteinModelPortal:   B8CWI8
- GeneID:   7314024
- GenomeReviews:   CP001098_GR
- KEGG:   hor:Hore_09010
- HOGENOM:   HBG302779
- OMA:   PQLDDPE
- GO:   GO:0005737
- HAMAP:   MF_01007
- InterPro:   IPR002903
- PANTHER:   PTHR11265
- PIRSF:   PIRSF004486
- TIGRFAMs:   TIGR00006

Pfam domain/function: PF01795 Methyltransf_5

EC number: NA

Molecular weight: Translated: 35796; Mature: 35796

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: NA

Important sites: BINDING 52-52 BINDING 78-78 BINDING 99-99 BINDING 106-106

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEHKPVLLKESLDYLKCKENGIYIDATLGRGGHTEEIIKAINDRGLVIGIDRDHEAIES
CCCCCCHHHHHCCHHHEECCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCHHHHHH
VKKRLKKYSSLRTVHDNFTNIPFILEQFNIKAVDGMLFDLGVSSPQFDNPERGFSYRKEG
HHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHCCCCEECCCCCCCCCCCCCCCCCCCCC
PLDMRMDKNQELTAEYIVNNFSHEELTNIFKEYGEERWASRIANFIIKSRQHKPIKTTLQ
CCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LTTIIKDAIPASARRKGGHPARRTFQALRIATNDELNILKKTINHVVKFLKPGGRICIIS
HHHHHHHHCCHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEE
FHSLEDRIVKKTFRELARDCVCPPDFPECVCDHKRKLKIITKKPVKPGENEVENNPRARS
ECCHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCEEEEEECCCCCCCCCHHCCCCCHHH
ARLRVAERVLN
HHHHHHHHHCC
>Mature Secondary Structure
MLEHKPVLLKESLDYLKCKENGIYIDATLGRGGHTEEIIKAINDRGLVIGIDRDHEAIES
CCCCCCHHHHHCCHHHEECCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCHHHHHH
VKKRLKKYSSLRTVHDNFTNIPFILEQFNIKAVDGMLFDLGVSSPQFDNPERGFSYRKEG
HHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHCCCCEECCCCCCCCCCCCCCCCCCCCC
PLDMRMDKNQELTAEYIVNNFSHEELTNIFKEYGEERWASRIANFIIKSRQHKPIKTTLQ
CCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LTTIIKDAIPASARRKGGHPARRTFQALRIATNDELNILKKTINHVVKFLKPGGRICIIS
HHHHHHHHCCHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEE
FHSLEDRIVKKTFRELARDCVCPPDFPECVCDHKRKLKIITKKPVKPGENEVENNPRARS
ECCHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCEEEEEECCCCCCCCCHHCCCCCHHH
ARLRVAERVLN
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA